An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice

Science Translational Medicine

Volumn 6, Issue 236, 2014, Pages

  Sheline, Yvette I ^a   West, Tim ^b   Yarasheski, Kevin ^c   Swarm, Robert ^d   Jasielec, Mateusz S ^c   Fisher, Jonathan R ^d   Ficker, Whitney D ^d   Yan, Ping ^d   Xiong, Chengjie ^c,d   Frederiksen, Christine ^c   Grzelak, Monica V ^d   Chott, Robert ^c   Bateman, Randall J ^d   Morris, John C ^d   Mintun, Mark A ^e   Lee, Jin Moo ^d   Cirrito, John R ^d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b C2N Diagnostics   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e AVID RADIOPHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CITALOPRAM; PLACEBO; AMYLOID PRECURSOR PROTEIN; ANTIDEPRESSANT AGENT; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; HUMAN; HUMAN EXPERIMENT; INTERSTITIAL FLUID; MALE; MOUSE; NAUSEA AND VOMITING; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; TRANSGENIC MOUSE; VOLUNTEER; AMYLOID PLAQUE; ANIMAL; BRAIN; C3H MOUSE; CEREBROSPINAL FLUID; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; MICRODIALYSIS; MIDDLE AGED; PROSPECTIVE STUDY; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADULT; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; MICRODIALYSIS; MIDDLE AGED; PLAQUE, AMYLOID; PROSPECTIVE STUDIES; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84901217810     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3008169     Document Type: Article

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