Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

Experimental Biology and Medicine

Volumn 242, Issue 16, 2017, Pages 1617-1632

  Lee Montiel, Felipe T ^a   George, Subin M ^a,b   Gough, Albert H ^a,b   Sharma, Anup D ^a,b   Wu, Juanfang ^a   DeBiasio, Richard ^a   Vernetti, Lawrence A ^a,b   Taylor, D Lansing ^a,b,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Liver; microphysiology systems; oxygen; zonation

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; CD31 ANTIGEN; CYTOCHROME P450 2E1; FAT DROPLET; GLUCOSE; INTERLEUKIN 6; LACTATE DEHYDROGENASE; PARACETAMOL; TUMOR NECROSIS FACTOR; IL6 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; OXYGEN;

ARTICLE; COLORIMETRY; COMPUTER SIMULATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE METABOLISM; GLYCOLYSIS; HEPATIC STELLATE CELL; HUMAN; HUMAN CELL; KUPFFER CELL; LIPOGENESIS; LIVER FUNCTION; MICROFLUIDICS; OXIDATIVE PHOSPHORYLATION; OXYGEN TENSION; STEATOSIS; ZONATION; CELL LINE; CYTOLOGY; FATTY LIVER; LAB ON A CHIP; LIVER; LIVER CELL; MACROPHAGE; METABOLISM; MICROCHIP ANALYSIS; MONOCYTE; OXYGEN CONSUMPTION; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SECRETION (PROCESS); U-937 CELL LINE;

ACETAMINOPHEN; CELL LINE; FATTY LIVER; GLUCOSE; GLYCOLYSIS; HEPATOCYTES; HUMANS; INTERLEUKIN-6; LAB-ON-A-CHIP DEVICES; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MICROCHIP ANALYTICAL PROCEDURES; MICROFLUIDICS; MONOCYTES; OXIDATIVE PHOSPHORYLATION; OXYGEN; OXYGEN CONSUMPTION; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 85028868557     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370217703978     Document Type: Article

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