Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections

Science Signaling

Volumn 10, Issue 476, 2017, Pages

  Wang, Wenshi ^a   Yin, Yuebang ^a   Xu, Lei ^a   Su, Junhong ^b   Huang, Fen ^b   Wang, Yijin ^a   Boor, Patrick P C ^a   Chen, Kan ^a   Wang, Wenhui ^a   Cao, Wanlu ^a   Zhou, Xinying ^a   Liu, Pengyu ^a   Van Der Laan, Luc J W ^a   Kwekkeboom, Jaap ^a   Peppelenbosch, Maikel P ^a   Pan, Qiuwei ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON RECEPTOR; IMMUNOGLOBULIN G; INTERFERON ALPHA RECEPTOR 1; INTERFERON DELTA RECEPTOR 1; INTERFERON RECEPTOR; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 9; INTERFERON STIMULATED GENE FACTOR 3; JANUS KINASE 1; JANUS KINASE INHIBITOR; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; ALPHA INTERFERON; ANTIVIRUS AGENT; IRF9 PROTEIN, HUMAN;

A-549 CELL LINE; ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CACO-2 CELL LINE; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CONDITIONED MEDIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; FIBROBLAST; GENE DOSAGE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HEPATITIS C; HEPATITIS C VIRUS; HEPATITIS E; HEPATITIS E VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IMMUNOHISTOCHEMISTRY; INFECTION PREVENTION; LIVER TISSUE; MOUSE; MYELOID DENDRITIC CELL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VIRUS REPLICATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPACIVIRUS; INTESTINE; KNOCKOUT MOUSE; LIVER; MAMMALIAN EMBRYO; METABOLISM; PHOSPHORYLATION; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION REGULATION; HEPACIVIRUS; HEPATITIS C; HEPATITIS E; HEPATITIS E VIRUS; HUMANS; INTERFERON-ALPHA; INTERFERON-STIMULATED GENE FACTOR 3; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; INTESTINES; LIVER; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; VIRUS REPLICATION;

EID: 85018313312     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aah4248     Document Type: Article

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