An in vitro hepatic zonation model with a continuous oxygen gradient in a microdevice

Biochemical and Biophysical Research Communications

Volumn 453, Issue 4, 2014, Pages 767-771

  Sato, Asako ^a   Kadokura, Kanae ^a   Uchida, Hideyuki ^a   Tsukada, Kosuke ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Hypoxia; Liver; Metabolic zonation; Microdevice; Oxygen gradient

Indexed keywords

ANTIMYCIN A1; MESSENGER RNA; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL CULTURE EQUIPMENT; CELL CULTURE MICRODEVICE; CELL DAMAGE; CELL DENSITY; CELL ISOLATION; CELL RESPIRATION; CELL STRESS; CONTROLLED STUDY; DIFFUSION COEFFICIENT; HEPATIC METABOLIC ZONATION; IN VITRO STUDY; LIVER CELL; LIVER CELL CULTURE; LIVER METABOLISM; LIVER REGENERATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN CONSUMPTION; OXYGEN DIFFUSION; OXYGEN SENSING; OXYGEN TENSION; PRIMARY CULTURE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BAGG ALBINO MOUSE; BATCH CELL CULTURE; BIOREACTOR; CELL CULTURE; CLASSIFICATION; CYTOLOGY; DEVICE FAILURE ANALYSIS; DEVICES; ELECTRONICS; EQUIPMENT DESIGN; FLOW CYTOMETRY; METABOLISM; MICROFLUIDIC ANALYSIS; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY;

ANIMALS; BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; CELLS, CULTURED; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW CYTOMETRY; HEPATOCYTES; MALE; MICE; MICE, INBRED BALB C; MICROFLUIDIC ANALYTICAL TECHNIQUES; MINIATURIZATION; ORGAN CULTURE TECHNIQUES; OXYGEN; OXYGEN CONSUMPTION;

EID: 84910011720     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.10.017     Document Type: Article

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