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Volumn 287, Issue 35, 2012, Pages 29406-29416

The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; CELLULAR FUNCTION; CHEMOKINES; DOSE-DEPENDENT MANNER; ENERGY DEMANDS; EX-VIVO; EXPERIMENTAL DATA; GLUCOSE UPTAKE; HUMAN CD3; T CELLS; UP-REGULATION;

EID: 84865479230     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.348946     Document Type: Article
Times cited : (63)

References (62)
  • 1
    • 0035063938 scopus 로고    scopus 로고
    • Chemokine signaling and functional responses: The role of receptor dimerization and TK pathway activation
    • Mellado, M., Rodríguez-Frade, J. M., Mañes, S., and Martínez-A, C. (2001) Chemokine signaling and functional responses: The role of receptor dimerization and TK pathway activation. Annu. Rev. Immunol. 19, 397-421
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 397-421
    • Mellado, M.1    Rodríguez-Frade, J.M.2    Mañes, S.3    Martínez-A, C.4
  • 2
    • 0842324615 scopus 로고    scopus 로고
    • Chemokines: Multiple levels of leukocyte migration control
    • Moser, B., Wolf, M., Walz, A., and Loetscher, P. (2004) Chemokines: Multiple levels of leukocyte migration control. Trends Immunol. 25, 75-84
    • (2004) Trends Immunol. , vol.25 , pp. 75-84
    • Moser, B.1    Wolf, M.2    Walz, A.3    Loetscher, P.4
  • 3
    • 0032127167 scopus 로고    scopus 로고
    • Chemokines and T lymphocytes: More than an attraction
    • Ward, S. G., Bacon, K., and Westwick, J. (1998) Chemokines and T lymphocytes: More than an attraction. Immunity 9, 1-11
    • (1998) Immunity , vol.9 , pp. 1-11
    • Ward, S.G.1    Bacon, K.2    Westwick, J.3
  • 4
    • 0037300378 scopus 로고    scopus 로고
    • Chemokines: Attractive mediators of the immune response
    • Wong, M. M., and Fish, E. N. (2003) Chemokines: Attractive mediators of the immune response. Semin. Immunol. 15, 5-14
    • (2003) Semin. Immunol. , vol.15 , pp. 5-14
    • Wong, M.M.1    Fish, E.N.2
  • 5
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill, F. (2004) Cancer and the chemokine network. Nat. Rev. Cancer 4, 540-550
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 6
    • 0035260758 scopus 로고    scopus 로고
    • Chemokines as regulators of T cell differentiation
    • Luther, S. A., and Cyster, J. G. (2001) Chemokines as regulators of T cell differentiation. Nat. Immunol. 2, 102-107
    • (2001) Nat. Immunol. , vol.2 , pp. 102-107
    • Luther, S.A.1    Cyster, J.G.2
  • 7
    • 67949107932 scopus 로고    scopus 로고
    • CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation
    • Murooka, T. T., Rahbar, R., and Fish, E. N. (2009) CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation. Biochem. Biophys. Res. Commun. 387, 381-386
    • (2009) Biochem. Biophys. Res. Commun. , vol.387 , pp. 381-386
    • Murooka, T.T.1    Rahbar, R.2    Fish, E.N.3
  • 8
    • 46749115220 scopus 로고    scopus 로고
    • CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1
    • Murooka, T. T., Rahbar, R., Platanias, L. C., and Fish, E. N. (2008) CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood 111, 4892-4901
    • (2008) Blood , vol.111 , pp. 4892-4901
    • Murooka, T.T.1    Rahbar, R.2    Platanias, L.C.3    Fish, E.N.4
  • 9
    • 33748751102 scopus 로고    scopus 로고
    • CCL5-CCR5-mediated apoptosis in T cells: Requirement for glycosaminoglycan binding and CCL5 aggregation
    • Murooka, T. T., Wong, M. M., Rahbar, R., Majchrzak-Kita, B., Proudfoot, A. E., and Fish, E. N. (2006) CCL5-CCR5-mediated apoptosis in T cells: Requirement for glycosaminoglycan binding and CCL5 aggregation. J. Biol. Chem. 281, 25184-25194
    • (2006) J. Biol. Chem. , vol.281 , pp. 25184-25194
    • Murooka, T.T.1    Wong, M.M.2    Rahbar, R.3    Majchrzak-Kita, B.4    Proudfoot, A.E.5    Fish, E.N.6
  • 10
    • 0029942460 scopus 로고    scopus 로고
    • Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro
    • Taub, D. D., Turcovski-Corrales, S. M., Key, M. L., Longo, D. L., and Murphy, W. J. (1996) Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro. J. Immunol. 156, 2095-2103
    • (1996) J. Immunol. , vol.156 , pp. 2095-2103
    • Taub, D.D.1    Turcovski-Corrales, S.M.2    Key, M.L.3    Longo, D.L.4    Murphy, W.J.5
  • 11
    • 0029126042 scopus 로고
    • RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase
    • Turner, L., Ward, S. G., and Westwick, J. (1995) RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase. J. Immunol. 155, 2437-2444
    • (1995) J. Immunol. , vol.155 , pp. 2437-2444
    • Turner, L.1    Ward, S.G.2    Westwick, J.3
  • 12
    • 0034918334 scopus 로고    scopus 로고
    • RANTES: A versatile and controversial chemokine
    • Appay, V., and Rowland-Jones, S. L. (2001) RANTES: A versatile and controversial chemokine. Trends Immunol. 22, 83-87
    • (2001) Trends Immunol. , vol.22 , pp. 83-87
    • Appay, V.1    Rowland-Jones, S.L.2
  • 13
    • 33845767989 scopus 로고    scopus 로고
    • Recognition of RANTES by extracellular parts of the CCR5 receptor
    • Duma, L., Häussinger, D., Rogowski, M., Lusso, P., and Grzesiek, S. (2007) Recognition of RANTES by extracellular parts of the CCR5 receptor. J. Mol. Biol. 365, 1063-1075
    • (2007) J. Mol. Biol. , vol.365 , pp. 1063-1075
    • Duma, L.1    Häussinger, D.2    Rogowski, M.3    Lusso, P.4    Grzesiek, S.5
  • 14
    • 0036389804 scopus 로고    scopus 로고
    • Selective CCL5/ RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4
    • Juremalm, M., Olsson, N., and Nilsson, G. (2002) Selective CCL5/ RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4. Biochem. Biophys. Res. Commun. 297, 480-485
    • (2002) Biochem. Biophys. Res. Commun. , vol.297 , pp. 480-485
    • Juremalm, M.1    Olsson, N.2    Nilsson, G.3
  • 15
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N., and Sonenberg, N. (2004) Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 16
    • 0036320205 scopus 로고    scopus 로고
    • Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    • Edinger, A. L., and Thompson, C. B. (2002) Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol. Biol. Cell 13, 2276-2288
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2276-2288
    • Edinger, A.L.1    Thompson, C.B.2
  • 17
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante, M., and Sabatini, D. M. (2009) An emerging role of mTOR in lipid biosynthesis. Curr. Biol. 19, R1046-1052
    • (2009) Curr. Biol. , vol.19
    • Laplante, M.1    Sabatini, D.M.2
  • 18
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R., and Hall, M. N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 19
    • 34247184208 scopus 로고    scopus 로고
    • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
    • Wieman, H. L., Wofford, J. A., and Rathmell, J. C. (2007) Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol. Biol. Cell 18, 1437-1446
    • (2007) Mol. Biol. Cell , vol.18 , pp. 1437-1446
    • Wieman, H.L.1    Wofford, J.A.2    Rathmell, J.C.3
  • 20
    • 0041975825 scopus 로고    scopus 로고
    • Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
    • Rathmell, J. C., Elstrom, R. L., Cinalli, R. M., and Thompson, C. B. (2003) Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur. J. Immunol. 33, 2223-2232
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2223-2232
    • Rathmell, J.C.1    Elstrom, R.L.2    Cinalli, R.M.3    Thompson, C.B.4
  • 21
    • 0141863388 scopus 로고    scopus 로고
    • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
    • Rathmell, J. C., Fox, C. J., Plas, D. R., Hammerman, P. S., Cinalli, R. M., and Thompson, C. B. (2003) Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol. Cell. Biol. 23, 7315-7328
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7315-7328
    • Rathmell, J.C.1    Fox, C.J.2    Plas, D.R.3    Hammerman, P.S.4    Cinalli, R.M.5    Thompson, C.B.6
  • 22
    • 41349093966 scopus 로고    scopus 로고
    • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5- mediated activation of Akt to support T-cell survival
    • Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y., and Rathmell, J. C. (2008) IL-7 promotes Glut1 trafficking and glucose uptake via STAT5- mediated activation of Akt to support T-cell survival. Blood 111, 2101-2111
    • (2008) Blood , vol.111 , pp. 2101-2111
    • Wofford, J.A.1    Wieman, H.L.2    Jacobs, S.R.3    Zhao, Y.4    Rathmell, J.C.5
  • 23
  • 26
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signaling and growth
    • Shaw, R. J. (2009) LKB1 and AMP-activated protein kinase control of mTOR signaling and growth. Acta Physiol. 196, 65-80
    • (2009) Acta Physiol. , vol.196 , pp. 65-80
    • Shaw, R.J.1
  • 30
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble, B. W., and Woodgett, J. R. (2003) GSK-3: Tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116, 1175-1186
    • (2003) J. Cell Sci. , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 31
    • 77951178974 scopus 로고    scopus 로고
    • GSK-3 represses growth factor-inducible genes by inhibiting NF-κB in quiescent cells
    • Graham, J. R., Tullai, J. W., and Cooper, G. M. (2010) GSK-3 represses growth factor-inducible genes by inhibiting NF-κB in quiescent cells. The Journal of biological chemistry 285, 4472-4480
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 4472-4480
    • Graham, J.R.1    Tullai, J.W.2    Cooper, G.M.3
  • 32
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope, R. S., and Johnson, G. V. (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci. 29, 95-102
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2
  • 33
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade - A unifying system for energy control
    • Carling, D. (2004) The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem. Sci. 29, 18-24
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 18-24
    • Carling, D.1
  • 34
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/ SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie, D. G., Carling, D., and Carlson, M. (1998) The AMP-activated/ SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67, 821-855
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 35
    • 0034070567 scopus 로고    scopus 로고
    • Metabolic stress and altered glucose transport: Activation of AMP-activated protein kinase as a unifying coupling mechanism
    • Hayashi, T., Hirshman, M. F., Fujii, N., Habinowski, S. A., Witters, L. A., and Goodyear, L. J. (2000) Metabolic stress and altered glucose transport: Activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49, 527-531
    • (2000) Diabetes , vol.49 , pp. 527-531
    • Hayashi, T.1    Hirshman, M.F.2    Fujii, N.3    Habinowski, S.A.4    Witters, L.A.5    Goodyear, L.J.6
  • 36
    • 3543140227 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A master switch in glucose and lipid metabolism
    • Hardie, D. G. (2004) AMP-activated protein kinase: A master switch in glucose and lipid metabolism. Rev. Endocr. Metab. Disord. 5, 119-125
    • (2004) Rev. Endocr. Metab. Disord. , vol.5 , pp. 119-125
    • Hardie, D.G.1
  • 38
    • 54249141095 scopus 로고    scopus 로고
    • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
    • Maciver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., and Rathmell, J. C. (2008) Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J. Leukoc. Biol. 84, 949-957
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 949-957
    • Maciver, N.J.1    Jacobs, S.R.2    Wieman, H.L.3    Wofford, J.A.4    Coloff, J.L.5    Rathmell, J.C.6
  • 39
    • 0141891296 scopus 로고    scopus 로고
    • Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
    • Bentley, J., Itchayanan, D., Barnes, K., McIntosh, E., Tang, X., Downes, C. P., Holman, G. D., Whetton, A. D., Owen-Lynch, P. J., and Baldwin, S. A. (2003) Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J. Biol. Chem. 278, 39337-39348
    • (2003) J. Biol. Chem. , vol.278 , pp. 39337-39348
    • Bentley, J.1    Itchayanan, D.2    Barnes, K.3    McIntosh, E.4    Tang, X.5    Downes, C.P.6    Holman, G.D.7    Whetton, A.D.8    Owen-Lynch, P.J.9    Baldwin, S.A.10
  • 40
    • 0034142172 scopus 로고    scopus 로고
    • Surface antigen CD98(4F2): Not a single membrane protein, but a family of proteins with multiple functions
    • Devés, R., and Boyd, C. A. (2000) Surface antigen CD98(4F2): Not a single membrane protein, but a family of proteins with multiple functions. J. Membr. Biol. 173, 165-177
    • (2000) J. Membr. Biol. , vol.173 , pp. 165-177
    • Devés, R.1    Boyd, C.A.2
  • 41
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: The leukocyte adhesion cascade updated
    • Ley, K., Laudanna, C., Cybulsky, M. I., and Nourshargh, S. (2007) Getting to the site of inflammation: The leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7, 678-689
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 42
    • 0032797272 scopus 로고    scopus 로고
    • Chemokines and cell migration in secondary lymphoid organs
    • Cyster, J. G. (1999) Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098-2102
    • (1999) Science , vol.286 , pp. 2098-2102
    • Cyster, J.G.1
  • 43
  • 46
    • 0035853833 scopus 로고    scopus 로고
    • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
    • Plas, D. R., Talapatra, S., Edinger, A. L., Rathmell, J. C., and Thompson, C. B. (2001) Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry 276, 12041-12048
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 12041-12048
    • Plas, D.R.1    Talapatra, S.2    Edinger, A.L.3    Rathmell, J.C.4    Thompson, C.B.5
  • 48
    • 27744519400 scopus 로고    scopus 로고
    • Fuel feeds function: Energy metabolism and the T-cell response
    • Fox, C. J., Hammerman, P. S., and Thompson, C. B. (2005) Fuel feeds function: Energy metabolism and the T-cell response. Nat. Rev. Immunol. 5, 844-852
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 844-852
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 49
    • 1842581892 scopus 로고    scopus 로고
    • Regulation of T lymphocyte metabolism
    • Frauwirth, K. A., and Thompson, C. B. (2004) Regulation of T lymphocyte metabolism. J. Immunol. 172, 4661-4665
    • (2004) J. Immunol. , vol.172 , pp. 4661-4665
    • Frauwirth, K.A.1    Thompson, C.B.2
  • 50
    • 0025946462 scopus 로고
    • Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats
    • Kahn, B. B., Rossetti, L., Lodish, H. F., and Charron, M. J. (1991) Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats. J. Clin. Invest. 87, 2197-2206
    • (1991) J. Clin. Invest. , vol.87 , pp. 2197-2206
    • Kahn, B.B.1    Rossetti, L.2    Lodish, H.F.3    Charron, M.J.4
  • 51
    • 0347721775 scopus 로고    scopus 로고
    • A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation
    • Somwar, R., Koterski, S., Sweeney, G., Sciotti, R., Djuric, S., Berg, C., Trevillyan, J., Scherer, P. E., Rondinone, C. M., and Klip, A. (2002) A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation. J. Biol. Chem. 277, 50386-50395
    • (2002) J. Biol. Chem. , vol.277 , pp. 50386-50395
    • Somwar, R.1    Koterski, S.2    Sweeney, G.3    Sciotti, R.4    Djuric, S.5    Berg, C.6    Trevillyan, J.7    Scherer, P.E.8    Rondinone, C.M.9    Klip, A.10
  • 52
    • 0034751107 scopus 로고    scopus 로고
    • High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cells
    • Sweeney, G., Keen, J., Somwar, R., Konrad, D., Garg, R., and Klip, A. (2001) High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cells. Endocrinology 142, 4806-4812
    • (2001) Endocrinology , vol.142 , pp. 4806-4812
    • Sweeney, G.1    Keen, J.2    Somwar, R.3    Konrad, D.4    Garg, R.5    Klip, A.6
  • 54
  • 55
    • 75749119313 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration
    • Finlay, D., and Cantrell, D. (2010) Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration. Ann. N.Y. Acad. Sci. 1183, 149-157
    • (2010) Ann. N.Y. Acad. Sci. , vol.1183 , pp. 149-157
    • Finlay, D.1    Cantrell, D.2
  • 56
    • 0037163688 scopus 로고    scopus 로고
    • Evaluation of 2-deoxy-Dglucose as a chemotherapeutic agent: Mechanism of cell death
    • Aft, R. L., Zhang, F. W., and Gius, D. (2002) Evaluation of 2-deoxy-Dglucose as a chemotherapeutic agent: Mechanism of cell death. Br. J. Cancer 87, 805-812
    • (2002) Br. J. Cancer , vol.87 , pp. 805-812
    • Aft, R.L.1    Zhang, F.W.2    Gius, D.3
  • 57
    • 0027960973 scopus 로고
    • Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production
    • Greiner, E. F., Guppy, M., and Brand, K. (1994) Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J. Biol. Chem. 269, 31484-31490
    • (1994) J. Biol. Chem. , vol.269 , pp. 31484-31490
    • Greiner, E.F.1    Guppy, M.2    Brand, K.3
  • 59
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: Cancer's Achilles' heel
    • Kroemer, G., and Pouyssegur, J. (2008) Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell 13, 472-482
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 61
    • 41149117383 scopus 로고    scopus 로고
    • LKB1 and AMPK in cell polarity and division
    • Williams, T., and Brenman, J. E. (2008) LKB1 and AMPK in cell polarity and division. Trends Cell Biol. 18, 193-198
    • (2008) Trends Cell Biol. , vol.18 , pp. 193-198
    • Williams, T.1    Brenman, J.E.2


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