Methamphetamine accelerates cellular senescence through stimulation of de novo Ceramide biosynthesis

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Astarita, Giuseppe ^a,f,g   Avanesian, Agnesa ^a   Grimaldi, Benedetto ^b   Realini, Natalia ^b   Justinova, Zuzana ^c,d   Panlilio, Leight V ^c   Basit, Abdul ^b   Goldberg, Steven R ^c   Piomelli, Daniele ^b,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CYTOCHROME P450; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHAMPHETAMINE; REACTIVE OXYGEN METABOLITE; CENTRAL STIMULANT AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL AGING; CELL CYCLE REGULATION; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; INFLAMMATION; LIPIDOMICS; LIPOGENESIS; MALE; METHAMPHETAMINE DEPENDENCE; MOUSE; MYOTUBE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTOMICS; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; DRUG SELF ADMINISTRATION; GENETIC TRANSCRIPTION; KINETICS; METABOLISM; RAT;

RATTUS;

ANIMALS; CELL AGING; CELL LINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CERAMIDES; CYTOCHROME P-450 ENZYME SYSTEM; KINETICS; MALE; METHAMPHETAMINE; MICE; NF-KAPPA B; RATS; SELF ADMINISTRATION; TRANSCRIPTION, GENETIC;

EID: 84923233694     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116961     Document Type: Article

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