Biotransformation of ( + )-and ( - )-clausenamide in rats

Yaoxue Xuebao

Volumn 36, Issue 3, 2001, Pages 224-228

  Yao, Qing Qiang ^a   Wang, Yan ^a   Yang, Shu Min ^b   Wang, Mu Zou ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b China Doping Control Center   (China)

Author keywords

( + ), ( ) clausenamide; Biotransforrnation in vivo; HPLC MS; Stereoselectivity

Indexed keywords

CLAUSENAMIDE; HERBACEOUS AGENT; LACTAM; LIGNAN;

ANIMAL; ARTICLE; BIOTRANSFORMATION; CHEMISTRY; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MALE; MEDICINAL PLANT; PLANT LEAF; RAT; RUTACEAE; STEREOISOMERISM; WISTAR RAT;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; LACTAMS; LIGNANS; MALE; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, WISTAR; RUTACEAE; STEREOISOMERISM;

EID: 0038142822     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Yang MH, Cao YH, Li WX, et al. Isolation and structure elucidation of clausenamide from the leaves of Clausena lansium (Lour.) Skeels [J]. Acta Pharm Sin (in Chinese), 1987, 22(1): 33-40.
2. Rao EC, Cheng JC, Yang GZ, et al. Synthesis of clausenamide [J]. Acta Pharm Sin (in Chinese), 1994, 29(7): 502-505.
3. Duan WZ, Zhang JT. Effects of ( - ), ( + ) clausenamide on anisodine-induced acetylcholine decrease and associated memory deficits in the mouse brain [J]. Acta Pharm Sin (in Chinese), 1998, 32(4): 259-263.
4. Yao QQ, Wang MZ. Metabolic transformation of ( - )-clausenamide in rat liver microsomes [J]. Acta Pharm Sin (in Chinese) 1998, 33(4): 296-299.
5. Yao QQ, Wang MZ. Metabolic transformation of ( + )-clausenamide in rat liver microsomes [J]. Acta Pharm Sin (in Chinese), 1999, 34(4): 303-307.
6. Yao QQ, Wang Y, and Wang MZ. LC-MS analysis of ( + ) and ( - )-clausenamide in rat liver microsomes [J]. Chin J Pharm Anal (in Chinese), 2000, 20(1): 3-7.
7. Yao QQ, Wang MZ. Stereoselectivity of chiral clausenmide biotransformation [J]. Chin J Pharm Toxicol (in Chinese), 1999, 13(3): 214-216.