The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells

Cytokine

Volumn 64, Issue 1, 2013, Pages 404-412

  Adamik, Juraj ^a   Henkel, Matthew ^b   Ray, Anuradha ^b   Auron, Philip E ^a   Duerr, Richard ^b   Barrie, Arthur ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Chromatin; IL 17A; IL 17F; Prostaglandin E2; Th17

Indexed keywords

CYCLIC AMP; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 1BETA; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2;

ARTICLE; CD4+ T LYMPHOCYTE; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; EFFECTOR CELL; GENE CONTROL; GENE EXPRESSION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IL17A GENE; IL1FA GENE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH17 CELL;

1-HYDROXY PROSTAGLANDIN E1; 1-OH-PGE1; C(T); CHIP; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; E PROSTANOID; EP; GENOME WIDE ASSOCIATION STUDIES; GWAS; IBD; IL-17A; IL-17F; INFLAMMATORY BOWEL DISEASE; PGE2; PROSTAGLANDIN E2; T HELPER; TH; TH17; THRESHOLD CYCLE;

CELL LINE; CHROMATIN; CYCLIC AMP; HISTONES; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-23; PROSTAGLANDINS E; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TH17 CELLS;

EID: 84883553200     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2013.05.010     Document Type: Article

References (37)

1. Cho J.H. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008, 8:458-466.
2. Yen D., Cheung J., Scheerens H., Poulet F., McClanahan T., McKenzie B., et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006, 116:1310-1316.
3. Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007, 204:1849-1861.
4. Iwakura Y., Ishigame H., Saijo S., Nakae S. Functional specialization of interleukin-17 family members. Immunity 2011, 34:149-162.
5. O'Connor W., Kamanaka M., Booth C.J., Town T., Nakae S., Iwakura Y., et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 2009, 10:603-609.
6. Yang X.O., Chang S.H., Park H., Nurieva R., Shah B., Acero L., et al. Regulation of inflammatory responses by IL-17F. J Exp Med 2008, 205:1063-1075.
7. Zhang X., Angkasekwinai P., Dong C., Tang H. Structure and function of interleukin-17 family cytokines. Protein Cell 2011, 2:26-40.
8. Franke A., McGovern D.P., Barrett J.C., Wang K., Radford-Smith G.L., Ahmad T., et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010, 42:1118-1125.
9. Libioulle C., Louis E., Hansoul S., Sandor C., Farnir F., Franchimont D., et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 2007, 3:e58.
10. Duerr R.H., Taylor K.D., Brant S.R., Rioux J.D., Silverberg M.S., Daly M.J., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006, 314:1461-1463.
11. Akimzhanov A.M., Yang X.O., Dong C. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem 2007, 282:5969-5972.
12. Mukasa R., Balasubramani A., Lee Y.K., Whitley S.K., Weaver B.T., Shibata Y., et al. Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity 2010, 32:616-627.
13. Solomou E.E., Juang Y.T., Gourley M.F., Kammer G.M., Tsokos G.C. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J Immunol 2001, 166:4216-4222.
14. Hedrich C.M., Rauen T., Kis-Toth K., Kyttaris V.C., Tsokos G.C. CAMP response element modulator (CREM)alpha suppresses IL-17F expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). J Biol Chem 2012, 287(7):4715-4725.
15. Rauen T., Hedrich C.M., Juang Y.T., Tenbrock K., Tsokos G.C. CAMP-responsive element modulator (CREM)alpha protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. J Biol Chem 2011, 286:43437-43446.
16. Fuss I.J., Becker C., Yang Z., Groden C., Hornung R.L., Heller F., et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 2006, 12:9-15.
17. Mahida Y.R., Wu K., Jewell D.P. Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease. Gut 1989, 30:835-838.
18. Wardle T.D., Hall L., Turnberg L.A. Use of coculture of colonic mucosal biopsies to investigate the release of eicosanoids by inflamed and uninflamed mucosa from patients with inflammatory bowel disease. Gut 1992, 33:1644-1651.
19. Barrie A., Khare A., Henkel M., Zhang Y., Barmada M.M., Duerr R., et al. Prostaglandin E2 and IL-23 plus IL-1beta differentially regulate the Th1/Th17 immune response of human CD161(+) CD4(+) memory T cells. Clin Transl Sci 2011, 4:268-273.
20. Boniface K., Bak-Jensen K.S., Li Y., Blumenschein W.M., McGeachy M.J., McClanahan T.K., et al. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med 2009, 206:535-548.
21. Napolitani G., Acosta-Rodriguez E.V., Lanzavecchia A., Sallusto F. Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells. Eur J Immunol 2009, 39:1301-1312.
22. Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., et al. Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9. J Biol Chem 2011, 286:21092-21099.
23. Maggi L., Santarlasci V., Capone M., Peired A., Frosali F., Crome S.Q., et al. CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur J Immunol 2010, 40:2174-2181.
24. Cosmi L., De Palma R., Santarlasci V., Maggi L., Capone M., Frosali F., et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J Exp Med 2008, 205:1903-1916.
25. Kleinschek M.A., Boniface K., Sadekova S., Grein J., Murphy E.E., Turner S.P., et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J Exp Med 2009, 206:525-534.
26. Gomez-Rodriguez J., Sahu N., Handon R., Davidson T.S., Anderson S.M., Kirby M.R., et al. Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity 2009, 31:587-597.
27. Bell O., Tiwari V.K., Thoma N.H., Schubeler D. Determinants and dynamics of genome accessibility. Nat Rev Genet 2011, 12:554-564.
28. Wang Z., Zang C., Cui K., Schones D.E., Barski A., Peng W., et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 2009, 138:1019-1031.
29. Henikoff S., Shilatifard A. Histone modification: cause or cog?. Trends Genet 2011, 27:389-396.
30. Guenther M.G., Young R.A. Transcription. Repressive transcription. Science 2010, 329:150-151.
31. Barski A., Jothi R., Cuddapah S., Cui K., Roh T.Y., Schones D.E., et al. Chromatin poises miRNA- and protein-coding genes for expression. Genome Res 2009, 19:1742-1751.
32. Schmechel S., Konrad A., Diegelmann J., Glas J., Wetzke M., Paschos E., et al. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008, 14:204-212.
33. Kabashima K., Saji T., Murata T., Nagamachi M., Matsuoka T., Segi E., et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest 2002, 109:883-893.
34. Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 2008, 28:29-39.
35. Wang X., Zhang Y., Yang X.O., Nurieva R.I., Chang S.H., Ojeda S.S., et al. Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity 2012, 36:23-31.
36. Hansen K.H., Bracken A.P., Pasini D., Dietrich N., Gehani S.S., Monrad A., et al. A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol 2008, 10:1291-1300.
37. Core L.J., Waterfall J.J., Gilchrist D.A., Fargo D.C., Kwak H., Adelman K., et al. Defining the status of RNA polymerase at promoters. Cell Rep 2012, 2:1025-1035.