The spread of neurodegenerative disease

New England Journal of Medicine

Volumn 366, Issue 22, 2012, Pages 2126-2128

  Hardy, John ^a,b   Revesz, Tamas ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CLINICAL FEATURE; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; DOWN REGULATION; HUMAN; NEUROANATOMY; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYNAPTIC TRANSMISSION;

EID: 84861671617     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr1202401     Document Type: Article

References (6)

1. Collinge J, Alpers MC. The end of kuru. Philos Trans R Soc Lond B Biol Sci 2008;363:3607-73.
2. Baker HF, Ridley RM, Duchen LW, Crow TJ, Bruton CJ. Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate: comparison with transmission of spongiform encephalopathy. Mol Neurobiol 1994;8:25-39.
3. Jucker M, Walker LC. Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 2011;70:532-40.
4. Brundin P, Li JY, Holton JL, Lindvall O, Revesz T. Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci 2008;9:741-5.
5. Liu L, Drouet V, Wu JW, et al. Trans-synaptic spread of tau pathology in vivo. PLoS One 2012;7(2):e31302.
6. de Calignon A, Polydoro M, Suárez-Calvet M, et al. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron 2012;73:685-97.