Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC)

European Journal of Immunology

Volumn 45, Issue 10, 2015, Pages 2834-2846

  Zheng, Jie ^a   van de Veerdonk, Frank L ^b   Crossland, Katherine L ^a   Smeekens, Sanne P ^b   Chan, Chun M ^a   Al Shehri, Tariq ^a   Abinun, Mario ^a,c   Gennery, Andrew R ^a,c   Mann, Jelena ^a   Lendrem, Dennis W ^a   Netea, Mihai G ^b   Rowan, Andrew D ^a   Lilic, Desa ^a,d  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UK   (United Kingdom)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

Chronic mucocutaneous candidiasis (CMC); HDAC inhibitors; IL 17; STAT1 gain of function mutation; STAT1 inhibitors; STAT3

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; INTERLEUKIN 10; INTERLEUKIN 22; MYC PROTEIN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT1 PROTEIN; STAT3 PROTEIN; CYTOKINE; GIVINOSTAT HYDROCHLORIDE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; TRICHOSTATIN A;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; EPIGENETICS; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MUCOCUTANEOUS CANDIDIASIS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; ACETYLATION; CLINICAL TRIAL; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MALE; MUTATION; PATHOLOGY; TH17 CELL;

ACETYLATION; CANDIDIASIS, CHRONIC MUCOCUTANEOUS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MALE; MUTATION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TH17 CELLS; TRANSCRIPTION, GENETIC;

EID: 84943200494     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445344     Document Type: Article

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