Zika virus persistently infects and is basolaterally released from primary human brain microvascular endothelial cells

mBio

Volumn 8, Issue 4, 2017, Pages

  Mladinich, Megan C ^a   Schwedes, John ^a   Mackow, Erich R ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Basolateral release; Cell survival; Chemokine CCL5; Human brain endothelial cells; IFN regulation; Innate immune regulation; ISG15 induction; Persistent infection; Transcriptome analysis; Zika virus

Indexed keywords

INTERFERON REGULATORY FACTOR 7; INTERFERON REGULATORY FACTOR 9; TRANSCRIPTOME; ALPHA INTERFERON; ANTIVIRUS AGENT; BETA INTERFERON; CCL5 PROTEIN, HUMAN; HERC5 PROTEIN, HUMAN; IRF7 PROTEIN, HUMAN; IRF9 PROTEIN, HUMAN; PROTEINASE; RANTES; SIGNAL PEPTIDE; USP18 PROTEIN, HUMAN;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; CAPILLARY ENDOTHELIAL CELL; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROCEPHALY; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; VERTICAL TRANSMISSION; VIRUS ENTRY; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSMISSION; ZIKA FEVER; BRAIN; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; GENE EXPRESSION PROFILING; GENETICS; INNATE IMMUNITY; MICROVASCULATURE; PATHOLOGY; PHYSIOLOGY; VASCULARIZATION; VIROLOGY; VIRUS RELEASE; ZIKA VIRUS;

ANTIVIRAL AGENTS; BRAIN; CELLS, CULTURED; CHEMOKINE CCL5; ENDOPEPTIDASES; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-7; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROVESSELS; VIRUS INTERNALIZATION; VIRUS RELEASE; VIRUS REPLICATION; ZIKA VIRUS;

EID: 85029177972     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00952-17     Document Type: Article

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