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Volumn 7, Issue 1, 2017, Pages

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ACID CERAMIDASE; ASAH1 PROTEIN, HUMAN; CERAMIDE; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

EID: 85027227639     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-07606-w     Document Type: Article
Times cited : (50)

References (59)
  • 1
    • 50049090026 scopus 로고    scopus 로고
    • Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1- phosphate
    • Mao, C. & Obeid, L. M. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1- phosphate. Biochim Biophys Acta 1781, 424-434 (2008).
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 424-434
    • Mao, C.1    Obeid, L.M.2
  • 2
    • 0036735129 scopus 로고    scopus 로고
    • Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant SQ20B cells
    • Alphonse, G. et al. Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant SQ20B cells. Int J Radiat Biol 78, 821-835 (2002).
    • (2002) Int J Radiat Biol , vol.78 , pp. 821-835
    • Alphonse, G.1
  • 3
    • 84891416141 scopus 로고    scopus 로고
    • A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis
    • Abuhusain, H. J. et al. A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. J Biol Chem 288, 37355-37364 (2013).
    • (2013) J Biol Chem , vol.288 , pp. 37355-37364
    • Abuhusain, H.J.1
  • 4
    • 84879836562 scopus 로고    scopus 로고
    • Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling
    • Beckham, T. H. et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis 2, e49 (2013).
    • (2013) Oncogenesis , vol.2 , pp. e49
    • Beckham, T.H.1
  • 5
    • 80051541986 scopus 로고    scopus 로고
    • Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine
    • Bedia, C., Casas, J., Andrieu-Abadie, N., Fabrias, G. & Levade, T. Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem 286, 28200-28209 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 28200-28209
    • Bedia, C.1    Casas, J.2    Andrieu-Abadie, N.3    Fabrias, G.4    Levade, T.5
  • 6
    • 84885029669 scopus 로고    scopus 로고
    • Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling
    • Beckham, T. H. et al. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One 8, e76593 (2013).
    • (2013) PLoS One , vol.8 , pp. e76593
    • Beckham, T.H.1
  • 7
    • 42549100356 scopus 로고    scopus 로고
    • The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy
    • Saad, A. F. et al. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther 6, 1455-1460 (2007).
    • (2007) Cancer Biol Ther , vol.6 , pp. 1455-1460
    • Saad, A.F.1
  • 8
    • 84969846800 scopus 로고    scopus 로고
    • Acid ceramidase in melanoma: Expression, localization and effects of pharmacological inhibition
    • Realini, N. et al. Acid Ceramidase in Melanoma: Expression, Localization and Effects of Pharmacological Inhibition. J Biol Chem (2015).
    • (2015) J Biol Chem
    • Realini, N.1
  • 9
    • 0033839592 scopus 로고    scopus 로고
    • Human acid ceramidase is overexpressed but not mutated in prostate cancer
    • Seelan, R. S. et al. Human acid ceramidase is overexpressed but not mutated in prostate cancer. Genes Chromosomes Cancer 29, 137-146 (2000).
    • (2000) Genes Chromosomes Cancer , vol.29 , pp. 137-146
    • Seelan, R.S.1
  • 10
    • 33845296931 scopus 로고    scopus 로고
    • Acid ceramidase and human disease
    • Park, J. H. & Schuchman, E. H. Acid ceramidase and human disease. Biochim Biophys Acta 1758, 2133-2138 (2006).
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 2133-2138
    • Park, J.H.1    Schuchman, E.H.2
  • 11
    • 52449089092 scopus 로고    scopus 로고
    • Molecular targeting of acid ceramidase: Implications to cancer therapy
    • Zeidan, Y. H. et al. Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets 9, 653-661 (2008).
    • (2008) Curr Drug Targets , vol.9 , pp. 653-661
    • Zeidan, Y.H.1
  • 12
    • 84957397475 scopus 로고    scopus 로고
    • Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways
    • Hajj, C., Becker-Flegler, K. A. & Haimovitz-Friedman, A. Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways. Biol Chem 396, 669-679 (2015).
    • (2015) Biol Chem , vol.396 , pp. 669-679
    • Hajj, C.1    Becker-Flegler, K.A.2    Haimovitz-Friedman, A.3
  • 13
    • 84939947329 scopus 로고    scopus 로고
    • Tumor suppressive functions of ceramide: Evidence and mechanisms
    • Galadari, S., Rahman, A., Pallichankandy, S. & Thayyullathil, F. Tumor suppressive functions of ceramide: evidence and mechanisms. Apoptosis 20, 689-711 (2015).
    • (2015) Apoptosis , vol.20 , pp. 689-711
    • Galadari, S.1    Rahman, A.2    Pallichankandy, S.3    Thayyullathil, F.4
  • 14
    • 84940720286 scopus 로고    scopus 로고
    • Ceramide induced mitophagy and tumor suppression
    • Dany, M. & Ogretmen, B. Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta 1853, 2834-2845 (2015).
    • (2015) Biochim Biophys Acta , vol.1853 , pp. 2834-2845
    • Dany, M.1    Ogretmen, B.2
  • 15
    • 61649091570 scopus 로고    scopus 로고
    • Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer
    • Mahdy, A. E. et al. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther 17, 430-438 (2009).
    • (2009) Mol Ther , vol.17 , pp. 430-438
    • Mahdy, A.E.1
  • 16
    • 79955829728 scopus 로고    scopus 로고
    • Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide
    • Gouaze-Andersson, V. et al. Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide. Prostate 71, 1064-1073 (2011).
    • (2011) Prostate , vol.71 , pp. 1064-1073
    • Gouaze-Andersson, V.1
  • 17
    • 34250732783 scopus 로고    scopus 로고
    • Role of acid ceramidase in resistance to FasL: Therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy
    • Elojeimy, S. et al. Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther 15, 1259-1263 (2007).
    • (2007) Mol Ther , vol.15 , pp. 1259-1263
    • Elojeimy, S.1
  • 18
    • 33847007670 scopus 로고    scopus 로고
    • Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo
    • Morales, A. et al. Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo. Oncogene 26, 905-916 (2007).
    • (2007) Oncogene , vol.26 , pp. 905-916
    • Morales, A.1
  • 19
    • 84872731428 scopus 로고    scopus 로고
    • Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
    • Realini, N. et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep 3, 1035 (2013).
    • (2013) Sci Rep , vol.3 , pp. 1035
    • Realini, N.1
  • 20
    • 84879751036 scopus 로고    scopus 로고
    • Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis
    • Berndt, N., Patel, R., Yang, H., Balasis, M. E. & Sebti, S. M. Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis. Cell Cycle 12, 2024-2032 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 2024-2032
    • Berndt, N.1    Patel, R.2    Yang, H.3    Balasis, M.E.4    Sebti, S.M.5
  • 21
    • 84907013142 scopus 로고    scopus 로고
    • EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis
    • Feng, H. et al. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J Clin Invest 124, 3741-3756 (2014).
    • (2014) J Clin Invest , vol.124 , pp. 3741-3756
    • Feng, H.1
  • 23
    • 47649114132 scopus 로고    scopus 로고
    • Ceramide signaling in cancer and stem cells
    • Bieberich, E. Ceramide signaling in cancer and stem cells. Future Lipidol 3, 273-300 (2008).
    • (2008) Future Lipidol , vol.3 , pp. 273-300
    • Bieberich, E.1
  • 24
    • 34247554203 scopus 로고    scopus 로고
    • Acid ceramidase is a novel factor required for early embryo survival
    • Eliyahu, E., Park, J. H., Shtraizent, N., He, X. & Schuchman, E. H. Acid ceramidase is a novel factor required for early embryo survival. FASEB J 21, 1403-1409 (2007).
    • (2007) FASEB J , vol.21 , pp. 1403-1409
    • Eliyahu, E.1    Park, J.H.2    Shtraizent, N.3    He, X.4    Schuchman, E.H.5
  • 25
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Hannun, Y. A. & Obeid, L. M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 9, 139-150 (2008).
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 26
    • 84971552303 scopus 로고    scopus 로고
    • SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells
    • Santini, R. et al. SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells. Oncogene 33, 4697-4708 (2014).
    • (2014) Oncogene , vol.33 , pp. 4697-4708
    • Santini, R.1
  • 27
    • 84923241422 scopus 로고    scopus 로고
    • Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans
    • Chen, X. et al. Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Sci Rep 4, 7581 (2014).
    • (2014) Sci Rep , vol.4 , pp. 7581
    • Chen, X.1
  • 28
    • 84962881975 scopus 로고    scopus 로고
    • Gene editing of DNAH11 restores normal cilia motility in primary ciliary dyskinesia
    • Lai, M. et al. Gene editing of DNAH11 restores normal cilia motility in primary ciliary dyskinesia. J Med Genet 53, 242-249 (2016).
    • (2016) J Med Genet , vol.53 , pp. 242-249
    • Lai, M.1
  • 29
    • 84887010498 scopus 로고    scopus 로고
    • Genome engineering using the CRISPR-Cas9 system
    • Ran, F. A. et al. Genome engineering using the CRISPR-Cas9 system. Nat Protoc 8, 2281-2308 (2013).
    • (2013) Nat Protoc , vol.8 , pp. 2281-2308
    • Ran, F.A.1
  • 30
    • 84929147435 scopus 로고    scopus 로고
    • Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
    • Chu, V. T. et al. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol 33, 543-548 (2015).
    • (2015) Nat Biotechnol , vol.33 , pp. 543-548
    • Chu, V.T.1
  • 31
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh, E. G. & Dyer, W. J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37, 911-917 (1959).
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 32
    • 84924266259 scopus 로고    scopus 로고
    • Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LCMS/ MS
    • Basit, A., Piomelli, D. & Armirotti, A. Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LCMS/ MS. Anal Bioanal Chem 407, 5189-5198 (2015).
    • (2015) Anal Bioanal Chem , vol.407 , pp. 5189-5198
    • Basit, A.1    Piomelli, D.2    Armirotti, A.3
  • 34
    • 71949111376 scopus 로고    scopus 로고
    • Ceramide induces endothelial cell senescence
    • Venable, M. E. & Yin, X. Ceramide induces endothelial cell senescence. Cell Biochem Funct 27, 547-551 (2009).
    • (2009) Cell Biochem Funct , vol.27 , pp. 547-551
    • Venable, M.E.1    Yin, X.2
  • 35
    • 50549104987 scopus 로고    scopus 로고
    • Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF
    • Wellbrock, C. et al. Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF. PLoS One 3, e2734 (2008).
    • (2008) PLoS One , vol.3 , pp. e2734
    • Wellbrock, C.1
  • 36
    • 0035545996 scopus 로고    scopus 로고
    • Mammalian G1- and S-phase checkpoints in response to DNA damage
    • Bartek, J. & Lukas, J. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol 13, 738-747 (2001).
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 738-747
    • Bartek, J.1    Lukas, J.2
  • 37
    • 84923233694 scopus 로고    scopus 로고
    • Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis
    • Astarita, G. et al. Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis. PLoS One 10, e0116961 (2015).
    • (2015) PLoS One , vol.10 , pp. e0116961
    • Astarita, G.1
  • 38
    • 0035260492 scopus 로고    scopus 로고
    • Enhancement of antitumor effect by intratumoral administration of bax gene in combination with anticancer drugs in gastric cancer
    • Kim, R., Minami, K., Nishimoto, N. & Toge, T. Enhancement of antitumor effect by intratumoral administration of bax gene in combination with anticancer drugs in gastric cancer. Int J Oncol 18, 363-367 (2001).
    • (2001) Int J Oncol , vol.18 , pp. 363-367
    • Kim, R.1    Minami, K.2    Nishimoto, N.3    Toge, T.4
  • 39
    • 84891512646 scopus 로고    scopus 로고
    • Melanoma stem cells and metastasis: Mimicking hematopoietic cell trafficking?
    • Lee, N., Barthel, S. R. & Schatton, T. Melanoma stem cells and metastasis: mimicking hematopoietic cell trafficking? Lab Invest 94, 13-30 (2014).
    • (2014) Lab Invest , vol.94 , pp. 13-30
    • Lee, N.1    Barthel, S.R.2    Schatton, T.3
  • 40
    • 85016444503 scopus 로고    scopus 로고
    • Repurposing of FDA-approved drugs against cancer - Focus on metastasis
    • Ozsvari, B., Lamb, R. & Lisanti, M. P. Repurposing of FDA-approved drugs against cancer - focus on metastasis. Aging (Albany NY) 8, 567-568 (2016).
    • (2016) Aging (Albany NY) , vol.8 , pp. 567-568
    • Ozsvari, B.1    Lamb, R.2    Lisanti, M.P.3
  • 41
    • 0033906468 scopus 로고    scopus 로고
    • Transcription factor hierarchy in Waardenburg syndrome: Regulation of MITF expression by SOX10 and PAX3
    • Potterf, S. B., Furumura, M., Dunn, K. J., Arnheiter, H. & Pavan, W. J. Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3. Hum Genet 107, 1-6 (2000).
    • (2000) Hum Genet , vol.107 , pp. 1-6
    • Potterf, S.B.1    Furumura, M.2    Dunn, K.J.3    Arnheiter, H.4    Pavan, W.J.5
  • 42
    • 77954238710 scopus 로고    scopus 로고
    • Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    • Boiko, A. D. et al. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature 466, 133-137 (2010).
    • (2010) Nature , vol.466 , pp. 133-137
    • Boiko, A.D.1
  • 43
    • 84876797558 scopus 로고    scopus 로고
    • Acid ceramidase as a therapeutic target in metastatic prostate cancer
    • Camacho, L. et al. Acid ceramidase as a therapeutic target in metastatic prostate cancer. J Lipid Res 54, 1207-1220 (2013).
    • (2013) J Lipid Res , vol.54 , pp. 1207-1220
    • Camacho, L.1
  • 44
    • 84885049170 scopus 로고    scopus 로고
    • Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse
    • Cheng, J. C. et al. Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse. The Journal of clinical investigation 123, 4344-4358 (2013).
    • (2013) The Journal of Clinical Investigation , vol.123 , pp. 4344-4358
    • Cheng, J.C.1
  • 45
    • 0035704938 scopus 로고    scopus 로고
    • Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes
    • Li, C. M. et al. Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics 79, 218-224 (2002).
    • (2002) Genomics , vol.79 , pp. 218-224
    • Li, C.M.1
  • 46
    • 84949500321 scopus 로고    scopus 로고
    • Targeting acid ceramidase sensitises head and neck cancer to cisplatin
    • Roh, J. L., Park, J. Y., Kim, E. H. & Jang, H. J. Targeting acid ceramidase sensitises head and neck cancer to cisplatin. Eur J Cancer 52, 163-172 (2016).
    • (2016) Eur J Cancer , vol.52 , pp. 163-172
    • Roh, J.L.1    Park, J.Y.2    Kim, E.H.3    Jang, H.J.4
  • 47
    • 4344614649 scopus 로고    scopus 로고
    • Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
    • Stratford, S., Hoehn, K. L., Liu, F. & Summers, S. A. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem 279, 36608-36615 (2004).
    • (2004) J Biol Chem , vol.279 , pp. 36608-36615
    • Stratford, S.1    Hoehn, K.L.2    Liu, F.3    Summers, S.A.4
  • 48
    • 30744433121 scopus 로고    scopus 로고
    • Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function
    • Sultan, I. et al. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J 393, 513-521 (2006).
    • (2006) Biochem J , vol.393 , pp. 513-521
    • Sultan, I.1
  • 49
    • 79951673359 scopus 로고    scopus 로고
    • Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide
    • Turner, L. S. et al. Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide. Prostate Cancer Prostatic Dis 14, 30-37 (2011).
    • (2011) Prostate Cancer Prostatic Dis , vol.14 , pp. 30-37
    • Turner, L.S.1
  • 50
    • 0036361027 scopus 로고    scopus 로고
    • Expression of bcl-2 and bax in chewing tobacco-induced oral cancers and oral lesions from India
    • Teni, T., Pawar, S., Sanghvi, V. & Saranath, D. Expression of bcl-2 and bax in chewing tobacco-induced oral cancers and oral lesions from India. Pathol Oncol Res 8, 109-114 (2002).
    • (2002) Pathol Oncol Res , vol.8 , pp. 109-114
    • Teni, T.1    Pawar, S.2    Sanghvi, V.3    Saranath, D.4
  • 51
    • 84969895693 scopus 로고    scopus 로고
    • The la protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2
    • Heise, T. et al. The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2. Oncotarget (2016).
    • (2016) Oncotarget
    • Heise, T.1
  • 52
    • 84961837933 scopus 로고    scopus 로고
    • TRAF2 multitasking in TNF receptor-induced signaling to NF-kappaB, MAP kinases and cell death
    • Borghi, A., Verstrepen, L. & Beyaert, R. TRAF2 multitasking in TNF receptor-induced signaling to NF-kappaB, MAP kinases and cell death. Biochem Pharmacol (2016).
    • (2016) Biochem Pharmacol
    • Borghi, A.1    Verstrepen, L.2    Beyaert, R.3
  • 53
    • 84964045814 scopus 로고    scopus 로고
    • TRAF2 exerts opposing effects on basal and TNFalpha-induced activation of the classic IKK complex in hematopoietic cells in mice
    • Zhang, L. et al. TRAF2 exerts opposing effects on basal and TNFalpha-induced activation of the classic IKK complex in hematopoietic cells in mice. J Cell Sci 129, 1455-1467 (2016).
    • (2016) J Cell Sci , vol.129 , pp. 1455-1467
    • Zhang, L.1
  • 54
    • 33646946746 scopus 로고    scopus 로고
    • Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
    • Lee, B. Y. et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell 5, 187-195 (2006).
    • (2006) Aging Cell , vol.5 , pp. 187-195
    • Lee, B.Y.1
  • 55
    • 33747882661 scopus 로고    scopus 로고
    • MITF: Master regulator of melanocyte development and melanoma oncogene
    • Levy, C., Khaled, M. & Fisher, D. E. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med 12, 406-414 (2006).
    • (2006) Trends Mol Med , vol.12 , pp. 406-414
    • Levy, C.1    Khaled, M.2    Fisher, D.E.3
  • 56
    • 77951743475 scopus 로고    scopus 로고
    • Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas
    • Giuliano, S. et al. Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas. Cancer Res 70, 3813-3822 (2010).
    • (2010) Cancer Res , vol.70 , pp. 3813-3822
    • Giuliano, S.1
  • 57
    • 0034641596 scopus 로고    scopus 로고
    • Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome
    • Bondurand, N. et al. Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome. Hum Mol Genet 9, 1907-1917 (2000).
    • (2000) Hum Mol Genet , vol.9 , pp. 1907-1917
    • Bondurand, N.1
  • 58
    • 84866671365 scopus 로고    scopus 로고
    • ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets
    • Luo, Y. et al. ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells 30, 2100-2113 (2012).
    • (2012) Stem Cells , vol.30 , pp. 2100-2113
    • Luo, Y.1
  • 59
    • 84905514443 scopus 로고    scopus 로고
    • Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway
    • Shao, C. et al. Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clin Cancer Res 20, 4154-4166 (2014).
    • (2014) Clin Cancer Res , vol.20 , pp. 4154-4166
    • Shao, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.