Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy

Circulation: Heart Failure

Volumn 6, Issue 5, 2013, Pages 1039-1048

  Zhang, Liyan ^a   Jaswal, Jagdip S ^a   Ussher, John R ^a   Sankaralingam, Sowndramalingam ^a   Wagg, Cory ^a   Zaugg, Michael ^a   Lopaschuk, Gary D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Abdominal aortic constriction; Cardiac insulin resistance; Cardiomegaly; Electron transport chain; Energy metabolism; Myocardial lipid accumulation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; FATTY ACID; GLUCOSE; LACTIC ACID;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DISEASE COURSE; ENERGY METABOLISM; ENERGY YIELD; GLUCOSE OXIDATION; GLUCOSE TOLERANCE TEST; GLYCOLYSIS; HEART LEFT VENTRICLE OVERLOAD; HEART VENTRICLE HYPERTROPHY; IN VIVO STUDY; INSULIN RESISTANCE; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTOLIC HEART FAILURE;

ABDOMINAL AORTIC CONSTRICTION; CARDIAC INSULIN-RESISTANCE; CARDIOMEGALY; ELECTRON TRANSPORT CHAIN; ENERGY METABOLISM; MYOCARDIAL LIPID ACCUMULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA, ABDOMINAL; ARTERIAL PRESSURE; BLOOD GLUCOSE; CARDIOMEGALY; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENERGY METABOLISM; FATTY ACIDS; GLUCOSE TRANSPORTER TYPE 4; GLYCOLYSIS; HEART FAILURE, SYSTOLIC; INSULIN; INSULIN RESISTANCE; LACTIC ACID; LIGATION; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MYOCARDIUM; OXIDATION-REDUCTION; PHOSPHOCREATINE; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 84887490616     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.112.000228     Document Type: Article

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