Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

Journal of Clinical Investigation

Volumn 120, Issue 5, 2010, Pages 1749-1761

  Ye, Hong ^a   Jeong, Suh Young ^a   Ghosh, Manik C ^a   Kovtunovych, Gennadiy ^a   Silvestri, Laura ^b   Ortillo, Danilo ^c   Uchida, Naoya ^d   Tisdale, John ^d   Camaschella, Clara ^b   Rouault, Tracey A ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c EMORY UNIVERSITY   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; ACONITATE HYDRATASE; FERROCHELATASE; FERROPORTIN; GLUTAREDOXIN; GLUTAREDOXIN 5; HEME; IRON REGULATORY FACTOR; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; IRON SULFUR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME ACTIVATION; ERYTHROBLAST; ERYTHROID CELL; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IRON DEPLETION; IRON OVERLOAD; MITOCHONDRION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; SIDEROBLASTIC ANEMIA; VIRAL GENE DELIVERY SYSTEM;

5-AMINOLEVULINATE SYNTHETASE; AMINO ACID SEQUENCE; ANEMIA, SIDEROBLASTIC; CYTOSOL; ERYTHROBLASTS; GLUTAREDOXINS; HELA CELLS; HEME; HUMANS; IRON; IRON-SULFUR PROTEINS; MOLECULAR SEQUENCE DATA; PHENOTYPE; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 77951843593     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI40372     Document Type: Article

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