Targeting acid ceramidase sensitises head and neck cancer to cisplatin

European Journal of Cancer

Volumn 52, Issue , 2016, Pages 163-172

  Roh, Jong Lyel ^a   Park, Jin Young ^a   Kim, Eun Hye ^a   Jang, Hye Jin ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Acid ceramidase; Cell death; Ceramide; Cisplatin; Head and neck cancer

Indexed keywords

ACID CERAMIDASE; CISPLATIN; MESSENGER RNA; N OLEOYLETHANOLAMINE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; ASAH1 PROTEIN, HUMAN; CERAMIDE; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT RESPONSE; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEAD AND NECK NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; RNAI THERAPEUTICS; TIME FACTOR; TUMOR CELL LINE;

ACID CERAMIDASE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CERAMIDES; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MICE, INBRED BALB C; MICE, NUDE; RNA INTERFERENCE; RNA, MESSENGER; RNAI THERAPEUTICS; TIME FACTORS; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84949500321     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2015.10.056     Document Type: Article

References (24)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J Clin 61 2 2011 69 90
2. R.I. Haddad, and D.M. Shin Recent advances in head and neck cancer N Engl J Med 359 11 2008 1143 1154
3. E.B. Lamont, and E.E. Vokes Chemotherapy in the management of squamous-cell carcinoma of the head and neck Lancet Oncol 2 5 2001 261 269
4. F. Petrelli, A. Coinu, V. Riboldi, K. Borgonovo, M. Ghilardi, M. Cabiddu, and et al. Concomitant platinum-based chemotherapy or cetuximab with radiotherapy for locally advanced head and neck cancer: a systematic review and meta-analysis of published studies Oral Oncol 50 11 2014 1041 1048
5. S.A. Morad, and M.C. Cabot Ceramide-orchestrated signalling in cancer cells Nat Rev Cancer 13 1 2013 51 65
6. M. Bektas, P.S. Jolly, C. Muller, J. Eberle, S. Spiegel, and C.C. Geilen Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression Oncogene 24 1 2005 178 187
7. J.C. Cheng, A. Bai, T.H. Beckham, S.T. Marrison, C.L. Yount, K. Young, and et al. Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse J Clin Invest 123 10 2013 4344 4358
8. N. Berndt, R. Patel, H. Yang, M.E. Balasis, and S.M. Sebti Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis Cell Cycle 12 13 2013 2024 2032
9. T.A. Yap, A. Zivi, A. Omlin, and J.S. de Bono The changing therapeutic landscape of castration-resistant prostate cancer Nat Rev Clin Oncol 8 10 2011 597 610
10. A. Senchenkov, D.A. Litvak, and M.C. Cabot Targeting ceramide metabolism - a strategy for overcoming drug resistance J Natl Cancer Inst 93 5 2001 347 357
11. A.E. Mahdy, J.C. Cheng, J. Li, S. Elojeimy, W.D. Meacham, L.S. Turner, and et al. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer Mol Ther 17 3 2009 430 438
12. L. Camacho, O. Meca-Cortés, J.L. Abad, S. García, N. Rubio, A. Díaz, and et al. Acid ceramidase as a therapeutic target in metastatic prostate cancer J Lipid Res 54 5 2013 1207 1220
13. A. Morales, R. París, A. Villanueva, L. Llacuna, C. García-Ruiz, and J.C. Fernández-Checa Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo Oncogene 26 6 2007 905 916
14. M. Flowers, G. Fabriás, A. Delgado, J. Casas, J.L. Abad, and M.C. Cabot C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth Breast Cancer Res Treat 133 2 2012 447 458
15. S.A. Morad, M.C. Messner, J.C. Levin, N. Abdelmageed, H. Park, A.H. Merrill Jr., and et al. Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells Cancer Chemother Pharmacol 71 3 2013 635 645
16. S. Elojeimy, X. Liu, J.C. McKillop, A.M. El-Zawahry, D.H. Holman, J.Y. Cheng, and et al. Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy Mol Ther 15 7 2007 1259 1263
17. T.C. Chou Drug combination studies and their synergy quantification using the Chou-Talalay method Cancer Res 70 2 2010 440 446
18. T.H. Beckham, P. Lu, J.C. Cheng, D. Zhao, L.S. Turner, X. Zhang, and et al. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B Int J Cancer 131 9 2012 2034 2043
19. C. Bedia, J. Casas, N. Andrieu-Abadie, G. Fabriàs, and T. Levade Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine J Biol Chem 286 32 2011 28200 28209
20. X. Hu, D. Yang, M. Zimmerman, F. Liu, J. Yang, S. Kannan, and et al. IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia Cancer Res 71 8 2011 2882 2891
21. S. ElOjeimy, J.C. McKillop, A.M. El-Zawahry, D.H. Holman, X. Liu, D.A. Schwartz, and et al. FasL gene therapy: a new therapeutic modality for head and neck cancer Cancer Gene Ther 13 8 2006 739 745
22. J.S. Norris, A. Bielawska, T. Day, A. El-Zawahri, S. ElOjeimy, Y. Hannun, and et al. Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report Cancer Gene Ther 13 12 2006 1045 1051
23. R. Brosh, and V. Rotter When mutants gain new powers: news from the mutant p53 field Nat Rev Cancer 9 10 2009 701 713
24. M.L. Poeta, J. Manola, M.A. Goldwasser, A. Forastiere, N. Benoit, J.A. Califano, and et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck N Engl J Med 357 25 2007 2552 2561