Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Nature Medicine

Volumn 23, Issue 6, 2017, Pages 775-781

  Jeon, Ok Hee ^a   Kim, Chaekyu ^a,b   Laberge, Remi Martin ^c,d   Demaria, Marco ^c,e   Rathod, Sona ^a   Vasserot, Alain P ^d   Chung, Jae Wook ^a   Kim, Do Hun ^a   Poon, Yan ^d   David, Nathaniel ^d   Baker, Darren J ^f   Van Deursen, Jan M ^f   Campisi, Judith ^c,g   Elisseeff, Jennifer H ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Ulsan National Institute of Science and Technology   (South Korea)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^d Unity Biotechnology Inc   (United States)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f Mayo Clinic College of Medicine   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; HYBRID PROTEIN; RED FLUORESCENT PROTEIN; RENILLA LUCIFERIN 2 MONOOXYGENASE; SCLEROPROTEIN; THYMIDINE KINASE; VIRUS ENZYME; ANTIVIRUS AGENT; CDKN2A PROTEIN, MOUSE; GANCICLOVIR; GLYCOSAMINOGLYCAN;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR CRUCIATE LIGAMENT INJURY; ARTICLE; ARTICULAR CARTILAGE; CELL AGING; CELL ISOLATION; CHONDROCYTE; CONTROLLED STUDY; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KNEE OSTEOARTHRITIS; MOUSE; NONHUMAN; OSTEOARTHRITIS; POSTTRAUMATIC ARTHROPATHY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SENESCENCE; SYNOVIUM; TOTAL KNEE ARTHROPLASTY; ANIMAL; ANTERIOR CRUCIATE LIGAMENT; COMPLICATION; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; OSTEOARTHRITIS, KNEE; REAL TIME POLYMERASE CHAIN REACTION; REGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURGERY; TRANSGENIC MOUSE; WEIGHT BEARING;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT INJURIES; ANTIVIRAL AGENTS; CARTILAGE, ARTICULAR; CELL AGING; CHONDROCYTES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EXTRACELLULAR MATRIX PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; GANCICLOVIR; GLYCOSAMINOGLYCANS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO TECHNIQUES; MICE; MICE, TRANSGENIC; OSTEOARTHRITIS, KNEE; REAL-TIME POLYMERASE CHAIN REACTION; REGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WEIGHT-BEARING;

EID: 85018396395     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4324     Document Type: Article

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