메뉴 건너뛰기




Volumn 5, Issue 1, 2015, Pages 15-28

Cardiac energy metabolic alterations in pressure overload–induced left and right heart failure (2013 Grover conference series)

Author keywords

Efficiency; Energy starvation; Fatty acid oxidation; Glucose oxidation; Glycolysis; Heart failure; Malonyl CoA decarboxylase; Pulmonary hypertension

Indexed keywords


EID: 85026337179     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.1086/679608     Document Type: Review
Times cited : (46)

References (129)
  • 2
    • 39749191084 scopus 로고    scopus 로고
    • Heart disease and stroke statistics—2008 update: A report from the American Heart Association statistics committee and stroke statistics subcommittee
    • Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, et al. Heart disease and stroke statistics—2008 update: a report from the American Heart Association statistics committee and stroke statistics subcommittee. Circulation 2008;117:e25-146.
    • (2008) Circulation , vol.117 , pp. 25-146
    • Rosamond, W.1    Flegal, K.2    Furie, K.3    Go, A.4    Greenlund, K.5    Haase, N.6    Hailpern, S.M.7
  • 3
    • 0035846616 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: Executive summary a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure): Developed in collaboration with the International Society for Heart and Lung Transplantation; endorsed by the Heart Failure Society of America
    • Hunt SA, Baker DW, Chin MH, Cinquegrani MP, Feldman AM, Francis GS, Ganiats TG, et al. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the International Society for Heart and Lung Transplantation; endorsed by the Heart Failure Society of America. Circulation 2001;104:2996-3007
    • (2001) Circulation , vol.104 , pp. 2996-3007
    • Hunt, S.A.1    Baker, D.W.2    Chin, M.H.3    Cinquegrani, M.P.4    Feldman, A.M.5    Francis, G.S.6    Ganiats, T.G.7
  • 5
    • 84877254940 scopus 로고    scopus 로고
    • Left ventricular dysfunction with pulmonary hypertension: Part 1: Epidemiology, pathophysiology, and definitions
    • Georgiopoulou VV, Kalogeropoulos AP, Borlaug BA, Gheorghiade M, Butler J. Left ventricular dysfunction with pulmonary hypertension: part 1: epidemiology, pathophysiology, and definitions. Circ Heart Fail 2013;6:344-354.
    • (2013) Circ Heart Fail , vol.6 , pp. 344-354
    • Georgiopoulou, V.V.1    Kalogeropoulos, A.P.2    Borlaug, B.A.3    Gheorghiade, M.4    Butler, J.5
  • 6
    • 0032126258 scopus 로고    scopus 로고
    • Animal models of human cardiovascular disease, heart failure and hypertrophy
    • Hasenfuss G. Animal models of human cardiovascular disease, heart failure and hypertrophy. Cardiovasc Res 1998;39:60-76.
    • (1998) Cardiovasc Res , vol.39 , pp. 60-76
    • Hasenfuss, G.1
  • 7
    • 84869419314 scopus 로고    scopus 로고
    • The economics of heart failure
    • Kazi DS, Mark DB. The economics of heart failure. Heart Fail Clin 2013;9:93-106.
    • (2013) Heart Fail Clin , vol.9 , pp. 93-106
    • Kazi, D.S.1    Mark, D.B.2
  • 8
    • 78149415338 scopus 로고    scopus 로고
    • Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure
    • Piao L, Marsboom G, Archer SL. Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure. J Mol Med (Berl) 2010;88:1011-1020.
    • (2010) J Mol Med (Berl) , vol.88 , pp. 1011-1020
    • Piao, L.1    Marsboom, G.2    Archer, S.L.3
  • 9
    • 84877275760 scopus 로고    scopus 로고
    • In the clinic: Pulmonary hypertension
    • Mandel J, Poch D. In the clinic: pulmonary hypertension. Ann Intern Med 2013;158:ITC51-ITC516
    • (2013) Ann Intern Med , vol.158
    • Mandel, J.1    Poch, D.2
  • 11
    • 84857882542 scopus 로고    scopus 로고
    • Dietary fat and heart failure: Moving from lipotoxicity to lipoprotection
    • Stanley WC, Dabkowski ER, Ribeiro RF Jr., O’Connell KA. Dietary fat and heart failure: moving from lipotoxicity to lipoprotection. Circ Res 2012;110:764-776
    • (2012) Circ Res , vol.110 , pp. 764-776
    • Stanley, W.C.1    Dabkowski, E.R.2    Ribeiro, R.F.3    O’Connell, K.A.4
  • 12
    • 0037046188 scopus 로고    scopus 로고
    • Pulmonary hypertension and risk of death in cardiomyopathy: Patients with myocarditis are at higher risk
    • Cappola TP, Felker GM, Kao WH, Hare JM, Baughman KL, Kasper EK. Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk. Circulation 2002;105:1663-1668
    • (2002) Circulation , vol.105 , pp. 1663-1668
    • Cappola, T.P.1    Felker, G.M.2    Kao, W.H.3    Hare, J.M.4    Baughman, K.L.5    Kasper, E.K.6
  • 14
    • 77649091020 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics—2010 update: A report from the American Heart Association
    • Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, et al. Executive summary: heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation 2010; 121:948-954
    • (2010) Circulation , vol.121 , pp. 948-954
    • Lloyd-Jones, D.1    Adams, R.J.2    Brown, T.M.3    Carnethon, M.4    Dai, S.5    De Simone, G.6    Ferguson, T.B.7
  • 15
    • 35848955451 scopus 로고    scopus 로고
    • Return to the fetal gene program protects the stressed heart: A strong hypothesis
    • Rajabi M, Kassiotis C, Razeghi P, Taegtmeyer H. Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev 2007;12:331-343
    • (2007) Heart Fail Rev , vol.12 , pp. 331-343
    • Rajabi, M.1    Kassiotis, C.2    Razeghi, P.3    Taegtmeyer, H.4
  • 16
    • 0037626650 scopus 로고    scopus 로고
    • Carvedilol Hibernating Reversible Ischaemia Trial: Marker of Success Investigators. Myocardial viability as a determinant of the ejection fraction response to carvedilol in patients with heart failure (Christmas trial): Randomised controlled trial
    • Cleland JG, Pennell DJ, Ray SG, Coats AJ, Macfarlane PW, Murray GD, Mule JD, Vered Z, Lahiri A; Carvedilol Hibernating Reversible Ischaemia Trial: Marker of Success Investigators. Myocardial viability as a determinant of the ejection fraction response to carvedilol in patients with heart failure (Christmas trial): randomised controlled trial. Lancet 2003;362:14-21
    • (2003) Lancet , vol.362 , pp. 14-21
    • Cleland, J.G.1    Pennell, D.J.2    Ray, S.G.3    Coats, A.J.4    Macfarlane, P.W.5    Murray, G.D.6    Mule, J.D.7    Vered, Z.8    Lahiri, A.9
  • 19
  • 20
    • 33750560212 scopus 로고    scopus 로고
    • Right ventricular function and failure: Report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure
    • Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, et al. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation 2006;114:1883-1891
    • (2006) Circulation , vol.114 , pp. 1883-1891
    • Voelkel, N.F.1    Quaife, R.A.2    Leinwand, L.A.3    Barst, R.J.4    McGoon, M.D.5    Meldrum, D.R.6    Dupuis, J.7
  • 21
    • 3342967512 scopus 로고    scopus 로고
    • Is the failing heart energy starved? On using chemical energy to support cardiac function
    • Ingwall JS, Weiss RG. Is the failing heart energy starved? on using chemical energy to support cardiac function. Circ Res 2004;95:135-145
    • (2004) Circ Res , vol.95 , pp. 135-145
    • Ingwall, J.S.1    Weiss, R.G.2
  • 22
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005;85:1093-1129
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 24
    • 0023657289 scopus 로고
    • Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes
    • Murthy MS, Pande SV. Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes. Biochem J 1987;248: 727-733
    • (1987) Biochem J , vol.248 , pp. 727-733
    • Murthy, M.S.1    Pande, S.V.2
  • 25
    • 0343505447 scopus 로고
    • Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane
    • Murthy MS, Pande SV. Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane. Proc Natl Acad Sci U S A 1987;84:378-382
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 378-382
    • Murthy, M.S.1    Pande, S.V.2
  • 26
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system: From concept to molecular analysis
    • McGarry JD, Brown NF. The mitochondrial carnitine palmitoyltransferase system: from concept to molecular analysis. Eur J Biochem 1997;244:1-14
    • (1997) Eur J Biochem , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 27
    • 79957937929 scopus 로고    scopus 로고
    • Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart
    • Jaswal JS, Keung W, Wang W, Ussher JR, Lopaschuk GD. Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart. Biochim Biophys Acta 2011;1813:1333-1350
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1333-1350
    • Jaswal, J.S.1    Keung, W.2    Wang, W.3    Ussher, J.R.4    Lopaschuk, G.D.5
  • 28
    • 46749113468 scopus 로고    scopus 로고
    • The malonyl CoA axis as a potential target for treating ischaemic heart disease
    • Ussher JR, Lopaschuk GD. The malonyl CoA axis as a potential target for treating ischaemic heart disease. Cardiovasc Res 2008;79:259-268
    • (2008) Cardiovasc Res , vol.79 , pp. 259-268
    • Ussher, J.R.1    Lopaschuk, G.D.2
  • 29
    • 0021716358 scopus 로고
    • Malonyl CoA inhibition of carnitine palmityltransferase in rat heart mitochondria
    • Paulson DJ, Ward KM, Shug AL. Malonyl CoA inhibition of carnitine palmityltransferase in rat heart mitochondria. FEBS Lett 1984;176:381-384
    • (1984) FEBS Lett , vol.176 , pp. 381-384
    • Paulson, D.J.1    Ward, K.M.2    Shug, A.L.3
  • 30
    • 0024795323 scopus 로고
    • Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase
    • Hardie DG. Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase. Prog Lipid Res 1989;28:117-146
    • (1989) Prog Lipid Res , vol.28 , pp. 117-146
    • Hardie, D.G.1
  • 31
    • 0026604926 scopus 로고
    • Regulation of fatty acid and cholesterol metabolism by the amp-activated protein kinase
    • Hardie DG. Regulation of fatty acid and cholesterol metabolism by the amp-activated protein kinase. Biochim Biophys Acta 1992;1123:231-238
    • (1992) Biochim Biophys Acta , vol.1123 , pp. 231-238
    • Hardie, D.G.1
  • 32
    • 0028580486 scopus 로고
    • An emerging role for protein kinases: The response to nutritional and environmental stress
    • Hardie DG. An emerging role for protein kinases: the response to nutritional and environmental stress. Cell Signal 1994;6:813-821
    • (1994) Cell Signal , vol.6 , pp. 813-821
    • Hardie, D.G.1
  • 33
    • 0035206455 scopus 로고    scopus 로고
    • The endosomal compartment is an insulinsensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes
    • Becker C, Sevilla L, Tomas E, Palacin M, Zorzano A, Fischer Y. The endosomal compartment is an insulinsensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes. Endocrinology 2001;142: 5267-5276
    • (2001) Endocrinology , vol.142 , pp. 5267-5276
    • Becker, C.1    Sevilla, L.2    Tomas, E.3    Palacin, M.4    Zorzano, A.5    Fischer, Y.6
  • 35
    • 84863552418 scopus 로고    scopus 로고
    • A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans
    • Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 2012;337:96-100
    • (2012) Science , vol.337 , pp. 96-100
    • Bricker, D.K.1    Taylor, E.B.2    Schell, J.C.3    Orsak, T.4    Boutron, A.5    Chen, Y.C.6    Cox, J.E.7
  • 36
    • 0346158376 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
    • Holness MJ, Sugden MC. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 2003;31:1143-1151
    • (2003) Biochem Soc Trans , vol.31 , pp. 1143-1151
    • Holness, M.J.1    Sugden, M.C.2
  • 37
    • 0037404976 scopus 로고    scopus 로고
    • Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
    • Sugden MC, Holness MJ. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab 2003;284:E855-E862
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , pp. E855-E862
    • Sugden, M.C.1    Holness, M.J.2
  • 38
    • 0036952122 scopus 로고    scopus 로고
    • Adrenergic pathways and left ventricular remodeling
    • Dorn GW 2nd. Adrenergic pathways and left ventricular remodeling. J Card Fail 2002;8:S370-S373
    • (2002) J Card Fail , vol.8 , pp. S370-S373
    • Dorn, G.W.1
  • 39
    • 0021723264 scopus 로고
    • Alpha- and beta-adrenergic receptor subtypes properties, distribution and regulation
    • Molinoff PB. Alpha- and beta-adrenergic receptor subtypes properties, distribution and regulation. Drugs 1984; 28(suppl 2):1-15
    • (1984) Drugs , vol.28 , pp. 1-15
    • Molinoff, P.B.1
  • 40
    • 0023035106 scopus 로고
    • Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: Progressive receptor down-regulation and subsensitivity to agonist response
    • Fowler MB, Laser JA, Hopkins GL, Minobe W, Bristow MR. Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response. Circulation 1986;74:1290-1302
    • (1986) Circulation , vol.74 , pp. 1290-1302
    • Fowler, M.B.1    Laser, J.A.2    Hopkins, G.L.3    Minobe, W.4    Bristow, M.R.5
  • 41
    • 0008591355 scopus 로고
    • Metabolic effects of epinephrine in the isolated, perfused rat heart. I. Dissociation of the glycogenolytic from the metabolic stimulatory effect
    • Williamson JR. Metabolic effects of epinephrine in the isolated, perfused rat heart. I. Dissociation of the glycogenolytic from the metabolic stimulatory effect. J Biologic Chem 1964;239:2721-2729
    • (1964) J Biologic Chem , vol.239 , pp. 2721-2729
    • Williamson, J.R.1
  • 42
    • 78651192421 scopus 로고
    • Effect of norepinephrine on myocardial free fatty acid uptake and oxidation
    • Gold M, Attar HJ, Spitzer JJ, Scott JC. Effect of norepinephrine on myocardial free fatty acid uptake and oxidation. Proc Soc Exp Bio Med 1965;118:876-879
    • (1965) Proc Soc Exp Bio Med , vol.118 , pp. 876-879
    • Gold, M.1    Attar, H.J.2    Spitzer, J.J.3    Scott, J.C.4
  • 44
  • 45
    • 0031827967 scopus 로고    scopus 로고
    • Betareceptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure
    • Panchal AR, Stanley WC, Kerner J, Sabbah HN. Betareceptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure. J Card Fail 1998;4: 121-126
    • (1998) J Card Fail , vol.4 , pp. 121-126
    • Panchal, A.R.1    Stanley, W.C.2    Kerner, J.3    Sabbah, H.N.4
  • 46
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart—an engine out of fuel
    • Neubauer S. The failing heart—an engine out of fuel. N Engl J Med 2007;356:1140-1151
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 47
    • 0037010011 scopus 로고    scopus 로고
    • Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy
    • Beer M, Seyfarth T, Sandstede J, Landschutz W, Lipke C, Kostler H, von Kienlin M, Harre K, Hahn D, Neubauer S. Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol 2002;40: 1267-1274
    • (2002) J am Coll Cardiol , vol.40 , pp. 1267-1274
    • Beer, M.1    Seyfarth, T.2    Sandstede, J.3    Landschutz, W.4    Lipke, C.5    Kostler, H.6    Von Kienlin, M.7    Harre, K.8    Hahn, D.9    Neubauer, S.10
  • 48
    • 0026000171 scopus 로고
    • Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy
    • Conway MA, Allis J, Ouwerkerk R, Niioka T, Rajagopalan B, Radda GK. Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy. Lancet 1991;338:973-976
    • (1991) Lancet , vol.338 , pp. 973-976
    • Conway, M.A.1    Allis, J.2    Ouwerkerk, R.3    Niioka, T.4    Rajagopalan, B.5    Radda, G.K.6
  • 49
    • 0029897792 scopus 로고    scopus 로고
    • Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters
    • Tian R, Nascimben L, Kaddurah-Daouk R, Ingwall JS. Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters. J Mol Cell Cardiol 1996;28:755-765
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 755-765
    • Tian, R.1    Nascimben, L.2    Kaddurah-Daouk, R.3    Ingwall, J.S.4
  • 50
    • 84865863479 scopus 로고    scopus 로고
    • Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy
    • Kolwicz SC Jr., Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R. Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res 2012;111:728-738
    • (2012) Circ Res , vol.111 , pp. 728-738
    • Kolwicz, S.C.1    Olson, D.P.2    Marney, L.C.3    Garcia-Menendez, L.4    Synovec, R.E.5    Tian, R.6
  • 51
    • 80052970004 scopus 로고    scopus 로고
    • PGC-1 β deficiency accelerates the transition to heart failure in pressure overload hypertrophy
    • Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, et al. PGC-1 β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res 2011;109:783-793
    • (2011) Circ Res , vol.109 , pp. 783-793
    • Riehle, C.1    Wende, A.R.2    Zaha, V.G.3    Pires, K.M.4    Wayment, B.5    Olsen, C.6    Bugger, H.7
  • 52
  • 54
    • 0028131205 scopus 로고
    • Preischemic glycogen reduction or glycolytic inhibition improves postischemic recovery of hypertrophied rat hearts
    • Allard MF, Emanuel PG, Russell JA, Bishop SP, Digerness SB, Anderson PG. Preischemic glycogen reduction or glycolytic inhibition improves postischemic recovery of hypertrophied rat hearts. Am J Physiol 1994;267: H66-H74
    • (1994) Am J Physiol , vol.267 , pp. H66-H74
    • Allard, M.F.1    Emanuel, P.G.2    Russell, J.A.3    Bishop, S.P.4    Digerness, S.B.5    Erson, P.G.6
  • 55
    • 0027930794 scopus 로고
    • Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts
    • Allard MF, Schonekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am J Physiol 1994;267:H742-H750
    • (1994) Am J Physiol , vol.267 , pp. H742-H750
    • Allard, M.F.1    Schonekess, B.O.2    Henning, S.L.3    English, D.R.4    Lopaschuk, G.D.5
  • 57
    • 0342710352 scopus 로고    scopus 로고
    • Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart
    • Schonekess BO, Allard MF, Henning SL, Wambolt RB, Lopaschuk GD. Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart. Circ Res 1997;81:540-549
    • (1997) Circ Res , vol.81 , pp. 540-549
    • Schonekess, B.O.1    Allard, M.F.2    Henning, S.L.3    Wambolt, R.B.4    Lopaschuk, G.D.5
  • 58
    • 10044249835 scopus 로고    scopus 로고
    • Energy substrate metabolism in cardiac hypertrophy
    • Allard MF. Energy substrate metabolism in cardiac hypertrophy. Curr Hypertens Rep 2004;6:430-435
    • (2004) Curr Hypertens Rep , vol.6 , pp. 430-435
    • Allard, M.F.1
  • 59
    • 84872515091 scopus 로고    scopus 로고
    • Hyperpolarized 13C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart
    • Schroeder MA, Lau AZ, Chen AP, Gu Y, Nagendran J, Barry J, Hu X, et al. Hyperpolarized 13C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur J Heart Fail 2013;15:130-140
    • (2013) Eur J Heart Fail , vol.15 , pp. 130-140
    • Schroeder, M.A.1    Lau, A.Z.2    Chen, A.P.3    Gu, Y.4    Nagendran, J.5    Barry, J.6    Hu, X.7
  • 60
    • 77952364346 scopus 로고    scopus 로고
    • Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload
    • Doenst T, Pytel G, Schrepper A, Amorim P, Farber G, Shingu Y, Mohr FW, Schwarzer M. Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload. Cardiovasc Res 2010;86:461-470
    • (2010) Cardiovasc Res , vol.86 , pp. 461-470
    • Doenst, T.1    Pytel, G.2    Schrepper, A.3    Amorim, P.4    Farber, G.5    Shingu, Y.6    Mohr, F.W.7    Schwarzer, M.8
  • 61
    • 84887490616 scopus 로고    scopus 로고
    • Cardiac insulin resistance and decreased mitochondrial energy production precede the development of systolic heart failure following pressure overload hypertrophy
    • Zhang L, Jaswal JS, Ussher JR, Sankaralingam S, Wagg C, Zaugg M, Lopaschuk GD. Cardiac insulin resistance and decreased mitochondrial energy production precede the development of systolic heart failure following pressure overload hypertrophy. Circ Heart Fail 2013;6(5):1039-1048
    • (2013) Circ Heart Fail , vol.6 , Issue.5 , pp. 1039-1048
    • Zhang, L.1    Jaswal, J.S.2    Ussher, J.R.3    Sankaralingam, S.4    Wagg, C.5    Zaugg, M.6    Lopaschuk, G.D.7
  • 62
    • 70749131551 scopus 로고    scopus 로고
    • Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in nondiabetic chronic heart failure patients independently of body composition
    • Doehner W, Gathercole D, Cicoira M, Krack A, Coats AJ, Camici PG, Anker SD. Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in nondiabetic chronic heart failure patients independently of body composition. Int J Cardiol 2010;138:19-24
    • (2010) Int J Cardiol , vol.138 , pp. 19-24
    • Doehner, W.1    Gathercole, D.2    Cicoira, M.3    Krack, A.4    Coats, A.J.5    Camici, P.G.6    Anker, S.D.7
  • 66
    • 84878441741 scopus 로고    scopus 로고
    • ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: A critical role of PDK4
    • Mori J, Alrob OA, Wagg CS, Harris RA, Lopaschuk GD, Oudit GY. ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4. Am J Physiol Heart Circ Physiol 2013;304:H1103-H1113
    • (2013) Am J Physiol Heart Circ Physiol , vol.304 , pp. H1103-H1113
    • Mori, J.1    Alrob, O.A.2    Wagg, C.S.3    Harris, R.A.4    Lopaschuk, G.D.5    Oudit, G.Y.6
  • 67
    • 84864609802 scopus 로고    scopus 로고
    • Agonistinduced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: A metabolic contribution to heart failure with normal ejection fraction
    • Mori J, Basu R, McLean BA, Das SK, Zhang L, Patel VB, Wagg CS, Kassiri Z, Lopaschuk GD, Oudit GY. Agonistinduced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction. Circ Heart Fail 2012;5:493-503
    • (2012) Circ Heart Fail , vol.5 , pp. 493-503
    • Mori, J.1    Basu, R.2    McLean, B.A.3    Das, S.K.4    Zhang, L.5    Patel, V.B.6    Wagg, C.S.7    Kassiri, Z.8    Lopaschuk, G.D.9    Oudit, G.Y.10
  • 68
    • 0025913812 scopus 로고
    • Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
    • The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991;325:293-302
    • (1991) N Engl J Med , vol.325 , pp. 293-302
    • The, S.1
  • 69
    • 0041909380 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensinconverting- enzyme inhibitors: The CHARM-alternative trial
    • CHARM Investigators and Committees
    • Granger CB, McMurray JJ, Yusuf S, Held P, Michelson EL, Olofsson B, Ostergren J, Pfeffer MA, Swedberg K, CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensinconverting- enzyme inhibitors: the CHARM-alternative trial. Lancet 2003;362:772-776
    • (2003) Lancet , vol.362 , pp. 772-776
    • Granger, C.B.1    McMurray, J.J.2    Yusuf, S.3    Held, P.4    Michelson, E.L.5    Olofsson, B.6    Ostergren, J.7    Pfeffer, M.A.8    Swedberg, K.9
  • 70
    • 39149097521 scopus 로고    scopus 로고
    • The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover
    • O’Donnell JM, Fields AD, Sorokina N, Lewandowski ED. The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover. J Mol Cell Cardiol 2008;44:315-322
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 315-322
    • O’Donnell, J.M.1    Fields, A.D.2    Sorokina, N.3    Lewandowski, E.D.4
  • 72
    • 0029800177 scopus 로고    scopus 로고
    • Fatty acid oxidation enzyme gene expression is downregulated in the failing heart
    • Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996;94:2837-2842
    • (1996) Circulation , vol.94 , pp. 2837-2842
    • Sack, M.N.1    Rader, T.A.2    Park, S.3    Bastin, J.4    McCune, S.A.5    Kelly, D.P.6
  • 74
    • 84867073668 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity
    • He L, Kim T, Long Q, Liu J, Wang P, Zhou Y, Ding Y, Prasain J, Wood PA, Yang Q. Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. Circulation 2012;126: 1705-1716
    • (2012) Circulation , vol.126 , pp. 1705-1716
    • He, L.1    Kim, T.2    Long, Q.3    Liu, J.4    Wang, P.5    Zhou, Y.6    Ding, Y.7    Prasain, J.8    Wood, P.A.9    Yang, Q.10
  • 75
    • 84874638486 scopus 로고    scopus 로고
    • Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium
    • Friehs I, Cowan DB, Choi YH, Black KM, Barnett R, Bhasin MK, Daly C, et al. Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium. Am J Physiol Heart Circ Physiol 2013;304:H697-H708
    • (2013) Am J Physiol Heart Circ Physiol , vol.304 , pp. H697-H708
    • Friehs, I.1    Cowan, D.B.2    Choi, Y.H.3    Black, K.M.4    Barnett, R.5    Bhasin, M.K.6    Daly, C.7
  • 76
    • 13444268937 scopus 로고    scopus 로고
    • Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    • Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res 2005;96:225-233
    • (2005) Circ Res , vol.96 , pp. 225-233
    • Chiu, H.C.1    Kovacs, A.2    Blanton, R.M.3    Han, X.4    Courtois, M.5    Weinheimer, C.J.6    Yamada, K.A.7
  • 77
    • 0037316670 scopus 로고    scopus 로고
    • Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
    • Yagyu H, Chen G, Yokoyama M, Hirata K, Augustus A, Kako Y, Seo T, et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest 2003;111:419-426
    • (2003) J Clin Invest , vol.111 , pp. 419-426
    • Yagyu, H.1    Chen, G.2    Yokoyama, M.3    Hirata, K.4    Augustus, A.5    Kako, Y.6    Seo, T.7
  • 79
    • 0036143320 scopus 로고    scopus 로고
    • The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    • Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, et al. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest 2002;109:121-130
    • (2002) J Clin Invest , vol.109 , pp. 121-130
    • Finck, B.N.1    Lehman, J.J.2    Leone, T.C.3    Welch, M.J.4    Bennett, M.J.5    Kovacs, A.6    Han, X.7
  • 80
    • 34247231646 scopus 로고    scopus 로고
    • Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts
    • Sorokina N, O’Donnell JM, McKinney RD, Pound KM, Woldegiorgis G, LaNoue KF, Ballal K, Taegtmeyer H, Buttrick PM, Lewandowski ED. Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts. Circulation 2007;115:2033-2041
    • (2007) Circulation , vol.115 , pp. 2033-2041
    • Sorokina, N.1    O’Donnell, J.M.2    McKinney, R.D.3    Pound, K.M.4    Woldegiorgis, G.5    Lanoue, K.F.6    Ballal, K.7    Taegtmeyer, H.8    Buttrick, P.M.9    Lewandowski, E.D.10
  • 81
    • 84866610058 scopus 로고    scopus 로고
    • Metabolism of the right ventricle and the response to hypertrophy and failure
    • Altin SE, Schulze PC. Metabolism of the right ventricle and the response to hypertrophy and failure. Prog Cardiovasc Dis 2012;55:229-233
    • (2012) Prog Cardiovasc Dis , vol.55 , pp. 229-233
    • Altin, S.E.1    Schulze, P.C.2
  • 82
    • 70349481328 scopus 로고    scopus 로고
    • Possible involvement of mitochondrial energy-producing ability in the development of right ventricular failure in monocrotaline-induced pulmonary hypertensive rats
    • Daicho T, Yagi T, Abe Y, Ohara M, Marunouchi T, Takeo S, Tanonaka K. Possible involvement of mitochondrial energy-producing ability in the development of right ventricular failure in monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Sci 2009;111:33-43
    • (2009) J Pharmacol Sci , vol.111 , pp. 33-43
    • Daicho, T.1    Yagi, T.2    Abe, Y.3    Ohara, M.4    Marunouchi, T.5    Takeo, S.6    Tanonaka, K.7
  • 84
    • 0000063565 scopus 로고
    • Study of heart mitochondria and glycolytic metabolism in experimentally induced cardiac failure
    • Schwartz A, Lee KS. Study of heart mitochondria and glycolytic metabolism in experimentally induced cardiac failure. Circ Res 1962;10:321-332
    • (1962) Circ Res , vol.10 , pp. 321-332
    • Schwartz, A.1    Lee, K.S.2
  • 85
    • 0029048043 scopus 로고
    • Effects of chronic right ventricular pressure overload on myocardial glucose and free fatty acid metabolism in the conscious rat
    • Takeyama D, Kagaya Y, Yamane Y, Shiba N, Chida M, Takahashi T, Ido T, Ishide N, Takishima T. Effects of chronic right ventricular pressure overload on myocardial glucose and free fatty acid metabolism in the conscious rat. Cardiovasc Res 1995;29:763-767
    • (1995) Cardiovasc Res , vol.29 , pp. 763-767
    • Takeyama, D.1    Kagaya, Y.2    Yamane, Y.3    Shiba, N.4    Chida, M.5    Takahashi, T.6    Ido, T.7    Ishide, N.8    Takishima, T.9
  • 86
    • 0025072082 scopus 로고
    • Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts
    • Anderson PG, Allard MF, Thomas GD, Bishop SP, Digerness SB. Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts. Circ Res 1990;67: 948-959
    • (1990) Circ Res , vol.67 , pp. 948-959
    • Anderson, P.G.1    Allard, M.F.2    Thomas, G.D.3    Bishop, S.P.4    Digerness, S.B.5
  • 87
    • 20344370701 scopus 로고    scopus 로고
    • Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol
    • Oikawa M, Kagaya Y, Otani H, Sakuma M, Demachi J, Suzuki J, Takahashi T, et al. Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. J Am Coll Cardiol 2005;45:1849-1855
    • (2005) J am Coll Cardiol , vol.45 , pp. 1849-1855
    • Oikawa, M.1    Kagaya, Y.2    Otani, H.3    Sakuma, M.4    Demachi, J.5    Suzuki, J.6    Takahashi, T.7
  • 88
    • 75749133554 scopus 로고    scopus 로고
    • The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricu- lar hypertrophy: Resuscitating the hibernating right ventricle
    • Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricu- lar hypertrophy: resuscitating the hibernating right ventricle. J Mol Med (Berl) 2010;88:47-60
    • (2010) J Mol Med (Berl) , vol.88 , pp. 47-60
    • Piao, L.1    Fang, Y.H.2    Cadete, V.J.3    Wietholt, C.4    Urboniene, D.5    Toth, P.T.6    Marsboom, G.7
  • 89
    • 78349286375 scopus 로고    scopus 로고
    • Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension
    • Rich S, Pogoriler J, Husain AN, Toth PT, Gomberg- Maitland M, Archer SL. Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension. Chest 2010;138:1234-1239
    • (2010) Chest , vol.138 , pp. 1234-1239
    • Rich, S.1    Pogoriler, J.2    Husain, A.N.3    Toth, P.T.4    Gomberg-Maitland, M.5    Archer, S.L.6
  • 90
    • 84891671691 scopus 로고    scopus 로고
    • Foxo1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: Therapeutic benefits of dichloroacetate
    • Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, et al. Foxo1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl) 2013;91:333-346
    • (2013) J Mol Med (Berl) , vol.91 , pp. 333-346
    • Piao, L.1    Sidhu, V.K.2    Fang, Y.H.3    Ryan, J.J.4    Parikh, K.S.5    Hong, Z.6    Toth, P.T.7
  • 91
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-789
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 92
    • 0023845559 scopus 로고
    • Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocininduced diabetes
    • Reaven GM, Chang H, Hoffman BB. Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocininduced diabetes. Diabetes 1988;37:28-32
    • (1988) Diabetes , vol.37 , pp. 28-32
    • Reaven, G.M.1    Chang, H.2    Hoffman, B.B.3
  • 93
    • 0030778603 scopus 로고    scopus 로고
    • Etomoxir improves left ventricular performance of pressure-overloaded rat heart
    • Turcani M, Rupp H. Etomoxir improves left ventricular performance of pressure-overloaded rat heart. Circulation 1997;96:3681-3686
    • (1997) Circulation , vol.96 , pp. 3681-3686
    • Turcani, M.1    Rupp, H.2
  • 94
    • 0033910352 scopus 로고    scopus 로고
    • First clinical trial with etomoxir in patients with chronic congestive heart failure
    • Schmidt-Schweda S, Holubarsch C. First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin Sci (Lond) 2000;99:27-35
    • (2000) Clin Sci (Lond) , vol.99 , pp. 27-35
    • Schmidt-Schweda, S.1    Holubarsch, C.2
  • 95
    • 78049509377 scopus 로고    scopus 로고
    • Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy
    • Abozguia K, Elliott P, McKenna W, Phan TT, Nallur- Shivu G, Ahmed I, Maher AR, et al. Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy. Circulation 2010;122:1562-1569
    • (2010) Circulation , vol.122 , pp. 1562-1569
    • Abozguia, K.1    Elliott, P.2    McKenna, W.3    Phan, T.T.4    Nallur-Shivu, G.5    Ahmed, I.6    Maher, A.R.7
  • 96
    • 33644875657 scopus 로고    scopus 로고
    • Metabolic modulation with perhexiline in chronic heart failure: A randomized, controlled trial of short-term use of a novel treatment
    • Lee L, Campbell R, Scheuermann-Freestone M, Taylor R, Gunaruwan P, Williams L, Ashrafian H, et al. Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment. Circulation 2005;112:3280-3288
    • (2005) Circulation , vol.112 , pp. 3280-3288
    • Lee, L.1    Campbell, R.2    Scheuermann-Freestone, M.3    Taylor, R.4    Gunaruwan, P.5    Williams, L.6    Ashrafian, H.7
  • 97
    • 33644867891 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship of small-molecule malonyl coenzyme a decarboxylase inhibitors
    • Cheng JF, Chen M, Wallace D, Tith S, Haramura M, Liu B, Mak CC, et al. Synthesis and structure-activity relationship of small-molecule malonyl coenzyme a decarboxylase inhibitors. J Med Chem 2006;49:1517-1525
    • (2006) J Med Chem , vol.49 , pp. 1517-1525
    • Cheng, J.F.1    Chen, M.2    Wallace, D.3    Tith, S.4    Haramura, M.5    Liu, B.6    Mak, C.C.7
  • 98
    • 33745822073 scopus 로고    scopus 로고
    • Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents
    • Cheng JF, Huang Y, Penuliar R, Nishimoto M, Liu L, Arrhenius T, Yang G, et al. Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J Med Chem 2006;49:4055-4058
    • (2006) J Med Chem , vol.49 , pp. 4055-4058
    • Cheng, J.F.1    Huang, Y.2    Penuliar, R.3    Nishimoto, M.4    Liu, L.5    Arrhenius, T.6    Yang, G.7
  • 99
    • 4444226906 scopus 로고    scopus 로고
    • Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation
    • Dyck JR, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, Wallace D, et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ Res 2004;94:e78-e84
    • (2004) Circ Res , vol.94 , pp. e78-e84
    • Dyck, J.R.1    Cheng, J.F.2    Stanley, W.C.3    Barr, R.4    Chandler, M.P.5    Brown, S.6    Wallace, D.7
  • 101
    • 19544379673 scopus 로고    scopus 로고
    • Selective versus nonselective beta-adrenergic receptor blockade in chronic heart failure: Differential effects on myocardial energy substrate utilization
    • Al-Hesayen A, Azevedo ER, Floras JS, Hollingshead S, Lopaschuk GD, Parker JD. Selective versus nonselective beta-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization. Eur J Heart Fail 2005;7:618-623
    • (2005) Eur J Heart Fail , vol.7 , pp. 618-623
    • Al-Hesayen, A.1    Azevedo, E.R.2    Floras, J.S.3    Hollingshead, S.4    Lopaschuk, G.D.5    Parker, J.D.6
  • 102
    • 0036932990 scopus 로고    scopus 로고
    • Effect of selective and nonselective beta-blockers on resting energy production rate and total body substrate utilization in chronic heart failure
    • Podbregar M, Voga G. Effect of selective and nonselective beta-blockers on resting energy production rate and total body substrate utilization in chronic heart failure. J Card Fail 2002;8:369-378
    • (2002) J Card Fail , vol.8 , pp. 369-378
    • Podbregar, M.1    Voga, G.2
  • 103
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme a thiolase
    • Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme a thiolase. Circ Res 2000;86:580-588
    • (2000) Circ Res , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 104
    • 0141499890 scopus 로고    scopus 로고
    • Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase
    • Lopaschuk GD, Barr R, Thomas PD, Dyck JR. Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase. Circ Res 2003;93:e33-e37
    • (2003) Circ Res , vol.93 , pp. e33-e37
    • Lopaschuk, G.D.1    Barr, R.2    Thomas, P.D.3    Dyck, J.R.4
  • 106
    • 84874529386 scopus 로고    scopus 로고
    • Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: Results from an international multicentre retrospective cohort study
    • Fragasso G, Rosano G, Baek SH, Sisakian H, Di Napoli P, Alberti L, Calori G, et al. Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: results from an international multicentre retrospective cohort study. Int J Cardiol 2013; 163:320-325
    • (2013) Int J Cardiol , vol.163 , pp. 320-325
    • Fragasso, G.1    Rosano, G.2    Baek, S.H.3    Sisakian, H.4    Di Napoli, P.5    Alberti, L.6    Calori, G.7
  • 109
    • 53449101397 scopus 로고    scopus 로고
    • Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
    • Tuunanen H, Engblom E, Naum A, Nagren K, Scheinin M, Hesse B, Juhani Airaksinen KE, et al. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation 2008; 118:1250-1258
    • (2008) Circulation , vol.118 , pp. 1250-1258
    • Tuunanen, H.1    Engblom, E.2    Naum, A.3    Nagren, K.4    Scheinin, M.5    Hesse, B.6    Juhani Airaksinen, K.E.7
  • 110
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 1996; 93:135-142
    • (1996) Circulation , vol.93 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 112
    • 79960430593 scopus 로고    scopus 로고
    • Ranolazine for the treatment of heart failure with preserved ejection fraction: Background, aims, and design of the RALI-DHF study
    • Jacobshagen C, Belardinelli L, Hasenfuss G, Maier LS. Ranolazine for the treatment of heart failure with preserved ejection fraction: background, aims, and design of the RALI-DHF study. Clin Cardiol 2011;34:426-432
    • (2011) Clin Cardiol , vol.34 , pp. 426-432
    • Jacobshagen, C.1    Belardinelli, L.2    Hasenfuss, G.3    Maier, L.S.4
  • 113
    • 0029998606 scopus 로고    scopus 로고
    • Cardiac efficiency is improved after ischemia by altering both the source and fate of protons
    • Liu B, Clanachan AS, Schulz R, Lopaschuk GD. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res 1996;79:940-948
    • (1996) Circ Res , vol.79 , pp. 940-948
    • Liu, B.1    Clanachan, A.S.2    Schulz, R.3    Lopaschuk, G.D.4
  • 114
    • 0037138548 scopus 로고    scopus 로고
    • High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation
    • Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol 2002;39: 718-725
    • (2002) J am Coll Cardiol , vol.39 , pp. 718-725
    • Liu, Q.1    Docherty, J.C.2    Rendell, J.C.3    Clanachan, A.S.4    Lopaschuk, G.D.5
  • 116
    • 0031773645 scopus 로고    scopus 로고
    • Effects of dichloroacetate in patients with congestive heart failure
    • Lewis JF, DaCosta M, Wargowich T, Stacpoole P. Effects of dichloroacetate in patients with congestive heart failure. Clin Cardiol 1998;21:888-892
    • (1998) Clin Cardiol , vol.21 , pp. 888-892
    • Lewis, J.F.1    Dacosta, M.2    Wargowich, T.3    Stacpoole, P.4
  • 123
    • 0027966932 scopus 로고
    • Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men
    • Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994;17:961-969
    • (1994) Diabetes Care , vol.17 , pp. 961-969
    • Chan, J.M.1    Rimm, E.B.2    Colditz, G.A.3    Stampfer, M.J.4    Willett, W.C.5
  • 124
    • 0025745107 scopus 로고
    • Epidemiologic findings on body mass and blood pressure in adults
    • Stamler J. Epidemiologic findings on body mass and blood pressure in adults. Ann Epidemiol 1991;1:347-362
    • (1991) Ann Epidemiol , vol.1 , pp. 347-362
    • Stamler, J.1
  • 128
    • 0038463835 scopus 로고    scopus 로고
    • NFATc3 and NFATc4 are required for cardiac development and mitochondrial function
    • Bushdid PB, Osinska H, Waclaw RR, Molkentin JD, Yutzey KE. NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res 2003; 92:1305-1313
    • (2003) Circ Res , vol.92 , pp. 1305-1313
    • Bushdid, P.B.1    Osinska, H.2    Waclaw, R.R.3    Molkentin, J.D.4    Yutzey, K.E.5
  • 129
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 2005;5:472-484.
    • (2005) Nat Rev Immunol , vol.5 , pp. 472-484
    • Macian, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.