-
1
-
-
0018793190
-
Relative abundance of specific messenger-RNA species in the free mRNP fraction of rat liver
-
Zahringer, J., Baliga, B. S., and Munro, H. N. (1979) Relative abundance of specific messenger-RNA species in the free mRNP fraction of rat liver. FEBS Lett. 108, 317–320
-
(1979)
FEBS Lett.
, vol.108
, pp. 317-320
-
-
Zahringer, J.1
Baliga, B.S.2
Munro, H.N.3
-
2
-
-
0021183212
-
Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit
-
Leibold, E. A., Aziz, N., Brown, A. J., and Munro, H. N. (1984) Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit. J. Biol. Chem. 259, 4327–4334
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 4327-4334
-
-
Leibold, E.A.1
Aziz, N.2
Brown, A.J.3
Munro, H.N.4
-
3
-
-
0023612118
-
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA
-
Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., and Klausner, R. D. (1987) Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science 238, 1570–1573
-
(1987)
Science
, vol.238
, pp. 1570-1573
-
-
Hentze, M.W.1
Caughman, S.W.2
Rouault, T.A.3
Barriocanal, J.G.4
Dancis, A.5
Harford, J.B.6
Klausner, R.D.7
-
4
-
-
0024121621
-
Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- And light-subunit mRNAs
-
Leibold, E. A., and Munro, H. N. (1988) Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc. Natl. Acad. Sci. U.S.A. 85, 2171–2175
-
(1988)
Proc. Natl. Acad. Sci. U.S.A.
, vol.85
, pp. 2171-2175
-
-
Leibold, E.A.1
Munro, H.N.2
-
5
-
-
0025009117
-
Cloning of the cDNA encoding an RNA regulatory protein–the human iron-responsive element-binding protein
-
Rouault, T. A., Tang, C. K., Kaptain, S., Burgess, W. H., Haile, D. J., Samaniego, F., McBride, O. W., Harford, J. B., and Klausner, R. D. (1990) Cloning of the cDNA encoding an RNA regulatory protein–the human iron-responsive element-binding protein. Proc. Natl. Acad. Sci. U.S.A. 87, 7958–7962
-
(1990)
Proc. Natl. Acad. Sci. U.S.A.
, vol.87
, pp. 7958-7962
-
-
Rouault, T.A.1
Tang, C.K.2
Kaptain, S.3
Burgess, W.H.4
Haile, D.J.5
Samaniego, F.6
McBride, O.W.7
Harford, J.B.8
Klausner, R.D.9
-
6
-
-
0021112587
-
The role of iron in the activation-inactivation of aconitase
-
Kennedy, M. C., Emptage, M. H., Dreyer, J. L., and Beinert, H. (1983) The role of iron in the activation-inactivation of aconitase. J. Biol. Chem. 258, 11098 –11105
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 11098-11105
-
-
Kennedy, M.C.1
Emptage, M.H.2
Dreyer, J.L.3
Beinert, H.4
-
7
-
-
34248653740
-
Metabolic regulation of citrate and iron by aconitases: Role of iron-sulfur cluster biogenesis
-
Tong, W. H., and Rouault, T. A. (2007) Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis. Biometals 20, 549–564
-
(2007)
Biometals
, vol.20
, pp. 549-564
-
-
Tong, W.H.1
Rouault, T.A.2
-
8
-
-
0025748777
-
A regulated RNA binding protein also possesses aconitase activity
-
Kaptain, S., Downey, W. E., Tang, C., Philpott, C., Haile, D., Orloff, D. G., Harford, J. B., Rouault, T. A., and Klausner, R. D. (1991) A regulated RNA binding protein also possesses aconitase activity. Proc. Natl. Acad. Sci. U.S.A. 88, 10109–10113
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 10109-10113
-
-
Kaptain, S.1
Downey, W.E.2
Tang, C.3
Philpott, C.4
Haile, D.5
Orloff, D.G.6
Harford, J.B.7
Rouault, T.A.8
Klausner, R.D.9
-
9
-
-
0027081042
-
Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein
-
Kennedy, M. C., Mende-Mueller, L., Blondin, G. A., and Beinert, H. (1992) Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc. Natl. Acad. Sci. U.S.A. 89, 11730 –11734
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 11730-11734
-
-
Kennedy, M.C.1
Mende-Mueller, L.2
Blondin, G.A.3
Beinert, H.4
-
10
-
-
0027050315
-
Cellular regulation of the iron-responsive element binding protein: Disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding
-
Haile, D. J., Rouault, T. A., Harford, J. B., Kennedy, M. C., Blondin, G. A., Beinert, H., and Klausner, R. D. (1992) Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding. Proc. Natl. Acad. Sci. U.S.A. 89, 11735–11739
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 11735-11739
-
-
Haile, D.J.1
Rouault, T.A.2
Harford, J.B.3
Kennedy, M.C.4
Blondin, G.A.5
Beinert, H.6
Klausner, R.D.7
-
11
-
-
0025822118
-
Identification of a novel iron-responsive element in murine and human erythroid δ-aminolevulinic acid synthase mRNA
-
Dandekar, T., Stripecke, R., Gray, N. K., Goossen, B., Constable, A., Johansson, H. E., and Hentze, M. W. (1991) Identification of a novel iron-responsive element in murine and human erythroid δ-aminolevulinic acid synthase mRNA. EMBO J. 10, 1903–1909
-
(1991)
EMBO J.
, vol.10
, pp. 1903-1909
-
-
Dandekar, T.1
Stripecke, R.2
Gray, N.K.3
Goossen, B.4
Constable, A.5
Johansson, H.E.6
Hentze, M.W.7
-
12
-
-
0029793466
-
Identification of a conserved and functional iron-responsive element in the 5′-untranslated region of mammalian mitochondrial aconitase
-
Kim, H. Y., LaVaute, T., Iwai, K., Klausner, R. D., and Rouault, T. A. (1996) Identification of a conserved and functional iron-responsive element in the 5′-untranslated region of mammalian mitochondrial aconitase. J. Biol. Chem. 271, 24226 –24230
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24226-24230
-
-
Kim, H.Y.1
Lavaute, T.2
Iwai, K.3
Klausner, R.D.4
Rouault, T.A.5
-
13
-
-
34247628002
-
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
-
Sanchez, M., Galy, B., Muckenthaler, M. U., and Hentze, M. W. (2007) Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency. Nat. Struct. Mol. Biol. 14, 420 – 426
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 420-426
-
-
Sanchez, M.1
Galy, B.2
Muckenthaler, M.U.3
Hentze, M.W.4
-
14
-
-
0034733635
-
A novel mammalian iron-regulated protein involved in intracellular iron metabolism
-
Abboud, S., and Haile, D. J. (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem. 275, 19906–19912
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19906-19912
-
-
Abboud, S.1
Haile, D.J.2
-
15
-
-
0028266818
-
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening
-
Binder, R., Horowitz, J. A., Basilion, J. P., Koeller, D. M., Klausner, R. D., and Harford, J. B. (1994) Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening. EMBO J. 13, 1969 –1980
-
(1994)
EMBO J.
, vol.13
, pp. 1969-1980
-
-
Binder, R.1
Horowitz, J.A.2
Basilion, J.P.3
Koeller, D.M.4
Klausner, R.D.5
Harford, J.B.6
-
16
-
-
18244389488
-
Iron-dependent regulation of the divalent metal ion transporter
-
Gunshin, H., Allerson, C. R., Polycarpou-Schwarz, M., Rofts, A., Rogers, J. T., Kishi, F., Hentze, M. W., Rouault, T. A., Andrews, N. C., and Hediger, M. A. (2001) Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 509, 309 –316
-
(2001)
FEBS Lett.
, vol.509
, pp. 309-316
-
-
Gunshin, H.1
Allerson, C.R.2
Polycarpou-Schwarz, M.3
Rofts, A.4
Rogers, J.T.5
Kishi, F.6
Hentze, M.W.7
Rouault, T.A.8
Andrews, N.C.9
Hediger, M.A.10
-
17
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer’s amyloid precursor protein transcript
-
Rogers, J. T., Randall, J. D., Cahill, C. M., Eder, P. S., Huang, X., Gunshin, H., Leiter, L., McPhee, J., Sarang, S. S., Utsuki, T., Greig, N. H., Lahiri, D. K., Tanzi, R. E., Bush, A. I., Giordano, T., and Gullans, S. R. (2002) An iron-responsive element type II in the 5′-untranslated region of the Alzheimer’s amyloid precursor protein transcript. J. Biol. Chem. 277, 45518 – 45528
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45518-45528
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
Eder, P.S.4
Huang, X.5
Gunshin, H.6
Leiter, L.7
McPhee, J.8
Sarang, S.S.9
Utsuki, T.10
Greig, N.H.11
Lahiri, D.K.12
Tanzi, R.E.13
Bush, A.I.14
Giordano, T.15
Gullans, S.R.16
-
18
-
-
33747349746
-
Iron regulation and the cell cycle: Identification of an iron-responsive element in the 3′-untrans-lated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy
-
Sanchez, M., Galy, B., Dandekar, T., Bengert, P., Vainshtein, Y., Stolte, J., Muckenthaler, M. U., and Hentze, M. W. (2006) Iron regulation and the cell cycle: identification of an iron-responsive element in the 3′-untrans-lated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J. Biol. Chem. 281, 22865–22874
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 22865-22874
-
-
Sanchez, M.1
Galy, B.2
Dandekar, T.3
Bengert, P.4
Vainshtein, Y.5
Stolte, J.6
Muckenthaler, M.U.7
Hentze, M.W.8
-
19
-
-
84875169786
-
System-wide identification of RNA-binding proteins by interactome capture
-
Castello, A., Horos, R., Strein, C., Fischer, B., Eichelbaum, K., Steinmetz, L. M., Krijgsveld, J., and Hentze, M. W. (2013) System-wide identification of RNA-binding proteins by interactome capture. Nat. Protoc. 8, 491–500
-
(2013)
Nat. Protoc.
, vol.8
, pp. 491-500
-
-
Castello, A.1
Horos, R.2
Strein, C.3
Fischer, B.4
Eichelbaum, K.5
Steinmetz, L.M.6
Krijgsveld, J.7
Hentze, M.W.8
-
20
-
-
33644804529
-
Crystal structure of human iron regulatory protein 1 as cytosolic aconitase
-
Dupuy, J., Volbeda, A., Carpentier, P., Darnault, C., Moulis, J. M., and Fontecilla-Camps, J. C. (2006) Crystal structure of human iron regulatory protein 1 as cytosolic aconitase. Structure 14, 129–139
-
(2006)
Structure
, vol.14
, pp. 129-139
-
-
Dupuy, J.1
Volbeda, A.2
Carpentier, P.3
Darnault, C.4
Moulis, J.M.5
Fontecilla-Camps, J.C.6
-
21
-
-
33845865301
-
Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA
-
Walden, W. E., Selezneva, A. I., Dupuy, J., Volbeda, A., Fontecilla-Camps, J. C., Theil, E. C., and Volz, K. (2006) Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA. Science 314, 1903–1908
-
(2006)
Science
, vol.314
, pp. 1903-1908
-
-
Walden, W.E.1
Selezneva, A.I.2
Dupuy, J.3
Volbeda, A.4
Fontecilla-Camps, J.C.5
Theil, E.C.6
Volz, K.7
-
22
-
-
0028143071
-
Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation
-
Samaniego, F., Chin, J., Iwai, K., Rouault, T. A., and Klausner, R. D. (1994) Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. J. Biol. Chem. 269, 30904 –30910
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 30904-30910
-
-
Samaniego, F.1
Chin, J.2
Iwai, K.3
Rouault, T.A.4
Klausner, R.D.5
-
23
-
-
0028131454
-
Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity
-
Guo, B., Yu, Y., and Leibold, E. A. (1994) Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J. Biol. Chem. 269, 24252–24260
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 24252-24260
-
-
Guo, B.1
Yu, Y.2
Leibold, E.A.3
-
24
-
-
70350613915
-
Control of iron homeostasis by an iron-regulated ubiquitin ligase
-
Vashisht, A. A., Zumbrennen, K. B., Huang, X., Powers, D. N., Durazo, A., Sun, D., Bhaskaran, N., Persson, A., Uhlen, M., Sangfelt, O., Spruck, C., Leibold, E. A., and Wohlschlegel, J. A. (2009) Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science 326, 718 –721
-
(2009)
Science
, vol.326
, pp. 718-721
-
-
Vashisht, A.A.1
Zumbrennen, K.B.2
Huang, X.3
Powers, D.N.4
Durazo, A.5
Sun, D.6
Bhaskaran, N.7
Persson, A.8
Uhlen, M.9
Sangfelt, O.10
Spruck, C.11
Leibold, E.A.12
Wohlschlegel, J.A.13
-
25
-
-
70350576223
-
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis
-
Salahudeen, A. A., Thompson, J. W., Ruiz, J. C., Ma, H. W., Kinch, L. N., Li, Q., Grishin, N. V., and Bruick, R. K. (2009) An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Science 326, 722–726
-
(2009)
Science
, vol.326
, pp. 722-726
-
-
Salahudeen, A.A.1
Thompson, J.W.2
Ruiz, J.C.3
Ma, H.W.4
Kinch, L.N.5
Li, Q.6
Grishin, N.V.7
Bruick, R.K.8
-
26
-
-
33746361251
-
The role of iron regulatory proteins in mammalian iron homeostasis and disease
-
Rouault, T. A. (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2, 406 – 414
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 406-414
-
-
Rouault, T.A.1
-
27
-
-
10744223491
-
Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
-
Meyron-Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U. V., Land, W., Ollivierre-Wilson, H., Grinberg, A., Love, P., and Rouault, T. A. (2004) Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 23, 386 –395
-
(2004)
EMBO J.
, vol.23
, pp. 386-395
-
-
Meyron-Holtz, E.G.1
Ghosh, M.C.2
Iwai, K.3
Lavaute, T.4
Brazzolotto, X.5
Berger, U.V.6
Land, W.7
Ollivierre-Wilson, H.8
Grinberg, A.9
Love, P.10
Rouault, T.A.11
-
28
-
-
10844282789
-
Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo
-
Meyron-Holtz, E. G., Ghosh, M. C., and Rouault, T. A. (2004) Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science 306, 2087–2090
-
(2004)
Science
, vol.306
, pp. 2087-2090
-
-
Meyron-Holtz, E.G.1
Ghosh, M.C.2
Rouault, T.A.3
-
29
-
-
33645307993
-
Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development
-
Smith, S. R., Ghosh, M. C., Ollivierre-Wilson, H., Hang Tong, W., and Rouault, T. A. (2006) Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol. Dis. 36, 283–287
-
(2006)
Blood Cells Mol. Dis.
, vol.36
, pp. 283-287
-
-
Smith, S.R.1
Ghosh, M.C.2
Ollivierre-Wilson, H.3
Hang Tong, W.4
Rouault, T.A.5
-
30
-
-
84902438197
-
Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments
-
Zumbrennen-Bullough, K. B., Becker, L., Garrett, L., Hölter, S. M., Calzada-Wack, J., Mossbrugger, I., Quintanilla-Fend, L., Racz, I., Rathkolb, B., Klopstock, T., Wurst, W., Zimmer, A., Wolf, E., Fuchs, H., Gailus-Durner, V., et al. (2014) Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. PLoS ONE 9, e98072
-
(2014)
Plos ONE
, vol.9
, pp. e98072
-
-
Zumbrennen-Bullough, K.B.1
Becker, L.2
Garrett, L.3
Hölter, S.M.4
Calzada-Wack, J.5
Mossbrugger, I.6
Quintanilla-Fend, L.7
Racz, I.8
Rathkolb, B.9
Klopstock, T.10
Wurst, W.11
Zimmer, A.12
Wolf, E.13
Fuchs, H.14
Gailus-Durner, V.15
-
31
-
-
0035138456
-
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
-
LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., Switzer, R., 3rd., Grinberg, A., Love, P., Tresser, N., and Rouault, T. A. (2001) Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat. Genet. 27, 209–214
-
(2001)
Nat. Genet.
, vol.27
, pp. 209-214
-
-
Lavaute, T.1
Smith, S.2
Cooperman, S.3
Iwai, K.4
Land, W.5
Meyron-Holtz, E.6
Drake, S.K.7
Miller, G.8
Abu-Asab, M.9
Tsokos, M.10
Switzer, R.11
Grinberg, A.12
Love, P.13
Tresser, N.14
Rouault, T.A.15
-
32
-
-
23044503950
-
Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2
-
Cooperman, S. S., Meyron-Holtz, E. G., Olivierre-Wilson, H., Ghosh, M. C., McConnell, J. P., and Rouault, T. A. (2005) Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood 106, 1084–1091
-
(2005)
Blood
, vol.106
, pp. 1084-1091
-
-
Cooperman, S.S.1
Meyron-Holtz, E.G.2
Olivierre-Wilson, H.3
Ghosh, M.C.4
McConnell, J.P.5
Rouault, T.A.6
-
33
-
-
80053902000
-
Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice
-
Jeong, S. Y., Crooks, D. R., Wilson-Ollivierre, H., Ghosh, M. C., Sougrat, R., Lee, J., Cooperman, S., Mitchell, J. B., Beaumont, C., and Rouault, T. A. (2011) Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice. PLoS ONE 6, e25404
-
(2011)
Plos ONE
, vol.6
, pp. e25404
-
-
Jeong, S.Y.1
Crooks, D.R.2
Wilson-Ollivierre, H.3
Ghosh, M.C.4
Sougrat, R.5
Lee, J.6
Cooperman, S.7
Mitchell, J.B.8
Beaumont, C.9
Rouault, T.A.10
-
34
-
-
27144467097
-
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
-
Galy, B., Ferring, D., Minana, B., Bell, O., Janser, H. G., Muckenthaler, M., Schümann, K., and Hentze, M. W. (2005) Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood 106, 2580 –2589
-
(2005)
Blood
, vol.106
, pp. 2580-2589
-
-
Galy, B.1
Ferring, D.2
Minana, B.3
Bell, O.4
Janser, H.G.5
Muckenthaler, M.6
Schümann, K.7
Hentze, M.W.8
-
35
-
-
84873338684
-
Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2alpha
-
Ghosh, M. C., Zhang, D. L., Jeong, S. Y., Kovtunovych, G., Ollivierre-Wilson, H., Noguchi, A., Tu, T., Senecal, T., Robinson, G., Crooks, D. R., Tong, W. H., Ramaswamy, K., Singh, A., Graham, B. B., Tuder, R. M., et al. (2013) Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2alpha. Cell Metab. 17, 271–281
-
(2013)
Cell Metab.
, vol.17
, pp. 271-281
-
-
Ghosh, M.C.1
Zhang, D.L.2
Jeong, S.Y.3
Kovtunovych, G.4
Ollivierre-Wilson, H.5
Noguchi, A.6
Tu, T.7
Senecal, T.8
Robinson, G.9
Crooks, D.R.10
Tong, W.H.11
Ramaswamy, K.12
Singh, A.13
Graham, B.B.14
Tuder, R.M.15
-
36
-
-
84873361483
-
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption
-
Anderson, S. A., Nizzi, C. P., Chang, Y. I., Deck, K. M., Schmidt, P. J., Galy, B., Damnernsawad, A., Broman, A. T., Kendziorski, C., Hentze, M. W., Fleming, M. D., Zhang, J., and Eisenstein, R. S. (2013) The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab. 17, 282–290
-
(2013)
Cell Metab
, vol.17
, pp. 282-290
-
-
Anderson, S.A.1
Nizzi, C.P.2
Chang, Y.I.3
Deck, K.M.4
Schmidt, P.J.5
Galy, B.6
Damnernsawad, A.7
Broman, A.T.8
Kendziorski, C.9
Hentze, M.W.10
Fleming, M.D.11
Zhang, J.12
Eisenstein, R.S.13
-
37
-
-
1542378729
-
Synthetic analogues of the active sites of iron-sulfur proteins
-
Venkateswara Rao, P., and Holm, R. H. (2004) Synthetic analogues of the active sites of iron-sulfur proteins. Chem. Rev. 104, 527–559
-
(2004)
Chem. Rev.
, vol.104
, pp. 527-559
-
-
Venkateswara Rao, P.1
Holm, R.H.2
-
38
-
-
0024617020
-
Physical and genetic map of the major nif gene cluster from Azotobacter vinelandii
-
Jacobson, M. R., Brigle, K. E., Bennett, L. T., Setterquist, R. A., Wilson, M. S., Cash, V. L., Beynon, J., Newton, W. E., and Dean, D. R. (1989) Physical and genetic map of the major nif gene cluster from Azotobacter vinelandii. J. Bacteriol. 171, 1017–1027
-
(1989)
J. Bacteriol.
, vol.171
, pp. 1017-1027
-
-
Jacobson, M.R.1
Brigle, K.E.2
Bennett, L.T.3
Setterquist, R.A.4
Wilson, M.S.5
Cash, V.L.6
Beynon, J.7
Newton, W.E.8
Dean, D.R.9
-
39
-
-
84878909112
-
Protected sulfur transfer reactions by the Escherichia coli Suf system
-
Selbach, B. P., Pradhan, P. K., and Dos Santos, P. C. (2013) Protected sulfur transfer reactions by the Escherichia coli Suf system. Biochemistry 52, 4089–4096
-
(2013)
Biochemistry
, vol.52
, pp. 4089-4096
-
-
Selbach, B.P.1
Pradhan, P.K.2
Dos Santos, P.C.3
-
40
-
-
26444455549
-
How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins
-
Barras, F., Loiseau, L., and Py, B. (2005) How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins. Adv. Microb. Physiol. 50, 41–101
-
(2005)
Adv. Microb. Physiol.
, vol.50
, pp. 41-101
-
-
Barras, F.1
Loiseau, L.2
Py, B.3
-
41
-
-
14844295427
-
AtNAP1 represents an atypical SufB protein in Arabidopsis plastids
-
Xu, X. M., Adams, S., Chua, N. H., and Møller, S. G. (2005) AtNAP1 represents an atypical SufB protein in Arabidopsis plastids. J. Biol. Chem. 280, 6648 – 6654
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 6648-6654
-
-
Xu, X.M.1
Adams, S.2
Chua, N.H.3
Møller, S.G.4
-
42
-
-
0027450059
-
Cysteine desulfurase activity indicates a role for NIFS in metallocluster biosynthesis
-
Zheng, L., White, R. H., Cash, V. L., Jack, R. F., and Dean, D. R. (1993) Cysteine desulfurase activity indicates a role for NIFS in metallocluster biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 90, 2754 –2758
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 2754-2758
-
-
Zheng, L.1
White, R.H.2
Cash, V.L.3
Jack, R.F.4
Dean, D.R.5
-
43
-
-
0032245425
-
Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization
-
Land, T., and Rouault, T. A. (1998) Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization. Mol. Cell 2, 807– 815
-
(1998)
Mol. Cell
, vol.2
, pp. 807-815
-
-
Land, T.1
Rouault, T.A.2
-
44
-
-
0034331239
-
Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells
-
Tong, W. H., and Rouault, T. (2000) Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. EMBO J. 19, 5692–5700
-
(2000)
EMBO J.
, vol.19
, pp. 5692-5700
-
-
Tong, W.H.1
Rouault, T.2
-
45
-
-
30444433568
-
The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria
-
Adam, A. C., Bornhövd, C., Prokisch, H., Neupert, W., and Hell, K. (2006) The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. EMBO J. 25, 174 –183
-
(2006)
EMBO J.
, vol.25
, pp. 174-183
-
-
Adam, A.C.1
Bornhövd, C.2
Prokisch, H.3
Neupert, W.4
Hell, K.5
-
46
-
-
30444449009
-
Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins
-
Wiedemann, N., Urzica, E., Guiard, B., Müller, H., Lohaus, C., Meyer, H. E., Ryan, M. T., Meisinger, C., Mühlenhoff, U., Lill, R., and Pfanner, N. (2006) Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J. 25, 184–195
-
(2006)
EMBO J.
, vol.25
, pp. 184-195
-
-
Wiedemann, N.1
Urzica, E.2
Guiard, B.3
Müller, H.4
Lohaus, C.5
Meyer, H.E.6
Ryan, M.T.7
Meisinger, C.8
Mühlenhoff, U.9
Lill, R.10
Pfanner, N.11
-
47
-
-
68049086933
-
Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis
-
Shi, Y., Ghosh, M. C., Tong, W. H., and Rouault, T. A. (2009) Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis. Hum. Mol. Genet. 18, 3014–3025
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3014-3025
-
-
Shi, Y.1
Ghosh, M.C.2
Tong, W.H.3
Rouault, T.A.4
-
48
-
-
77955405138
-
Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis
-
Sheftel, A. D., Stehling, O., Pierik, A. J., Elsässer, H. P., Mühlenhoff, U., Webert, H., Hobler, A., Hannemann, F., Bernhardt, R., and Lill, R. (2010) Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 107, 11775–11780
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 11775-11780
-
-
Sheftel, A.D.1
Stehling, O.2
Pierik, A.J.3
Elsässer, H.P.4
Mühlenhoff, U.5
Webert, H.6
Hobler, A.7
Hannemann, F.8
Bernhardt, R.9
Lill, R.10
-
49
-
-
84855766784
-
Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis
-
Shi, Y., Ghosh, M., Kovtunovych, G., Crooks, D. R., and Rouault, T. A. (2012) Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis. Biochim. Biophys. Acta 1823, 484 – 492
-
(2012)
Biochim. Biophys. Acta
, vol.1823
, pp. 484-492
-
-
Shi, Y.1
Ghosh, M.2
Kovtunovych, G.3
Crooks, D.R.4
Rouault, T.A.5
-
50
-
-
77956513437
-
Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis
-
Uhrigshardt, H., Singh, A., Kovtunovych, G., Ghosh, M., and Rouault, T. A. (2010) Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis. Hum. Mol. Genet. 19, 3816 –3834
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3816-3834
-
-
Uhrigshardt, H.1
Singh, A.2
Kovtunovych, G.3
Ghosh, M.4
Rouault, T.A.5
-
51
-
-
0041691163
-
Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster
-
Tong, W. H., Jameson, G. N., Huynh, B. H., and Rouault, T. A. (2003) Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Proc. Natl. Acad. Sci. U.S.A. 100, 9762–9767
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 9762-9767
-
-
Tong, W.H.1
Jameson, G.N.2
Huynh, B.H.3
Rouault, T.A.4
-
52
-
-
33644623262
-
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis
-
Tong, W. H., and Rouault, T. A. (2006) Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. Cell Metab. 3, 199 –210
-
(2006)
Cell Metab.
, vol.3
, pp. 199-210
-
-
Tong, W.H.1
Rouault, T.A.2
-
53
-
-
84895735383
-
Cochaperone binding to LYR motifs confers specificity of iron-sulfur cluster delivery
-
Maio, N., Singh, A., Uhrigshardt, H., Saxena, N., Tong, W. H., and Rouault, T. A. (2014) Cochaperone binding to LYR motifs confers specificity of iron-sulfur cluster delivery. Cell Metab. 19, 445– 457
-
(2014)
Cell Metab.
, vol.19
, pp. 445-457
-
-
Maio, N.1
Singh, A.2
Uhrigshardt, H.3
Saxena, N.4
Tong, W.H.5
Rouault, T.A.6
-
54
-
-
33744956665
-
Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly
-
Li, K., Tong, W. H., Hughes, R. M., and Rouault, T. A. (2006) Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly. J. Biol. Chem. 281, 12344–12351
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12344-12351
-
-
Li, K.1
Tong, W.H.2
Hughes, R.M.3
Rouault, T.A.4
-
55
-
-
84876073834
-
The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans
-
Marelja, Z., Mullick Chowdhury, M., Dosche, C., Hille, C., Baumann, O., Löhmannsröben, H. G., and Leimkühler, S. (2013) The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans. PLoS ONE 8, e60869
-
(2013)
Plos ONE
, vol.8
, pp. e60869
-
-
Marelja, Z.1
Mullick Chowdhury, M.2
Dosche, C.3
Hille, C.4
Baumann, O.5
Löhmannsröben, H.G.6
Leimkühler, S.7
-
56
-
-
1842582668
-
Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs
-
Nakai, Y., Umeda, N., Suzuki, T., Nakai, M., Hayashi, H., Watanabe, K., and Kagamiyama, H. (2004) Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J. Biol. Chem. 279, 12363–12368
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12363-12368
-
-
Nakai, Y.1
Umeda, N.2
Suzuki, T.3
Nakai, M.4
Hayashi, H.5
Watanabe, K.6
Kagamiyama, H.7
-
57
-
-
4344595102
-
Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae
-
Mühlenhoff, U., Balk, J., Richhardt, N., Kaiser, J. T., Sipos, K., Kispal, G., and Lill, R. (2004) Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae. J. Biol. Chem. 279, 36906–36915
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36906-36915
-
-
Mühlenhoff, U.1
Balk, J.2
Richhardt, N.3
Kaiser, J.T.4
Sipos, K.5
Kispal, G.6
Lill, R.7
-
58
-
-
0035907297
-
J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins
-
Kim, R., Saxena, S., Gordon, D. M., Pain, D., and Dancis, A. (2001) J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins. J. Biol. Chem. 276, 17524–17532
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 17524-17532
-
-
Kim, R.1
Saxena, S.2
Gordon, D.M.3
Pain, D.4
Dancis, A.5
-
59
-
-
84876468556
-
Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis
-
Uhrigshardt, H., Rouault, T. A., and Missirlis, F. (2013) Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis. J. Biol. Inorg. Chem. 18, 441–449
-
(2013)
J. Biol. Inorg. Chem.
, vol.18
, pp. 441-449
-
-
Uhrigshardt, H.1
Rouault, T.A.2
Missirlis, F.3
-
60
-
-
84957933845
-
Disease-causing SDHAF1 mutations impair transfer of Fe-S clusters to SDHB
-
Maio, N., Ghezzi, D., Verrigni, D., Rizza, T., Bertini, E., Martinelli, D., Zeviani, M., Singh, A., Carrozzo, R., and Rouault, T. A. (2016) Disease-causing SDHAF1 mutations impair transfer of Fe-S clusters to SDHB. Cell Metab. 23, 292–302
-
(2016)
Cell Metab
, vol.23
, pp. 292-302
-
-
Maio, N.1
Ghezzi, D.2
Verrigni, D.3
Rizza, T.4
Bertini, E.5
Martinelli, D.6
Zeviani, M.7
Singh, A.8
Carrozzo, R.9
Rouault, T.A.10
-
61
-
-
85016975674
-
A single adaptable cochaperone-scaffold complex delivers nascent iron-sulfur clusters to mammalian respiratory chain complexes I–III
-
Maio, N., Kim, K. S., Singh, A., and Rouault, T. A. (2017) A single adaptable cochaperone-scaffold complex delivers nascent iron-sulfur clusters to mammalian respiratory chain complexes I–III. Cell Metab. 25, 945–953
-
(2017)
Cell Metab
, vol.25
, pp. 945-953
-
-
Maio, N.1
Kim, K.S.2
Singh, A.3
Rouault, T.A.4
-
62
-
-
84908380518
-
The role of mitochondria in cytosolic-nuclear iron-sulfur protein biogenesis and in cellular iron regulation
-
Lill, R., Srinivasan, V., and Mühlenhoff, U. (2014) The role of mitochondria in cytosolic-nuclear iron-sulfur protein biogenesis and in cellular iron regulation. Curr. Opin. Microbiol. 22, 111–119
-
(2014)
Curr. Opin. Microbiol.
, vol.22
, pp. 111-119
-
-
Lill, R.1
Srinivasan, V.2
Mühlenhoff, U.3
-
63
-
-
84906545328
-
A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly
-
Schaedler, T. A., Thornton, J. D., Kruse, I., Schwarzländer, M., Meyer, A. J., van Veen, H. W., and Balk, J. (2014) A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly. J. Biol. Chem. 289, 23264–23274
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 23264-23274
-
-
Schaedler, T.A.1
Thornton, J.D.2
Kruse, I.3
Schwarzländer, M.4
Meyer, A.J.5
Van Veen, H.W.6
Balk, J.7
-
64
-
-
84880376563
-
150 years of Friedreich ataxia: From its discovery to therapy
-
Schulz, J. B., and Pandolfo, M. (2013) 150 years of Friedreich ataxia: from its discovery to therapy. J. Neurochem. 126, 1–3
-
(2013)
J. Neurochem.
, vol.126
, pp. 1-3
-
-
Schulz, J.B.1
Pandolfo, M.2
-
65
-
-
84905674436
-
Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry
-
Bridwell-Rabb, J., Fox, N. G., Tsai, C. L., Winn, A. M., and Barondeau, D. P. (2014) Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry. Biochemistry 53, 4904 – 4913
-
(2014)
Biochemistry
, vol.53
, pp. 4904-4913
-
-
Bridwell-Rabb, J.1
Fox, N.G.2
Tsai, C.L.3
Winn, A.M.4
Barondeau, D.P.5
-
66
-
-
34247124148
-
Molecular chaperones HscA/Ssq1 and HscB/Jac1 and their roles in iron-sulfur protein maturation
-
Vickery, L. E., and Cupp-Vickery, J. R. (2007) Molecular chaperones HscA/Ssq1 and HscB/Jac1 and their roles in iron-sulfur protein maturation. Crit. Rev. Biochem. Mol. Biol. 42, 95–111
-
(2007)
Crit. Rev. Biochem. Mol. Biol.
, vol.42
, pp. 95-111
-
-
Vickery, L.E.1
Cupp-Vickery, J.R.2
-
67
-
-
84878638881
-
[2Fe-2S]-ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin
-
Kim, J. H., Frederick, R. O., Reinen, N. M., Troupis, A. T., and Markley, J. L. (2013) [2Fe-2S]-ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin. J. Am. Chem. Soc. 135, 8117–8120
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 8117-8120
-
-
Kim, J.H.1
Frederick, R.O.2
Reinen, N.M.3
Troupis, A.T.4
Markley, J.L.5
-
68
-
-
84983593773
-
The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron-sulfur cluster biogenesis
-
Van Vranken, J. G., Jeong, M. Y., Wei, P., Chen, Y. C., Gygi, S. P., Winge, D. R., and Rutter, J. (2016) The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron-sulfur cluster biogenesis. Elife 5, e17828
-
(2016)
Elife
, vol.5
, pp. e17828
-
-
Van Vranken, J.G.1
Jeong, M.Y.2
Wei, P.3
Chen, Y.C.4
Gygi, S.P.5
Winge, D.R.6
Rutter, J.7
-
69
-
-
23944500052
-
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis
-
Wingert, R. A., Galloway, J. L., Barut, B., Foott, H., Fraenkel, P., Axe, J. L., Weber, G. J., Dooley, K., Davidson, A. J., Schmidt, B., Paw, B. H., Shaw, G. C., Kingsley, P., Palis, J., Schubert, H., et al. (2005) Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature 436, 1035–1039
-
(2005)
Nature
, vol.436
, pp. 1035-1039
-
-
Wingert, R.A.1
Galloway, J.L.2
Barut, B.3
Foott, H.4
Fraenkel, P.5
Axe, J.L.6
Weber, G.J.7
Dooley, K.8
Davidson, A.J.9
Schmidt, B.10
Paw, B.H.11
Shaw, G.C.12
Kingsley, P.13
Palis, J.14
Schubert, H.15
-
70
-
-
77951843593
-
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
-
Ye, H., Jeong, S. Y., Ghosh, M. C., Kovtunovych, G., Silvestri, L., Ortillo, D., Uchida, N., Tisdale, J., Camaschella, C., and Rouault, T. A. (2010) Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. J. Clin. Invest. 120, 1749–1761
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 1749-1761
-
-
Ye, H.1
Jeong, S.Y.2
Ghosh, M.C.3
Kovtunovych, G.4
Silvestri, L.5
Ortillo, D.6
Uchida, N.7
Tisdale, J.8
Camaschella, C.9
Rouault, T.A.10
-
71
-
-
84873672762
-
Monothiol glutaredoxins and A-type proteins: Partners in Fe-S cluster trafficking
-
Mapolelo, D. T., Zhang, B., Randeniya, S., Albetel, A. N., Li, H., Couturier, J., Outten, C. E., Rouhier, N., and Johnson, M. K. (2013) Monothiol glutaredoxins and A-type proteins: partners in Fe-S cluster trafficking. Dalton Trans. 42, 3107–3115
-
(2013)
Dalton Trans.
, vol.42
, pp. 3107-3115
-
-
Mapolelo, D.T.1
Zhang, B.2
Randeniya, S.3
Albetel, A.N.4
Li, H.5
Couturier, J.6
Outten, C.E.7
Rouhier, N.8
Johnson, M.K.9
-
72
-
-
80053898097
-
Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes
-
Cameron, J. M., Janer, A., Levandovskiy, V., Mackay, N., Rouault, T. A., Tong, W. H., Ogilvie, I., Shoubridge, E. A., and Robinson, B. H. (2011) Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes. Am. J. Hum. Genet. 89, 486–495
-
(2011)
Am. J. Hum. Genet.
, vol.89
, pp. 486-495
-
-
Cameron, J.M.1
Janer, A.2
Levandovskiy, V.3
Mackay, N.4
Rouault, T.A.5
Tong, W.H.6
Ogilvie, I.7
Shoubridge, E.A.8
Robinson, B.H.9
-
73
-
-
80955133245
-
A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins
-
Navarro-Sastre, A., Tort, F., Stehling, O., Uzarska, M. A., Arranz, J. A., Del Toro, M., Labayru, M. T., Landa, J., Font, A., Garcia-Villoria, J., Merinero, B., Ugarte, M., Gutierrez-Solana, L. G., Campistol, J., Garcia-Cazorla, A., et al. (2011) A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins. Am. J. Hum. Genet. 89, 656 – 667
-
(2011)
Am. J. Hum. Genet.
, vol.89
, pp. 656-667
-
-
Navarro-Sastre, A.1
Tort, F.2
Stehling, O.3
Uzarska, M.A.4
Arranz, J.A.5
Del Toro, M.6
Labayru, M.T.7
Landa, J.8
Font, A.9
Garcia-Villoria, J.10
Merinero, B.11
Ugarte, M.12
Gutierrez-Solana, L.G.13
Campistol, J.14
Garcia-Cazorla, A.15
-
74
-
-
84986200954
-
Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients
-
Melber, A., Na, U., Vashisht, A., Weiler, B. D., Lill, R., Wohlschlegel, J. A., and Winge, D. R. (2016) Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients. Elife 5, e15991
-
(2016)
Elife
, vol.5
, pp. e15991
-
-
Melber, A.1
Na, U.2
Vashisht, A.3
Weiler, B.D.4
Lill, R.5
Wohlschlegel, J.A.6
Winge, D.R.7
-
75
-
-
84991492609
-
Mammalian Fe-S proteins: Definition of a consensus motif recognized by the co-chaperone HSC20
-
Maio, N., and Rouault, T. A. (2016) Mammalian Fe-S proteins: definition of a consensus motif recognized by the co-chaperone HSC20. Metallomics 8, 1032–1046
-
(2016)
Metallomics
, vol.8
, pp. 1032-1046
-
-
Maio, N.1
Rouault, T.A.2
-
76
-
-
84925285506
-
Mammalian iron-sulphur proteins: Novel insights into biogenesis and function
-
Rouault, T. A. (2015) Mammalian iron-sulphur proteins: novel insights into biogenesis and function. Nat. Rev. Mol. Cell Biol. 16, 45–55
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 45-55
-
-
Rouault, T.A.1
-
77
-
-
84956575209
-
SDHB-deficient cancers: The role of mutations that impair iron-sulfur cluster delivery
-
Saxena, N., Maio, N., Crooks, D. R., Ricketts, C. J., Yang, Y., Wei, M. H., Fan, T. W., Lane, A. N., Sourbier, C., Singh, A., Killian, J. K., Meltzer, P. S., Vocke, C. D., Rouault, T. A., and Linehan, W. M. (2016) SDHB-deficient cancers: the role of mutations that impair iron-sulfur cluster delivery. J. Natl. Cancer Inst. 108
-
(2016)
J. Natl. Cancer Inst.
, vol.108
-
-
Saxena, N.1
Maio, N.2
Crooks, D.R.3
Ricketts, C.J.4
Yang, Y.5
Wei, M.H.6
Fan, T.W.7
Lane, A.N.8
Sourbier, C.9
Singh, A.10
Killian, J.K.11
Meltzer, P.S.12
Vocke, C.D.13
Rouault, T.A.14
Linehan, W.M.15
-
78
-
-
80053601731
-
The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria
-
Atkinson, A., Smith, P., Fox, J. L., Cui, T. Z., Khalimonchuk, O., and Winge, D. R. (2011) The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria. Mol. Cell. Biol. 31, 3988–3996
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3988-3996
-
-
Atkinson, A.1
Smith, P.2
Fox, J.L.3
Cui, T.Z.4
Khalimonchuk, O.5
Winge, D.R.6
-
79
-
-
77951880407
-
Co-evolution-driven switch of J-protein specificity towards an Hsp70 partner
-
Pukszta, S., Schilke, B., Dutkiewicz, R., Kominek, J., Moczulska, K., Stepien, B., Reitenga, K. G., Bujnicki, J. M., Williams, B., Craig, E. A., and Marszalek, J. (2010) Co-evolution-driven switch of J-protein specificity towards an Hsp70 partner. EMBO Rep. 11, 360 –365
-
(2010)
EMBO Rep.
, vol.11
, pp. 360-365
-
-
Pukszta, S.1
Schilke, B.2
Dutkiewicz, R.3
Kominek, J.4
Moczulska, K.5
Stepien, B.6
Reitenga, K.G.7
Bujnicki, J.M.8
Williams, B.9
Craig, E.A.10
Marszalek, J.11
-
80
-
-
57649158626
-
Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain
-
Bitto, E., Bingman, C. A., Bittova, L., Kondrashov, D. A., Bannen, R. M., Fox, B. G., Markley, J. L., and Phillips, G. N., Jr. (2008) Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain. J. Biol. Chem. 283, 30184 –30192
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 30184-30192
-
-
Bitto, E.1
Bingman, C.A.2
Bittova, L.3
Kondrashov, D.A.4
Bannen, R.M.5
Fox, B.G.6
Markley, J.L.7
Phillips, G.N.8
-
81
-
-
84655167921
-
Biogenesis of the cytochrome bc1 complex and role of assembly factors
-
Smith, P. M., Fox, J. L., and Winge, D. R. (2012) Biogenesis of the cytochrome bc1 complex and role of assembly factors. Biochim. Biophys. Acta 1817, 276–286
-
(2012)
Biochim. Biophys. Acta
, vol.1817
, pp. 276-286
-
-
Smith, P.M.1
Fox, J.L.2
Winge, D.R.3
-
82
-
-
84990066624
-
Accessory subunits are integral for assembly and function of human mitochondrial complex I
-
Stroud, D. A., Surgenor, E. E., Formosa, L. E., Reljic, B., Frazier, A. E., Dibley, M. G., Osellame, L. D., Stait, T., Beilharz, T. H., Thorburn, D. R., Salim, A., and Ryan, M. T. (2016) Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature 538, 123–126
-
(2016)
Nature
, vol.538
, pp. 123-126
-
-
Stroud, D.A.1
Surgenor, E.E.2
Formosa, L.E.3
Reljic, B.4
Frazier, A.E.5
Dibley, M.G.6
Osellame, L.D.7
Stait, T.8
Beilharz, T.H.9
Thorburn, D.R.10
Salim, A.11
Ryan, M.T.12
-
83
-
-
84928818532
-
Protein-mediated assembly of succinate dehydrogenase and its cofactors
-
Van Vranken, J. G., Na, U., Winge, D. R., and Rutter, J. (2015) Protein-mediated assembly of succinate dehydrogenase and its cofactors. Crit. Rev. Biochem. Mol. Biol. 50, 168 –180
-
(2015)
Crit. Rev. Biochem. Mol. Biol.
, vol.50
, pp. 168-180
-
-
Van Vranken, J.G.1
Na, U.2
Winge, D.R.3
Rutter, J.4
-
84
-
-
84992080197
-
The assembly pathway of mitochondrial respiratory chain complex I
-
Guerrero-Castillo, S., Baertling, F., Kownatzki, D., Wessels, H. J., Arnold, S., Brandt, U., and Nijtmans, L. (2017) The assembly pathway of mitochondrial respiratory chain complex I. Cell Metab. 25, 128 –139
-
(2017)
Cell Metab.
, vol.25
, pp. 128-139
-
-
Guerrero-Castillo, S.1
Baertling, F.2
Kownatzki, D.3
Wessels, H.J.4
Arnold, S.5
Brandt, U.6
Nijtmans, L.7
-
85
-
-
47049126468
-
The iron-sulphur protein Ind1 is required for effective complex I assembly
-
Bych, K., Kerscher, S., Netz, D. J., Pierik, A. J., Zwicker, K., Huynen, M. A., Lill, R., Brandt, U., and Balk, J. (2008) The iron-sulphur protein Ind1 is required for effective complex I assembly. EMBO J. 27, 1736–1746
-
(2008)
EMBO J.
, vol.27
, pp. 1736-1746
-
-
Bych, K.1
Kerscher, S.2
Netz, D.J.3
Pierik, A.J.4
Zwicker, K.5
Huynen, M.A.6
Lill, R.7
Brandt, U.8
Balk, J.9
-
86
-
-
71949116823
-
Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I
-
Sheftel, A. D., Stehling, O., Pierik, A. J., Netz, D. J., Kerscher, S., Elsässer, H. P., Wittig, I., Balk, J., Brandt, U., and Lill, R. (2009) Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Mol. Cell. Biol. 29, 6059–6073
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 6059-6073
-
-
Sheftel, A.D.1
Stehling, O.2
Pierik, A.J.3
Netz, D.J.4
Kerscher, S.5
Elsässer, H.P.6
Wittig, I.7
Balk, J.8
Brandt, U.9
Lill, R.10
-
87
-
-
84888424052
-
The evolutionarily conserved iron-sulfur protein INDH is required for complex I assembly and mitochondrial translation in Arabidopsis [corrected]
-
Wydro, M. M., Sharma, P., Foster, J. M., Bych, K., Meyer, E. H., and Balk, J. (2013) The evolutionarily conserved iron-sulfur protein INDH is required for complex I assembly and mitochondrial translation in Arabidopsis [corrected]. Plant Cell 25, 4014–4027
-
(2013)
Plant Cell
, vol.25
, pp. 4014-4027
-
-
Wydro, M.M.1
Sharma, P.2
Foster, J.M.3
Bych, K.4
Meyer, E.H.5
Balk, J.6
-
88
-
-
77957606541
-
High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency
-
Calvo, S. E., Tucker, E. J., Compton, A. G., Kirby, D. M., Crawford, G., Burtt, N. P., Rivas, M., Guiducci, C., Bruno, D. L., Goldberger, O. A., Redman, M. C., Wiltshire, E., Wilson, C. J., Altshuler, D., Gabriel, S. B., et al. (2010) High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nat. Genet. 42, 851–858
-
(2010)
Nat. Genet.
, vol.42
, pp. 851-858
-
-
Calvo, S.E.1
Tucker, E.J.2
Compton, A.G.3
Kirby, D.M.4
Crawford, G.5
Burtt, N.P.6
Rivas, M.7
Guiducci, C.8
Bruno, D.L.9
Goldberger, O.A.10
Redman, M.C.11
Wiltshire, E.12
Wilson, C.J.13
Altshuler, D.14
Gabriel, S.B.15
-
89
-
-
84863769552
-
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism
-
Gari, K., León Ortiz, A. M., Borel, V., Flynn, H., Skehel, J. M., and Boulton, S. J. (2012) MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science 337, 243–245
-
(2012)
Science
, vol.337
, pp. 243-245
-
-
Gari, K.1
León Ortiz, A.M.2
Borel, V.3
Flynn, H.4
Skehel, J.M.5
Boulton, S.J.6
-
90
-
-
84863747679
-
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity
-
Stehling, O., Vashisht, A. A., Mascarenhas, J., Jonsson, Z. O., Sharma, T., Netz, D. J., Pierik, A. J., Wohlschlegel, J. A., and Lill, R. (2012) MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science 337, 195–199
-
(2012)
Science
, vol.337
, pp. 195-199
-
-
Stehling, O.1
Vashisht, A.A.2
Mascarenhas, J.3
Jonsson, Z.O.4
Sharma, T.5
Netz, D.J.6
Pierik, A.J.7
Wohlschlegel, J.A.8
Lill, R.9
-
91
-
-
85045835706
-
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins
-
Stehling, O., Mascarenhas, J., Vashisht, A. A., Sheftel, A. D., Niggemeyer, B., Rösser, R., Pierik, A. J., Wohlschlegel, J. A., and Lill, R. (2013) Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab. 18, 187–198
-
(2013)
Cell Metab
, vol.18
, pp. 187-198
-
-
Stehling, O.1
Mascarenhas, J.2
Vashisht, A.A.3
Sheftel, A.D.4
Niggemeyer, B.5
Rösser, R.6
Pierik, A.J.7
Wohlschlegel, J.A.8
Lill, R.9
-
92
-
-
85011898483
-
The CIA targeting complex is highly regulated and provides two distinct binding sites for client iron-sulfur proteins
-
Odermatt, D. C., and Gari, K. (2017) The CIA targeting complex is highly regulated and provides two distinct binding sites for client iron-sulfur proteins. Cell Rep. 18, 1434–1443
-
(2017)
Cell Rep
, vol.18
, pp. 1434-1443
-
-
Odermatt, D.C.1
Gari, K.2
-
93
-
-
85013995740
-
The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport
-
O’Brien, E., Holt, M. E., Thompson, M. K., Salay, L. E., Ehlinger, A. C., Chazin, W. J., and Barton, J. K. (2017) The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport. Science 355, eaag1789
-
(2017)
Science
, vol.355
, pp. eaag1789
-
-
O’Brien, E.1
Holt, M.E.2
Thompson, M.K.3
Salay, L.E.4
Ehlinger, A.C.5
Chazin, W.J.6
Barton, J.K.7
-
94
-
-
0026499118
-
Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III
-
Kuo, C. F., McRee, D. E., Fisher, C. L., O’Handley, S. F., Cunningham, R. P., and Tainer, J. A. (1992) Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III. Science 258, 434 – 440
-
(1992)
Science
, vol.258
, pp. 434-440
-
-
Kuo, C.F.1
McRee, D.E.2
Fisher, C.L.3
O’Handley, S.F.4
Cunningham, R.P.5
Tainer, J.A.6
-
95
-
-
34347209921
-
Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1
-
Barthelme, D., Scheele, U., Dinkelaker, S., Janoschka, A., Macmillan, F., Albers, S. V., Driessen, A. J., Stagni, M. S., Bill, E., Meyer-Klaucke, W., Schünemann, V., and Tampé, R. (2007) Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1. J. Biol. Chem. 282, 14598–14607
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14598-14607
-
-
Barthelme, D.1
Scheele, U.2
Dinkelaker, S.3
Janoschka, A.4
Macmillan, F.5
Albers, S.V.6
Driessen, A.J.7
Stagni, M.S.8
Bill, E.9
Meyer-Klaucke, W.10
Schünemann, V.11
Tampé, R.12
-
96
-
-
85016998140
-
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation
-
Heuer, A., Gerovac, M., Schmidt, C., Trowitzsch, S., Preis, A., Kötter, P., Berninghausen, O., Becker, T., Beckmann, R., and Tampé, R. (2017) Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation. Nat. Struct. Mol. Biol. 24, 453– 460
-
(2017)
Nat. Struct. Mol. Biol.
, vol.24
, pp. 453-460
-
-
Heuer, A.1
Gerovac, M.2
Schmidt, C.3
Trowitzsch, S.4
Preis, A.5
Kötter, P.6
Berninghausen, O.7
Becker, T.8
Beckmann, R.9
Tampé, R.10
-
97
-
-
84935016527
-
Iron-sulfur proteins hiding in plain sight
-
Rouault, T. A. (2015) Iron-sulfur proteins hiding in plain sight. Nat. Chem. Biol. 11, 442–445
-
(2015)
Nat. Chem. Biol.
, vol.11
, pp. 442-445
-
-
Rouault, T.A.1
-
99
-
-
85021724973
-
Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions
-
Cory, S. A., Van Vranken, J. G., Brignole, E. J., Patra, S., Winge, D. R., Drennan, C. L., Rutter, J., and Barondeau, D. P. (2017) Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. Proc. Natl. Acad. Sci. U.S.A. 114, E5325–E5334
-
(2017)
Proc. Natl. Acad. Sci. U.S.A.
, vol.114
, pp. E5325-E5334
-
-
Cory, S.A.1
Van Vranken, J.G.2
Brignole, E.J.3
Patra, S.4
Winge, D.R.5
Drennan, C.L.6
Rutter, J.7
Barondeau, D.P.8
|