Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration

Cell Reports

Volumn 20, Issue 5, 2017, Pages 1050-1060

  Asano, Jumpei ^a   Sato, Taku ^a,b   Ichinose, Shizuko ^a   Kajita, Mihoko ^a   Onai, Nobuyuki ^a   Shimizu, Shigeomi ^a   Ohteki, Toshiaki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

5 fluorouracil (5 FU); autophagy; intestinal epithelial cell (iEC); intestinal stem cell (ISC); irradiation; reactive oxygen species (ROS); regeneration

Indexed keywords

AUTOPHAGY RELATED PROTEIN 5; REACTIVE OXYGEN METABOLITE; ATG5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL COUNT; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; CRYPT CELL; EX VIVO STUDY; FLOW CYTOMETRY; INTESTINAL REGENERATION; INTESTINAL STEM CELL; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; TISSUE REGENERATION; ANIMAL; DEFICIENCY; EXPERIMENTAL RADIATION INJURY; GAMMA RADIATION; GENETICS; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PHYSIOLOGY; RADIATION RESPONSE; REGENERATION; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; GAMMA RAYS; INTESTINAL MUCOSA; MICE; MICE, TRANSGENIC; RADIATION INJURIES, EXPERIMENTAL; REACTIVE OXYGEN SPECIES; REGENERATION; STEM CELLS;

EID: 85026867231     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.07.019     Document Type: Article

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