Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts

Circulation

Volumn 115, Issue 15, 2007, Pages 2033-2041

  Sorokina, Natalia ^a   O'Donnell, J Michael ^a   McKinney, Ronald D ^a   Pound, Kayla M ^a   Woldegiorgis, Gebre ^b   LaNoue, Kathryn F ^c   Ballal, Kalpana ^d   Taegtmeyer, Heinrich ^d   Buttrick, Peter M ^a   Lewandowski, E Douglas ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Fatty acids; Glucose; Hypertrophy; Isotopes; Metabolism

Indexed keywords

ACETYL COENZYME A; CARBON; CARNITINE PALMITOYLTRANSFERASE; GLUCOSE; MALATE DEHYDROGENASE (DECARBOXYLATING); MESSENGER RNA; PALMITIC ACID; PALMITIC ACID DERIVATIVE; PYRUVATE DEHYDROGENASE; TRICARBOXYLIC ACID;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; COMPLEX FORMATION; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SYNTHESIS; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HEART HYPERTROPHY; HEART PERFUSION; HEART VENTRICLE HYPERTROPHY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PRIORITY JOURNAL; RAT;

ANIMALS; CARDIOMEGALY; CARNITINE O-PALMITOYLTRANSFERASE; CITRIC ACID CYCLE; ENERGY METABOLISM; GLUCOSE; HEART FUNCTION TESTS; MALE; ORGAN CULTURE TECHNIQUES; OXIDATION-REDUCTION; PALMITIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 34247231646     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.668665     Document Type: Article

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