First in vivo testing of compounds targeting group 3 medulloblastomas using an implantable microdevice as a new paradigm for drug development

Journal of Biomedical Nanotechnology

Volumn 12, Issue 6, 2016, Pages 1297-1302

  Jonas, Oliver ^a   Calligaris, David ^b   Methuku, Kashi Reddy ^c   Poe, Michael M ^c   Francois, Jessica Pierre ^d   Tranghese, Frank ^d   Changelian, Armen ^b   Sieghart, Werner ^e   Ernst, Margot ^e   Pomeranz Krummel, Daniel A ^f   Cook, James M ^c   Pomeroy, Scott L ^d   Cima, Michael ^a   Agar, Nathalie Y R ^b,g   Langer, Robert ^a   Sengupta, Soma ^g  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e Medical University of Vienna   (Austria)

^f BRANDEIS UNIVERSITY   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Benzodiazepine derivatives; Drug delivery; Mass spectrometry imaging; Medulloblastoma; Microdevice

Indexed keywords

BIOCHEMISTRY; DRUG DELIVERY; DRUG PRODUCTS; GENE EXPRESSION; IMPLANTS (SURGICAL); MASS SPECTROMETRY; SPECTROMETRY; THROUGHPUT; TUMORS;

BENZODIAZEPINE DERIVATIVES; CHEMOTHERAPEUTIC DRUGS; IMMUNOHISTOCHEMISTRY; IMPLANTABLE DEVICES; MASS-SPECTROMETRY IMAGING; MEDULLOBLASTOMA; MICRO-DEVICE; TUMOR MICROENVIRONMENT;

BRAIN;

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; CISPLATIN; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG DELIVERY DEVICE; DRUG DELIVERY SYSTEM; FEMALE; IN VIVO STUDY; MEDULLOBLASTOMA; NONHUMAN; ANIMAL; CEREBELLAR NEOPLASMS; DEVICES; HUMAN; MASS SPECTROMETRY; MOLECULAR IMAGING; MOUSE; NUDE MOUSE; PROCEDURES; PROSTHESES AND ORTHOSES; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; CELL LINE, TUMOR; CEREBELLAR NEOPLASMS; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MEDULLOBLASTOMA; MICE; MICE, NUDE; MOLECULAR IMAGING; PROSTHESES AND IMPLANTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84964758617     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2016.2262     Document Type: Article

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