Longer Telomere Length in Peripheral White Blood Cells Is Associated with Risk of Lung Cancer and the rs2736100 (CLPTM1L-TERT) Polymorphism in a Prospective Cohort Study among Women in China

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Lan, Qing ^a   Cawthon, Richard ^b   Gao, Yutang ^c   Hu, Wei ^a   Hosgood III, H Dean ^a   Barone Adesi, Francesco ^a   Ji, Bu Tian ^a   Bassig, Bryan ^a   Chow, Wong Ho ^a   Shu, Xiaoou ^d   Cai, Qiuyin ^d   Xiang, Yongbin ^d   Berndt, Sonja ^a   Kim, Christopher ^a   Chanock, Stephen ^a   Zheng, Wei ^d   Rothman, Nathaniel ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c SHANGHAI CANCER INSTITUTE   (China)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER RISK; CASE CONTROL STUDY; CHINA; CLPTM1L GENE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FAMILY HISTORY; FEMALE; GENE; GENETIC RISK; GENETIC VARIABILITY; HUMAN; LEUKOCYTE; LUNG CANCER; LUNG CARCINOGENESIS; PROSPECTIVE STUDY; RISK ASSESSMENT; SMOKING HABIT; TELOMERE HOMEOSTASIS; TERT GENE;

ADENOCARCINOMA; ADULT; AGED; CASE-CONTROL STUDIES; CHINA; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LEUKOCYTES, MONONUCLEAR; LUNG NEOPLASMS; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RISK; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 84875436593     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059230     Document Type: Article

References (42)

1. Wentzensen IM, Mirabello L, Pfeiffer RM, Savage SA, (2011) The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev 20: 1238-1250.
2. Han J, Qureshi AA, Prescott J, Guo Q, Ye L, et al. (2009) A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol 129: 415-421.
3. Lan Q, Cawthon R, Shen M, Weinstein SJ, Virtamo J, et al. (2009) A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res 15: 7429-7433.
4. Shen M, Cawthon R, Rothman N, Weinstein SJ, Virtamo J, et al. (2011) A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer. Lung Cancer 73: 133-137.
5. Fu X, Wan S, Hann HW, Myers RE, Hann RS, et al. (2012) Relative telomere length: a novel non-invasive biomarker for the risk of non-cirrhotic hepatocellular carcinoma in patients with chronic hepatitis B infection. Eur J Cancer 48: 1014-1022.
6. Gramatges MM, Telli ML, Balise R, Ford JM, (2010) Longer relative telomere length in blood from women with sporadic and familial breast cancer compared with healthy controls. Cancer Epidemiol Biomarkers Prev 19: 605-613.
7. Svenson U, Nordfjall K, Stegmayr B, Manjer J, Nilsson P, et al. (2008) Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Res 68: 3618-3623.
8. Jones AM, Beggs AD, Carvajal-Carmona L, Farrington S, Tenesa A, et al. (2012) TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut. 61: 248-254.
9. Shen J, Gammon MD, Terry MB, Bradshaw PT, Wang Q, et al. (2012) Genetic polymorphisms in telomere pathway genes, telomere length, and breast cancer survival. Breast Cancer Res Treat 134: 393-400.
10. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA, (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361: 393-395.
11. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, et al. (2007) Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol 165: 14-21.
12. Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, et al. (2007) Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A 104: 12135-12139.
13. Vasa-Nicotera M, Brouilette S, Mangino M, Thompson JR, Braund P, et al. (2005) Mapping of a major locus that determines telomere length in humans. Am J Hum Genet 76: 147-151.
14. Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, et al. (2010) Common variants near TERC are associated with mean telomere length. Nat Genet 42: 197-199.
15. Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang SJ, et al. (2010) Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A 107: 9293-9298.
16. Mirabello L, Yu K, Kraft P, De Vivo I, Hunter DJ, et al. (2010) The association of telomere length and genetic variation in telomere biology genes. Hum Mutat 31: 1050-1058.
17. Prescott J, Kraft P, Chasman DI, Savage SA, Mirabello L, et al. (2011) Genome-wide association study of relative telomere length. PLoS One 6: e19635.
18. Miki D, Kubo M, Takahashi A, Yoon KA, Kim J, et al. (2010) Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet 42: 893-896.
19. Hsiung CA, Lan Q, Hong YC, Chen CJ, Hosgood HD, et al. (2010) The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet 6: e1001051.
20. Hu Z, Wu C, Shi Y, Guo H, Zhao X, et al. (2011) A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet 43: 792-796.
21. McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, et al. (2008) Lung cancer susceptibility locus at 5p15.33. Nat Genet 40: 1404-1406.
22. Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, et al. (2010) A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42: 224-228.
23. Rafnar T, Sulem P, Stacey SN, Geller F, Gudmundsson J, et al. (2009) Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet 41: 221-227.
24. Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, et al. (2010) A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet 42: 978-984.
25. Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, et al. (2009) Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet 41: 899-904.
26. Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, et al. (2008) Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet 40: 1407-1409.
27. Zheng W, Chow WH, Yang G, Jin F, Rothman N, et al. (2005) The Shanghai Women's Health Study: rationale, study design, and baseline characteristics. Am J Epidemiol 162: 1123-1131.
28. Cawthon RM, (2009) Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 37: e21.
29. Royston P, Sauerbrei W, (2007) Multivariable modeling with cubic regression splines: A principled approach. Stata Jounal 7: 45-70.
30. Hosgood HD III, Cawthon R, He X, Chanock S, Lan Q, (2009) Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Lung Cancer 66: 157-161.
31. Jang JS, Choi YY, Lee WK, Choi JE, Cha SI, et al. (2008) Telomere length and the risk of lung cancer. Cancer Sci 99: 1385-1389.
32. Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, et al. (2003) Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 95: 1211-1218.
33. Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, et al. (2010) Telomere length in prospective and retrospective cancer case-control studies. Cancer Res 70: 3170-3176.
34. Lee JJ, Nam CE, Cho SH, Park KS, Chung IJ, et al. (2003) Telomere length shortening in non-Hodgkin's lymphoma patients undergoing chemotherapy. Ann Hematol 82: 492-495.
35. Schroder CP, Wisman GB, de Jong S, van der Graaf WT, Ruiters MH, et al. (2001) Telomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation. Br J Cancer 84: 1348-1353.
36. Kim S, Sandler DP, Carswell G, Weinberg CR, Taylor JA, (2011) Reliability and short-term intra-individual variability of telomere length measurement using monochrome multiplexing quantitative PCR. PLoS One 6: e25774.
37. Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, et al. (2003) hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 22: 131-146.
38. Wright WE, Shay JW, (2005) Telomere-binding factors and general DNA repair. Nat Genet 37: 116-118.
39. Ducray C, Pommier JP, Martins L, Boussin FD, Sabatier L, (1999) Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process. Oncogene 18: 4211-4223.
40. Mirabello L, Richards EG, Duong LM, Yu K, Wang Z, et al. (2011) Telomere length and variation in telomere biology genes in individuals with osteosarcoma. Int J Mol Epidemiol Genet 2: 19-29.
41. Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, et al. (2009) A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet 85: 679-691.
42. Miki D, Kubo M, Takahashi A, Yoon KA, Kim J, et al. (2010) Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet 42: 893-896.