Long telomeres and cancer risk among 95 568 individuals from the general population

International Journal of Epidemiology

Volumn 45, Issue 5, 2016, Pages 1634-1643

  Rode, Line ^a,b,c   Nordestgaard, Børge G ^a,b,c   Bojesen, Stig E ^a,b,c  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b FREDERIKSBERG HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cancer risk; Genetic; Telomere length

Indexed keywords

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ALLELE; ARTICLE; BODY MASS; CANCER DIAGNOSIS; CANCER RISK; FEMALE; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; LUNG CANCER; MALE; MALIGNANT NEOPLASM; MELANOMA; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TELOMERE HOMEOSTASIS; TELOMERE LENGTH; DENMARK; GENETIC SCREENING; GENETICS; LUNG TUMOR; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; STATISTICAL MODEL; TELOMERE;

ADULT; AGED; DENMARK; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; LOGISTIC MODELS; LUNG NEOPLASMS; MALE; MELANOMA; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 85011411057     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyw179     Document Type: Article

References (37)

1. de Lange T. How telomeres solve the end-protection problem. Science 2009;326:948–52.
2. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–74.
3. Low KC, Tergaonkar V. Telomerase: central regulator of all of the hallmarks of cancer. Trends Biochem Sci 2013;38:426–34.
4. Ma H, Zhou Z, Wei S et al. Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One 2011;6:e20466.
5. McGrath M, Wong JY, Michaud D, Hunter DJ, De Vivo I. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev 2007;16: 815–19.
6. Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Bojesen SE. Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst 2013;105:459–68.
7. Wentzensen IM, Mirabello L, Pfeiffer RM, Savage SA. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2011;20:1238–50.
8. Wu X, Amos CI, Zhu Y et al. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 2003;95: 1211–18.
9. Bojesen SE. Telomeres and human health. J Intern Med 2013;274:399–413.
10. Weischer M, Bojesen SE, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Nordestgaard BG. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol 2012;32:822–29.
11. Codd V, Mangino M, van der Harst P et al. Common variants near TERC are associated with mean telomere length. Nat Genet 2010;42:197–99.
12. Levy D, Neuhausen SL, Hunt SC et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A 2010; 107:9293–98.
13. Pooley KA, Bojesen SE, Weischer M et al. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet 2013;22: 5056–64.
14. Zhang C, Doherty JA, Burgess S et al. Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study. Hum Mol Genet 2015;24:5356–66.
15. Mangino M, Hwang SJ, Spector TD et al. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet 2012;21: 5385–94.
16. Chen LY, Redon S, Lingner J. The human CST complex is a terminator of telomerase activity. Nature 2012;488:540–44.
17. Bojesen SE, Pooley KA, Johnatty SE et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 2013;45: 371–84.
18. Scherczinger CA, Bourke MT, Ladd C, Lee HC. DNA extraction from liquid blood using QIAamp. J Forensic Sci 1997;42: 893–96.
19. Cawthon RM. Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 2009;37:e21.
20. Gjerstorff ML. The Danish Cancer Registry. Scand J Public Health 2011;39:42–45.
21. Bray F, Sankila R, Ferlay J, Parkin DM. Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 2002;38:99–166.
22. Willcox JK, Ash SL, Catignani GL. Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 2004;44:275–95.
23. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2012;3:CD007176.
24. Borah S, Xi L, Zaug AJ et al. Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science 2015;347:1006–10.
25. Alexandrov LB, Nik-Zainal S, Wedge DC et al. Signatures of mutational processes in human cancer. Nature 2013 22;500: 415–21.
26. Rode L, Nordestgaard BG, Bojesen SE. Peripheral blood leukocyte telomere length and mortality in 64637 individuals from the general population. J Natl Cancer Inst 2015;107. doi: 10.1093/ jnci/djv074
27. Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer 2008;8:167–79.
28. Lan Q, Cawthon R, Gao Y et al. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS One 2013;8:e59230.
29. Machiela MJ, Hsiung CA, Shu XO et al. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia. Int J Cancer 2015;137:311–19.
30. Seow WJ, Cawthon RM, Purdue MP et al. Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts. Cancer Res 2014;74:4090–98.
31. Zou P, Gu A, Ji G, Zhao L, Zhao P, Lu A. The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies. BMC Cancer 2012;12:7.
32. Codd V, Nelson CP, Albrecht E et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 2013;45:422–27.
33. Iles MM, Bishop DT, Taylor JC et al. The effect on melanoma risk of genes previously associated with telomere length. J Natl Cancer Inst 2014;106. doi:10.1093/jnci/dju267
34. Winkel P, Statland BE, Saunders AM, Osborn H, Kupperman H. Within-day physiologic variation of leukocyte types in healthy subjects as assayed by two automated leukocyte differential analyzers. Am J Clin Pathol 1981;75:693–700.
35. Lin Y, Damjanovic A, Metter EJ et al. Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Clin Sci (Lond) 2015;128:367–77.
36. Friedrich U, Griese E, Schwab M, Fritz P, Thon K, Klotz U. Telomere length in different tissues of elderly patients. Mech Ageing Dev 2000;119:89–99.
37. Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey SG. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 2008;27:1133–63.