Leucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer

Gut

Volumn 66, Issue 6, 2017, Pages 1116-1122

  Bao, Ying ^a   Prescott, Jennifer ^a   Yuan, Chen ^b,c   Zhang, Mingfeng ^d   Kraft, Peter ^b   Babic, Ana ^c   Morales Oyarvide, Vicente ^c   Qian, Zhi Rong ^c   Buring, Julie E ^a,e   Cochrane, Barbara B ^f   Gaziano, J Michael ^a,g   Giovannucci, Edward L ^a,b   Manson, Joann E ^a,b   Ng, Kimmie ^c   Ogino, Shuji ^a,b,c   Rohan, Thomas E ^h   Sesso, Howard D ^a,b   Stampfer, Meir J ^a,b   Fuchs, Charles S ^a,c   De Vivo, Immaculata ^a,b   Amundadottir, Laufey T ^d   Wolpin, Brian M ^a,c   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

^g VA BOSTON HEALTHCARE SYSTEM   (United States)

^h ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

PANCREATIC CANCER

Indexed keywords

TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE; TERT PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; BODY MASS; CANCER RISK; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PANCREAS CANCER; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TELOMERE LENGTH; TERT GENE; ADENOCARCINOMA; AGED; CASE CONTROL STUDY; FOLLOW UP; GENETICS; LEUKOCYTE; MIDDLE AGED; ODDS RATIO; PANCREATIC NEOPLASMS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; TELOMERE SHORTENING; UNITED STATES; VERY ELDERLY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ALLELES; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; ODDS RATIO; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; TELOMERASE; TELOMERE SHORTENING; UNITED STATES;

EID: 84994506103     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2016-312510     Document Type: Article

References (48)

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016;66:7-30.
2. Vincent A, Herman J, Schulick R, et al. Pancreatic cancer. Lancet 2011;378:607-20.
3. Lennon AM, Wolfgang CL, Canto MI, et al. The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? Cancer Res 2014;74:3381-9.
4. Klein AP, Lindström S, Mendelsohn JB, et al. An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population. PLoS ONE 2013;8:e72311.
5. Stewart SA, Weinberg RA. Telomeres: cancer to human aging. Annu Rev Cell Dev Biol 2006;22:531-57.
6. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: A twin study of three age groups. Am J Hum Genet 1994;55:876-82.
7. Valdes AM, Andrew T, Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005;366:662-4.
8. Hezel AF, Kimmelman AC, Stanger BZ, et al. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 2006;20:1218-49.
9. van Heek NT, Meeker AK, Kern SE, et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol 2002;161:1541-7.
10. Wolpin BM, Rizzato C, Kraft P, et al. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat Genet 2014;46:994-1000.
11. Petersen GM, Amundadottir L, Fuchs CS, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 2010;42:224-8.
12. Rafnar T, Sulem P, Stacey SN, et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet 2009;41:221-7.
13. Mocellin S, Verdi D, Pooley KA, et al. Telomerase reverse transcriptase locus polymorphisms and cancer risk: A field synopsis and meta-Analysis. J Natl Cancer Inst 2012;104:840-54.
14. Campa D, Mergarten B, De Vivo I, et al. Leukocyte telomere length in relation to pancreatic cancer risk: A prospective study. Cancer Epidemiol Biomarkers Prev 2014;23:2447-54.
15. Lynch SM, Major JM, Cawthon R, et al. A prospective analysis of telomere length and pancreatic cancer in the alpha-Tocopherol beta-carotene cancer (ATBC) prevention study. Int J Cancer 2013;133:2672-80.
16. Diez Roux AV, Ranjit N, Jenny NS, et al. Race/ethnicity and telomere length in the multi-ethnic study of atherosclerosis. Aging Cell 2009;8:251-7.
17. Hunt SC, Chen W, Gardner JP, et al. Leukocyte telomeres are longer in African Americans than in whites: The National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell 2008;7:451-8.
18. Wang H, Chen H, Gao X, et al. Telomere length and risk of Parkinsons disease. Mov Disord 2008;23:302-5.
19. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002;30:e47.
20. McKay JD, Hung RJ, Gaborieau V, et al. Lung cancer susceptibility locus at 5p15.33. Nat Genet 2008;40:1404-6.
21. Shete S, Hosking FJ, Robertson LB, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet 2009;41:899-904.
22. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 2009;41:986-90.
23. Wang Z, Zhu B, Zhang M, et al. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet 2014;23:6616-33.
24. Skinner HG, Gangnon RE, Litzelman K, et al. Telomere length and pancreatic cancer: A case-control study. Cancer Epidemiol Biomarkers Prev 2012;21:2095-100.
25. Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med 1989;8:551-61.
26. Bojesen SE, Pooley KA, Johnatty SE, et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 2013;45:371-84, 84e1-2.
27. Kote-Jarai Z, Saunders EJ, Leongamornlert DA, et al. Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. Hum Mol Genet 2013;22:2520-8.
28. Campa D, Rizzato C, Stolzenberg-Solomon R, et al. TERT gene harbors multiple variants associated with pancreatic cancer susceptibility. Int J Cancer 2015;137:2175-83.
29. Willeit P, Willeit J, Mayr A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA 2010;304:69-75.
30. Ma H, Zhou Z, Wei S, et al. Shortened telomere length is associated with increased risk of cancer: A meta-Analysis. PLoS ONE 2011;6:e20466.
31. Wentzensen IM, Mirabello L, Pfeiffer RM, et al. The association of telomere length and cancer: A meta-Analysis. Cancer Epidemiol Biomarkers Prev 2011;20:1238-50.
32. Weischer M, Nordestgaard BG, Cawthon RM, et al. Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst 2013;105:459-68.
33. Zhang C, Chen X, Li L, et al. The Association between telomere length and cancer prognosis: evidence from a meta-Analysis. PLoS One 2015;10:e0133174.
34. Savage SA, Gadalla SM, Chanock SJ. The long and short of telomeres and cancer association studies. J Natl Cancer Inst 2013;105:448-9.
35. Hou L, Joyce BT, Gao T, et al. Blood telomere length attrition and cancer development in the normative aging study cohort. EBioMedicine 2015;2:591-6.
36. Benitez-Buelga C, Sanchez-Barroso L, Gallardo M, et al. Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients. Breast Cancer Res Treat 2015;149:385-94.
37. Martin-Ruiz CM, Baird D, Roger L, et al. Reproducibility of telomere length assessment: An international collaborative study. Int J Epidemiol 2015;44: 1673-83.
38. Iles MM, Bishop DT, Taylor JC, et al. The effect on melanoma risk of genes previously associated with telomere length. J Natl Cancer Inst 2014;106.
39. Rode L, Nordestgaard BG, Bojesen SE. Peripheral blood leukocyte telomere length and mortality among 64, 637 individuals from the general population. J Natl Cancer Inst 2015;107:djv074.
40. Zhang C, Doherty JA, Burgess S, et al. Genetic determinants of telomere length and risk of common cancers: A Mendelian randomization study. Hum Mol Genet 2015;24:5356-66.
41. Machiela MJ, Lan Q, Slager SL, et al. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Hum Mol Genet 2016;25:1663-76.
42. Matsuda Y, Ishiwata T, Izumiyama-Shimomura N, et al. Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas. PLoS ONE 2015;10:e0117575.
43. Daniali L, Benetos A, Susser E, et al. Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun 2013;4:1597.
44. Walsh KM, Codd V, Smirnov IV, et al. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet 2014;46:731-5.
45. Codd V, Nelson CP, Albrecht E, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 2013;45:422-7, 7e1-2.
46. Youngren K, Jeanclos E, Aviv H, et al. Synchrony in telomere length of the human fetus. Hum Genet 1998;102:640-3.
47. Kimura M, Gazitt Y, Cao X, et al. Synchrony of telomere length among hematopoietic cells. Exp Hematol 2010;38:854-9.
48. Okuda K, Bardeguez A, Gardner JP, et al. Telomere length in the newborn. Pediatr Res 2002;52:377-81.