Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions

Brain, Behavior, and Immunity

Volumn 67, Issue , 2018, Pages 101-117

  Wang, Yunjie ^a   Ruan, Wenchen ^a   Mi, Junru ^b   Xu, Jingzi ^b   Wang, Haojie ^a   Cao, Zhengyu ^a   Saavedra, Juan M ^c   Zhang, Luyong ^a,b   Lin, Hansen ^b   Pang, Tao ^a,c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

AMPK; Balasubramide; Microglia; Neuroinflammation; PGC 1 ; Stroke

Indexed keywords

ANTIINFLAMMATORY AGENT; BALASUBRAMIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; COMPOUND 3C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPOPOLYSACCHARIDE; NATURAL PRODUCT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; FUSED HETEROCYCLIC RINGS; NEUROPROTECTIVE AGENT; PPARGC1A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BV-2 CELL LINE; CELL ACTIVATION; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MICROGLIA; MOLECULAR MECHANICS; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; ANIMAL; BRAIN; C57BL MOUSE; CELL LINE; CEREBRAL ARTERY DISEASE; CHEMISTRY; ENCEPHALITIS; METABOLISM; SPRAGUE DAWLEY RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BRAIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CELL LINE; DEPRESSION; ENCEPHALITIS; HETEROCYCLIC COMPOUNDS, 3-RING; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION MEDIATORS; MALE; MICE, INBRED C57BL; MICROGLIA; NEUROPROTECTIVE AGENTS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 85027976131     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2017.08.006     Document Type: Article

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