The association of telomere length in peripheral blood cells with cancer risk:ASystematic review and meta-Analysis of prospective studies

Cancer Epidemiology Biomarkers and Prevention

Volumn 26, Issue 9, 2017, Pages 1381-1390

  Zhang, Xia ^a   Zhao, Qian ^b   Zhu, Wei ^c   Liu, Tao ^c   Xie, Shao Hua ^d   Zhong, Li Xin ^a   Cai, Yuan Yuan ^a   Li, Xiao Na ^a   Liang, Mei ^a   Chen, Wen ^a   Hu, Qian Sheng ^a   Zhang, Bo ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c GUANGZHOU CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL CELL CARCINOMA; BLOOD; BLOOD CELL; BREAST CANCER; CANCER RISK; COHORT ANALYSIS; COLORECTAL CANCER; DNA EXTRACTION; FOLLOW UP; HUMAN; LUNG CANCER; MELANOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CANCER; REVIEW; SKIN CANCER; SQUAMOUS CELL CARCINOMA; SYSTEMATIC REVIEW; TELOMERE LENGTH; FEMALE; GENETICS; MALE; META ANALYSIS; METABOLISM; NEOPLASM; RISK FACTOR; TELOMERE;

FEMALE; HUMANS; MALE; NEOPLASMS; PROSPECTIVE STUDIES; RISK FACTORS; TELOMERE;

EID: 85028913036     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-16-0968     Document Type: Review

References (66)

1. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-60.
2. Blackburn EH. Switching and signaling at the telomere. Cell 2001;106: 661-73.
3. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: A twin study of three age groups. Am J Hum Genet 1994;55: 876-82.
4. Zhang X, Lin S, Funk WE, Hou L. Environmental and occupational exposure to chemicals and telomere length in human studies. Occup Environ Med 2013;70:743-9.
5. Freitas-Simoes TM, Ros E, Sala-Vila A. Nutrients, foods, dietary patterns and telomere length: Update of epidemiological studies and randomized trials. Metabolism 2016;65:406-15.
6. Latifovic L, Peacock SD, Massey TE, King WD. The influence of alcohol consumption, cigarette smoking, and physical activity on leukocyte telomere length. Cancer Epidemiol Biomarkers Prev 2016;25: 374-80.
7. Pieters N, Janssen BG, Dewitte H, Cox B, Cuypers A, Lefebvre W, et al. Biomolecular markers within the core axis of aging and particulate air pollution exposure in the elderly: A cross-sectional study. Environ Health Perspect 2016;124:943-50.
8. Du M, Prescott J, Kraft P, Han J, Giovannucci E, Hankinson SE, et al. Physical activity, sedentary behavior, and leukocyte telomere length in women. Am J Epidemiol 2012;175:414-22.
9. Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun 2014;2:4172.
10. Hackett JA, Greider CW. Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene 2002;21:619-26.
11. Roos WP, Thomas AD, Kaina B. DNA damage and the balance between survival and death in cancer biology. Nat Rev Cancer 2016;16:20-33.
12. Boveri T. Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci 2008;121 Suppl 1: 1-84.
13. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:4240-8.
14. Mooi WJ, Peeper DS. Oncogene-induced cell senescence-halting on the road to cancer. N Engl J Med 2006;355:1037-46.
15. Shen J, Gammon MD, Terry MB, Wang Q, Bradshaw P, Teitelbaum SL, et al. Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer. 2009;124:1637-43.
16. Zheng YL, Ambrosone C, Byrne C, Davis W, Nesline M, McCann SE. Telomere length in blood cells and breast cancer risk: investigations in two case-control studies. Br Cancer Res Treat 2010;120:769-75.
17. De Vivo, I, Prescott J, Wong JY, Kraft P, Hankinson SE, Hunter DJ. A prospective study of relative telomere length and postmenopausal breast cancer risk. Cancer Epidemiol Biomark Prev 2009;18:1152-6.
18. Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, Luben RN, et al. Telomere length in prospective and retrospective cancer case-control studies. Cancer Res 2010;70:3170-6.
19. Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Bojesen SE. Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst 2013;105:459-68.
20. Cunningham JM, Johnson RA, Litzelman K, Skinner HG, Seo S, Engelman CD, et al. Telomere length varies by DNA extraction method: implications for epidemiologic research. Cancer Epidemiol Biomark Prev 2013;22: 2047-54.
21. Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, et al. Association between telomere length and risk of cancer and non-neoplastic diseases: A Mendelian randomization study. JAMA Oncol 2017;3:636-51.
22. Zhu X, Han W, Xue W, Zou Y, Xie C, Du J, et al. The association between telomere length and cancer risk in population studies. Sci Rep 2016;6: 22243.
23. Chene G, Thompson SG. Methods for summarizing the risk associations of quantitative variables in epidemiologic studies in a consistent form. Am J Epidemiol 1996;144:610-21.
24. Liang G, Qureshi AA, Guo Q, De Vivo, I, Han J. No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer. Cancer Epidemiol Biomark Prev 2011;20: 1043-5.
25. Lynch SM, Major JM, Cawthon R, Weinstein SJ, Virtamo J, Lan Q, et al. A prospective analysis of telomere length and pancreatic cancer in the alphatocopherol beta-carotene cancer (ATBC) prevention study. Int J Cancer. 2013;133:2672-80.
26. Hofmann JN, Lan Q, Cawthon R, Hosgood HD III, Shuch B, Moore LE, et al. A prospective study of leukocyte telomere length and risk of renal cell carcinoma. Cancer Epidemiol Biomark Prev 2013;22:997-1000.
27. Shen M, Cawthon R, Rothman N, Weinstein SJ, Virtamo J, Hosgood HD III, et al. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer. Lung Cancer 2011;73: 133-7.
28. Lan Q, Cawthon R, Gao Y, Hu W, Hosgood HD III, Barone-Adesi F, et al. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS One. 2013;8: E59230.
29. Hosnijeh FS, Matullo G, Russo A, Guarrera S, Modica F, Nieters A, et al. Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study. Int J Cancer 2014;135:2910-7.
30. Lan Q, Cawthon R, Shen M, Weinstein SJ, Virtamo J, Lim U, et al. A prospective study of telomere length measured bymonochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res 2009;15:7429-33.
31. Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, Brandstatter A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA. 2010;304:69-75.
32. Prescott J, McGrath M, Lee IM, Buring JE, De Vivo, I. Telomere length and genetic analyses in population-based studies of endometrial cancer risk. Cancer 2010;116:4275-82.
33. McGrath M, Wong JY, Michaud D, Hunter DJ, De Vivo, I. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomark Prev 2007;16:815-9.
34. Mirabello L, Huang WY, Wong JY, Chatterjee N, Reding D, Crawford ED, et al. The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell 2009;8:405-13.
35. Han J, Qureshi AA, Prescott J, Guo Q, Ye L, Hunter DJ, et al. A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol 2009;129:415-21.
36. Campa D, Mergarten B, De Vivo, I, Boutron-Ruault MC, Racine A, Severi G, et al. Leukocyte telomere length in relation to pancreatic cancer risk: A prospective study. Cancer Epidemiol Biomark Prev 2014;23: 2447-54.
37. Lee IM, Lin J, Castonguay AJ, Barton NS, Buring JE, Zee RY. Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: A prospective, nested case-control study. Clin Chem Lab Med 2010;48: 259-62.
38. Qu S, Wen W, Shu XO, Chow WH, Xiang YB, Wu J, et al. Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women's Health Study. Am J Epidemiol 2013;177:617-24.
39. Nan H, Du M, De Vivo, I, Manson JE, Liu S, McTiernan A, et al. Shorter telomeres associatewith a reduced risk of melanoma development. Cancer Res 2011;71:6758-63.
40. Walcott F, Rajaraman P, Gadalla SM, Inskip PD, Purdue MP, Albanes D, et al. Telomere length and risk of glioma. Cancer Epidemiol 2013;37: 935-8.
41. Seow WJ, Cawthon RM, Purdue MP, Hu W, Gao YT, Huang WY, et al. Telomere length in white blood cell DNA and lung cancer: A pooled analysis of three prospective cohorts. Cancer Res 2014;74:4090-8.
42. Rode L, Nordestgaard BG, Bojesen SE. Long telomeres and cancer risk among 95 568 individuals from the general population. Int J Epidemiol 2016;45:1634-43.
43. Julin B, Shui I, Heaphy CM, Joshu CE, Meeker AK, Giovannucci E, et al. Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer. Br J Cancer 2015;112:769-76.
44. Bao Y, Prescott J, Yuan C, Zhang M, Kraft P, Babic A, et al. Leucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer. Gut 2017;66:1116-22.
45. Zeng H, Wu HC, Wang Q, Yang HI, Chen CJ, Santella RM, et al. Telomere length and risk of hepatocellular carcinoma: A nested case-control study in Taiwan cancer screening program cohort. Anticancer Res 2017;37:637-44.
46. Yang M, Prescott J, Poole EM, Rice MS, Kubzansky LD, Idahl A, et al. Prediagnosis leukocyte telomere length and risk of ovarian cancer. Cancer Epidemiol Biomark Prev 2017;26:339-45.
47. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002;30:e47.
48. Cawthon RM. Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 2009;37:e21.
49. Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 2013;45:422-7, 7e1-2.
50. Machiela MJ, Hsiung CA, Shu XO, Seow WJ, Wang Z, Matsuo K, et al. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: A report from the female lung cancer consortium in Asia. Int J Cancer 2015; 137:311-9.
51. Luu HN, Long J, Wen W, Zheng Y, Cai Q, Gao YT, et al. Association between genetic risk score for telomere length and risk of breast cancer. Cancer Causes Control 2016;27:1219-28.
52. Smith GD, Ebrahim S. Mendelian randomization: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
53. Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, et al. Gender and telomere length: systematic review and meta-Analysis. Exp Gerontol 2014;51:15-27.
54. Zhang C, Lauderdale DS, Pierce BL. Sex-Specific and Time-Varying Associations Between Cigarette Smoking and Telomere Length Among Older Adults. Am J Epidemiol 2016;184:922-32.
55. Hofmann JN, Hutchinson AA, Cawthon R, Liu CS, Lynch SM, Lan Q, et al. Telomere length varies by DNA extraction method: implications for epidemiologic research-letter. Cancer Epidemiol Biomark Prev 2014;23: 1129-30.
56. Ghosh A, Saginc G, Leow SC, Khattar E, Shin EM, Yan TD, et al. Telomerase directly regulates NF-kappaB-dependent transcription. Nat Cell Biol 2012; 14:1270-81.
57. Koh CM, Khattar E, Leow SC, Liu CY, Muller J, Ang WX, et al. Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest 2015;125:2109-22.
58. Li H, Engstrom K, Vahter M, Broberg K. Arsenic exposure through drinking water is associated with longer telomeres in peripheral blood. Chem Res Toxicol 2012;25:2333-9.
59. Shin JY, Choi YY, Jeon HS, Hwang JH, Kim SA, Kang JH, et al. Low-dose persistent organic pollutants increased telomere length in peripheral leukocytes of healthy Koreans. Mutagenesis 2010;25:511-6.
60. Bassig BA, Zhang L, Cawthon RM, Smith MT, Yin S, Li G, et al. Alterations in leukocyte telomere length in workers occupationally exposed to benzene. Environ Mol Mutagen 2014;55:673-8.
61. Dioni L, Hoxha M, Nordio F, Bonzini M, Tarantini L, Albetti B, et al. Effects of short-Termexposure to inhalable particulate matter on telomere length, telomerase expression, and telomerase methylation in steel workers. Environ Health Perspect 2011;119:622-7.
62. Hou L, Wang S, Dou C, Zhang X, Yu Y, Zheng Y, et al. Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: A repeated-measure study. Environ Int 2012;48:71-7.
63. Cui Y, Cai Q, Qu S, Chow WH, Wen W, Xiang YB, et al. Association of leukocyte telomere length with colorectal cancer risk: nested case-control findings from the Shanghai Women's Health Study. Cancer Epidemiol Biomark Prev 2012;21:1807-13.
64. Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001;107:67-77.
65. Xing J, Ajani JA, Chen M, Izzo J, Lin J, Chen Z, et al. Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prevention Res 2009;2:459-65.
66. Britt-Compton B, Rowson J, Locke M, Mackenzie I, Kipling D, Baird DM. Structural stability and chromosome-specific telomere length is governed by cis-Acting determinants in humans. HumanMol Genet 2006;15:725-33.