-
1
-
-
84960414362
-
Precision oncology: A strategy we were not ready to deploy
-
Fojo, T. Precision oncology: A strategy we were not ready to deploy. Semin. Oncol. 43, 9-12 (2016).
-
(2016)
Semin. Oncol
, vol.43
, pp. 9-12
-
-
Fojo, T.1
-
2
-
-
84948716424
-
Precision medicine for cancer with next-generation functional diagnostics
-
Friedman, A.A., Letai, A., Fisher, D.E. & Flaherty, K.T. Precision medicine for cancer with next-generation functional diagnostics. Nat. Rev. Cancer 15, 747-756 (2015).
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 747-756
-
-
Friedman, A.A.1
Letai, A.2
Fisher, D.E.3
Flaherty, K.T.4
-
3
-
-
84986596477
-
Perspective the precision-oncology illusion
-
Prasad, V. Perspective: The precision-oncology illusion. Nature 537, S63 (2016).
-
(2016)
Nature
, vol.537
, pp. S63
-
-
Prasad, V.1
-
4
-
-
84959311037
-
Precision oncology: Origins, optimism, and potential
-
Prasad, V., Fojo, T. & Brada, M. Precision oncology: origins, optimism, and potential. Lancet Oncol. 17, e81-e86 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. e81-e86
-
-
Prasad, V.1
Fojo, T.2
Brada, M.3
-
5
-
-
84990048297
-
Limits to personalized cancer medicine
-
Tannock, I.F. & Hickman, J.A. Limits to personalized cancer medicine. N. Engl. J. Med. 375, 1289-1294 (2016).
-
(2016)
N. Engl. J. Med
, vol.375
, pp. 1289-1294
-
-
Tannock, I.F.1
Hickman, J.A.2
-
6
-
-
85010460401
-
No solid evidence, only hollow argument for universal tumor sequencing: Show me the data
-
West, H.J. No solid evidence, only hollow argument for universal tumor sequencing: show me the data. JAMA Oncol. 2, 717-718 (2016).
-
(2016)
JAMA Oncol
, vol.2
, pp. 717-718
-
-
West, H.J.1
-
7
-
-
84985038330
-
Consensus on precision medicine for metastatic cancers: A report from the MAP conference
-
Swanton, C. et al. Consensus on precision medicine for metastatic cancers: A report from the MAP conference. Ann. Oncol. 27, 1443-1448 (2016).
-
(2016)
Ann. Oncol
, vol.27
, pp. 1443-1448
-
-
Swanton, C.1
-
8
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker, B.J. et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344, 1031-1037 (2001).
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
-
9
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T.J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
-
10
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez, J.G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
-
11
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag, G. et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467, 596-599 (2010).
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
-
12
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty, K.T. et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 809-819 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
-
13
-
-
84993993467
-
Programmed death-1 blockade with pembrolizumab in patients with classical Hodgkin lymphoma after brentuximab vedotin failure
-
Armand, P. et al. Programmed death-1 blockade with pembrolizumab in patients with classical Hodgkin lymphoma after brentuximab vedotin failure. J. Clin. Oncol. 34, JCO673467 (2016).
-
(2016)
J. Clin. Oncol
, vol.34
, pp. JCO673467
-
-
Armand, P.1
-
14
-
-
84994525384
-
Nivolumab for classical Hodgkins lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: A multicentre, multicohort, single-Arm phase 2 trial
-
Younes, A. et al. Nivolumab for classical Hodgkins lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: A multicentre, multicohort, single-Arm phase 2 trial. Lancet Oncol. 17, 1283-1294 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. 1283-1294
-
-
Younes, A.1
-
15
-
-
84922369377
-
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints
-
Llosa, N.J. et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov. 5, 43-51 (2015).
-
(2015)
Cancer Discov
, vol.5
, pp. 43-51
-
-
Llosa, N.J.1
-
16
-
-
84898732516
-
Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy
-
Voss, M.H. et al. Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy. Clin. Cancer Res. 20, 1955-1964 (2014).
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 1955-1964
-
-
Voss, M.H.1
-
17
-
-
84899680978
-
Activating mTOR mutations in a patient with an extraordinary response on a phase i trial of everolimus and pazopanib
-
Wagle, N. et al. Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov. 4, 546-553 (2014).
-
(2014)
Cancer Discov
, vol.4
, pp. 546-553
-
-
Wagle, N.1
-
18
-
-
84867333656
-
Genome sequencing identifies a basis for everolimus sensitivity
-
Iyer, G. et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 338, 221 (2012).
-
(2012)
Science
, vol.338
, pp. 221
-
-
Iyer, G.1
-
19
-
-
77957364747
-
Translating cancer research into targeted therapeutics
-
de Bono, J.S. & Ashworth, A. Translating cancer research into targeted therapeutics. Nature 467, 543-549 (2010).
-
(2010)
Nature
, vol.467
, pp. 543-549
-
-
De Bono, J.S.1
Ashworth, A.2
-
20
-
-
84954510453
-
Routine molecular profiling of patients with advanced non-small-cell lung cancer: Results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT
-
Barlesi, F. et al. Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT). Lancet 387, 1415-1426 (2016).
-
(2016)
Lancet
, vol.387
, pp. 1415-1426
-
-
Barlesi, F.1
-
21
-
-
84900031607
-
A targeted next-generation sequencing assay detects a high frequency of therapeutically targetable alterations in primary and metastatic breast cancers: Implications for clinical practice
-
Vasan, N. et al. A targeted next-generation sequencing assay detects a high frequency of therapeutically targetable alterations in primary and metastatic breast cancers: implications for clinical practice. Oncologist 19, 453-458 (2014).
-
(2014)
Oncologist
, vol.19
, pp. 453-458
-
-
Vasan, N.1
-
22
-
-
85055595914
-
Institutional implementation of clinical tumor profiling on an unselected cancer population
-
Sholl, L.M. et al. Institutional implementation of clinical tumor profiling on an unselected cancer population. JCI Insight 1, e87062 (2016).
-
(2016)
JCI Insight
, vol.1
, pp. e87062
-
-
Sholl, L.M.1
-
23
-
-
84927164071
-
Molecular profiling and targeted therapy for advanced thoracic malignancies: A biomarker-derived, multiarm, multihistology phase II basket trial
-
Lopez-Chavez, A. et al. Molecular profiling and targeted therapy for advanced thoracic malignancies: A biomarker-derived, multiarm, multihistology phase II basket trial. J. Clin. Oncol. 33, 1000-1007 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 1000-1007
-
-
Lopez-Chavez, A.1
-
24
-
-
84953236641
-
Characteristics of exceptional or super responders to cancer drugs
-
Prasad, V. & Vandross, A. Characteristics of exceptional or super responders to cancer drugs. Mayo Clin. Proc. 90, 1639-1649 (2015).
-
(2015)
Mayo Clin. Proc
, vol.90
, pp. 1639-1649
-
-
Prasad, V.1
Vandross, A.2
-
25
-
-
84900829967
-
Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
-
Kris, M.G. et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. J. Am. Med. Assoc. 311, 1998-2006 (2014).
-
(2014)
J. Am. Med. Assoc
, vol.311
, pp. 1998-2006
-
-
Kris, M.G.1
-
26
-
-
84907912530
-
Personalized medicine for patients with advanced cancer in the phase i program at MD Anderson: Validation and landmark analyses
-
Tsimberidou, A.M. et al. Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: validation and landmark analyses. Clin. Cancer Res. 20, 4827-4836 (2014).
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 4827-4836
-
-
Tsimberidou, A.M.1
-
27
-
-
84946053976
-
Impact of precision medicine in diverse cancers: A meta-Analysis of phase II clinical trials
-
Schwaederle, M. et al. Impact of precision medicine in diverse cancers: A meta-Analysis of phase II clinical trials. J. Clin. Oncol. 33, 3817-3825 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 3817-3825
-
-
Schwaederle, M.1
-
28
-
-
84954026435
-
Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): A multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial
-
Le Tourneau, C. et al. Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): A multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial. Lancet Oncol. 16, 1324-1334 (2015).
-
(2015)
Lancet Oncol
, vol.16
, pp. 1324-1334
-
-
Le Tourneau, C.1
-
29
-
-
84961662117
-
Precision medicine: Lessons learned from the SHIVA trial
-
Tsimberidou, A.M. & Kurzrock, R. Precision medicine: lessons learned from the SHIVA trial. Lancet Oncol. 16, e579-e580 (2015).
-
(2015)
Lancet Oncol
, vol.16
, pp. e579-e580
-
-
Tsimberidou, A.M.1
Kurzrock, R.2
-
30
-
-
84941361474
-
Feasibility of large-scale genomic testing to facilitate enrollment onto genomically matched clinical trials
-
Meric-Bernstam, F. et al. Feasibility of large-scale genomic testing to facilitate enrollment onto genomically matched clinical trials. J. Clin. Oncol. 33, 2753-2762 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 2753-2762
-
-
Meric-Bernstam, F.1
-
31
-
-
84902148239
-
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine
-
Van Allen, E.M. et al. Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat. Med. 20, 682-688 (2014).
-
(2014)
Nat. Med
, vol.20
, pp. 682-688
-
-
Van Allen, E.M.1
-
32
-
-
84964691672
-
Defining actionable mutations for oncology therapeutic development
-
Carr, T.H. et al. Defining actionable mutations for oncology therapeutic development. Nat. Rev. Cancer 16, 319-329 (2016).
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 319-329
-
-
Carr, T.H.1
-
33
-
-
42149139456
-
ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007
-
Richards, C.S. et al. ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007. Genet. Med. 10, 294-300 (2008).
-
(2008)
Genet. Med
, vol.10
, pp. 294-300
-
-
Richards, C.S.1
-
34
-
-
84928209346
-
Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology
-
Richards, S. et al. Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet. Med. 17, 405-424 (2015).
-
(2015)
Genet. Med
, vol.17
, pp. 405-424
-
-
Richards, S.1
-
35
-
-
84928498231
-
Prioritizing targets for precision cancer medicine
-
Andre, F. et al. Prioritizing targets for precision cancer medicine. Ann. Oncol. 25, 2295-2303 (2014).
-
(2014)
Ann. Oncol
, vol.25
, pp. 2295-2303
-
-
Andre, F.1
-
36
-
-
84938209813
-
A decision support framework for genomically informed investigational cancer therapy
-
Meric-Bernstam, F. et al. A decision support framework for genomically informed investigational cancer therapy. J. Natl. Cancer Inst. 107, 107 (2015).
-
(2015)
J. Natl. Cancer Inst
, vol.107
, pp. 107
-
-
Meric-Bernstam, F.1
-
37
-
-
84953251975
-
Targeted therapies for CLL: Practical issues with the changing treatment paradigm
-
Jain, N. & OBrien, S. Targeted therapies for CLL: practical issues with the changing treatment paradigm. Blood Rev. 30, 233-244 (2016).
-
(2016)
Blood Rev
, vol.30
, pp. 233-244
-
-
Jain, N.1
Obrien, S.2
-
38
-
-
85026422523
-
Defining a cancer dependency map
-
Tsherniak, A. et al. Defining a cancer dependency map. Cell 170, 564-576.e516 (2017).
-
(2017)
Cell
, vol.170
, pp. 564-576e516
-
-
Tsherniak, A.1
-
39
-
-
0025230399
-
Highly specific prediction of antineoplastic drug resistance with an in vitro assay using suprapharmacologic drug exposures
-
Kern, D.H. & Weisenthal, L.M. Highly specific prediction of antineoplastic drug resistance with an in vitro assay using suprapharmacologic drug exposures. J. Natl. Cancer Inst. 82, 582-588 (1990).
-
(1990)
J. Natl. Cancer Inst
, vol.82
, pp. 582-588
-
-
Kern, D.H.1
Weisenthal, L.M.2
-
40
-
-
4444324909
-
Chemotherapy sensitivity and resistance assays: A systematic review
-
Samson, D.J., Seidenfeld, J., Ziegler, K. & Aronson, N. Chemotherapy sensitivity and resistance assays: A systematic review. J. Clin. Oncol. 22, 3618-3630 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, pp. 3618-3630
-
-
Samson, D.J.1
Seidenfeld, J.2
Ziegler, K.3
Aronson, N.4
-
41
-
-
84890040482
-
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
-
Pemovska, T. et al. Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov. 3, 1416-1429 (2013).
-
(2013)
Cancer Discov
, vol.3
, pp. 1416-1429
-
-
Pemovska, T.1
-
42
-
-
85018214882
-
Novel drug candidates for blast phase chronic myeloid leukemia from high-Throughput drug sensitivity and resistance testing
-
Pietarinen, P.O. et al. Novel drug candidates for blast phase chronic myeloid leukemia from high-Throughput drug sensitivity and resistance testing. Blood Cancer J. 5, e309 (2015).
-
(2015)
Blood Cancer J
, vol.5
, pp. e309
-
-
Pietarinen, P.O.1
-
43
-
-
84902095891
-
Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
-
Yadav, B. et al. Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies. Sci. Rep. 4, 5193 (2014).
-
(2014)
Sci. Rep
, vol.4
, pp. 5193
-
-
Yadav, B.1
-
44
-
-
85015886035
-
Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia
-
Frismantas, V. et al. Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia. Blood 129, e26-e37 (2017).
-
(2017)
Blood
, vol.129
, pp. e26-e37
-
-
Frismantas, V.1
-
45
-
-
84904121066
-
Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
-
Yu, M. et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science 345, 216-220 (2014).
-
(2014)
Science
, vol.345
, pp. 216-220
-
-
Yu, M.1
-
46
-
-
84919443958
-
Patient-derived models of acquired resistance can identify effective drug combinations for cancer
-
Crystal, A.S. et al. Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Science 346, 1480-1486 (2014).
-
(2014)
Science
, vol.346
, pp. 1480-1486
-
-
Crystal, A.S.1
-
47
-
-
84937034223
-
Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy-The SpheroNEO study
-
Halfter, K. et al. Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy-The SpheroNEO study. BMC Cancer 15, 519 (2015).
-
(2015)
BMC Cancer
, vol.15
, pp. 519
-
-
Halfter, K.1
-
48
-
-
84906895091
-
Patient-derived xenograft models: An emerging platform for translational cancer research
-
Hidalgo, M. et al. Patient-derived xenograft models: An emerging platform for translational cancer research. Cancer Discov. 4, 998-1013 (2014).
-
(2014)
Cancer Discov
, vol.4
, pp. 998-1013
-
-
Hidalgo, M.1
-
49
-
-
84962740421
-
The public repository of xenografts enables discovery and
-
randomized phase II-like trials in ice
-
Townsend, E.C. et al. The public repository of xenografts enables discovery and randomized phase II-like trials in ice. Cancer Cell 29, 574-586 (2016).
-
(2016)
Cancer Cell
, vol.29
, pp. 574-586
-
-
Townsend, E.C.1
-
50
-
-
84988664167
-
A biobank of breast cancer explants with preserved intra-Tumor heterogeneity to screen anticancer compounds
-
Bruna, A. et al. A biobank of breast cancer explants with preserved intra-Tumor heterogeneity to screen anticancer compounds. Cell 167, 260-274.e22 (2016).
-
(2016)
Cell
, vol.167
, pp. 260e22
-
-
Bruna, A.1
-
51
-
-
84923375991
-
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy
-
Montero, J. et al. Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy. Cell 160, 977-989 (2015).
-
(2015)
Cell
, vol.160
, pp. 977-989
-
-
Montero, J.1
-
52
-
-
84959463045
-
Mitochondria-judges and executioners of cell death sentences
-
Bhola, P.D. & Letai, A. Mitochondria-judges and executioners of cell death sentences. Mol. Cell 61, 695-704 (2016).
-
(2016)
Mol. Cell
, vol.61
, pp. 695-704
-
-
Bhola, P.D.1
Letai, A.2
-
53
-
-
33646354381
-
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
-
Certo, M. et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9, 351-365 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 351-365
-
-
Certo, M.1
-
54
-
-
34547603628
-
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
-
Deng, J. et al. BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell 12, 171-185 (2007).
-
(2007)
Cancer Cell
, vol.12
, pp. 171-185
-
-
Deng, J.1
-
55
-
-
82255192310
-
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
-
Ni Chonghaile, T. et al. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 334, 1129-1133 (2011).
-
(2011)
Science
, vol.334
, pp. 1129-1133
-
-
Ni Chonghaile, T.1
-
56
-
-
84974733613
-
IBH3: Simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
-
Ryan, J., Montero, J., Rocco, J. & Letai, A. iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry. Biol. Chem. 397, 671-678 (2016).
-
(2016)
Biol. Chem
, vol.397
, pp. 671-678
-
-
Ryan, J.1
Montero, J.2
Rocco, J.3
Letai, A.4
-
57
-
-
84867490138
-
Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML
-
Vo, T.T. et al. Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML. Cell 151, 344-355 (2012).
-
(2012)
Cell
, vol.151
, pp. 344-355
-
-
Vo, T.T.1
-
58
-
-
33845994359
-
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
-
Del Gaizo Moore, V. et al. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J. Clin. Invest. 117, 112-121 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 112-121
-
-
Del Gaizo Moore, V.1
-
59
-
-
84895788062
-
Selective BCL-2 inhibition by ABT-199 causes on-Target cell death in acute myeloid leukemia
-
Pan, R. et al. Selective BCL-2 inhibition by ABT-199 causes on-Target cell death in acute myeloid leukemia. Cancer Discov. 4, 362-375 (2014).
-
(2014)
Cancer Discov
, vol.4
, pp. 362-375
-
-
Pan, R.1
-
60
-
-
84953352221
-
Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice
-
Etchin, J. et al. Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice. Leukemia 30, 190-199 (2016).
-
(2016)
Leukemia
, vol.30
, pp. 190-199
-
-
Etchin, J.1
-
61
-
-
84937395764
-
Activity of the type II JAK2 inhibitor CHZ868 in B cell acute lymphoblastic leukemia
-
Wu, S.C. et al. Activity of the type II JAK2 inhibitor CHZ868 in B cell acute lymphoblastic leukemia. Cancer Cell 28, 29-41 (2015).
-
(2015)
Cancer Cell
, vol.28
, pp. 29-41
-
-
Wu, S.C.1
-
62
-
-
84992388359
-
High-Throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays
-
Cermak, N. et al. High-Throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays. Nat. Biotechnol. 34, 1052-1059 (2016).
-
(2016)
Nat. Biotechnol
, vol.34
, pp. 1052-1059
-
-
Cermak, N.1
-
63
-
-
84994879687
-
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate
-
Stevens, M.M. et al. Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat. Biotechnol. 34, 1161-1167 (2016).
-
(2016)
Nat. Biotechnol
, vol.34
, pp. 1161-1167
-
-
Stevens, M.M.1
-
64
-
-
84928677711
-
An implantable microdevice to perform high-Throughput in vivo drug sensitivity testing in tumors
-
284ra57
-
Jonas, O. et al. An implantable microdevice to perform high-Throughput in vivo drug sensitivity testing in tumors. Sci. Transl. Med. 7, 284ra57 (2015).
-
(2015)
Sci. Transl. Med
, vol.7
-
-
Jonas, O.1
-
65
-
-
84964758617
-
First in vivo testing of compounds targeting group 3 medulloblastomas using an implantable microdevice as a new paradigm for drug development
-
Jonas, O. et al. First in vivo testing of compounds targeting group 3 medulloblastomas using an implantable microdevice as a new paradigm for drug development. J. Biomed. Nanotechnol. 12, 1297-1302 (2016).
-
(2016)
J. Biomed. Nanotechnol
, vol.12
, pp. 1297-1302
-
-
Jonas, O.1
-
66
-
-
85006963782
-
Parallel in vivo assessment of drug phenotypes at various time points during systemic BRAF inhibition reveals tumor adaptation and altered treatment vulnerabilities
-
Jonas, O. et al. Parallel in vivo assessment of drug phenotypes at various time points during systemic BRAF inhibition reveals tumor adaptation and altered treatment vulnerabilities. Clin. Cancer Res. 22, 6031-6038 (2016).
-
(2016)
Clin. Cancer Res
, vol.22
, pp. 6031-6038
-
-
Jonas, O.1
-
67
-
-
84977090997
-
A platform for rapid, quantitative assessment of multiple drug combinations simultaneously in solid tumors
-
Dey, J. et al. A platform for rapid, quantitative assessment of multiple drug combinations simultaneously in solid tumors in vivo. PLoS One 11, e0158617 (2016).
-
(2016)
Vivo. PLoS One
, vol.11
, pp. e0158617
-
-
Dey, J.1
-
68
-
-
84928653972
-
A technology platform to assess multiple cancer agents simultaneously within a patients tumor
-
Klinghoffer, R.A. et al. A technology platform to assess multiple cancer agents simultaneously within a patients tumor. Sci. Transl. Med. 7, 284ra58 (2015).
-
(2015)
Sci. Transl. Med
, vol.7
, pp. 284ra58
-
-
Klinghoffer, R.A.1
-
69
-
-
84982946696
-
Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade
-
Chen, P.L. et al. Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade. Cancer Discov. 6, 827-837 (2016).
-
(2016)
Cancer Discov
, vol.6
, pp. 827-837
-
-
Chen, P.L.1
|