Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C 6 ceramide

Prostate Cancer and Prostatic Diseases

Volumn 14, Issue 1, 2011, Pages 30-37

  Turner, L S ^a   Cheng, J C ^b   Beckham, T H ^b   Keane, T E ^b   Norris, J S ^b   Liu, X ^b  

^a FRANCIS MARION UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

acid ceramidase; apoptosis; autophagy; ceramide; sphingolipids

Indexed keywords

ACID CERAMIDASE; CERAMIDE; KINESIN 5; KINESIN 5B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER RESISTANCE; CELL DENSITY; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; LYSOSOME; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ACID CERAMIDASE; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL LINE, TUMOR; CERAMIDES; DRUG RESISTANCE, NEOPLASM; HUMANS; MALE; PROSTATIC NEOPLASMS;

EID: 79951673359     PISSN: 13657852     EISSN: 14765608     Source Type: Journal    
DOI: 10.1038/pcan.2010.47     Document Type: Article

References (28)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer Statistics, 2010. CA Cancer J Clin 2010; 60: 277-300.
2. Ries L, Melbert D, Krapcho M, Stinchcomb D, Howlader N, Horner M et al. SEER Cancer Statistics Review, 1975-2005. In: Ries LAG MD, Krapcho M, Stinchcomb DG, Howlader N, Horner MJ, Mariotto A, Miller BA, Feuer EJ, Altekruse SF, Lewis DR, Clegg L, Eisner MP, Reichman M, Edwards BK (ed). National Cancer Institute: Bethesda MD, 2008.
3. Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004; 4: 604-616. (Pubitemid 39025055)
4. Norris JS, Bielawska A, Day T, El-Zawahri A, ElOjeimy S, Hannun Y et al. Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report. Cancer Gene Ther 2006; 13: 1045-1051. (Pubitemid 44760102)
5. Seelan RS, Qian C, Yokomizo A, Bostwick DG, Smith DI, Liu W. Human acid ceramidase is overexpressed but not mutated in prostate cancer. Genes Chromosomes Cancer 2000; 29: 137-146.
6. Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE et al. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther 2007; 6: 1455-1460. (Pubitemid 351590358)
7. Mahdy AEM, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS et al. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: ac inhibition, a potential radiosensitizer. Mol Ther 2009; 17: 430-438.
8. Morales A, Paris R, Villanueva A, Llacuna L, Garcia-Ruiz C, Fernandez-Checa JC. Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo. Oncogene 2007; 26: 905-916.
9. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290: 1717-1721. (Pubitemid 32004796)
10. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
11. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5: 726-734. (Pubitemid 41486365)
12. Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8: 931-937. (Pubitemid 47622558)
13. Sato K, Tsuchihara K, Fujii S, Sugiyama M, Goya T, Atomi Yet al. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res 2007; 67: 9677-9684. (Pubitemid 47621214)
14. Fujii S,Mitsunaga S, Yamazaki M, Hasebe T, Ishii G, KojimaMet al. Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci 2008; 99: 1813-1819.
15. Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P et al. The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ 2009; 17: 666-676.
16. Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 2009; 4: e6251.
17. Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY et al. Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther 2007; 15: 1259-1263. (Pubitemid 46965321)
18. Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J et al. Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol 2008; 61: 231-242. (Pubitemid 350160321)
19. Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A et al. Acid ceramidase inhibition: a novel target for cancer therapy. Front Biosci 2008; 13: 2293-2298. (Pubitemid 351589254)
20. Brothman AR, Lesho LJ, Somers KD,Wright GL, Merchant Jr DJ. Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinoma. Int J Cancer 1989; 44: 898-903. (Pubitemid 20007990)
21. Cardoso CM, Groth-Pedersen L, Hoyer-Hansen M, Kirkegaard T, Corcelle E, Andersen JS et al. Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. PLoS One 2009; 4: e4424.
22. Fehrenbacher N, Bastholm L, Kirkegaard-Sorensen T, Rafn B, Bottzauw T, Nielsen C et al. Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2. Cancer Res 2008; 68: 6623-6633.
23. Szulc ZM, Mayroo N, Bai A, Bielawski J, Liu X, Norris JS et al. Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. Bioorg Med Chem 2008; 16: 1015-1031. (Pubitemid 351163041)
24. Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439-444. (Pubitemid 32128593)
25. Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008; 68: 1485-1494. (Pubitemid 351346857)
26. Elojeimy S, Holman DH, Liu X, El-Zawahry A, Villani M, Cheng JC et al. New insights on the use of desipramine as an inhibitor for acid ceramidase. FEBS Lett 2006; 580: 4751-4756. (Pubitemid 44189397)
27. Nakata T, Hirokawa N. Point mutation of adenosine triphosphate- binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport. J Cell Biol 1995; 131: 1039-1053.
28. Guenther GG, Peralta ER, Rosales KR, Wong SY, Siskind LJ, Edinger AL. Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc Natl Acad Sci USA 2008; 105: 17402-17407.