메뉴 건너뛰기




Volumn , Issue , 2016, Pages 290-317

Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders

Author keywords

cerebrospinal fluid biomarker; confounding; dementia; factors; neuropathology; Parkinson's disease; tau protein; synuclein; amyloid

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; FLUOXETINE; LEVODOPA; TAU PROTEIN;

EID: 85028252032     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13390     Document Type: Review
Times cited : (60)

References (171)
  • 1
    • 77950813474 scopus 로고    scopus 로고
    • The epidemiology of dementia associated with Parkinson's disease
    • Aarsland D. and Kurz M. W. (2010) The epidemiology of dementia associated with Parkinson's disease. Brain Pathol. 20, 633–639.
    • (2010) Brain Pathol. , vol.20 , pp. 633-639
    • Aarsland, D.1    Kurz, M.W.2
  • 2
    • 0141628889 scopus 로고    scopus 로고
    • Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease
    • Aarsland D., Litvan I., Salmon D., Galasko D., Wentzel-Larsen T. and Larsen J. P. (2003) Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 74, 1215–1220.
    • (2003) J. Neurol. Neurosurg. Psychiatry , vol.74 , pp. 1215-1220
    • Aarsland, D.1    Litvan, I.2    Salmon, D.3    Galasko, D.4    Wentzel-Larsen, T.5    Larsen, J.P.6
  • 3
    • 65249115240 scopus 로고    scopus 로고
    • Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study
    • Aarsland D., Bronnick K., Larsen J. P., Tysnes O. B. and Alves G. (2009) Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study. Neurology 72, 1121–1126.
    • (2009) Neurology , vol.72 , pp. 1121-1126
    • Aarsland, D.1    Bronnick, K.2    Larsen, J.P.3    Tysnes, O.B.4    Alves, G.5
  • 4
    • 84907162800 scopus 로고    scopus 로고
    • Elevated levels of cerebrospinal fluid alpha-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers
    • Aasly J. O., Johansen K. K., Bronstad G. et al. (2014) Elevated levels of cerebrospinal fluid alpha-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers. Front. Aging Neurosci. 6, 248.
    • (2014) Front. Aging Neurosci. , vol.6 , pp. 248
    • Aasly, J.O.1    Johansen, K.K.2    Bronstad, G.3
  • 5
    • 84905822184 scopus 로고    scopus 로고
    • Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study
    • Adler C. H., Beach T. G., Hentz J. G. et al. (2014) Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology 83, 406–412.
    • (2014) Neurology , vol.83 , pp. 406-412
    • Adler, C.H.1    Beach, T.G.2    Hentz, J.G.3
  • 6
    • 82755194923 scopus 로고    scopus 로고
    • CSF alpha-synuclein does not differentiate between parkinsonian disorders
    • Aerts M. B., Esselink R. A., Abdo W. F., Bloem B. R. and Verbeek M. M. (2012) CSF alpha-synuclein does not differentiate between parkinsonian disorders. Neurobiol. Aging 33, e431–e433.
    • (2012) Neurobiol. Aging , vol.33 , pp. e431-e433
    • Aerts, M.B.1    Esselink, R.A.2    Abdo, W.F.3    Bloem, B.R.4    Verbeek, M.M.5
  • 8
    • 77958071837 scopus 로고    scopus 로고
    • CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study
    • Alves G., Bronnick K., Aarsland D. et al. (2010) CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study. J. Neurol. Neurosurg. Psychiatry 81, 1080–1086.
    • (2010) J. Neurol. Neurosurg. Psychiatry , vol.81 , pp. 1080-1086
    • Alves, G.1    Bronnick, K.2    Aarsland, D.3
  • 9
    • 84876133397 scopus 로고    scopus 로고
    • Cerebrospinal fluid amyloid-beta and phenotypic heterogeneity in de novo Parkinson's disease
    • Alves G., Pedersen K. F., Bloem B. R. et al. (2013) Cerebrospinal fluid amyloid-beta and phenotypic heterogeneity in de novo Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 84, 537–543.
    • (2013) J. Neurol. Neurosurg. Psychiatry , vol.84 , pp. 537-543
    • Alves, G.1    Pedersen, K.F.2    Bloem, B.R.3
  • 11
    • 78650315484 scopus 로고    scopus 로고
    • The cognitive profile and CSF biomarkers in dementia with Lewy bodies and Parkinson's disease dementia
    • Andersson M., Zetterberg H., Minthon L., Blennow K. and Londos E. (2011) The cognitive profile and CSF biomarkers in dementia with Lewy bodies and Parkinson's disease dementia. Int. J. Geriatr. Psychiatry 26, 100–105.
    • (2011) Int. J. Geriatr. Psychiatry , vol.26 , pp. 100-105
    • Andersson, M.1    Zetterberg, H.2    Minthon, L.3    Blennow, K.4    Londos, E.5
  • 12
    • 0034047021 scopus 로고    scopus 로고
    • Beta-amyloid deposition in the temporal lobe of patients with dementia with Lewy bodies: comparison with non-demented cases and Alzheimer's disease
    • Armstrong R. A., Cairns N. J. and Lantos P. L. (2000) Beta-amyloid deposition in the temporal lobe of patients with dementia with Lewy bodies: comparison with non-demented cases and Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 11, 187–192.
    • (2000) Dement. Geriatr. Cogn. Disord. , vol.11 , pp. 187-192
    • Armstrong, R.A.1    Cairns, N.J.2    Lantos, P.L.3
  • 13
    • 80052398365 scopus 로고    scopus 로고
    • alpha-synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    • Bartels T., Choi J. G. and Selkoe D. J. (2011) alpha-synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477, 107–110.
    • (2011) Nature , vol.477 , pp. 107-110
    • Bartels, T.1    Choi, J.G.2    Selkoe, D.J.3
  • 14
    • 33947507128 scopus 로고    scopus 로고
    • Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker
    • Bateman R. J., Wen G., Morris J. C. and Holtzman D. M. (2007) Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker. Neurology 68, 666–669.
    • (2007) Neurology , vol.68 , pp. 666-669
    • Bateman, R.J.1    Wen, G.2    Morris, J.C.3    Holtzman, D.M.4
  • 15
    • 84865529158 scopus 로고    scopus 로고
    • Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    • Bateman R. J., Xiong C., Benzinger T. L. et al. (2012) Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367, 795–804.
    • (2012) N. Engl. J. Med. , vol.367 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.3
  • 16
    • 84655161556 scopus 로고    scopus 로고
    • Amyloid-related biomarkers and axonal damage proteins in parkinsonian syndromes
    • Bech S., Hjermind L. E., Salvesen L. et al. (2012) Amyloid-related biomarkers and axonal damage proteins in parkinsonian syndromes. Parkinsonism Relat. Disord. 18, 69–72.
    • (2012) Parkinsonism Relat. Disord. , vol.18 , pp. 69-72
    • Bech, S.1    Hjermind, L.E.2    Salvesen, L.3
  • 17
    • 84875546993 scopus 로고    scopus 로고
    • Cerebrospinal fluid Abeta levels correlate with structural brain changes in Parkinson's disease
    • Beyer M. K., Alves G., Hwang K. S. et al. (2013) Cerebrospinal fluid Abeta levels correlate with structural brain changes in Parkinson's disease. Mov. Disord. 28, 302–310.
    • (2013) Mov. Disord. , vol.28 , pp. 302-310
    • Beyer, M.K.1    Alves, G.2    Hwang, K.S.3
  • 18
    • 33646266021 scopus 로고    scopus 로고
    • CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
    • Bibl M., Mollenhauer B., Esselmann H. et al. (2006) CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia. Brain 129, 1177–1187.
    • (2006) Brain , vol.129 , pp. 1177-1187
    • Bibl, M.1    Mollenhauer, B.2    Esselmann, H.3
  • 19
    • 34347272662 scopus 로고    scopus 로고
    • Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    • Bibl M., Mollenhauer B., Lewczuk P. (2007a) Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias. Mol. Psychiatry 12, 671–680.
    • (2007) Mol. Psychiatry , vol.12 , pp. 671-680
    • Bibl, M.1    Mollenhauer, B.2    Lewczuk, P.3
  • 20
    • 34347272662 scopus 로고    scopus 로고
    • Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    • Bibl M., Mollenhauer B., Lewczuk P. et al. (2007b) Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias. Mol. Psychiatry 12, 671–680.
    • (2007) Mol. Psychiatry , vol.12 , pp. 671-680
    • Bibl, M.1    Mollenhauer, B.2    Lewczuk, P.3
  • 21
    • 77957869895 scopus 로고    scopus 로고
    • Combined analysis of CSF tau, Abeta42, Abeta1-42% and Abeta1-40% in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
    • Bibl M., Esselmann H., Lewczuk P., Trenkwalder C., Otto M., Kornhuber J., Wiltfang J. and Mollenhauer B. (2010) Combined analysis of CSF tau, Abeta42, Abeta1-42% and Abeta1-40% in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia. Int. J. Alzheimers Dis. 2010, pii: 761571. doi: 10.4061/2010/761571.
    • (2010) Int. J. Alzheimers Dis. , vol.2010
    • Bibl, M.1    Esselmann, H.2    Lewczuk, P.3    Trenkwalder, C.4    Otto, M.5    Kornhuber, J.6    Wiltfang, J.7    Mollenhauer, B.8
  • 23
    • 77956028825 scopus 로고    scopus 로고
    • Confounding factors influencing amyloid Beta concentration in cerebrospinal fluid
    • Bjerke M., Portelius E., Minthon L. et al. (2010) Confounding factors influencing amyloid Beta concentration in cerebrospinal fluid. Int. J. Alzheimers Dis. 2010, pii: 986310. doi: 10.4061/2010/986310.
    • (2010) Int. J. Alzheimers Dis. , vol.2010
    • Bjerke, M.1    Portelius, E.2    Minthon, L.3
  • 24
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • Blennow K., Hampel H., Weiner M. and Zetterberg H. (2010) Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat. Rev. Neurol. 6, 131–144.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 26
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • Braak H. and Braak E. (1997) Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging 18, 351–357.
    • (1997) Neurobiol. Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 28
    • 84878765032 scopus 로고    scopus 로고
    • Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies
    • Brunnstrom H., Hansson O., Zetterberg H., Londos E. and Englund E. (2013) Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies. Int. J. Geriatr. Psychiatry 28, 738–744.
    • (2013) Int. J. Geriatr. Psychiatry , vol.28 , pp. 738-744
    • Brunnstrom, H.1    Hansson, O.2    Zetterberg, H.3    Londos, E.4    Englund, E.5
  • 29
    • 33750589818 scopus 로고    scopus 로고
    • CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    • Buerger K., Ewers M., Pirttila T. et al. (2006) CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain 129, 3035–3041.
    • (2006) Brain , vol.129 , pp. 3035-3041
    • Buerger, K.1    Ewers, M.2    Pirttila, T.3
  • 30
    • 84865477339 scopus 로고    scopus 로고
    • Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update
    • del Campo M., Mollenhauer B., Bertolotto A. et al. (2012) Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update. Biomark Med. 6, 419–430.
    • (2012) Biomark Med. , vol.6 , pp. 419-430
    • del Campo, M.1    Mollenhauer, B.2    Bertolotto, A.3
  • 31
    • 84862782622 scopus 로고    scopus 로고
    • The influence of ageing in the cerebrospinal fluid concentrations of proteins that are derived from the choroid plexus, brain, and plasma
    • Chen C. P., Chen R. L. and Preston J. E. (2012) The influence of ageing in the cerebrospinal fluid concentrations of proteins that are derived from the choroid plexus, brain, and plasma. Exp. Gerontol. 47, 323–328.
    • (2012) Exp. Gerontol. , vol.47 , pp. 323-328
    • Chen, C.P.1    Chen, R.L.2    Preston, J.E.3
  • 32
    • 84936941824 scopus 로고    scopus 로고
    • Preanalytical confounding factors in the analysis of cerebrospinal fluid biomarkers for Alzheimer's disease: the issue of diurnal variation
    • Cicognola C., Chiasserini D. and Parnetti L. (2015) Preanalytical confounding factors in the analysis of cerebrospinal fluid biomarkers for Alzheimer's disease: the issue of diurnal variation. Front. Neurol. 6, 143.
    • (2015) Front. Neurol. , vol.6 , pp. 143
    • Cicognola, C.1    Chiasserini, D.2    Parnetti, L.3
  • 33
    • 0346124139 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
    • Clark C. M., Xie S., Chittams J. et al. (2003) Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Arch. Neurol. 60, 1696–1702.
    • (2003) Arch. Neurol. , vol.60 , pp. 1696-1702
    • Clark, C.M.1    Xie, S.2    Chittams, J.3
  • 35
    • 84865589973 scopus 로고    scopus 로고
    • Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia
    • Compta Y., Ibarretxe-Bilbao N., Pereira J. B. et al. (2012) Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia. Parkinsonism Relat. Disord. 18, 941–947.
    • (2012) Parkinsonism Relat. Disord. , vol.18 , pp. 941-947
    • Compta, Y.1    Ibarretxe-Bilbao, N.2    Pereira, J.B.3
  • 36
    • 84879411933 scopus 로고    scopus 로고
    • Combined dementia-risk biomarkers in Parkinson's disease: a prospective longitudinal study
    • Compta Y., Pereira J. B., Rios J. et al. (2013) Combined dementia-risk biomarkers in Parkinson's disease: a prospective longitudinal study. Parkinsonism Relat. Disord. 19, 717–724.
    • (2013) Parkinsonism Relat. Disord. , vol.19 , pp. 717-724
    • Compta, Y.1    Pereira, J.B.2    Rios, J.3
  • 37
    • 84925498290 scopus 로고    scopus 로고
    • Correlates of cerebrospinal fluid levels of oligomeric- and total-alpha-synuclein in premotor, motor and dementia stages of Parkinson's disease
    • Compta Y., Valente T., Saura J. et al. (2015) Correlates of cerebrospinal fluid levels of oligomeric- and total-alpha-synuclein in premotor, motor and dementia stages of Parkinson's disease. J. Neurol. 262, 294–306.
    • (2015) J. Neurol. , vol.262 , pp. 294-306
    • Compta, Y.1    Valente, T.2    Saura, J.3
  • 39
    • 77955453909 scopus 로고    scopus 로고
    • Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people
    • De Meyer G., Shapiro F., Vanderstichele H. et al. (2010) Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people. Arch. Neurol. 67, 949–956.
    • (2010) Arch. Neurol. , vol.67 , pp. 949-956
    • De Meyer, G.1    Shapiro, F.2    Vanderstichele, H.3
  • 40
    • 56749185181 scopus 로고    scopus 로고
    • Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography
    • Edison P., Rowe C. C., Rinne J. O. et al. (2008) Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J. Neurol. Neurosurg. Psychiatry 79, 1331–1338.
    • (2008) J. Neurol. Neurosurg. Psychiatry , vol.79 , pp. 1331-1338
    • Edison, P.1    Rowe, C.C.2    Rinne, J.O.3
  • 41
    • 84878614977 scopus 로고    scopus 로고
    • Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology
    • Eisbach S. E. and Outeiro T. F. (2013) Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology. J. Mol. Med. 91, 693–703.
    • (2013) J. Mol. Med. , vol.91 , pp. 693-703
    • Eisbach, S.E.1    Outeiro, T.F.2
  • 42
    • 85109083933 scopus 로고    scopus 로고
    • Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
    • El-Agnaf O. M., Salem S. A., Paleologou K. E. et al. (2003) Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J. 17, 1945–1947.
    • (2003) FASEB J. , vol.17 , pp. 1945-1947
    • El-Agnaf, O.M.1    Salem, S.A.2    Paleologou, K.E.3
  • 43
  • 46
    • 33646360835 scopus 로고    scopus 로고
    • The effects of cerebral ischemia on the rat choroid plexus
    • Ennis S. R. and Keep R. F. (2006) The effects of cerebral ischemia on the rat choroid plexus. J. Cereb. Blood Flow Metab. 26, 675–683.
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 675-683
    • Ennis, S.R.1    Keep, R.F.2
  • 48
    • 33645116252 scopus 로고    scopus 로고
    • Genetics of Parkinson disease: paradigm shifts and future prospects
    • Farrer M. J. (2006) Genetics of Parkinson disease: paradigm shifts and future prospects. Nat. Rev. Genet. 7, 306–318.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 306-318
    • Farrer, M.J.1
  • 49
    • 81955167983 scopus 로고    scopus 로고
    • Post mortem cerebrospinal fluid alpha-synuclein levels are raised in multiple system atrophy and distinguish this from the other alpha-synucleinopathies, Parkinson's disease and dementia with Lewy bodies
    • Foulds P. G., Yokota O., Thurston A. et al. (2012) Post mortem cerebrospinal fluid alpha-synuclein levels are raised in multiple system atrophy and distinguish this from the other alpha-synucleinopathies, Parkinson's disease and dementia with Lewy bodies. Neurobiol. Dis. 45, 188–195.
    • (2012) Neurobiol. Dis. , vol.45 , pp. 188-195
    • Foulds, P.G.1    Yokota, O.2    Thurston, A.3
  • 50
    • 77958044527 scopus 로고    scopus 로고
    • The Parkinson's progression markers initiative: a prospective biomarker study
    • Frasier M., Chowdhury S., Sherer T. et al. (2010) The Parkinson's progression markers initiative: a prospective biomarker study. Mov. Disord. 25, P340.
    • (2010) Mov. Disord. , vol.25 , pp. P340
    • Frasier, M.1    Chowdhury, S.2    Sherer, T.3
  • 51
    • 79954602288 scopus 로고    scopus 로고
    • Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?
    • Frigerio R., Fujishiro H., Ahn T. B. et al. (2011) Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol. Aging 32, 857–863.
    • (2011) Neurobiol. Aging , vol.32 , pp. 857-863
    • Frigerio, R.1    Fujishiro, H.2    Ahn, T.B.3
  • 52
    • 0032529707 scopus 로고    scopus 로고
    • Multiple-system atrophy: a new alpha-synuclein disease?
    • Gai W. P., Power J. H., Blumbergs P. C. and Blessing W. W. (1998) Multiple-system atrophy: a new alpha-synuclein disease? Lancet 352, 547–548.
    • (1998) Lancet , vol.352 , pp. 547-548
    • Gai, W.P.1    Power, J.H.2    Blumbergs, P.C.3    Blessing, W.W.4
  • 53
    • 38049072194 scopus 로고    scopus 로고
    • A more efficient enzyme-linked immunosorbent assay for measurement of alpha-synuclein in cerebrospinal fluid
    • van Geel W. J., Abdo W. F., Melis R., Williams S., Bloem B. R. and Verbeek M. M. (2008) A more efficient enzyme-linked immunosorbent assay for measurement of alpha-synuclein in cerebrospinal fluid. J. Neurosci. Methods 168, 182–185.
    • (2008) J. Neurosci. Methods , vol.168 , pp. 182-185
    • van Geel, W.J.1    Abdo, W.F.2    Melis, R.3    Williams, S.4    Bloem, B.R.5    Verbeek, M.M.6
  • 56
    • 0026646604 scopus 로고
    • Amyloid beta-peptide is produced by cultured cells during normal metabolism
    • Haass C., Schlossmacher M. G., Hung A. Y. et al. (1992) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359, 322–325.
    • (1992) Nature , vol.359 , pp. 322-325
    • Haass, C.1    Schlossmacher, M.G.2    Hung, A.Y.3
  • 57
    • 84868585835 scopus 로고    scopus 로고
    • Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or Parkinsonian disorders
    • Hall S., Öhrfelt A., Constantinescu R. et al. (2012) Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or Parkinsonian disorders. Arch. Neurol. 69, 1445–1452.
    • (2012) Arch. Neurol. , vol.69 , pp. 1445-1452
    • Hall, S.1    Öhrfelt, A.2    Constantinescu, R.3
  • 59
    • 77949897463 scopus 로고    scopus 로고
    • The progression of pathology in Parkinson's disease
    • Halliday G. M. and McCann H. (2010) The progression of pathology in Parkinson's disease. Ann. N. Y. Acad. Sci. 1184, 188–195.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1184 , pp. 188-195
    • Halliday, G.M.1    McCann, H.2
  • 60
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday G. M., Holton J. L., Revesz T. and Dickson D. W. (2011) Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol. 122, 187–204.
    • (2011) Acta Neuropathol. , vol.122 , pp. 187-204
    • Halliday, G.M.1    Holton, J.L.2    Revesz, T.3    Dickson, D.W.4
  • 61
    • 32544435900 scopus 로고    scopus 로고
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    • Hansson O., Zetterberg H., Buchhave P., Londos E., Blennow K. and Minthon L. (2006) Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 5, 228–234.
    • (2006) Lancet Neurol. , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 62
    • 84989182833 scopus 로고    scopus 로고
    • Levels of cerebrospinal fluid alpha-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease
    • Hansson O., Hall S., Ohrfelt A. et al. (2014) Levels of cerebrospinal fluid alpha-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease. Alzheimers Res. Ther. 6, 25.
    • (2014) Alzheimers Res. Ther. , vol.6 , pp. 25
    • Hansson, O.1    Hall, S.2    Ohrfelt, A.3
  • 63
    • 84861671617 scopus 로고    scopus 로고
    • The spread of neurodegenerative disease
    • Hardy J. and Revesz T. (2012) The spread of neurodegenerative disease. N. Engl. J. Med. 366, 2126–2128.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2126-2128
    • Hardy, J.1    Revesz, T.2
  • 64
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    • Hely M. A., Reid W. G., Adena M. A., Halliday G. M. and Morris J. G. (2008) The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 23, 837–844.
    • (2008) Mov. Disord. , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.2    Adena, M.A.3    Halliday, G.M.4    Morris, J.G.5
  • 65
    • 77950223687 scopus 로고    scopus 로고
    • DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    • Hong Z., Shi M., Chung K. A. et al. (2010) DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain 133, 713–726.
    • (2010) Brain , vol.133 , pp. 713-726
    • Hong, Z.1    Shi, M.2    Chung, K.A.3
  • 66
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases
    • Hughes A. J., Daniel S. E., Kilford L. and Lees A. J. (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 55, 181–184.
    • (1992) J. Neurol. Neurosurg. Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 67
    • 0036209085 scopus 로고    scopus 로고
    • The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service
    • Hughes A. J., Daniel S. E., Ben-Shlomo Y. and Lees A. J. (2002) The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 125, 861–870.
    • (2002) Brain , vol.125 , pp. 861-870
    • Hughes, A.J.1    Daniel, S.E.2    Ben-Shlomo, Y.3    Lees, A.J.4
  • 68
    • 84868200922 scopus 로고    scopus 로고
    • Neuropathologic substrates of Parkinson disease dementia
    • Irwin D. J., White M. T., Toledo J. B. et al. (2012) Neuropathologic substrates of Parkinson disease dementia. Ann. Neurol. 72, 587–598.
    • (2012) Ann. Neurol. , vol.72 , pp. 587-598
    • Irwin, D.J.1    White, M.T.2    Toledo, J.B.3
  • 69
    • 84860488891 scopus 로고    scopus 로고
    • Dementia from Alzheimer disease and mixed pathologies in the oldest old
    • James B. D., Bennett D. A., Boyle P. A., Leurgans S. and Schneider J. A. (2012) Dementia from Alzheimer disease and mixed pathologies in the oldest old. JAMA 307, 1798–1800.
    • (2012) JAMA , vol.307 , pp. 1798-1800
    • James, B.D.1    Bennett, D.A.2    Boyle, P.A.3    Leurgans, S.4    Schneider, J.A.5
  • 70
    • 0141725659 scopus 로고    scopus 로고
    • Neuropathological spectrum of synucleinopathies
    • Jellinger K. A. (2003) Neuropathological spectrum of synucleinopathies. Mov. Disord. 18(Suppl 6), S2–S12.
    • (2003) Mov. Disord. , vol.18 , pp. S2-S12
    • Jellinger, K.A.1
  • 71
    • 40449127705 scopus 로고    scopus 로고
    • Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia
    • Jellinger K. A. (2008) Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia. Neurodegener. Dis. 5, 118–121.
    • (2008) Neurodegener. Dis. , vol.5 , pp. 118-121
    • Jellinger, K.A.1
  • 72
    • 84863478529 scopus 로고    scopus 로고
    • CSF biomarkers in different phenotypes of Parkinson disease
    • Jellinger K. A. (2012) CSF biomarkers in different phenotypes of Parkinson disease. J. Neural. Transm. 119, 455–456.
    • (2012) J. Neural. Transm. , vol.119 , pp. 455-456
    • Jellinger, K.A.1
  • 73
    • 77953024802 scopus 로고    scopus 로고
    • Prevalence of dementia disorders in the oldest-old: an autopsy study
    • Jellinger K. A. and Attems J. (2010) Prevalence of dementia disorders in the oldest-old: an autopsy study. Acta Neuropathol. 119, 421–433.
    • (2010) Acta Neuropathol. , vol.119 , pp. 421-433
    • Jellinger, K.A.1    Attems, J.2
  • 76
    • 84887223575 scopus 로고    scopus 로고
    • Using cerebrospinal fluid marker profiles in clinical diagnosis of dementia with Lewy bodies, Parkinson's disease, and Alzheimer's disease
    • Kaerst L., Kuhlmann A., Wedekind D., Stoeck K., Lange P. and Zerr I. (2014) Using cerebrospinal fluid marker profiles in clinical diagnosis of dementia with Lewy bodies, Parkinson's disease, and Alzheimer's disease. J. Alzheimers Dis. 38, 63–73.
    • (2014) J. Alzheimers Dis. , vol.38 , pp. 63-73
    • Kaerst, L.1    Kuhlmann, A.2    Wedekind, D.3    Stoeck, K.4    Lange, P.5    Zerr, I.6
  • 77
    • 84885699313 scopus 로고    scopus 로고
    • Association of cerebrospinal fluid beta-amyloid 1-42, T-tau, P-tau181, and alpha-synuclein levels with clinical features of drug-naive patients with early Parkinson disease
    • Kang J. H., Irwin D. J., Chen-Plotkin A. S. et al. (2013) Association of cerebrospinal fluid beta-amyloid 1-42, T-tau, P-tau181, and alpha-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. JAMA Neurol. 70, 1277–1287.
    • (2013) JAMA Neurol. , vol.70 , pp. 1277-1287
    • Kang, J.H.1    Irwin, D.J.2    Chen-Plotkin, A.S.3
  • 78
    • 84896730461 scopus 로고    scopus 로고
    • The diagnostic value of CSF alpha-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease
    • Kapaki E., Paraskevas G. P., Emmanouilidou E. and Vekrellis K. (2013) The diagnostic value of CSF alpha-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease. PLoS ONE 8, e81654.
    • (2013) PLoS ONE , vol.8
    • Kapaki, E.1    Paraskevas, G.P.2    Emmanouilidou, E.3    Vekrellis, K.4
  • 79
    • 77953716788 scopus 로고    scopus 로고
    • Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
    • Kasuga K., Tokutake T., Ishikawa A., Uchiyama T., Tokuda T., Onodera O., Nishizawa M. and Ikeuchi T. (2010) Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 81, 608–610.
    • (2010) J. Neurol. Neurosurg. Psychiatry , vol.81 , pp. 608-610
    • Kasuga, K.1    Tokutake, T.2    Ishikawa, A.3    Uchiyama, T.4    Tokuda, T.5    Onodera, O.6    Nishizawa, M.7    Ikeuchi, T.8
  • 80
    • 0042421730 scopus 로고    scopus 로고
    • Positron emission tomography of striatal serotonin transporters in Parkinson disease
    • Kerenyi L., Ricaurte G. A., Schretlen D. J. et al. (2003) Positron emission tomography of striatal serotonin transporters in Parkinson disease. Arch. Neurol. 60, 1223–1229.
    • (2003) Arch. Neurol. , vol.60 , pp. 1223-1229
    • Kerenyi, L.1    Ricaurte, G.A.2    Schretlen, D.J.3
  • 81
    • 67349214609 scopus 로고    scopus 로고
    • Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-tau(181P)
    • Koopman K., Le Bastard N., Martin J. J., Nagels G., De Deyn P. P. and Engelborghs S. (2009) Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-tau(181P). Neurochem. Int. 55, 214–218.
    • (2009) Neurochem. Int. , vol.55 , pp. 214-218
    • Koopman, K.1    Le Bastard, N.2    Martin, J.J.3    Nagels, G.4    De Deyn, P.P.5    Engelborghs, S.6
  • 82
    • 33846997878 scopus 로고    scopus 로고
    • Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    • Kramer M. L. and Schulz-Schaeffer W. J. (2007) Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J. Neurosci. 27, 1405–1410.
    • (2007) J. Neurosci. , vol.27 , pp. 1405-1410
    • Kramer, M.L.1    Schulz-Schaeffer, W.J.2
  • 84
    • 84872463342 scopus 로고    scopus 로고
    • Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia
    • Le Bastard N., Coart E., Vanderstichele H., Vanmechelen E., Martin J. J. and Engelborghs S. (2013) Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia. J. Alzheimers Dis. 33, 117–131.
    • (2013) J. Alzheimers Dis. , vol.33 , pp. 117-131
    • Le Bastard, N.1    Coart, E.2    Vanderstichele, H.3    Vanmechelen, E.4    Martin, J.J.5    Engelborghs, S.6
  • 85
    • 44749090147 scopus 로고    scopus 로고
    • Clearance and deposition of extracellular alpha-synuclein aggregates in microglia
    • Lee H. J., Suk J. E., Bae E. J. and Lee S. J. (2008) Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem. Biophys. Res. Commun. 372, 423–428.
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 423-428
    • Lee, H.J.1    Suk, J.E.2    Bae, E.J.3    Lee, S.J.4
  • 87
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • Louveau A., Smirnov I., Keyes T. J. et al. (2015) Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337–341.
    • (2015) Nature , vol.523 , pp. 337-341
    • Louveau, A.1    Smirnov, I.2    Keyes, T.J.3
  • 88
  • 89
    • 84858113047 scopus 로고    scopus 로고
    • Age and diagnostic performance of Alzheimer disease CSF biomarkers
    • Mattsson N., Rosen E., Hansson O. et al. (2012) Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology 78, 468–476.
    • (2012) Neurology , vol.78 , pp. 468-476
    • Mattsson, N.1    Rosen, E.2    Hansson, O.3
  • 90
    • 0025870546 scopus 로고
    • Blood-brain-barrier in a geriatric population: barrier function in degenerative and vascular dementias
    • Mecocci P., Parnetti L., Reboldi G. P. et al. (1991) Blood-brain-barrier in a geriatric population: barrier function in degenerative and vascular dementias. Acta Neurol. Scand. 84, 210–213.
    • (1991) Acta Neurol. Scand. , vol.84 , pp. 210-213
    • Mecocci, P.1    Parnetti, L.2    Reboldi, G.P.3
  • 91
    • 84877923872 scopus 로고    scopus 로고
    • Movement disorders in cerebrovascular disease
    • Mehanna R. and Jankovic J. (2013) Movement disorders in cerebrovascular disease. Lancet Neurol. 12, 597–608.
    • (2013) Lancet Neurol. , vol.12 , pp. 597-608
    • Mehanna, R.1    Jankovic, J.2
  • 93
    • 84871273435 scopus 로고    scopus 로고
    • Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
    • Milber J. M., Noorigian J. V., Morley J. F., Petrovitch H., White L., Ross G. W. and Duda J. E. (2012) Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease. Neurology 79, 2307–2314.
    • (2012) Neurology , vol.79 , pp. 2307-2314
    • Milber, J.M.1    Noorigian, J.V.2    Morley, J.F.3    Petrovitch, H.4    White, L.5    Ross, G.W.6    Duda, J.E.7
  • 94
    • 84863167950 scopus 로고    scopus 로고
    • Cerebrospinal fluid Abeta and tau level fluctuation in an older clinical cohort
    • Moghekar A., Goh J., Li M., Albert M. and O'Brien R. J. (2012) Cerebrospinal fluid Abeta and tau level fluctuation in an older clinical cohort. Arch. Neurol. 69, 246–250.
    • (2012) Arch. Neurol. , vol.69 , pp. 246-250
    • Moghekar, A.1    Goh, J.2    Li, M.3    Albert, M.4    O'Brien, R.J.5
  • 95
    • 20944432380 scopus 로고    scopus 로고
    • Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease
    • Mollenhauer B., Bibl M., Trenkwalder C. et al. (2005a) Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease. J. Neural. Transm. 112, 933–948.
    • (2005) J. Neural. Transm. , vol.112 , pp. 933-948
    • Mollenhauer, B.1    Bibl, M.2    Trenkwalder, C.3
  • 96
    • 20644469257 scopus 로고    scopus 로고
    • Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies
    • Mollenhauer B., Cepek L., Bibl M. et al. (2005b) Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies. Dement. Geriatr. Cogn. Disord. 19, 164–170.
    • (2005) Dement. Geriatr. Cogn. Disord. , vol.19 , pp. 164-170
    • Mollenhauer, B.1    Cepek, L.2    Bibl, M.3
  • 97
    • 32544446902 scopus 로고    scopus 로고
    • Total tau protein, phosphorylated tau (181p) protein, beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies
    • Mollenhauer B., Bibl M., Wiltfang J., Steinacker P., Ciesielczyk B., Neubert K., Trenkwalder C. and Otto M. (2006a) Total tau protein, phosphorylated tau (181p) protein, beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies. Clin. Chem. Lab. Med. 44, 192–195.
    • (2006) Clin. Chem. Lab. Med. , vol.44 , pp. 192-195
    • Mollenhauer, B.1    Bibl, M.2    Wiltfang, J.3    Steinacker, P.4    Ciesielczyk, B.5    Neubert, K.6    Trenkwalder, C.7    Otto, M.8
  • 98
    • 33748163112 scopus 로고    scopus 로고
    • Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia
    • Mollenhauer B., Trenkwalder C., von Ahsen N. et al. (2006b) Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia. Dement. Geriatr. Cogn. Disord. 22, 200–208.
    • (2006) Dement. Geriatr. Cogn. Disord. , vol.22 , pp. 200-208
    • Mollenhauer, B.1    Trenkwalder, C.2    von Ahsen, N.3
  • 99
    • 34347360619 scopus 로고    scopus 로고
    • Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?
    • Mollenhauer B., Bibl M., Esselmann H., Steinacker P., Trenkwalder C., Wiltfang J. and Otto M. (2007) Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis? J. Neural. Transm. 114, 919–927.
    • (2007) J. Neural. Transm. , vol.114 , pp. 919-927
    • Mollenhauer, B.1    Bibl, M.2    Esselmann, H.3    Steinacker, P.4    Trenkwalder, C.5    Wiltfang, J.6    Otto, M.7
  • 100
    • 49449105990 scopus 로고    scopus 로고
    • Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
    • Mollenhauer B., Cullen V., Kahn I. et al. (2008) Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp. Neurol. 213, 315–325.
    • (2008) Exp. Neurol. , vol.213 , pp. 315-325
    • Mollenhauer, B.1    Cullen, V.2    Kahn, I.3
  • 101
    • 77958065285 scopus 로고    scopus 로고
    • Quantification of alpha-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies
    • Mollenhauer B., El-Agnaf O. M., Marcus K., Trenkwalder C. and Schlossmacher M. G. (2010) Quantification of alpha-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies. Biomark Med. 4, 683–699.
    • (2010) Biomark Med. , vol.4 , pp. 683-699
    • Mollenhauer, B.1    El-Agnaf, O.M.2    Marcus, K.3    Trenkwalder, C.4    Schlossmacher, M.G.5
  • 104
    • 84863425120 scopus 로고    scopus 로고
    • alpha-synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system
    • Mollenhauer B., Trautmann E., Otte B. et al. (2012) alpha-synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system. J. Neural. Transm. 119, 739–746.
    • (2012) J. Neural. Transm. , vol.119 , pp. 739-746
    • Mollenhauer, B.1    Trautmann, E.2    Otte, B.3
  • 105
    • 84887909616 scopus 로고    scopus 로고
    • Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort
    • Mollenhauer B., Trautmann E., Sixel-Doring F. et al. (2013a) Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort. Neurology 81, 1226–1234.
    • (2013) Neurology , vol.81 , pp. 1226-1234
    • Mollenhauer, B.1    Trautmann, E.2    Sixel-Doring, F.3
  • 107
    • 78349237282 scopus 로고    scopus 로고
    • CSF Abeta(42) and tau in Parkinson's disease with cognitive impairment
    • Montine T. J., Shi M., Quinn J. F. et al. (2010) CSF Abeta(42) and tau in Parkinson's disease with cognitive impairment. Mov. Disord. 25, 2682–2685.
    • (2010) Mov. Disord. , vol.25 , pp. 2682-2685
    • Montine, T.J.1    Shi, M.2    Quinn, J.F.3
  • 108
    • 47949087461 scopus 로고    scopus 로고
    • Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes
    • Mukaetova-Ladinska E. B., Milne J., Andras A. et al. (2008) Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Dement. Geriatr. Cogn. Disord. 26, 32–42.
    • (2008) Dement. Geriatr. Cogn. Disord. , vol.26 , pp. 32-42
    • Mukaetova-Ladinska, E.B.1    Milne, J.2    Andras, A.3
  • 112
    • 84874678235 scopus 로고    scopus 로고
    • Abeta1-15/16 as a potential diagnostic marker in neurodegenerative diseases
    • Nutu M., Bourgeois P., Zetterberg H. et al. (2013) Abeta1-15/16 as a potential diagnostic marker in neurodegenerative diseases. Neuromolecular Med. 15, 169–179.
    • (2013) Neuromolecular Med. , vol.15 , pp. 169-179
    • Nutu, M.1    Bourgeois, P.2    Zetterberg, H.3
  • 114
    • 0037154135 scopus 로고    scopus 로고
    • Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease
    • Otto M., Wiltfang J., Cepek L. et al. (2002) Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease. Neurology 58, 192–197.
    • (2002) Neurology , vol.58 , pp. 192-197
    • Otto, M.1    Wiltfang, J.2    Cepek, L.3
  • 115
    • 84924185649 scopus 로고    scopus 로고
    • Protein transmission, seeding and degradation: key steps for alpha-synuclein prion-like propagation
    • Oueslati A., Ximerakis M. and Vekrellis K. (2014) Protein transmission, seeding and degradation: key steps for alpha-synuclein prion-like propagation. Exp. Neurobiol. 23, 324–336.
    • (2014) Exp. Neurobiol. , vol.23 , pp. 324-336
    • Oueslati, A.1    Ximerakis, M.2    Vekrellis, K.3
  • 116
    • 47049100511 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies
    • Parnetti L., Tiraboschi P., Lanari A. et al. (2008) Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies. Biol. Psychiatry 64, 850–855.
    • (2008) Biol. Psychiatry , vol.64 , pp. 850-855
    • Parnetti, L.1    Tiraboschi, P.2    Lanari, A.3
  • 117
    • 79960613150 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/alpha-synuclein ratio in Parkinson's disease and degenerative dementias
    • Parnetti L., Chiasserini D., Bellomo G. et al. (2011) Cerebrospinal fluid tau/alpha-synuclein ratio in Parkinson's disease and degenerative dementias. Mov. Disord. 26, 1428–1435.
    • (2011) Mov. Disord. , vol.26 , pp. 1428-1435
    • Parnetti, L.1    Chiasserini, D.2    Bellomo, G.3
  • 119
    • 84898031335 scopus 로고    scopus 로고
    • Differential role of CSF alpha-synuclein species, tau, and Abeta42 in Parkinson's disease
    • Parnetti L., Farotti L., Eusebi P. et al. (2014) Differential role of CSF alpha-synuclein species, tau, and Abeta42 in Parkinson's disease. Front. Aging Neurosci. 6, 53.
    • (2014) Front. Aging Neurosci. , vol.6 , pp. 53
    • Parnetti, L.1    Farotti, L.2    Eusebi, P.3
  • 120
    • 81455143969 scopus 로고    scopus 로고
    • Serotonergic dysfunction in Parkinson's disease and its relevance to disability
    • Politis M. and Loane C. (2011) Serotonergic dysfunction in Parkinson's disease and its relevance to disability. ScientificWorldJournal 11, 1726–1734.
    • (2011) ScientificWorldJournal , vol.11 , pp. 1726-1734
    • Politis, M.1    Loane, C.2
  • 121
    • 77955844658 scopus 로고    scopus 로고
    • Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study
    • Politis M., Wu K., Loane C., Kiferle L., Molloy S., Brooks D. J. and Piccini P. (2010) Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study. Neurobiol. Dis. 40, 216–221.
    • (2010) Neurobiol. Dis. , vol.40 , pp. 216-221
    • Politis, M.1    Wu, K.2    Loane, C.3    Kiferle, L.4    Molloy, S.5    Brooks, D.J.6    Piccini, P.7
  • 122
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M. H., Lavedan C., Leroy E. et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045–2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 125
    • 78650638645 scopus 로고    scopus 로고
    • CSF alpha-synuclein does not discriminate dementia with lewy bodies from Alzheimer's disease
    • Reesink F. E., Lemstra A. W., van Dijk K. D. et al. (2010) CSF alpha-synuclein does not discriminate dementia with lewy bodies from Alzheimer's disease. J. Alzheimers Dis. 22, 87–95.
    • (2010) J. Alzheimers Dis. , vol.22 , pp. 87-95
    • Reesink, F.E.1    Lemstra, A.W.2    van Dijk, K.D.3
  • 126
    • 84863440187 scopus 로고    scopus 로고
    • Biomarkers in Alzheimer's disease
    • Riverol M. and Lopez O. L. (2011) Biomarkers in Alzheimer's disease. Front. Neurol. 2, 46.
    • (2011) Front. Neurol. , vol.2 , pp. 46
    • Riverol, M.1    Lopez, O.L.2
  • 128
    • 70349151839 scopus 로고    scopus 로고
    • Parkinson disease with dementia: comparing patients with and without Alzheimer pathology
    • Sabbagh M. N., Adler C. H., Lahti T. J. et al. (2009) Parkinson disease with dementia: comparing patients with and without Alzheimer pathology. Alzheimer Dis. Assoc. Disord. 23, 295–297.
    • (2009) Alzheimer Dis. Assoc. Disord. , vol.23 , pp. 295-297
    • Sabbagh, M.N.1    Adler, C.H.2    Lahti, T.J.3
  • 129
    • 77957131926 scopus 로고    scopus 로고
    • Alpha-synuclein and synucleinopathies
    • in, John H Growdon, Martin R Rossor, eds), Butterworth-Heinemann, Oxford
    • Schlossmacher M. (2007) Alpha-synuclein and synucleinopathies, in The Dementias 2 (John H Growdon and Martin R Rossor, eds), pp. 186–215. Butterworth-Heinemann, Oxford.
    • (2007) The Dementias 2 , pp. 186-215
    • Schlossmacher, M.1
  • 130
    • 77958023741 scopus 로고    scopus 로고
    • Biomarker research in Parkinson's disease: objective measures needed for patient stratification in future cause-directed trials
    • Schlossmacher M. G. and Mollenhauer B. (2010) Biomarker research in Parkinson's disease: objective measures needed for patient stratification in future cause-directed trials. Biomark. Med. 4, 647–650.
    • (2010) Biomark. Med. , vol.4 , pp. 647-650
    • Schlossmacher, M.G.1    Mollenhauer, B.2
  • 131
    • 70149097327 scopus 로고    scopus 로고
    • The neuropathology of probable Alzheimer disease and mild cognitive impairment
    • Schneider J. A., Arvanitakis Z., Leurgans S. E. and Bennett D. A. (2009) The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann. Neurol. 66, 200–208.
    • (2009) Ann. Neurol. , vol.66 , pp. 200-208
    • Schneider, J.A.1    Arvanitakis, Z.2    Leurgans, S.E.3    Bennett, D.A.4
  • 132
    • 84856617005 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
    • Schoonenboom N. S., Reesink F. E., Verwey N. A. et al. (2012) Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort. Neurology 78, 47–54.
    • (2012) Neurology , vol.78 , pp. 47-54
    • Schoonenboom, N.S.1    Reesink, F.E.2    Verwey, N.A.3
  • 133
    • 77957264418 scopus 로고    scopus 로고
    • The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia
    • Schulz-Schaeffer W. J. (2010) The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia. Acta Neuropathol. 120, 131–143.
    • (2010) Acta Neuropathol. , vol.120 , pp. 131-143
    • Schulz-Schaeffer, W.J.1
  • 134
    • 84871285797 scopus 로고    scopus 로고
    • Neurodegeneration in Parkinson disease: moving Lewy bodies out of focus
    • Schulz-Schaeffer W. J. (2012) Neurodegeneration in Parkinson disease: moving Lewy bodies out of focus. Neurology 79, 2298–2299.
    • (2012) Neurology , vol.79 , pp. 2298-2299
    • Schulz-Schaeffer, W.J.1
  • 136
    • 0026646605 scopus 로고
    • Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
    • Seubert P., Vigo-Pelfrey C., Esch F. et al. (1992) Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 359, 325–327.
    • (1992) Nature , vol.359 , pp. 325-327
    • Seubert, P.1    Vigo-Pelfrey, C.2    Esch, F.3
  • 137
    • 84901217810 scopus 로고    scopus 로고
    • An antidepressant decreases CSF Abeta production in healthy individuals and in transgenic AD mice
    • Sheline Y. I., West T., Yarasheski K. et al. (2014) An antidepressant decreases CSF Abeta production in healthy individuals and in transgenic AD mice. Sci. Transl. Med. 6, 236re234.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 236re234
    • Sheline, Y.I.1    West, T.2    Yarasheski, K.3
  • 138
    • 79960353168 scopus 로고    scopus 로고
    • CSF alpha-synuclein, tau, and amyloid beta in Parkinson's disease
    • author's reply 681-683
    • Shi M. and Zhang J. (2011) CSF alpha-synuclein, tau, and amyloid beta in Parkinson's disease. Lancet Neurol. 10, 681; author's reply 681-683.
    • (2011) Lancet Neurol. , vol.10 , pp. 681
    • Shi, M.1    Zhang, J.2
  • 139
    • 79953283868 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    • Shi M., Bradner J., Hancock A. M. et al. (2011) Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann. Neurol. 69, 570–580.
    • (2011) Ann. Neurol. , vol.69 , pp. 570-580
    • Shi, M.1    Bradner, J.2    Hancock, A.M.3
  • 140
    • 77957220702 scopus 로고    scopus 로고
    • CSF amyloid beta 1–42 predicts cognitive decline in Parkinson disease
    • Siderowf A., Xie S. X., Hurtig H. et al. (2010) CSF amyloid beta 1–42 predicts cognitive decline in Parkinson disease. Neurology 75, 1055–1061.
    • (2010) Neurology , vol.75 , pp. 1055-1061
    • Siderowf, A.1    Xie, S.X.2    Hurtig, H.3
  • 141
    • 70549088602 scopus 로고    scopus 로고
    • Genome-wide association study reveals genetic risk underlying Parkinson's disease
    • Simon-Sanchez J., Schulte C., Bras J. M. et al. (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 41, 1308–1312.
    • (2009) Nat. Genet. , vol.41 , pp. 1308-1312
    • Simon-Sanchez, J.1    Schulte, C.2    Bras, J.M.3
  • 142
    • 78049377229 scopus 로고    scopus 로고
    • Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain
    • Simpson J. E., Wharton S. B., Cooper J. et al. (2010) Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain. Neurosci. Lett. 486, 246–251.
    • (2010) Neurosci. Lett. , vol.486 , pp. 246-251
    • Simpson, J.E.1    Wharton, S.B.2    Cooper, J.3
  • 143
    • 0242300619 scopus 로고    scopus 로고
    • alpha-synuclein locus triplication causes Parkinson's disease
    • Singleton A. B., Farrer M., Johnson J. et al. (2003) alpha-synuclein locus triplication causes Parkinson's disease. Science 302, 841.
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1    Farrer, M.2    Johnson, J.3
  • 144
    • 0036182732 scopus 로고    scopus 로고
    • Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms
    • Sjogren M., Davidsson P., Wallin A., Granerus A. K., Grundstrom E., Askmark H., Vanmechelen E. and Blennow K. (2002) Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms. Dement. Geriatr. Cogn. Disord. 13, 112–118.
    • (2002) Dement. Geriatr. Cogn. Disord. , vol.13 , pp. 112-118
    • Sjogren, M.1    Davidsson, P.2    Wallin, A.3    Granerus, A.K.4    Grundstrom, E.5    Askmark, H.6    Vanmechelen, E.7    Blennow, K.8
  • 145
    • 84876355554 scopus 로고    scopus 로고
    • Amyloid pathology influences abeta1-42 cerebrospinal fluid levels in dementia with lewy bodies
    • Slaets S., Le Bastard N., Theuns J. et al. (2013) Amyloid pathology influences abeta1-42 cerebrospinal fluid levels in dementia with lewy bodies. J. Alzheimers Dis. 35, 137–146.
    • (2013) J. Alzheimers Dis. , vol.35 , pp. 137-146
    • Slaets, S.1    Le Bastard, N.2    Theuns, J.3
  • 146
    • 84856962043 scopus 로고    scopus 로고
    • Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers
    • Slats D., Claassen J. A., Spies P. E. et al. (2012) Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers. Neurobiol. Aging 33, e831–e839.
    • (2012) Neurobiol. Aging , vol.33 , pp. e831-e839
    • Slats, D.1    Claassen, J.A.2    Spies, P.E.3
  • 148
    • 60349122813 scopus 로고    scopus 로고
    • Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders
    • Spies P. E., Melis R. J., Sjogren M. J., Rikkert M. G. and Verbeek M. M. (2009) Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders. J. Alzheimers Dis. 16, 363–369.
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 363-369
    • Spies, P.E.1    Melis, R.J.2    Sjogren, M.J.3    Rikkert, M.G.4    Verbeek, M.M.5
  • 149
    • 82455167944 scopus 로고    scopus 로고
    • CSF alpha-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid beta in humans
    • Spies P. E., Slats D., Rikkert M. G., Tseng J., Claassen J. A. and Verbeek M. M. (2011) CSF alpha-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid beta in humans. Neurosci. Lett. 504, 336–338.
    • (2011) Neurosci. Lett. , vol.504 , pp. 336-338
    • Spies, P.E.1    Slats, D.2    Rikkert, M.G.3    Tseng, J.4    Claassen, J.A.5    Verbeek, M.M.6
  • 151
    • 84930760402 scopus 로고    scopus 로고
    • Amyloid-beta and alpha-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease
    • Stav A. L., Aarsland D., Johansen K. K., Hessen E., Auning E. and Fladby T. (2015) Amyloid-beta and alpha-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease. Parkinsonism Relat. Disord. 21, 758–764.
    • (2015) Parkinsonism Relat. Disord. , vol.21 , pp. 758-764
    • Stav, A.L.1    Aarsland, D.2    Johansen, K.K.3    Hessen, E.4    Auning, E.5    Fladby, T.6
  • 152
    • 84897840006 scopus 로고    scopus 로고
    • Cerebrospinal fluid alpha-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort
    • Stewart T., Liu C., Ginghina C., Cain K. C., Auinger P., Cholerton B., Shi M. and Zhang J. and Parkinson Study Group, D. I. (2014) Cerebrospinal fluid alpha-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort. Am. J. Pathol. 184, 966–975.
    • (2014) Am. J. Pathol. , vol.184 , pp. 966-975
    • Stewart, T.1    Liu, C.2    Ginghina, C.3    Cain, K.C.4    Auinger, P.5    Cholerton, B.6    Shi, M.7    Zhang, J.8
  • 153
    • 0037465449 scopus 로고    scopus 로고
    • CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
    • Strozyk D., Blennow K., White L. R. and Launer L. J. (2003) CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study. Neurology 60, 652–656.
    • (2003) Neurology , vol.60 , pp. 652-656
    • Strozyk, D.1    Blennow, K.2    White, L.R.3    Launer, L.J.4
  • 154
    • 0028260081 scopus 로고
    • Bundles of amyloid precursor protein-immunoreactive axons in human cerebrovascular white matter lesions
    • Suenaga T., Ohnishi K., Nishimura M., Nakamura S., Akiguchi I. and Kimura J. (1994) Bundles of amyloid precursor protein-immunoreactive axons in human cerebrovascular white matter lesions. Acta Neuropathol. 87, 450–455.
    • (1994) Acta Neuropathol. , vol.87 , pp. 450-455
    • Suenaga, T.1    Ohnishi, K.2    Nishimura, M.3    Nakamura, S.4    Akiguchi, I.5    Kimura, J.6
  • 155
    • 62449262536 scopus 로고    scopus 로고
    • Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
    • Tapiola T., Alafuzoff I., Herukka S. K., Parkkinen L., Hartikainen P., Soininen H. and Pirttila T. (2009) Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain. Arch. Neurol. 66, 382–389.
    • (2009) Arch. Neurol. , vol.66 , pp. 382-389
    • Tapiola, T.1    Alafuzoff, I.2    Herukka, S.K.3    Parkkinen, L.4    Hartikainen, P.5    Soininen, H.6    Pirttila, T.7
  • 158
    • 78649990079 scopus 로고    scopus 로고
    • Detection of elevated levels of {alpha}-synuclein oligomers in CSF from patients with Parkinson disease
    • Tokuda T., Qureshi M. M., Ardah M. T. et al. (2010) Detection of elevated levels of {alpha}-synuclein oligomers in CSF from patients with Parkinson disease. Neurology 75, 1766–1772.
    • (2010) Neurology , vol.75 , pp. 1766-1772
    • Tokuda, T.1    Qureshi, M.M.2    Ardah, M.T.3
  • 160
    • 84888202286 scopus 로고    scopus 로고
    • CSF alpha-synuclein improves diagnostic and prognostic performance of CSF tau and Abeta in Alzheimer's disease
    • Toledo J. B., Korff A., Shaw L. M., Trojanowski J. Q. and Zhang J. (2013a) CSF alpha-synuclein improves diagnostic and prognostic performance of CSF tau and Abeta in Alzheimer's disease. Acta Neuropathol. 126, 683–697.
    • (2013) Acta Neuropathol. , vol.126 , pp. 683-697
    • Toledo, J.B.1    Korff, A.2    Shaw, L.M.3    Trojanowski, J.Q.4    Zhang, J.5
  • 161
    • 84888201046 scopus 로고    scopus 로고
    • Longitudinal change in CSF tau and Abeta biomarkers for up to 48 months in ADNI
    • Toledo J. B., Xie S. X., Trojanowski J. Q. and Shaw L. M. (2013b) Longitudinal change in CSF tau and Abeta biomarkers for up to 48 months in ADNI. Acta Neuropathol. 126, 659–670.
    • (2013) Acta Neuropathol. , vol.126 , pp. 659-670
    • Toledo, J.B.1    Xie, S.X.2    Trojanowski, J.Q.3    Shaw, L.M.4
  • 163
    • 84858157780 scopus 로고    scopus 로고
    • Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of alpha-synucleinopathy
    • Ubhi K., Inglis C., Mante M. et al. (2012) Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of alpha-synucleinopathy. Exp. Neurol. 234, 405–416.
    • (2012) Exp. Neurol. , vol.234 , pp. 405-416
    • Ubhi, K.1    Inglis, C.2    Mante, M.3
  • 164
    • 84904247027 scopus 로고    scopus 로고
    • Tau protein, beta-amyloid(1)(-)(4)(2) and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia
    • Vranova H. P., Henykova E., Kaiserova M. et al. (2014) Tau protein, beta-amyloid(1)(-)(4)(2) and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia. J. Neurol. Sci. 343, 120–124.
    • (2014) J. Neurol. Sci. , vol.343 , pp. 120-124
    • Vranova, H.P.1    Henykova, E.2    Kaiserova, M.3
  • 165
    • 34547676021 scopus 로고    scopus 로고
    • Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy study
    • Wada-Isoe K., Kitayama M., Nakaso K. and Nakashima K. (2007) Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy study. J. Neurol. Sci. 260, 33–37.
    • (2007) J. Neurol. Sci. , vol.260 , pp. 33-37
    • Wada-Isoe, K.1    Kitayama, M.2    Nakaso, K.3    Nakashima, K.4
  • 166
    • 84863164994 scopus 로고    scopus 로고
    • Phosphorylated alpha-synuclein in Parkinson's disease
    • Wang Y., Shi M., Chung K. A. et al. (2012) Phosphorylated alpha-synuclein in Parkinson's disease. Sci. Transl. Med. 4, 121ra120.
    • (2012) Sci. Transl. Med. , vol.4 , pp. 121ra120
    • Wang, Y.1    Shi, M.2    Chung, K.A.3
  • 167
    • 84858136734 scopus 로고    scopus 로고
    • Altered CSF orexin and alpha-synuclein levels in dementia patients
    • Wennstrom M., Londos E., Minthon L. and Nielsen H. M. (2012) Altered CSF orexin and alpha-synuclein levels in dementia patients. J. Alzheimers Dis. 29, 125–132.
    • (2012) J. Alzheimers Dis. , vol.29 , pp. 125-132
    • Wennstrom, M.1    Londos, E.2    Minthon, L.3    Nielsen, H.M.4
  • 168
    • 84872189834 scopus 로고    scopus 로고
    • Low CSF levels of both alpha-synuclein and the alpha-synuclein cleaving enzyme neurosin in patients with synucleinopathy
    • Wennstrom M., Surova Y., Hall S., Nilsson C., Minthon L., Bostrom F., Hansson O. and Nielsen H. M. (2013) Low CSF levels of both alpha-synuclein and the alpha-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS ONE 8, e53250.
    • (2013) PLoS ONE , vol.8
    • Wennstrom, M.1    Surova, Y.2    Hall, S.3    Nilsson, C.4    Minthon, L.5    Bostrom, F.6    Hansson, O.7    Nielsen, H.M.8
  • 169
    • 84885775321 scopus 로고    scopus 로고
    • Sleep drives metabolite clearance from the adult brain
    • Xie L., Kang H., Xu Q. et al. (2013) Sleep drives metabolite clearance from the adult brain. Science 342, 373–377.
    • (2013) Science , vol.342 , pp. 373-377
    • Xie, L.1    Kang, H.2    Xu, Q.3
  • 170
    • 0030825372 scopus 로고    scopus 로고
    • Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesion
    • Yam P. S., Takasago T., Dewar D., Graham D. I. and McCulloch J. (1997) Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesion. Brain Res. 760, 150–157.
    • (1997) Brain Res. , vol.760 , pp. 150-157
    • Yam, P.S.1    Takasago, T.2    Dewar, D.3    Graham, D.I.4    McCulloch, J.5
  • 171
    • 42949119345 scopus 로고    scopus 로고
    • CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    • Zhang J., Sokal I., Peskind E. R. et al. (2008) CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases. Am. J. Clin. Pathol. 129, 526–529.
    • (2008) Am. J. Clin. Pathol. , vol.129 , pp. 526-529
    • Zhang, J.1    Sokal, I.2    Peskind, E.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.