High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive Dahl salt-sensitive rat

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 10, 2005, Pages 825-831

  Okere, Isidore C ^a   Chess, David J ^a   McElfresh, Tracy A ^a   Johnson, Janean ^b   Rennison, Julie ^b   Ernsberger, Paul ^b   Hoit, Brian D ^a   Chandler, Margaret P ^a   Stanley, William C ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Fatty acids; Heart; Hypertension; Hypertrophy

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; FATTY ACID; LIPID; SODIUM CHLORIDE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; HEART CATHETERIZATION; HEART CONTRACTION; HEART FUNCTION; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; LIPID DIET; MALE; NONHUMAN; RAT; SALT INTAKE; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; UPREGULATION; ANIMAL; BLOOD; BLOOD PRESSURE; BODY SIZE; CARDIOMEGALY; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DAHL SALT SENSITIVE RAT; DRUG EFFECT; ELECTROCARDIOGRAPHY; FAT INTAKE; HEART MUSCLE; HEART VENTRICLE; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; BLOOD PRESSURE; BODY SIZE; CARDIOMEGALY; DIETARY FATS; ELECTROCARDIOGRAPHY; FATTY ACIDS, NONESTERIFIED; HEART VENTRICLES; HYPERTENSION; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; ORGAN SIZE; RATS; RATS, INBRED DAHL; SODIUM CHLORIDE, DIETARY; TRIGLYCERIDES;

EID: 33644696274     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2005.04272.x     Document Type: Article

References (36)

1. Levy D Anderson KM Savage DD Kannel WB Christiansen JC Castelli WP. Echocardiographically detected left ventricular hypertrophy: Prevalence and risk factors. The Framingham Heart Study. Ann. Intern. Med. 1988 108 : 7 13.
2. Panidis IP Kotler MN Ren JF Mintz GS Ross J Kalman P. Development and regression of left ventricular hypertrophy. J. Am. Coll. Cardiol. 1984 3 : 1309 20.
3. Yagyu H Chen G Yokoyama M et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J. Clin. Invest. 2003 111 : 419 26.
4. Finck BN Lehman JJ Leone TC et al. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J. Clin. Invest. 2002 109 : 121 30.
5. Chiu HC Kovacs A Blanton RM et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ. Res. 2005 96 : 225 33.
6. Chiu HC Kovacs A Ford DA et al. A novel mouse model of lipotoxic cardiomyopathy. J. Clin. Invest. 2001 107 : 813 22.
7. Lee Y Naseem RH Duplomb L et al. Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. Proc. Natl Acad. Sci. USA 2004 101 : 13 24 9.
8. Zhou YT Grayburn P Karim A et al. Lipotoxic heart disease in obese rats: Implications for human obesity. Proc. Natl Acad. Sci. USA 2000 97 : 1784 9.
9. Sparagna GC Hickson-Bick DL Buja LM McMillin JB. A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis. Am. J. Physiol. Heart Circ. Physiol. 2000 279 : H2124 32.
10. Gudz TI Tserng KY Hoppel CL. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J. Biol. Chem. 1997 272 : 24 54 8.
11. de las FL Herrero P Peterson LR Kelly DP Gropler RJ Davila-Roman VG. Myocardial fatty acid metabolism: Independent predictor of left ventricular mass in hypertensive heart disease. Hypertension 2003 41 : 83 7.
12. Hajri T Ibrahimi A Coburn CT et al. Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial hypertrophy. J. Biol. Chem. 2001 276 : 23 61 6.
13. Lehman JJ Kelly DP. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail. Rev. 2002 7 : 175 85.
14. Kang PM Yue P Liu Z Tarnavski O Bodyak N Izumo S. Alterations in apoptosis regulatory factors during hypertrophy and heart failure. Am. J. Physiol. Heart Circ. Physiol. 2004 287 : H72 80.
15. Fujii N Nozawa T Igawa A et al. Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure. Am. J. Physiol. Heart Circ. Physiol. 2004 287 : H760 6.
16. Kanda H Nohara R Hasegawa K Kishimoto C Sasayama S. A nuclear complex containing PPARalpha/RXRalpha is markedly downregulated in the hypertrophied rat left ventricular myocardium with normal systolic function. Heart Vessels 2000 15 : 191 6.
17. 14C-labeled substrates in humans. J. Clin. Invest. 1987 79 : 359 66.
18. van der Vusse GJ van Bilsen M Glatz JF Hasselbaink DM Luiken JJ. Critical steps in cellular fatty acid uptake and utilization. Mol. Cell. Biochem. 2002 239 : 9 15.
19. Ernsberger P Nelson DO. Refeeding hypertension in dietary obesity. Am. J. Physiol. 1988 254 : R47 55.
20. Morgan EE Faulx MD McElfresh TA et al. Validation of echocardiographic methods for assessing left ventricular dysfunction in rats with myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2004 287 : H2049 53.
21. Panchal AR Stanley WC Kerner J Sabbah HN. Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure. J. Card. Fail. 1998 4 : 121 6.
22. Chandler MP Huang H McElfresh TA Stanley WC. Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia. Am. J. Physiol. Heart Circ. Physiol. 2002 282 : H1871 8.
23. Tserng KY Griffin R. Quantitation and molecular species determination of diacylglycerols, phosphatidylcholines, ceramides, and sphingomyelins with gas chromatography. Anal. Biochem. 2003 323 : 84 93.
24. Huang BW Chiang MT Yao HT Chiang W. The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes Obes. Metab. 2004 6 : 120 6.
25. Berkin KE Ball SG. Essential hypertension: The heart and hypertension. Heart 2001 86 : 467 75.
26. Huss JM Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ. Res. 2004 95 : 568 78.
27. Cheng L Ding G Qin Q et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat. Med. 2004 10 : 1245 50.
28. Bing RJ. The metabolism of the heart. Harvey Lect. 1955 50 : 27 70.
29. Christe ME Rodgers RL. Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat. J. Mol. Cell. Cardiol. 1994 26 : 1371 5.
30. Abumrad NA Park JH Park CR. Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. J. Biol. Chem. 1984 259 : 8945 53.
31. Rupp H Zarain-Herzberg A Maisch B. The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz 2002 27 : 621 36.
32. Kelly DP Strauss AW. Inherited cardiomyopathies. N. Engl. J. Med. 1994 330 : 913 19.
33. Mjos OD. Effect of free fatty acids on myocardial function and oxygen consumption in intact dogs. J. Clin. Invest. 1971 50 : 1386 9.
34. Korvald C Elvenes OP Myrmel T. Myocardial substrate metabolism influences left ventricular energetics in vivo. Am. J. Physiol. Heart Circ. Physiol. 2000 278 : H1345 51.
35. Fitzgerald SM Henegar JR Brands MW Henegar LK Hall JE. Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001 281 : R547 52.
36. Jalili T Manning J Kim S. Increased translocation of cardiac protein kinase C beta2 accompanies mild cardiac hypertrophy in rats fed saturated fat. J. Nutr. 2003 133 : 358 61.