-
1
-
-
18244394793
-
Clinical features of LRRK2-associated Parkinson's disease in central Norway
-
Aasly, J. O., Toft, M., Fernandez-Mata, I., Kachergus, J., Hulihan, M., White, L. R., & Farrer, M. (2005). Clinical features of LRRK2-associated Parkinson's disease in central Norway. Ann Neurol, 57(5), 762-765. doi: 10.1002/ana.20456
-
(2005)
Ann Neurol
, vol.57
, Issue.5
, pp. 762-765
-
-
Aasly, J.O.1
Toft, M.2
Fernandez-Mata, I.3
Kachergus, J.4
Hulihan, M.5
White, L.R.6
Farrer, M.7
-
2
-
-
77954623892
-
Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease
-
Aasly, J. O., Vilariño-Gu¨ell, C., Dachsel, J. C., Webber, P. J., West, A. B., Haugarvoll, K., Farrer, M. J. (2010). Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease. Mov Disord, 25(13), 2156-2163. doi: 10.1002/mds.23265
-
(2010)
Mov Disord
, vol.25
, Issue.13
, pp. 2156-2163
-
-
Aasly, J.O.1
Vilariño-Gu¨ell, C.2
Dachsel, J.C.3
Webber, P.J.4
West, A.B.5
Haugarvoll, K.6
Farrer, M.J.7
-
3
-
-
19944431081
-
A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease
-
Di Fonzo, A., Rohe´, C. F., Ferreira, J., Chien, H. F., Vacca, L., Stocchi, F., Network, I. P. G. (2005). A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Lancet, 365(9457), 412-415. doi: 10.1016/S0140-6736(05)17829-5
-
(2005)
Lancet
, vol.365
, Issue.9457
, pp. 412-415
-
-
Di Fonzo, A.1
Rohe´, C.F.2
Ferreira, J.3
Chien, H.F.4
Vacca, L.5
Stocchi, F.6
Network, I.P.G.7
-
4
-
-
77952122496
-
LRRK2 and Parkinson disease
-
Da¨chsel, J. C., & Farrer, M. J. (2010). LRRK2 and Parkinson disease. Arch Neurol, 67(5), 542-547. doi: 10.1001/archneurol.2010.79
-
(2010)
Arch Neurol
, vol.67
, Issue.5
, pp. 542-547
-
-
Da¨chsel, J.C.1
Farrer, M.J.2
-
5
-
-
85109083933
-
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
-
El-Agnaf, O. M., Salem, S. A., Paleologou, K. E., Cooper, L. J., Fullwood, 334 N. J., Gibson, M. J., Allsop, D. (2003). Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J, 17(13), 1945-1947. doi: 10.1096/fj.03-0098fje
-
(2003)
FASEB J
, vol.17
, Issue.13
, pp. 1945-1947
-
-
El-Agnaf, O.M.1
Salem, S.A.2
Paleologou, K.E.3
Cooper, L.J.4
Fullwood 334, N.J.5
Gibson, M.J.6
Allsop, D.7
-
6
-
-
33645833848
-
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
-
El-Agnaf, O. M., Salem, S. A., Paleologou, K. E., Curran, M. D., Gibson, M. J., Court, J. A., Allsop, D. (2006). Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J, 20(3), 419-425. doi: 10.1096/fj.03-1449com
-
(2006)
FASEB J
, vol.20
, Issue.3
, pp. 419-425
-
-
El-Agnaf, O.M.1
Salem, S.A.2
Paleologou, K.E.3
Curran, M.D.4
Gibson, M.J.5
Court, J.A.6
Allsop, D.7
-
7
-
-
84860222537
-
Regulation of physiologic actions of LRRK2: focus on autophagy
-
Ferree, A., Guillily, M., Li, H., Smith, K., Takashima, A., Squillace, R., Wolozin, B. (2012). Regulation of physiologic actions of LRRK2: focus on autophagy. Neurodegener Dis, 10(1-4), 238-241. doi: 10.1159/000332599
-
(2012)
Neurodegener Dis
, vol.10
, Issue.1-4
, pp. 238-241
-
-
Ferree, A.1
Guillily, M.2
Li, H.3
Smith, K.4
Takashima, A.5
Squillace, R.6
Wolozin, B.7
-
8
-
-
19944432921
-
A common LRRK2 mutation in idiopathic Parkinson's disease
-
Gilks, W. P., Abou-Sleiman, P. M., Gandhi, S., Jain, S., Singleton, A., Lees, A. J., Wood, N. W. (2005). A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet, 365(9457), 415-416. doi: 10.1016/S0140-6736(05)17830-1
-
(2005)
Lancet
, vol.365
, Issue.9457
, pp. 415-416
-
-
Gilks, W.P.1
Abou-Sleiman, P.M.2
Gandhi, S.3
Jain, S.4
Singleton, A.5
Lees, A.J.6
Wood, N.W.7
-
9
-
-
77950223687
-
DJ-1 and alpha347 synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
-
Hong, Z., Shi, M., Chung, K. A., Quinn, J. F., Peskind, E. R., Galasko, D., Zhang, J. (2010). DJ-1 and alpha347 synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain, 133(Pt 3), 713-726. doi: 10.1093/brain/awq008
-
(2010)
Brain
, vol.133
, pp. 713-726
-
-
Hong, Z.1
Shi, M.2
Chung, K.A.3
Quinn, J.F.4
Peskind, E.R.5
Galasko, D.6
Zhang, J.7
-
10
-
-
48149108245
-
Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases
-
Irvine, G. B., El-Agnaf, O. M., Shankar, G. M., & Walsh, D. M. (2008). Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol Med, 14(7-8), 451-464. doi: 10.2119/2007-00100.Irvine
-
(2008)
Mol Med
, vol.14
, Issue.7-8
, pp. 451-464
-
-
Irvine, G.B.1
El-Agnaf, O.M.2
Shankar, G.M.3
Walsh, D.M.4
-
11
-
-
77956175000
-
Genealogical studies in LRRK2- associated Parkinson's disease in central Norway
-
Johansen, K. K., Hasselberg, K., White, L. R., Farrer, M. J., & Aasly, J. O. (2010). Genealogical studies in LRRK2- associated Parkinson's disease in central Norway. Parkinsonism Relat Disord, 16(8), 527-530. doi: 10.1016/j.parkreldis.2010.05.005
-
(2010)
Parkinsonism Relat Disord
, vol.16
, Issue.8
, pp. 527-530
-
-
Johansen, K.K.1
Hasselberg, K.2
White, L.R.3
Farrer, M.J.4
Aasly, J.O.5
-
12
-
-
79960265588
-
Subclinical signs in LRRK2 mutation carriers
-
Johansen, K. K., White, L. R., Farrer, M. J., & Aasly, J. O. (2011). Subclinical signs in LRRK2 mutation carriers. Parkinsonism Relat Disord, 17(7), 528-532. doi: 10.1016/j.parkreldis.2011.04.014
-
(2011)
Parkinsonism Relat Disord
, vol.17
, Issue.7
, pp. 528-532
-
-
Johansen, K.K.1
White, L.R.2
Farrer, M.J.3
Aasly, J.O.4
-
13
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Kru¨ger, R., Kuhn, W., Mu¨ller, T., Woitalla, D., Graeber, M., Ko¨sel, S., Riess, O. (1998). Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet, 18(2), 106-108. doi: 10.1038/ng0298-106
-
(1998)
Nat Genet
, vol.18
, Issue.2
, pp. 106-108
-
-
Kru¨ger, R.1
Kuhn, W.2
Mu¨ller, T.3
Woitalla, D.4
Graeber, M.5
Ko¨sel, S.6
Riess, O.7
-
14
-
-
72149087091
-
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha362 synuclein
-
Lin, X., Parisiadou, L., Gu, X. L., Wang, L., Shim, H., Sun, L., Cai, H. (2009). Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha362 synuclein. Neuron, 64(6), 807-827. doi: 10.1016/j.neuron.2009.11.006
-
(2009)
Neuron
, vol.64
, Issue.6
, pp. 807-827
-
-
Lin, X.1
Parisiadou, L.2
Gu, X.L.3
Wang, L.4
Shim, H.5
Sun, L.6
Cai, H.7
-
15
-
-
58149242840
-
Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study
-
Nandhagopal, R., Mak, E., Schulzer, M., McKenzie, J., McCormick, S., Sossi, V., Stoessl, A. J. (2008). Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study. Neurology, 71(22), 1790-1795. doi: 10.1212/01.wnl.0000335973.66333.58
-
(2008)
Neurology
, vol.71
, Issue.22
, pp. 1790-1795
-
-
Nandhagopal, R.1
Mak, E.2
Schulzer, M.3
McKenzie, J.4
McCormick, S.5
Sossi, V.6
Stoessl, A.J.7
-
16
-
-
19944432606
-
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease
-
Nichols, W. C., Pankratz, N., Hernandez, D., Paisa´n-Rui´z, C., Jain, S., Halter, C. A., investigators, P. S. G.-P. (2005). Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease. Lancet, 365(9457), 410-412. doi: 10.1016/S0140-6736(05)17828-3
-
(2005)
Lancet
, vol.365
, Issue.9457
, pp. 410-412
-
-
Nichols, W.C.1
Pankratz, N.2
Hernandez, D.3
Paisa´n-Rui´z, C.4
Jain, S.5
Halter, C.A.6
Investigators, P.S.G.-P.7
-
17
-
-
65249162241
-
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
-
Paleologou, K. E., Kragh, C. L., Mann, D. M., Salem, S. A., Al-Shami, R., Allsop, D., El-Agnaf, O. M. (2009). Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain, 132(Pt 4), 1093-1101. doi: 10.1093/brain/awn349
-
(2009)
Brain
, vol.132
, pp. 1093-1101
-
-
Paleologou, K.E.1
Kragh, C.L.2
Mann, D.M.3
Salem, S.A.4
Al-Shami, R.5
Allsop, D.6
El-Agnaf, O.M.7
-
18
-
-
84862916400
-
Elevated levels of a-synuclein oligomer in the cerebrospinal fluid of drug-nai¨ve patients with Parkinson's disease
-
Park, M. J., Cheon, S. M., Bae, H. R., Kim, S. H., & Kim, J. W. (2011). Elevated levels of a-synuclein oligomer in the cerebrospinal fluid of drug-nai¨ve patients with Parkinson's disease. J Clin Neurol, 7(4), 215-222. doi: 10.3988/jcn.2011.7.4.215
-
(2011)
J Clin Neurol
, vol.7
, Issue.4
, pp. 215-222
-
-
Park, M.J.1
Cheon, S.M.2
Bae, H.R.3
Kim, S.H.4
Kim, J.W.5
-
19
-
-
84904427435
-
Cerebrospinal fluid lysosomal enzymes and a-synuclein in Parkinson's disease
-
Parnetti, L., Chiasserini, D., Persichetti, E., Eusebi, P., Varghese, S., Qureshi, M. M., Calabresi, P. (2014). Cerebrospinal fluid lysosomal enzymes and a-synuclein in Parkinson's disease. Mov Disord. doi: 10.1002/mds.25772
-
(2014)
Mov Disord
-
-
Parnetti, L.1
Chiasserini, D.2
Persichetti, E.3
Eusebi, P.4
Varghese, S.5
Qureshi, M.M.6
Calabresi, P.7
-
20
-
-
84898031335
-
Differential role of CSF alpha-synuclein species, tau, and Aß42 in Parkinson's Disease
-
Parnetti, L., Farotti, L., Eusebi, P., Chiasserini, D., De Carlo, C., Giannandrea, D., Calabresi, P. (2014). Differential role of CSF alpha-synuclein species, tau, and Aß42 in Parkinson's Disease. Front Aging Neurosci, 6, 53. doi: 10.3389/fnagi.2014.00053
-
(2014)
Front Aging Neurosci
, vol.6
, pp. 53
-
-
Parnetti, L.1
Farotti, L.2
Eusebi, P.3
Chiasserini, D.4
De Carlo, C.5
Giannandrea, D.6
Calabresi, P.7
-
21
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Nussbaum, R. L. (1997). Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science, 276(5321), 2045-2047.
-
(1997)
Science,
, vol.276
, Issue.5321
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Nussbaum, R.L.7
-
22
-
-
80052962219
-
Olfactory deficits and cardiac 123I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations
-
Ruiz-Marti´nez, J., Gorostidi, A., Goyenechea, E., Alzualde, A., Poza, J. J., Rodri´guez, F., Marti´ Masso´, J. F. (2011). Olfactory deficits and cardiac 123I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations. Mov Disord, 26(11), 2026-2031. doi: 10.1002/mds.23773
-
(2011)
Mov Disord
, vol.26
, Issue.11
, pp. 2026-2031
-
-
Ruiz-Marti´nez, J.1
Gorostidi, A.2
Goyenechea, E.3
Alzualde, A.4
Poza, J.J.5
Rodri´guez, F.6
Marti´ Masso´, J.F.7
-
23
-
-
80051513364
-
Olfactory dysfunction in LRRK2 G2019S mutation carriers
-
Saunders-Pullman, R., Stanley, K., Wang, C., San Luciano, M., Shanker, V., Hunt, A., Bressman, S. B. (2011). Olfactory dysfunction in LRRK2 G2019S mutation carriers. Neurology, 77(4), 319-324. doi: 10.1212/WNL.0b013e318227041c
-
(2011)
Neurology
, vol.77
, Issue.4
, pp. 319-324
-
-
Saunders-Pullman, R.1
Stanley, K.2
Wang, C.3
San Luciano, M.4
Shanker, V.5
Hunt, A.6
Bressman, S.B.7
-
24
-
-
0033616458
-
Science, medicine, and the future: Parkinson's disease
-
Schapira, A. H. (1999). Science, medicine, and the future: Parkinson's disease. BMJ, 318(7179), 311-314.
-
(1999)
BMJ,
, vol.318
, Issue.7179
, pp. 311-314
-
-
Schapira, A.H.1
-
25
-
-
79953283868
-
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
-
Shi, M., Bradner, J., Hancock, A. M., Chung, K. A., Quinn, J. F., Peskind, E. R., Zhang, J. (2011). Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol, 69(3), 570-580. doi: 10.1002/ana.22311
-
(2011)
Ann Neurol
, vol.69
, Issue.3
, pp. 570-580
-
-
Shi, M.1
Bradner, J.2
Hancock, A.M.3
Chung, K.A.4
Quinn, J.F.5
Peskind, E.R.6
Zhang, J.7
-
26
-
-
84856970318
-
DJ-1 and alphaSYN in LRRK2 CSF do not correlate with striatal dopaminergic function
-
e835-836.e837
-
Shi, M., Furay, A. R., Sossi, V., Aasly, J. O., Armaly, J., Wang, Y., Zhang, J. (2012). DJ-1 and alphaSYN in LRRK2 CSF do not correlate with striatal dopaminergic function. Neurobiol Aging, 33(4), 836.e835-837. doi: 10.1016/j.neurobiolaging.2011.09.015
-
(2012)
Neurobiol Aging
, vol.33
, Issue.4
, pp. 836
-
-
Shi, M.1
Furay, A.R.2
Sossi, V.3
Aasly, J.O.4
Armaly, J.5
Wang, Y.6
Zhang, J.7
-
27
-
-
82355191922
-
CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease
-
Sierks, M. R., Chatterjee, G., McGraw, C., Kasturirangan, S., Schulz, P., & Prasad, S. (2011). CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease. Integr Biol (Camb), 3(12), 1188-1196. doi: 10.1039/c1ib00018g
-
(2011)
Integr Biol (Camb)
, vol.3
, Issue.12
, pp. 1188-1196
-
-
Sierks, M.R.1
Chatterjee, G.2
McGraw, C.3
Kasturirangan, S.4
Schulz, P.5
Prasad, S.6
-
28
-
-
0242300619
-
alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Gwinn-Hardy, K. (2003). alpha-Synuclein locus triplication causes Parkinson's disease. Science, 302(5646), 841. doi: 10.1126/science.1090278
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Gwinn-Hardy, K.7
-
29
-
-
84873453232
-
The genetics of Parkinson's disease: progress and therapeutic implications
-
Singleton, A. B., Farrer, M. J., & Bonifati, V. (2013). The genetics of Parkinson's disease: progress and therapeutic implications. Mov Disord, 28(1), 14-23. doi: 10.1002/mds.25249
-
(2013)
Mov Disord
, vol.28
, Issue.1
, pp. 14-23
-
-
Singleton, A.B.1
Farrer, M.J.2
Bonifati, V.3
-
30
-
-
78650209340
-
Dopamine turnover increases in asymptomatic LRRK2 mutations carriers
-
Sossi, V., de la Fuente-Ferna´ndez, R., Nandhagopal, R., Schulzer, M., McKenzie, J., Ruth, T. J., Stoessl, J. A. (2010). Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Mov Disord, 25(16), 2717-2723. doi: 10.1002/mds.23356
-
(2010)
Mov Disord
, vol.25
, Issue.16
, pp. 2717-2723
-
-
Sossi, V.1
de la Fuente-Ferna´ndez, R.2
Nandhagopal, R.3
Schulzer, M.4
McKenzie, J.5
Ruth, T.J.6
Stoessl, J.A.7
-
31
-
-
0030882856
-
Alpha409 synuclein in Lewy bodies
-
Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997). Alpha409 synuclein in Lewy bodies. Nature, 388(6645), 839-840. doi: 10.1038/42166
-
(1997)
Nature
, vol.388
, Issue.6645
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
32
-
-
78649990079
-
Detection of elevated levels of a-synuclein oligomers in CSF from patients with Parkinson disease
-
Tokuda, T., Qureshi, M. M., Ardah, M. T., Varghese, S., Shehab, S. A., Kasai, T., El-Agnaf, O. M. (2010). Detection of elevated levels of a-synuclein oligomers in CSF from patients with Parkinson disease. Neurology, 75(20), 1766-1772. doi: 10.1212/WNL.0b013e3181fd613b
-
(2010)
Neurology
, vol.75
, Issue.20
, pp. 1766-1772
-
-
Tokuda, T.1
Qureshi, M.M.2
Ardah, M.T.3
Varghese, S.4
Shehab, S.A.5
Kasai, T.6
El-Agnaf, O.M.7
-
33
-
-
84863294414
-
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
-
Tong, Y., Giaime, E., Yamaguchi, H., Ichimura, T., Liu, Y., Si, H., Shen, J. (2012). Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener, 7, 2. doi: 10.1186/1750-1326-7-2
-
(2012)
Mol Neurodegener
, vol.7
, Issue.2
-
-
Tong, Y.1
Giaime, E.2
Yamaguchi, H.3
Ichimura, T.4
Liu, Y.5
Si, H.6
Shen, J.7
-
34
-
-
77449098331
-
Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation
-
Wider, C., Dickson, D. W., & Wszolek, Z. K. (2010). Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation. Neurodegener Dis, 7(1-3), 175-179. doi: 10.1159/000289232
-
(2010)
Neurodegener Dis
, vol.7
, Issue.1-3
, pp. 175-179
-
-
Wider, C.1
Dickson, D.W.2
Wszolek, Z.K.3
-
35
-
-
79952742454
-
In vivo demonstration that alpha-synuclein oligomers are toxic
-
Winner, B., Jappelli, R., Maji, S. K., Desplats, P. A., Boyer, L., Aigner, S., Riek, R. (2011). In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A, 108(10), 4194-4199. doi: 10.1073/pnas.1100976108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.10
, pp. 4194-4199
-
-
Winner, B.1
Jappelli, R.2
Maji, S.K.3
Desplats, P.A.4
Boyer, L.5
Aigner, S.6
Riek, R.7
|