Bile acid-mediated sphingosine-1-phosphate receptor 2 signaling promotes neuroinflammation during hepatic encephalopathy in mice

Frontiers in Cellular Neuroscience

Volumn 11, Issue , 2017, Pages

  McMillin, Matthew ^a,b   Frampton, Gabriel ^a,b   Grant, Stephanie ^a,b   Khan, Shamyal ^c   Diocares, Juan ^c   Petrescu, Anca ^a,b   Wyatt, Amy ^a,b   Kain, Jessica ^a,b   Jefferson, Brandi ^a,b   DeMorrow, Sharon ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

^c SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

Acute liver failure; CCL2; Cytokines; Microglia; Neurons; S1PR2

Indexed keywords

4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; ALPHA MURICHOLIC ACID; BILE ACID; COLESTYRAMINE; CXCL2 CHEMOKINE; DEOXYCHOLIC ACID; DIMETHYL SULFOXIDE; INTERLEUKIN 6; MESSENGER RNA; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROMURICHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AZOXYMETHANE INDUCED HEPATIC ENCEPHALOPATHY; BIOASSAY; BRAIN TISSUE; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEPATIC ENCEPHALOPATHY; IMMUNOFLUORESCENCE TEST; INTRACELLULAR SIGNALING; MALE; METABOLISM; METABOLITE; MOUSE; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TEMPORAL CORTEX;

EID: 85026458844     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2017.00191     Document Type: Article

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