Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA

Science

Volumn 314, Issue 5807, 2006, Pages 1903-1908

  Walden, William E ^a   Selezneva, Anna I ^a   Dupuy, Jérôme ^b,c,d   Volbeda, Anne ^b,c,d   Fontecilla Camps, Juan C ^b,c,d   Theil, Elizabeth C ^e,f   Volz, Karl ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c CEA GRENOBLE   (France)

^d CNRS   (France)

^e CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; DEGRADATION; IRON; RNA; SULFUR;

IRON REGULATORY PROTEIN; IRON-SULFUR CLUSTER; OPEN PROTEIN CONFORMATION;

PROTEINS;

ACONITATE HYDRATASE; FERRITIN; IRON REGULATORY PROTEIN 1; MESSENGER RNA; RNA;

CHEMICAL BINDING; COMPLEXATION; CRYSTAL STRUCTURE; IRON; PROTEIN; RNA;

ARTICLE; BINDING KINETICS; COMPLEX FORMATION; CRYSTAL STRUCTURE; GENE REPRESSION; IRON RESPONSIVE ELEMENT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA DEGRADATION; RNA TRANSLATION;

APOFERRITINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; IRON; IRON REGULATORY PROTEIN 1; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; REGULATORY SEQUENCES, RIBONUCLEIC ACID; RESPONSE ELEMENTS; RNA, MESSENGER; SULFUR; UNTRANSLATED REGIONS;

EID: 33845865301     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1133116     Document Type: Article

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39. Supported by grants from the National Institutes of Health (DK47281 to W.E.W., DK20251 to E.C.T., and GM47522 to K.V.). We thank E. A. Craig, R. S. Eisenstein, H. Noller, T. A. Steitz, and D. S. Ucker for critical review of the manuscript. Data were collected at the Southeast regional collaborative access team (SER-CAT) 22-ID at the Advanced Photon Source, Argonne National laboratory. Use of the Advanced Photon Source was supported by the Department of Energy under contract No. W-31-109-Eng-38. Structure factors and coordinates have been deposited in the Protein Data Bank (accession code 2IPY).