Precise flux redistribution to glyoxylate cycle for 5-aminolevulinic acid production in Escherichia coli

Metabolic Engineering

Volumn 43, Issue , 2017, Pages 1-8

  Noh, Myung Hyun ^a   Lim, Hyun Gyu ^a   Park, Sunghoon ^b   Seo, Sang Woo ^c   Jung, Gyoo Yeol ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Ulsan National Institute of Science and Technology   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

5 Aminolevulinic acid; Glyoxylate cycle; Metabolic engineering; Synthetic biology

Indexed keywords

ESCHERICHIA COLI; METABOLISM;

5-AMINOLEVULINIC ACID; BIOSYNTHETIC PATHWAY; CLINICAL APPLICATION; GLYOXYLATE CYCLES; MICROBIAL PRODUCTION; SYNTHETIC BIOLOGY; UNTRANSLATED REGIONS; VALUE ADDED PRODUCTS;

METABOLIC ENGINEERING;

ACETIC ACID; AMINOLEVULINIC ACID; CARBON; CITRATE SYNTHASE; GLYOXYLIC ACID; ISOCITRATE LYASE; TRICARBOXYLIC ACID; BACTERIAL PROTEIN; GLYOXYLIC ACID DERIVATIVE;

5' UNTRANSLATED REGION; ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; CELL GROWTH; CITRIC ACID CYCLE; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; HEMA GENE; HEML GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECOMBINANT PLASMID; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; GENETICS; METABOLIC ENGINEERING; METABOLISM;

AMINOLEVULINIC ACID; BACTERIAL PROTEINS; ESCHERICHIA COLI; GLYOXYLATES; METABOLIC ENGINEERING; SALMONELLA TYPHIMURIUM;

EID: 85025583264     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.07.006     Document Type: Article

References (50)

1. Chang, D.E., Shin, S., Rhee, J.S., Pan, J.G., Acetate metabolism in a pta mutant of Escherichia coli W3110: importance of maintaining acetyl coenzyme A flux for growth and survival. J. Bacteriol. 181:21 (1999), 6656–6663.
2. Cress, B.F., Toparlak, O.D., Guleria, S., Lebovich, M., Stieglitz, J.T., Englaender, J.A., Jones, J.A., Linhardt, R.J., Koffas, M.A.G., CRISPathBrick: modular combinatorial assembly of type II-A CRISPR arrays for dCas9-mediated multiplex transcriptional repression in E. coli. ACS Synth. Biol. 4:9 (2015), 987–1000.
3. Datsenko, K.A., Wanner, B.L., One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97:12 (2000), 6640–6645.
4. Dixon, G., Kornberg, H., Assay methods for key enzymes of the glyoxylate cycle. Biochem. J., 72, 1959, 3.
5. Engler, C., Kandzia, R., Marillonnet, S., A one pot, one step, precision cloning method with high throughput capability. PLoS One, 3(11), 2008, e3647.
6. Ensign, S.A., Revisiting the glyoxylate cycle: alternate pathways for microbial acetate assimilation. Mol. Microbiol. 61:2 (2006), 274–276.
7. Fu, W.Q., Lin, H.P., Cen, P.L., Enhancement of 5-aminolevulinate production with recombinant Escherichia coli using batch and fed-batch culture system. Bioresour. Technol. 99:11 (2008), 4864–4870.
8. Harder, B.J., Bettenbrock, K., Klamt, S., Model-based metabolic engineering enables high yield itaconic acid production by Escherichia coli. Metab. Eng. 38 (2016), 29–37.
9. Iverson, S.V., Haddock, T.L., Beal, J., Densmore, D.M., CIDAR MoClo: improved MoClo assembly standard and new E. coli part library enable rapid combinatorial design for synthetic and traditional biology. ACS Synth. Biol. 5:1 (2016), 99–103.
10. Kang, Z., Wang, Y., Gu, P.F., Wang, Q., Qi, Q.S., Engineering Escherichia coli for efficient production of 5-aminolevulinic acid from glucose. Metab. Eng. 13:5 (2011), 492–498.
11. Kang, Z., Zhang, J.L., Zhou, J.W., Qi, Q.S., Du, G.C., Chen, J., Recent advances in microbial production of delta-aminolevulinic acid and vitamin B12. Biotechnol. Adv. 30:6 (2012), 1533–1542.
12. Kelwick, R., Kopniczky, M., Bower, I., Chi, W.Q., Chin, M.H.W., Fan, S., Pilcher, J., Strutt, J., Webb, A.J., Jensen, K., Stan, G.B., Kitney, R., Freemont, P., A forward-design approach to increase the production of poly-3-hydroxybutyrate in genetically engineered Escherichia coli. PLoS One, 10, 2015, 2.
13. Kim, S.C., Min, B.E., Hwang, H.G., Seo, S.W., Jung, G.Y., Pathway optimization by re-design of untranslated regions for L-tyrosine production in Escherichia coli. Sci. Rep., 5, 2015, 13853.
14. Lee, D.H., Jun, W.J., Kim, K.M., Shin, D.H., Cho, H.Y., Hong, B.S., Inhibition of 5-aminolevulinic acid dehydratase in recombinant Escherichia coli using D-glucose. Enzym. Microb. Technol. 32:1 (2003), 27–34.
15. Li, F.F., Wang, Y., Gong, K., Wang, Q., Liang, Q.F., Qi, Q.S., Constitutive expression of RyhB regulates the heme biosynthesis pathway and increases the 5-aminolevulinic acid accumulation in Escherichia coli. FEMS Microbiol. Lett. 350:2 (2014), 209–215.
16. Li, J.-M., Brathwaite, O., Cosloy, S., Russell, C., 5-Aminolevulinic acid synthesis in. Escherichia coli. J. Bacteriol. 171:5 (1989), 2547–2552.
17. Li, M., Ho, P.Y., Yao, S.J., Shimizu, K., Effect of sucA or sucC gene knockout on the metabolism in Escherichia coli based on gene expressions, enzyme activities, intracellular metabolite concentrations and metabolic fluxes by C-13-labeling experiments. Biochem. Eng. J. 30:3 (2006), 286–296.
18. Li, N., Zhang, B., Wang, Z.W., Tang, Y.J., Chen, T., Zhao, X.M., Engineering Escherichia coli for fumaric acid production from glycerol. Bioresour. Technol. 174 (2014), 81–87.
19. Li, T., Guo, Y.Y., Qiao, G.Q., Chen, G.Q., Microbial synthesis of 5-aminolevulinic acid and its coproduction with polyhydroxybutyrate. ACS Synth. Biol. 5:11 (2016), 1264–1274.
20. Lim, H.G., Noh, M.H., Jeong, J.H., Park, S., Jung, G.Y., Optimum rebalancing of the 3-hydroxypropionic acid production pathway from glycerol in Escherichia coli. ACS Synth. Biol. 5:11 (2016), 1247–1255.
21. Lim, S.I., Min, B.E., Jung, G.Y., Lagging strand-biased initiation of Red recombination by linear double-stranded DNAS. J. Mol. Biol. 384:5 (2008), 1098–1105.
22. Lin, H., Bennett, G.N., San, K.Y., Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield. Metab. Eng. 7:2 (2005), 116–127.
23. Lin, H., Bennett, G.N., San, K.Y., Genetic reconstruction of the aerobic central metabolism in Escherichia coli for the absolute aerobic production of succinate. Biotechnol. Bioeng. 89:2 (2005), 148–156.
24. Mandal, N.C., Chakrabartty, P.K., Regulation of enzymes of glyoxylate pathway in root-nodule bacteria. J. Gen. Appl. Microbiol. 38:5 (1992), 417–427.
25. Mauzerall, D., Granick, S., The occurrence and determination of delta-amino-levulinic acid and porphobilinogen in urine. J. Biol. Chem. 219:1 (1956), 435–446.
26. Mohammadpour, H., Majidzadeh-A, K., Antitumor effect of conditioned media derived from murine MSCs and 5-aminolevulinic acid (5-ALA) mediated photodynamic therapy in breast cancer in vitro. Photodiagn. Photodyn. Ther. 12:2 (2015), 238–243.
27. Nguyen, H., Kim, H.S., Jung, S., Altered tetrapyrrole metabolism and transcriptome during growth-promoting actions in rice plants treated with 5-aminolevulinic acid. J. Plant Growth Regul. 78:1 (2016), 133–144.
28. Nishikawa, S., Watanabe, K., Tanaka, T., Miyachi, N., Hotta, Y., Murooka, Y., Rhodobacter sphaeroides mutants which accumulate 5-aminolevulinic acid under aerobic and dark conditions. J. Biosci. Bioeng. 87:6 (1999), 798–804.
29. Noor, E., Eden, E., Milo, R., Alon, U., Central carbon metabolism as a minimal biochemical walk between precursors for biomass and energy. J. Mol. Cell Biol. 39:5 (2010), 809–820.
30. Okamoto, S., Chin, T., Hiratsuka, K., Aso, Y., Tanaka, Y., Takahashi, T., Ohara, H., Production of itaconic acid using metabolically engineered Escherichia coli. J. Gen. Appl. Microbiol. 60:5 (2014), 191–197.
31. Pandey, U., Pandey, J., Enhanced production of delta-aminolevulinic acid, bilipigments, and antioxidants from tropical algae of India. Biotechnol. Bioprocess Eng. 14:3 (2009), 316–321.
32. Sasaki, K., Tanaka, T., Nishizawa, Y., Hayashi, M., Production of a herbicide, 5-aminolevulinic acid, by Rhodobacter sphaeroides using the effluent of swine waste from an anaerobic digestor. Appl. Microbiol. Biotechnol. 32:6 (1990), 727–731.
33. Sasaki, K., Watanabe, M., Tanaka, T., Tanaka, T., Biosynthesis, biotechnological production and applications of 5-aminolevulinic acid. Appl. Microbiol. Biotechnol. 58:1 (2002), 23–29.
34. Seo, S.W., Kim, S.C., Jung, G.Y., Synthetic regulatory tools for microbial engineering. Biotechnol. Bioprocess Eng. 17:1 (2012), 1–7.
35. Seo, S.W., Yang, J.S., Kim, I., Yang, J., Min, B.E., Kim, S., Jung, G.Y., Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency. Metab. Eng. 15 (2013), 67–74.
36. Seo, S.W., Yang, J.S., Cho, H.S., Yang, J., Kim, S.C., Park, J.M., Kim, S., Jung, G.Y., Predictive combinatorial design of mRNA translation initiation regions for systematic optimization of gene expression levels. Sci. Rep., 4, 2014, 4515.
37. Soma, Y., Tsuruno, K., Wada, M., Yokota, A., Hanai, T., Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch. Metab. Eng. 23 (2014), 175–184.
38. Vuoristo, K.S., Mars, A.E., Sangra, J.V., Springer, J., Eggink, G., Sanders, J.P.M., Weusthuis, R.A., Metabolic engineering of itaconate production in Escherichia coli. Appl. Microbiol. Biotechnol. 99:1 (2015), 221–228.
39. Vuoristo, K.S., Mars, A.E., Sanders, J.P.M., Eggink, G., Weusthuis, R.A., Metabolic engineering of TCA cycle for production of chemicals. Trends Biotechnol. 34:3 (2016), 191–197.
40. Waegeman, H., Beauprez, J., Moens, H., Maertens, J., De Mey, M., Foulquie-Moreno, M.R., Heijnen, J.J., Charlier, D., Soetaert, W., Effect of iclR and arcA knockouts on biomass formation and metabolic fluxes in Escherichia coli K12 and its implications on understanding the metabolism of Escherichia coli BL21 (DE3). BMC Microbiol., 11, 2011, 70.
41. Walsh, K., Koshland, D.E. Jr., Characterization of rate-controlling steps in vivo by use of an adjustable expression vector. Proc. Natl. Acad. Sci. USA 82:11 (1985), 3577–3581.
42. Wang, L.Y., Brown, L., Elliott, M., Elliott, T., Regulation of heme biosynthesis in Salmonella typhimurium: activity of glutamyl-tRNA reductase (HemA) is greatly elevated during heme limitation by a mechanism which increases abundance of the protein. J. Bacteriol. 179:9 (1997), 2907–2914.
43. Wang, L.Y., Wilson, S., Elliott, T., A mutant HemA protein with positive charge close to the N terminus is stabilized against heme-regulated proteolysis in Salmonella typhimurium. J. Bacteriol. 181:19 (1999), 6033–6041.
44. Woodard, S.I., Dailey, H.A., Regulation of heme-biosynthesis in Escherichia-coli. Arch. Biochem. Biophys. 316:1 (1995), 110–115.
45. Xu, P., Ranganathan, S., Fowler, Z.L., Maranas, C.D., Koffas, M.A.G., Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metab. Eng. 13:5 (2011), 578–587.
46. Xu, P., Gu, Q., Wang, W.Y., Wong, L., Bower, A.G.W., Collins, C.H., Koffas, M.A.G., Modular optimization of multi-gene pathways for fatty acids production in E. coli. Nat. Commun., 2013, 4.
47. Yamamoto, K., Nagata, K., Ohara, H., Aso, Y., Challenges in the production of itaconic acid by metabolically engineered Escherichia coli. Bioengineered 6:5 (2015), 303–306.
48. Yang, P., Liu, W.J., Cheng, X.L., Wang, J., Wang, Q., Qi, Q.S., A new strategy for production of 5-aminolevulinic acid in recombinant corynebacterium glutamicum with high yield. Appl. Environ. Microbiol. 82:9 (2016), 2709–2717.
49. Yu, C.H., Yu, C.C., Photodynamic therapy with 5-Aminolevulinic acid (ALA) impairs tumor initiating and chemo-resistance property in head and neck cancer-derived cancer stem cells. PLoS One, 9(1), 2014, e87129.
50. Zhang, J.L., Kang, Z., Chen, J., Du, G.C., Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli. Sci. Rep., 5, 2015, 8584.