Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Wattacheril, Julia ^a   Seeley, Erin H ^b   Angel, Peggi ^b   Chen, Heidi ^c   Bowen, Benjamin P ^d   Lanciault, Christian ^c   M Caprioli, Richard ^b   Abumrad, Naji ^c   Flynn, Charles Robb ^c  

^a Columbia University Medical Center ^*  (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FATTY LIVER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIPID STORAGE; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PHOSPHOLIPID METABOLISM; PROTEIN EXPRESSION;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY LIVER; FEMALE; HUMANS; LIVER; MALE; PHOSPHOLIPIDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84874786444     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057165     Document Type: Article

References (46)

1. Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, et al. (2011) Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology 141: 1249-1253.
2. Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, et al. (2009) Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. The Journal of biological chemistry 284: 33425-33436.
3. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, et al. (2003) Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proceedings of the National Academy of Sciences of the United States of America 100: 3077-3082.
4. Gebhardt R, (1992) Metabolic zonation of the liver: regulation and implications for liver function. Pharmacology & therapeutics 53: 275-354.
5. Jungermann K, Kietzmann T, (1996) Zonation of parenchymal and nonparenchymal metabolism in liver. Annual review of nutrition 16: 179-203.
6. Guzman M, Castro J, (1989) Zonation of fatty acid metabolism in rat liver. Biochem J 264: 107-113.
7. Morrison GR, Brock FE, Karl IE, Shank RE, (1965) Quantitative analysis of regenerating and degenerating areas within the lobule of the carbon tetrachloride-injured liver. Archives of biochemistry and biophysics 111: 448-460.
8. Royo T, Pedragosa MJ, Ayte J, Gil-Gomez G, Vilaro S, et al. (1995) Immunolocalization of mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase in rat liver. Journal of cellular physiology 162: 103-109.
9. Tosh D, Alberti GM, Agius L, (1988) Glucagon regulation of gluconeogenesis and ketogenesis in periportal and perivenous rat hepatocytes. Heterogeneity of hormone action and of the mitochondrial redox state. The Biochemical journal 256: 197-204.
10. Quistorff B, Katz N, Witters LA, (1992) Hepatocyte heterogeneity in the metabolism of fatty acids: discrepancies on zonation of acetyl-CoA carboxylase. Enzyme 46: 59-71.
11. Braeuning A, Ittrich C, Kohle C, Hailfinger S, Bonin M, et al. (2006) Differential gene expression in periportal and perivenous mouse hepatocytes. The FEBS journal 273: 5051-5061.
12. Jungermann K, Kietzmann T, (2000) Oxygen: modulator of metabolic zonation and disease of the liver. Hepatology 31: 255-260.
13. van der Veen JN, Lingrell S, Vance DE, (2012) The membrane lipid phosphatidylcholine is an unexpected source of triacylglycerol in the liver. The Journal of biological chemistry 287: 23418-23426.
14. Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, et al. (2007) A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 46: 1081-1090.
15. Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE, (2008) Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. The Journal of biological chemistry 283: 2147-2155.
16. Kennedy EP, Smith SW, Weiss SB, (1956) New synthesis of lecithin in an isolated enzyme system. Nature 178: 594-595.
17. Vance DE, Walkey CJ, Cui Z, (1997) Phosphatidylethanolamine N-methyltransferase from liver. Biochimica et biophysica acta 1348: 142-150.
18. DeLong CJ, Shen YJ, Thomas MJ, Cui Z, (1999) Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. The Journal of biological chemistry 274: 29683-29688.
19. Reo NV, Adinehzadeh M, Foy BD, (2002) Kinetic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis using (13)C NMR spectroscopy. Biochimica et biophysica acta 1580: 171-188.
20. Sundler R, Akesson B, (1975) Biosynthesis of phosphatidylethanolamines and phosphatidylcholines from ethanolamine and choline in rat liver. The Biochemical journal 146: 309-315.
21. Debois D, Bralet MP, Le Naour F, Brunelle A, Laprevote O, (2009) In situ lipidomic analysis of nonalcoholic fatty liver by cluster TOF-SIMS imaging. Analytical chemistry 81: 2823-2831.
22. Castro-Perez JM, Kamphorst J, DeGroot J, Lafeber F, Goshawk J, et al. (2010) Comprehensive LC-MS E lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. J Proteome Res 9: 2377-2389.
23. Nygren H, Seppanen-Laakso T, Castillo S, Hyotylainen T, Oresic M, (2011) Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol Biol 708: 247-257.
24. Hankin JA, Barkley RM, Murphy RC, (2007) Sublimation as a method of matrix application for mass spectrometric imaging. J Am Soc Mass Spectrom 18: 1646-1652.
25. Seeley EH, Oppenheimer SR, Mi D, Chaurand P, Caprioli RM, (2008) Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections. J Am Soc Mass Spectrom 19: 1069-1077.
26. Chen S, Li M, Hong D, Billheimer D, Li H, et al. (2009) A novel comprehensive wave-form MS data processing method. Bioinformatics 25: 808-814.
27. Coombes KR, Tsavachidis S, Morris JS, Baggerly KA, Hung MC, et al. (2005) Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform. Proteomics 5: 4107-4117.
28. Morris JS, Coombes KR, Koomen J, Baggerly KA, Kobayashi R, (2005) Feature extraction and quantification for mass spectrometry in biomedical applications using the mean spectrum. Bioinformatics 21: 1764-1775.
29. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41: 1313-1321.
30. Han X, Gross RW, (2005) Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass spectrometry reviews 24: 367-412.
31. Gorden DL, Ivanova PT, Myers DS, McIntyre JO, VanSaun MN, et al. (2011) Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. PLoS One 6: e22775.
32. Berry KA, Li B, Reynolds SD, Barkley RM, Gijon MA, et al. (2011) MALDI imaging MS of phospholipids in the mouse lung. J Lipid Res 52: 1551-1560.
33. Petkovic M, Schiller J, Muller M, Benard S, Reichl S, et al. (2001) Detection of individual phospholipids in lipid mixtures by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: phosphatidylcholine prevents the detection of further species. Analytical biochemistry 289: 202-216.
34. Jacobs RL, Devlin C, Tabas I, Vance DE, (2004) Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. The Journal of biological chemistry 279: 47402-47410.
35. Li Z, Agellon LB, Allen TM, Umeda M, Jewell L, et al. (2006) The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell metabolism 3: 321-331.
36. Yao ZM, Vance DE, (1988) The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. The Journal of biological chemistry 263: 2998-3004.
37. Weltman MD, Farrell GC, Liddle C, (1996) Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 111: 1645-1653.
38. Allard JP, Aghdassi E, Mohammed S, Raman M, Avand G, et al. (2008) Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study. Journal of hepatology 48: 300-307.
39. Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, et al. (2004) Increase in long-chain polyunsaturated fatty acid n- 6/n- 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clinical science 106: 635-643.
40. Elias H (1963) Anatomy of the liver. In: Rouiller C, editor. The liver: morphology, biochemistry, physiology. New York: Academic Press. 41.
41. Katz N, Jungermann K, (1976) Autoregulatory shift from fructolysis to lactate gluconeogenisis in rat hepatocyte suspensions. The problem of metabolic zonation of liver parenchyma. Hoppe-Seyler's Zeitschrift fur physiologische Chemie 357: 359-375.
42. Torre C, Perret C, Colnot S, (2011) Transcription dynamics in a physiological process: beta-catenin signaling directs liver metabolic zonation. The international journal of biochemistry & cell biology 43: 271-278.
43. Katz N, Teutsch HF, Jungermann K, Sasse D, (1977) Heterogeneous reciprocal localization of fructose-1,6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue. FEBS letters 83: 272-276.
44. Gebhardt R, Baldysiak-Figiel A, Krugel V, Ueberham E, Gaunitz F, (2007) Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Progress in histochemistry and cytochemistry 41: 201-266.
45. Gebhardt R, Lindros K, Lamers WH, Moorman AF, (1991) Hepatocellular heterogeneity in ammonia metabolism: demonstration of limited colocalization of carbamoylphosphate synthetase and glutamine synthetase. European journal of cell biology 56: 464-467.
46. Haussinger D, Lamers WH, Moorman AF, (1992) Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. Enzyme 46: 72-93.