Impaired natural killer cell functions in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations

Journal of Allergy and Clinical Immunology

Volumn 140, Issue 2, 2017, Pages 553-564.e4

  Tabellini, Giovanna ^a   Vairo, Donatella ^a   Scomodon, Omar ^a   Tamassia, Nicola ^b   Ferraro, Rosalba Monica ^a   Patrizi, Ornella ^a   Gasperini, Sara ^b   Soresina, Annarosa ^c   Giardino, Giuliana ^d   Pignata, Claudio ^d   Lougaris, Vassilios ^a   Plebani, Alessandro ^a   Dotta, Laura ^a   Cassatella, Marco A ^b   Parolini, Silvia ^a   Badolato, Raffaele ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c SPEDALI CIVILI   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

candidiasis; cytotoxic activity; IL 15; Natural killer cells; signal transducer and activator of transcription 1; signal transducer and activator of transcription 5

Indexed keywords

CD56 ANTIGEN; CD57 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR1; GAMMA INTERFERON; INTERFERON INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEAT 1; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; KI 67 ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MESSENGER RNA; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D; STAT1 PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; TETRATRICOPEPTIDE REPEAT PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; STAT1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; CELL STIMULATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; DEGRANULATION; FEMALE; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; INTRACELLULAR SIGNALING; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MIDDLE AGED; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SCHOOL CHILD; UPREGULATION; YOUNG ADULT; CASE REPORT; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; MUCOCUTANEOUS CANDIDIASIS; MUTATION; PHOSPHORYLATION;

ADOLESCENT; ADULT; CANDIDIASIS, CHRONIC MUCOCUTANEOUS; CHILD; CYTOKINES; FEMALE; GENE EXPRESSION; HUMANS; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; MUTATION; PHOSPHORYLATION; STAT1 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR;

EID: 85011838425     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.10.051     Document Type: Article

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