메뉴 건너뛰기




Volumn 214, Issue 8, 2017, Pages 2369-2385

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; LIPOPOLYSACCHARIDE;

EID: 85027370052     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20170074     Document Type: Article
Times cited : (78)

References (82)
  • 1
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: a doubleedged sword
    • Aggarwal, B.B. 2003. Signalling pathways of the TNF superfamily: a doubleedged sword. Nat. Rev. Immunol. 3:745-756. http ://dx .doi .org /10 .1038 /nri1184.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 3
    • 84951304572 scopus 로고    scopus 로고
    • The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
    • Amit, I., D.R. Winter, and S. Jung. 2016. The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis. Nat. Immunol. 17:18-25. http ://dx .doi .org /10 .1038 /ni .3325.
    • (2016) Nat. Immunol , vol.17 , pp. 18-25
    • Amit, I.1    Winter, D.R.2    Jung, S.3
  • 4
    • 84928987900 scopus 로고    scopus 로고
    • HTSeq-a Python framework to work with high-throughput sequencing data
    • Anders, S., P.T. Pyl, and W. Huber. 2015. HTSeq-a Python framework to work with high-throughput sequencing data. Bioinformatics. 31:166-169.http ://dx .doi .org /10 .1093 /bioinformatics /btu638.
    • (2015) Bioinformatics , vol.31 , pp. 166-169
    • Anders, S.1    Pyl, P.T.2    Huber, W.3
  • 8
    • 43149125857 scopus 로고    scopus 로고
    • Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules
    • Calderon, B., A. Suri, M.J. Miller, and E.R. Unanue. 2008. Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules. Proc. Natl. Acad. Sci. USA.105:6121-6126. http ://dx .doi .org /10 .1073 /pnas .0801973105.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 6121-6126
    • Calderon, B.1    Suri, A.2    Miller, M.J.3    Unanue, E.R.4
  • 9
    • 79952143765 scopus 로고    scopus 로고
    • Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans
    • Calderon, B., J.A. Carrero, M.J. Miller, and E.R. Unanue. 2011. Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc. Natl. Acad. Sci. USA. 108:1561-1566. http ://dx .doi .org /10 .1073 /pnas .1018973108.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 1561-1566
    • Calderon, B.1    Carrero, J.A.2    Miller, M.J.3    Unanue, E.R.4
  • 11
    • 84875451200 scopus 로고    scopus 로고
    • Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse
    • Carrero, J.A., B. Calderon, F. Towfic, M.N. Artyomov, and E.R. Unanue. 2013.Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS One. 8:e59701. http ://dx .doi .org /10 .1371 / journal .pone .0059701.
    • (2013) PLoS One , vol.8
    • Carrero, J.A.1    Calderon, B.2    Towfic, F.3    Artyomov, M.N.4    Unanue, E.R.5
  • 12
    • 33645866471 scopus 로고    scopus 로고
    • Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction
    • Castellino, F., A.Y. Huang, G. Altan-Bonnet, S. Stoll, C. Scheinecker, and R.N. Germain. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature.440:890-895. http ://dx .doi .org /10 .1038 /nature04651.
    • (2006) Nature , vol.440 , pp. 890-895
    • Castellino, F.1    Huang, A.Y.2    Altan-Bonnet, G.3    Stoll, S.4    Scheinecker, C.5    Germain, R.N.6
  • 14
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen, L., and D.B. Flies. 2013. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat. Rev. Immunol. 13:227-242. http ://dx .doi .org /10 .1038 /nri3405.
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 16
    • 79955670895 scopus 로고    scopus 로고
    • Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference? Cell
    • Christen, U., and M.G. von Herrath. 2011. Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference? Cell. Mol.Immunol. 8:193-198. http ://dx .doi .org /10 .1038 /cmi .2010 .71.
    • (2011) Mol.Immunol , vol.8 , pp. 193-198
    • Christen, U.1    von Herrath, M.G.2
  • 18
    • 84905409273 scopus 로고    scopus 로고
    • Macrophages and ß-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes
    • Diana, J., and A. Lehuen. 2014. Macrophages and ß-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes. EMBO Mol. Med. 6:1090-1104. http ://dx .doi .org /10 .15252 /emmm .201404144.
    • (2014) EMBO Mol. Med , vol.6 , pp. 1090-1104
    • Diana, J.1    Lehuen, A.2
  • 19
    • 84872053925 scopus 로고    scopus 로고
    • Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes
    • Diana, J., Y. Simoni, L. Furio, L. Beaudoin, B. Agerberth, F. Barrat, and A. Lehuen. 2013. Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat. Med. 19:65-73. http ://dx .doi .org /10 .1038 /nm .3042.
    • (2013) Nat. Med , vol.19 , pp. 65-73
    • Diana, J.1    Simoni, Y.2    Furio, L.3    Beaudoin, L.4    Agerberth, B.5    Barrat, F.6    Lehuen, A.7
  • 20
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello, C.A. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27:519-550. http ://dx .doi .org /10 .1146 /annurev .immunol .021908 .132612.
    • (2009) Annu. Rev. Immunol , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 22
    • 84976501879 scopus 로고    scopus 로고
    • fqtools: an efficient software suite for modern FAS TQ file manipulation
    • Droop, A.P. 2016. fqtools: an efficient software suite for modern FAS TQ file manipulation. Bioinformatics. 32:1883-1884. http ://dx .doi .org /10 .1093 / bioinformatics /btw088.
    • (2016) Bioinformatics , vol.32 , pp. 1883-1884
    • Droop, A.P.1
  • 23
    • 85009810559 scopus 로고    scopus 로고
    • Postprandial macrophage-derived IL-1ß stimulates insulin, and both synergistically promote glucose disposal and inflammation
    • Dror, E., E. Dalmas, D.T. Meier, S. Wueest, J. Thévenet, C. Thienel, K. Timper, T.M. Nordmann, S. Traub, F. Schulze, et al. 2017. Postprandial macrophage-derived IL-1ß stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat. Immunol. 18:283-292.http ://dx .doi .org /10 .1038 /ni .3659.
    • (2017) Nat. Immunol , vol.18 , pp. 283-292
    • Dror, E.1    Dalmas, E.2    Meier, D.T.3    Wueest, S.4    Thévenet, J.5    Thienel, C.6    Timper, K.7    Nordmann, T.M.8    Traub, S.9    Schulze, F.10
  • 24
    • 0036533663 scopus 로고    scopus 로고
    • IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking
    • Dufour, J.H., M. Dziejman, M.T. Liu, J.H. Leung, T.E. Lane, and A.D. Luster. 2002. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J. Immunol. 168:3195-3204. http ://dx .doi .org /10 .4049 /jimmunol .168 .7 .3195.
    • (2002) J. Immunol , vol.168 , pp. 3195-3204
    • Dufour, J.H.1    Dziejman, M.2    Liu, M.T.3    Leung, J.H.4    Lane, T.E.5    Luster, A.D.6
  • 25
    • 79955743119 scopus 로고    scopus 로고
    • Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
    • Ewald, S.E., A. Engel, J. Lee, M. Wang, M. Bogyo, and G.M. Barton. 2011. Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J. Exp. Med. 208:643-651. http ://dx .doi .org /10 .1084 /jem .20100682.
    • (2011) J. Exp. Med , vol.208 , pp. 643-651
    • Ewald, S.E.1    Engel, A.2    Lee, J.3    Wang, M.4    Bogyo, M.5    Barton, G.M.6
  • 26
    • 84908134654 scopus 로고    scopus 로고
    • A minor subset of Batf3-dependent antigenpresenting cells in islets of Langerhans is essential for the development of autoimmune diabetes
    • Ferris, S.T., J.A. Carrero, J.F. Mohan, B. Calderon, K.M. Murphy, and E.R. Unanue. 2014. A minor subset of Batf3-dependent antigenpresenting cells in islets of Langerhans is essential for the development of autoimmune diabetes. Immunity. 41:657-669. http ://dx .doi .org /10 .1016 /j .immuni .2014 .09 .012.
    • (2014) Immunity , vol.41 , pp. 657-669
    • Ferris, S.T.1    Carrero, J.A.2    Mohan, J.F.3    Calderon, B.4    Murphy, K.M.5    Unanue, E.R.6
  • 27
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications.
    • Foster, S.L., D.C. Hargreaves, and R. Medzhitov. 2007. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature.447:972-978.
    • (2007) Nature , vol.447 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 28
    • 0029053451 scopus 로고
    • Superoxide radical and superoxide dismutases
    • Fridovich, I. 1995. Superoxide radical and superoxide dismutases. Annu. Rev. Biochem. 64:97-112. http ://dx .doi .org /10 .1146 /annurev .bi .64 .070195 .000525.
    • (1995) Annu. Rev. Biochem , vol.64 , pp. 97-112
    • Fridovich, I.1
  • 30
    • 84867740805 scopus 로고    scopus 로고
    • Immunological Genome Consortium.Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Gautier, E.L., T. Shay, J. Miller, M. Greter, C. Jakubzick, S. Ivanov, J. Helft, A. Chow, K.G. Elpek, S. Gordonov, et al. Immunological Genome Consortium. 2012. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13:1118-1128. http ://dx .doi .org /10 .1038 /ni .2419.
    • (2012) Nat. Immunol , vol.13 , pp. 1118-1128
    • Gautier, E.L.1    Shay, T.2    Miller, J.3    Greter, M.4    Jakubzick, C.5    Ivanov, S.6    Helft, J.7    Chow, A.8    Elpek, K.G.9    Gordonov, S.10
  • 33
    • 84896902938 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors: positioning cells for host defense and immunity
    • Griffith, J.W., C.L. Sokol, and A.D. Luster. 2014. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu. Rev.Immunol. 32:659-702. http ://dx .doi .org /10 .1146 /annurev -immunol -032713 -120145.
    • (2014) Annu. Rev.Immunol , vol.32 , pp. 659-702
    • Griffith, J.W.1    Sokol, C.L.2    Luster, A.D.3
  • 34
    • 84896366680 scopus 로고    scopus 로고
    • Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
    • Haldar, M., M. Kohyama, A.Y. So, W. Kc, X. Wu, C.G. Briseño, A.T. Satpathy, N.M. Kretzer, H. Arase, N.S. Rajasekaran, et al. 2014. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 156:1223-1234. http ://dx .doi .org /10 .1016 /j .cell .2014 .01 .069.
    • (2014) Cell , vol.156 , pp. 1223-1234
    • Haldar, M.1    Kohyama, M.2    So, A.Y.3    Kc, W.4    Wu, X.5    Briseño, C.G.6    Satpathy, A.T.7    Kretzer, N.M.8    Arase, H.9    Rajasekaran, N.S.10
  • 36
    • 52649097448 scopus 로고    scopus 로고
    • Immunological Genome Project Consortium.The Immunological Genome Project: networks of gene expression in immune cells
    • Heng, T.S., and M.W. Painter. Immunological Genome Project Consortium. 2008. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9:1091-1094. http ://dx .doi .org /10 .1038 /ni1008 -1091.
    • (2008) Nat. Immunol , vol.9 , pp. 1091-1094
    • Heng, T.S.1    Painter, M.W.2
  • 37
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson, W.E., C. Li, and A. Rabinovic. 2007. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 8:118-127. http ://dx .doi .org /10 .1093 /biostatistics /kxj037.
    • (2007) Biostatistics , vol.8 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 38
    • 0033561630 scopus 로고    scopus 로고
    • TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes
    • Kägi, D., A. Ho, B. Odermatt, A. Zakarian, P.S. Ohashi, and T.W. Mak. 1999.TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J. Immunol. 162:4598-4605.
    • (1999) J. Immunol , vol.162 , pp. 4598-4605
    • Kägi, D.1    Ho, A.2    Odermatt, B.3    Zakarian, A.4    Ohashi, P.S.5    Mak, T.W.6
  • 40
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: kyoto encyclopedia of genes and genomes
    • Kanehisa, M., and S. Goto. 2000. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27-30. http ://dx .doi .org /10 .1093 /nar /28 .1 .27.
    • (2000) Nucleic Acids Res , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 41
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai, T., and S. Akira. 2011. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity. 34:637-650. http ://dx .doi .org /10 .1016 /j .immuni .2011 .05 .006.
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 42
    • 34548036686 scopus 로고    scopus 로고
    • Toll-like receptor 2 senses betacell death and contributes to the initiation of autoimmune diabetes
    • Kim, H.S., M.S. Han, K.W. Chung, S. Kim, E. Kim, M.J. Kim, E. Jang, H.A. Lee, J. Youn, S. Akira, and M.S. Lee. 2007. Toll-like receptor 2 senses betacell death and contributes to the initiation of autoimmune diabetes. Immunity. 27:321-333. http ://dx .doi .org /10 .1016 /j .immuni .2007 .06 .010.
    • (2007) Immunity , vol.27 , pp. 321-333
    • Le, M.S.1
  • 43
    • 84872761427 scopus 로고    scopus 로고
    • Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
    • Koblansky, A.A., D. Jankovic, H. Oh, S. Hieny, W. Sungnak, R. Mathur, M.S. Hayden, S. Akira, A. Sher, and S. Ghosh. 2013. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity. 38:119-130. http ://dx .doi .org /10 .1016 /j .immuni .2012 .09 .016.
    • (2013) Immunity , vol.38 , pp. 119-130
    • Koblansky, A.A.1    Jankovic, D.2    Oh, H.3    Hieny, S.4    Sungnak, W.5    Mathur, R.6    Hayden, M.S.7    Akira, S.8    Sher, A.9    Ghosh, S.10
  • 44
    • 84923357083 scopus 로고    scopus 로고
    • Homeostasis, inflammation, and disease susceptibility
    • Kotas, M.E., and R. Medzhitov. 2015. Homeostasis, inflammation, and disease susceptibility. Cell. 160:816-827. http ://dx .doi .org /10 .1016 /j .cell .2015 .02 .010.
    • (2015) Cell , vol.160 , pp. 816-827
    • Kotas, M.E.1    Medzhitov, R.2
  • 45
    • 0035903305 scopus 로고    scopus 로고
    • Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development
    • Kurth, I., K. Willimann, P. Schaerli, T. Hunziker, I. Clark-Lewis, and B. Moser. 2001. Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development. J. Exp. Med. 194:855-862. http ://dx .doi .org /10 .1084 /jem .194 .6 .855.
    • (2001) J. Exp. Med , vol.194 , pp. 855-862
    • Mos, B.1
  • 46
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin, Y., D. Winter, R. Blecher-Gonen, E. David, H. Keren-Shaul, M. Merad, S. Jung, and I. Amit. 2014. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell. 159:1312- 1326. http ://dx .doi .org /10 .1016 /j .cell .2014 .11 .018.
    • (2014) Cell , vol.159 , pp. 1312- 1326
    • Am, I.1
  • 47
    • 62849092708 scopus 로고    scopus 로고
    • Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals
    • Litvak, V., S.A. Ramsey, A.G. Rust, D.E. Zak, K.A. Kennedy, A.E. Lampano, M. Nykter, I. Shmulevich, and A. Aderem. 2009. Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat. Immunol. 10:437-443. http ://dx .doi .org /10 .1038 /ni .1721.
    • (2009) Nat. Immunol , vol.10 , pp. 437-443
    • Litvak, V.1    Ramsey, S.A.2    Rust, A.G.3    Zak, D.E.4    Kennedy, K.A.5    Lampano, A.E.6    Nykter, M.7    Shmulevich, I.8    Aderem, A.9
  • 48
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
    • Love, M.I., W. Huber, and S. Anders. 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:550. http ://dx .doi .org /10 .1186 /s13059 -014 -0550 -8.
    • (2014) Genome Biol , vol.15 , pp. 550
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 49
    • 77649108168 scopus 로고    scopus 로고
    • Blockade of interleukin 1 in type 1 diabetes mellitus
    • Mandrup-Poulsen, T., L. Pickersgill, and M.Y. Donath. 2010. Blockade of interleukin 1 in type 1 diabetes mellitus. Nat. Rev. Endocrinol. 6:158-166.http ://dx .doi .org /10 .1038 /nrendo .2009 .271.
    • (2010) Nat. Rev. Endocrinol , vol.6 , pp. 158-166
    • Mandrup-Poulsen, T.1    Pickersgill, L.2    Donath, M.Y.3
  • 51
    • 0034304479 scopus 로고    scopus 로고
    • A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.Nat
    • Matloubian, M., A. David, S. Engel, J.E. Ryan, and J.G. Cyster. 2000. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.Nat. Immunol. 1:298-304. http ://dx .doi .org /10 .1038 /79738.
    • (2000) Immunol , vol.1 , pp. 298-304
    • Matloubian, M.1    David, A.2    Engel, S.3    Ryan, J.E.4    Cyster, J.G.5
  • 52
    • 64849085429 scopus 로고    scopus 로고
    • Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues
    • Melli, K., R.S. Friedman, A.E. Martin, E.B. Finger, G. Miao, G.L. Szot, M.F. Krummel, and Q. Tang. 2009. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J. Immunol. 182:2590-2600. http ://dx .doi .org /10 .4049 /jimmunol .0803543.
    • (2009) J. Immunol , vol.182 , pp. 2590-2600
    • Melli, K.1    Friedman, R.S.2    Martin, A.E.3    Finger, E.B.4    Miao, G.5    Szot, G.L.6    Krummel, M.F.7    Tang, Q.8
  • 53
    • 84892511644 scopus 로고    scopus 로고
    • Large-scale gene function analysis with the PAN THER classification system
    • Mi, H., A. Muruganujan, J.T. Casagrande, and P.D. Thomas. 2013. Large-scale gene function analysis with the PAN THER classification system. Nat.Protoc. 8:1551-1566. http ://dx .doi .org /10 .1038 /nprot .2013 .092.
    • (2013) Nat.Protoc , vol.8 , pp. 1551-1566
    • Mi, H.1    Muruganujan, A.2    Casagrande, J.T.3    Thomas, P.D.4
  • 54
    • 84976875034 scopus 로고    scopus 로고
    • PAN THER version 10: expanded protein families and functions, and analysis tools
    • Mi, H., S. Poudel, A. Muruganujan, J.T. Casagrande, and P.D. Thomas. 2016.PAN THER version 10: expanded protein families and functions, and analysis tools. Nucleic Acids Res. 44(D1):D336-D342. http ://dx .doi .org /10 .1093 /nar /gkv1194.
    • (2016) Nucleic Acids Res , vol.44 , Issue.1 , pp. D336-D342
    • Mi, H.1    Poudel, S.2    Muruganujan, A.3    Casagrande, J.T.4    Thomas, P.D.5
  • 57
    • 2942753952 scopus 로고    scopus 로고
    • Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice
    • Moratz, C., J.R. Hayman, H. Gu, and J.H. Kehrl. 2004. Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice. Mol. Cell. Biol. 24:5767- 5775. http ://dx .doi .org /10 .1128 /MCB .24 .13 .5767 -5775 .2004.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 5767- 5775
    • Moratz, C.1    Hayman, J.R.2    Gu, H.3    Kehrl, J.H.4
  • 59
    • 0033526068 scopus 로고    scopus 로고
    • In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
    • Pakala, S.V., M. Chivetta, C.B. Kelly, and J.D. Katz. 1999. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J. Exp. Med. 189:1053- 1062. http ://dx .doi .org /10 .1084 /jem .189 .7 .1053.
    • (1999) J. Exp. Med , vol.189 , pp. 1053- 1062
    • Pakala, S.V.1    Chivetta, M.2    Kelly, C.B.3    Katz, J.D.4
  • 60
    • 0033557102 scopus 로고    scopus 로고
    • Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase
    • Park, C., J.R. Kim, J.K. Shim, B.S. Kang, Y.G. Park, K.S. Nam, Y.C. Lee, and C.H. Kim. 1999. Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase. Arch. Biochem.Biophys. 362:217-224. http ://dx .doi .org /10 .1006 /abbi .1998 .1004.
    • (1999) Arch. Biochem.Biophys , vol.362 , pp. 217-224
    • Park, C.1    Kim, J.R.2    Shim, J.K.3    Kang, B.S.4    Park, Y.G.5    Nam, K.S.6    Lee, Y.C.7    Kim, C.H.8
  • 61
    • 70350513270 scopus 로고    scopus 로고
    • Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases
    • Pasparakis, M. 2009. Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat. Rev. Immunol.9:778-788. http ://dx .doi .org /10 .1038 /nri2655.
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 778-788
    • Pasparakis, M.1
  • 63
    • 0034192097 scopus 로고    scopus 로고
    • RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines
    • Reif, K., and J.G. Cyster. 2000. RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines. J. Immunol. 164:4720-4729. http ://dx .doi .org /10 .4049 / jimmunol .164 .9 .4720.
    • (2000) J. Immunol , vol.164 , pp. 4720-4729
    • Reif, K.1    Cyster, J.G.2
  • 64
    • 84926507971 scopus 로고    scopus 로고
    • limma powers differential expression analyses for RNAsequencing and microarray studies
    • Ritchie, M.E., B. Phipson, D. Wu, Y. Hu, C.W. Law, W. Shi, and G.K. Smyth. 2015. limma powers differential expression analyses for RNAsequencing and microarray studies. Nucleic Acids Res. 43:e47. http ://dx .doi .org /10 .1093 /nar /gkv007.
    • (2015) Nucleic Acids Res , vol.43
    • Ritchie, M.E.1    Phipson, B.2    Wu, D.3    Hu, Y.4    Law, C.W.5    Shi, W.6    Smyth, G.K.7
  • 65
    • 84958078161 scopus 로고    scopus 로고
    • IL-13 improves beta-cell survival and protects against IL-1betainduced beta-cell death
    • Rütti, S., C. Howald, C. Arous, E. Dermitzakis, P.A. Halban, and K. Bouzakri. 2016. IL-13 improves beta-cell survival and protects against IL-1betainduced beta-cell death. Mol. Metab. 5:122-131. http ://dx .doi .org /10 .1016 /j .molmet .2015 .11 .003.
    • (2016) Mol. Metab , vol.5 , pp. 122-131
    • Rütti, S.1    Howald, C.2    Arous, C.3    Dermitzakis, E.4    Halban, P.A.5    Bouzakri, K.6
  • 69
    • 0036467345 scopus 로고    scopus 로고
    • In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket
    • Suri, A., I. Vidavsky, K. van der Drift, O. Kanagawa, M.L. Gross, and E.R. Unanue. 2002. In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket. J. Immunol. 168:1235-1243. http ://dx .doi .org /10 .4049 /jimmunol .168 .3 .1235.
    • (2002) J. Immunol , vol.168 , pp. 1235-1243
    • Suri, A.1    Vidavsky, I.2    van der Drift, K.3    Kanagawa, O.4    Gross, M.L.5    Unanue, E.R.6
  • 70
    • 84961843538 scopus 로고    scopus 로고
    • The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes
    • Tai, N., F.S. Wong, and L. Wen. 2016. The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes. J. Autoimmun. 71:26-34. http ://dx .doi .org /10 .1016 /j .jaut .2016 .03 .006.
    • (2016) J. Autoimmun , vol.71 , pp. 26-34
    • Tai, N.1    Wong, F.S.2    Wen, L.3
  • 71
    • 0032909703 scopus 로고    scopus 로고
    • Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    • Terauchi, Y., Y. Tsuji, S. Satoh, H. Minoura, K. Murakami, A. Okuno, K. Inukai, T. Asano, Y. Kaburagi, K. Ueki, et al. 1999. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat. Genet. 21:230-235. http ://dx .doi .org /10 .1038 /6023.
    • (1999) Nat. Genet , vol.21 , pp. 230-235
    • Terauchi, Y.1    Tsuji, Y.2    Satoh, S.3    Minoura, H.4    Murakami, K.5    Okuno, A.6    Inukai, K.7    Asano, T.8    Kaburagi, Y.9    Ueki, K.10
  • 72
    • 0347360367 scopus 로고    scopus 로고
    • IL-1 receptor deficiency slows progression to diabetes in the NOD mouse
    • Thomas, H.E., W. Irawaty, R. Darwiche, T.C. Brodnicki, P. Santamaria, J. Allison, and T.W. Kay. 2004. IL-1 receptor deficiency slows progression to diabetes in the NOD mouse. Diabetes. 53:113-121. http ://dx .doi .org /10 .2337 /diabetes .53 .1 .113.
    • (2004) Diabetes , vol.53 , pp. 113-121
    • Thomas, H.E.1    Irawaty, W.2    Darwiche, R.3    Brodnicki, T.C.4    Santamaria, P.5    Allison, J.6    Kay, T.W.7
  • 75
    • 0037222255 scopus 로고    scopus 로고
    • Structure, mechanism and regulation of peroxiredoxins
    • Wood, Z.A., E. Schröder, J. Robin Harris, and L.B. Poole. 2003. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem. Sci. 28:32- 40. http ://dx .doi .org /10 .1016 /S0968 -0004(02)00003 -8.
    • (2003) Trends Biochem. Sci , vol.28 , pp. 32- 40
    • Wood, Z.A.1    Schröder, E.2    Robin Harris, J.3    Poole, L.B.4
  • 76
    • 0037125972 scopus 로고    scopus 로고
    • Tumor necrosis factor-a regulation of CD4+CD25+ T cell levels in NOD mice
    • Wu, A.J., H. Hua, S.H. Munson, and H.O. McDevitt. 2002. Tumor necrosis factor-a regulation of CD4+CD25+ T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA. 99:12287-12292. http ://dx .doi .org /10 .1073 /pnas .172382999.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12287-12292
    • Wu, A.J.1    Hua, H.2    Munson, S.H.3    McDevitt, H.O.4
  • 77
    • 84866359284 scopus 로고    scopus 로고
    • Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice
    • Yamada, Y., Y. Okubo, A. Shimada, Y. Oikawa, S. Yamada, S. Narumi, K. Matsushima, and H. Itoh. 2012. Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice.Diabetologia. 55:2238-2245. http ://dx .doi .org /10 .1007 /s00125 -012 -2547 -8.
    • (2012) Diabetologia , vol.55 , pp. 2238-2245
    • Yamada, Y.1    Okubo, Y.2    Shimada, A.3    Oikawa, Y.4    Yamada, S.5    Narumi, S.6    Matsushima, K.7    Itoh, H.8
  • 79
    • 79952672993 scopus 로고    scopus 로고
    • Impulse control: temporal dynamics in gene transcription
    • Yosef, N., and A. Regev. 2011. Impulse control: temporal dynamics in gene transcription. Cell. 144:886-896. http ://dx .doi .org /10 .1016 /j .cell .2011 .02 .015.
    • (2011) Cell , vol.144 , pp. 886-896
    • Yosef, N.1    Regev, A.2
  • 80
    • 84990988075 scopus 로고    scopus 로고
    • Writ large: genomic dissection of the effect of cellular environment on immune response
    • Yosef, N., and A. Regev. 2016. Writ large: genomic dissection of the effect of cellular environment on immune response. Science. 354:64-68. http ://dx .doi .org /10 .1126 /science .aaf5453.
    • (2016) Science , vol.354 , pp. 64-68
    • Yosef, N.1    Regev, A.2
  • 81
    • 84929338101 scopus 로고    scopus 로고
    • Microbiota and autoimmunity: exploring new avenues
    • Yurkovetskiy, L.A., J.M. Pickard, and A.V. Chervonsky. 2015. Microbiota and autoimmunity: exploring new avenues. Cell Host Microbe. 17:548-552.http ://dx .doi .org /10 .1016 /j .chom .2015 .04 .010.
    • (2015) Cell Host Microbe , vol.17 , pp. 548-552
    • Yurkovetskiy, L.A.1    Pickard, J.M.2    Chervonsky, A.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.