Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition

European Journal of Pharmacology

Volumn 776, Issue , 2016, Pages 19-25

  Liu, Weihua ^a   Liu, Bin ^a   Liu, Shaojun ^a   Zhang, Jingzhi ^a   Lin, Shuangfeng ^b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Akt; Diabetes; Endothelial cells; PI3K; Sphingosine 1 phosphate; Sphingosine 1 phosphate receptor 2

Indexed keywords

4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MYELOPEROXIDASE; NITRATE REDUCTASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; SPHINGOSINE 1 PHOSPHATE RECEPTOR 4; SPHINGOSINE 1 PHOSPHATE RECEPTOR 5; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; WORTMANNIN; LYSOPHOSPHOLIPID; S1PR2 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ARTERY ENDOTHELIUM; ARTICLE; BIOLOGICAL ACTIVITY; CARDIOVASCULAR DISEASE; CELL ADHESION; COLORIMETRY; CONTROLLED STUDY; CORONARY ARTERY; DIABETES MELLITUS; DIABETIC ANGIOPATHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY;

CELL ADHESION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; LYSOPHOSPHOLIPIDS; NEUTROPHILS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84959374016     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.02.056     Document Type: Article

References (30)

1. A.M. Abu El-Asrar, M.I. Nawaz, G. Mohammad, M.M. Siddiquei, K. Alam, A. Mousa, and G. Opdenakker Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy Lipids Health Dis. 13 2014 187
2. W.T. Cade Diabetes-related microvascular and macrovascular diseases in the physical therapy setting Phys. Ther. 88 2008 1322 1335
3. S. Chen, J. Yang, H. Xiang, W. Chen, H. Zhong, G. Yang, T. Fang, H. Deng, H. Yuan, A.F. Chen, and H. Lu Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction Int. J. Mol. Med. 35 2015 1103 1108
4. H. Cui, Y. Okamoto, K. Yoshioka, W. Du, N. Takuwa, W. Zhang, M. Asano, T. Shibamoto, and Y. Takuwa Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice J. Allergy Clin. Immunol. 132 2013 1205 1214 e9
5. J. Dou, H. Li, X. Ma, M. Zhang, Q. Fang, M. Nie, Y. Bao, and W. Jia Osteocalcin attenuates High fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway Cardiovasc. Diabetol. 13 2014 74
6. D.M. Dudzinski, and T. Michel Life history of eNOS: partners and pathways Cardiovasc. Res. 75 2007 247 260
7. O. Erdogdu, D. Nathanson, A. Sjoholm, T. Nystrom, and Q. Zhang Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor Mol. Cell. Endocrinol. 325 2010 26 35
8. A. Hirose, T. Tanikawa, H. Mori, Y. Okada, and Y. Tanaka Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway FEBS Lett. 584 2010 61 66
9. F.M. Ho, W.W. Lin, B.C. Chen, C.M. Chao, C.R. Yang, L.Y. Lin, C.C. Lai, S.H. Liu, and C.S. Liau High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway Cell. Signal. 18 2006 391 399
10. K. Huang, W. Liu, T. Lan, X. Xie, J. Peng, J. Huang, S. Wang, X. Shen, P. Liu, and H. Huang Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models PLoS One 7 2012 e43874
11. Y. Kitamura, M. Koide, Y. Akakabe, K. Matsuo, Y. Shimoda, Y. Soma, T. Ogata, T. Ueyama, S. Matoba, H. Yamada, and K. Ikeda Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy J. Biol. Chem. 289 2014 2788 2800
12. T. Lan, H. Bi, W. Liu, X. Xie, S. Xu, and H. Huang Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography-tandem mass spectrometry J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 879 2011 520 526
13. T. Lan, W. Liu, X. Xie, S. Xu, K. Huang, J. Peng, X. Shen, P. Liu, L. Wang, P. Xia, and H. Huang Sphingosine kinase-1 pathway mediates High glucose-induced fibronectin expression in glomerular mesangial cells Mol. Endocrinol. 25 2011 2094 2105
14. T. Lan, X. Shen, P. Liu, W. Liu, S. Xu, X. Xie, Q. Jiang, W. Li, and H. Huang Berberine ameliorates renal injury in diabetic C57BL/6 mice: involvement of suppression of SphK-S1P signaling pathway Arch. Biochem. Biophys. 502 2010 112 120
15. Q. Li, B. Chen, C. Zeng, A. Fan, Y. Yuan, X. Guo, X. Huang, and Q. Huang Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells Exp. Physiol. 100 2015 95 107
16. W. Liu, T. Lan, X. Xie, K. Huang, J. Peng, J. Huang, X. Shen, P. Liu, and H. Huang S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition Exp. Cell. Res. 318 2012 936 943
17. J.B. Meigs Epidemiology of type 2 diabetes and cardiovascular disease: translation from population to prevention: the Kelly west award lecture 2009 Diabetes Care 33 2010 1865 1871
18. W.O. Sampaio, R.A. Souza dos Santos, R. Faria-Silva, L.T. da Mata Machado, E.L. Schiffrin, and R.M. Touyz Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways Hypertension 49 2007 185 192
19. T. Sanchez, A. Skoura, M.T. Wu, B. Casserly, E.O. Harrington, and T. Hla Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN Arterioscler. Thromb. Vasc. Biol. 27 2007 1312 1318
20. C.M. Sena, A.M. Pereira, and R. Seica Endothelial dysfunction-a major mediator of diabetic vascular disease Biochim. Biophys. Acta 1832 2013 2216 2231
21. S. Sharma, M. Singh, and P.L. Sharma Mechanism of hyperhomocysteinemia-induced vascular endothelium dysfunction-possible dysregulation of phosphatidylinositol-3-kinase and its downstream phosphoinositide dependent kinase and protein kinase B Eur. J. Pharmacol. 721 2013 365 372
22. I. Shiojima, and K. Walsh Role of Akt signaling in vascular homeostasis and angiogenesis Circ. Res. 90 2002 1243 1250
23. P. Song, Y. Wu, J. Xu, Z. Xie, Y. Dong, M. Zhang, and M.H. Zou Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in An LKB1-dependent manner Circulation 116 2007 1585 1595
24. A.V. Thuy, C.M. Reimann, N.Y. Hemdan, and M.H. Graler Sphingosine 1-phosphate in blood: function, metabolism, and fate Cell. Physiol. Biochem. 34 2014 158 171
25. X. Tong, H. Peng, D. Liu, L. Ji, C. Niu, J. Ren, B. Pan, J. Hu, L. Zheng, and Y. Huang High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate Cardiovasc. Diabetol. 12 2013 27
26. S. Varma, B.K. Lal, R. Zheng, J.W. Breslin, S. Saito, P.J. Pappas, R.W. Hobson 2nd, and W.N. Duran Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction Am. J. Physiol. Heart Circ. Physiol. 289 2005 H1744 H1751
27. D. Versari, E. Daghini, A. Virdis, L. Ghiadoni, and S. Taddei Endothelial dysfunction as a target for prevention of cardiovascular disease Diabetes Care 32 Suppl. 2 2009 S314 S321
28. G. Zeng, F.H. Nystrom, L.V. Ravichandran, L.N. Cong, M. Kirby, H. Mostowski, and M.J. Quon Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells Circulation 101 2000 1539 1545
29. G. Zhang, L. Yang, G.S. Kim, K. Ryan, S. Lu, R.K. O'Donnell, K. Spokes, N. Shapiro, W.C. Aird, M.J. Kluk, K. Yano, and T. Sanchez Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation Blood 122 2013 443 455
30. K.X. Zhu, S.P. Nie, C. Li, D. Gong, and M.Y. Xie Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway Carbohydr. Polym. 103 2014 520 527