PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients

Journal of Experimental Medicine

Volumn 214, Issue 9, 2017, Pages 2523-2533

  Zhang, Yuan ^a   Ma, Chi A ^a   Lawrence, Monica G ^b   Break, Timothy J ^a   O'Connell, Michael P ^a   Lyons, Jonathan J ^a   López, Diego B ^c   Barber, John S ^d   Zhao, Yongge ^e   Barber, Daniel L ^a   Freeman, Alexandra F ^a   Holland, Steven M ^a   Lionakis, Michail S ^a   Milner, Joshua D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PROGRAMMED DEATH 1 LIGAND 1; STAT1 PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; CD274 PROTEIN, HUMAN; IL27 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; SOCS3 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CHILD; CONTROLLED STUDY; FEMALE; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TH17 CELL; UPREGULATION; ANIMAL; GENETICS; IMMUNE DEFICIENCY; IMMUNOLOGY; KNOCKOUT MOUSE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; ANTIGENS, CD274; CELL DIFFERENTIATION; CHILD; CYTOKINES; FEMALE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTERLEUKINS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN; TH17 CELLS; UP-REGULATION; YOUNG ADULT;

EID: 85028840716     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20161427     Document Type: Article

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