Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo

Oncogene

Volumn 26, Issue 6, 2007, Pages 905-916

  Morales, A ^a,c   Paris R ^a   Villanueva, A ^b   Llacuna, L ^a,c   Garcia Ruiz C ^a,c   Fernandez Checa J C ^a,c  

^a HOSPITAL CLÍNIC   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c INST D INVESTIGACIONS B   (Spain)

Author keywords

Apoptosis; Cancer therapy; Ceramide; Mitochondria; Sphingosine 1 phosphate

Indexed keywords

ACYLSPHINGOSINE DEACYLASE; CASPASE 3; CERAMIDE; CYTOCHROME C; DAUNORUBICIN; N OLEOYLETHANOLAMINE; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CELL GROWTH; CELL STRAIN HEPG2; CONTROLLED STUDY; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR XENOGRAFT; ULTRASTRUCTURE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL PROLIFERATION; CERAMIDE TRIHEXOSIDASE; DAUNORUBICIN; DRUG THERAPY; ETHANOLAMINES; HUMANS; LYSOPHOSPHOLIPIDS; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; PROTEASE INHIBITORS; RNA, MESSENGER; RNA, SMALL INTERFERING; SPHINGOSINE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MURINAE;

EID: 33847007670     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209834     Document Type: Article

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