Production of itaconic acid using metabolically engineered escherichia coli shusuke okamoto1

Journal of General and Applied Microbiology

Volumn 60, Issue 5, 2014, Pages 191-197

  Okamoto, Shusuke ^a   Chin, Taejun ^a   Hiratsuka, Ken ^a   Aso, Yuji ^a   Tanaka, Yasutomo ^a   Takahashi, Tetsuya ^b   Ohara, Hitomi ^a  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

Author keywords

Aconitase; Cis aconitate decarboxylase; Isocitrate dehydrogenase; Isocitrate lyase; Itaconic Acid; Metabolic engineering

Indexed keywords

GLUCOSE; ISOCITRATE DEHYDROGENASE; ISOCITRATE LYASE; ITACONIC ACID; ACONITATE DECARBOXYLASE; CARBOXYLYASE; CULTURE MEDIUM; SUCCINIC ACID DERIVATIVE;

ACONITASE B GENE; ARTICLE; BACTERIAL STRAIN; CIS ACONITATE DECARBOXYLASE GENE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE; GENE INACTIVATION; GENE OVEREXPRESSION; ISOCITRATE DEHYDROGENASE GENE; ISOCITRATE LYASE GENE; METABOLIC ENGINEERING; NONHUMAN; PH; CHEMISTRY; CULTURE MEDIUM; GENE DELETION; GENE EXPRESSION; GENETICS; METABOLISM; TEMPERATURE; TIME;

ESCHERICHIA COLI; LURIA;

CARBOXY-LYASES; CULTURE MEDIA; ESCHERICHIA COLI; GENE DELETION; GENE EXPRESSION; METABOLIC ENGINEERING; SUCCINATES; TEMPERATURE; TIME FACTORS;

EID: 84925183205     PISSN: 00221260     EISSN: 13498037     Source Type: Journal    
DOI: 10.2323/jgam.60.191     Document Type: Article

References (34)

1. Blumhoff, M. L., Steiger, M. G., Mattanovich, D., and Sauer, M. (2013) Targeting enzymes to the right compartment: Metabolic engineering for itaconic acid production by Aspergillus niger. Metab. Eng., 19, 26-32.
2. Bonnarme, P., Gillet, B., Sepulchre, A. M., Role, C., Beloeil, J. C. et al. (1995) Itaconate biosynthesis in Aspergillus terreus. J. Bacteriol., 177, 3573-3578.
3. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
4. Chen, B. P. and Hai, T. (1994) Expression vectors for affinity purification and radiolabeling of proteins using Escherichia coli as host. Gene, 139, 73-75.
5. Cote-Sierra, J., Jongert, E., Bredan, A., Gautam, D. C., Parkhouse, M., et al. (1998) A new membrane-bound OprI lipoprotein expression vector. High production of heterologous fusion proteins in gram (－) bacteria and the implications for oral vaccination. Gene, 221, 25-34.
6. Datsenko, K. A. and Wanner, B. L. (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA, 97, 6640-6645.
7. Dwiarti, L., Yamane, K., Yamatani, H., Kahar, P., and Okabe, M. (2002) Purification and characterization of cis-aconitic acid decarboxylase from Aspergillus terreus TN484-M1. J. Biosci. Bioeng., 94, 29-33.
8. Ishimoto, K., Arimoto, M., Okuda, T., Yamaguchi, S., Aso, Y. et al. (2012) Biobased polymers: Synthesis of graft copolymers and comb polymers using lactic acid macromonomer and properties of the product polymers. Biomacromolecules, 13, 3757-3768
9. Jantama, K., Haupt, M. J., Svoronos, S. A., Zhang, X., Moore, J. C. et al. (2008) Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate. Biotechnol. Bioeng., 99, 1140-1153.
10. Kabir, M. M. and Shimizu, K. (2004) Metabolic regulation analysis of icd-gene knockout Escherichia coli based on 2D electrophoresis with MALDI-TOF mass spectrometry and enzyme activity measurements. Appl. Microbiol. Biotechnol., 65, 84-96.
11. Kanamasa, S., Dwiarti, L., Okabe, M., and Park, E. Y. (2008) Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus. Appl. Microbiol. Biotechnol., 80, 223-229.
12. Kobayashi, T. and Nakamura, I. (1964) Dynamics in mycelia concentration of A. terreus K26 in steady state of continuous culture. J. Ferment. Technol., 44, 264-274.
13. Li, A., van Luijk, N., ter Beek, M., Caspers, M., Punt, P. et al. (2011) A clone-based transcriptomics approach for the identification of genes relevant for itaconic acid production in Aspergillus. Fungal Genet. Biol., 48, 602-611.
14. Li, A., Pfelzer, N., Zuijderwijk, R., and Punt, P. (2012) Enhanced itaconic acid production in Aspergillus niger using genetic modification and medium optimization. BMC Biotechnol., 12, 57
15. Lin, Y. H., Li, Y. F., Huang, M. C., and Tsai, Y. C. (2004) Intracellular expression of Vitreoscilla hemoglobin in Aspergillus terreus to alleviate the effect of a short break in aeration during culture. Biotechnol. Lett., 26, 1067-1072.
16. Milson, P. E. and Meers, J. L. (1985) Gluconic and itaconic acid. In Comprehensive Biotechnology, Vol. 3, The Practice of Biotechnology, ed. by Blanch, H. W., Drew, S., and Wang, D. I., Pergamon Press, Oxford, pp. 681-700.
17. Okabe, M., Lies, D., Kanamasa, S., and Park, E. Y. (2009) Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus. Appl. Microbiol. Biotechnol., 84, 597-606
18. Okabe, M., Ohta, N., and Park Y. (1993) Itaconic acid production in an airlift bioreactor using a modified draft tube. J. Ferment. Bioeng., 76, 117-122.
19. Okuda, T., Ishimoto, K., Ohara, H., and Kobayashi, S. (2012) Renewable biobased polymeric materials: Facile synthesis of itaconic anhydride-based copolymers with poly(L-lactic acid) grafts. Macromolecules, 45, 4166-4174.
20. Park, Y., Itida, M., Ohta, N., and Okabe, M. (1994) Itaconic acid production using an air-lift bioreactor in repeated batch culture of Aspergillus terreus. J. Ferment. Bioeng., 77, 329-331
21. Riscaldati, E., Moresi, M., Federici, F., and Petruccioli, M. (2000) Effect of pH and stirring rate on itaconate production by Aspergillus terreus. Biotechnol. J., 83, 219-230.
22. Sambrook, J. and Russell, D. W. (2001) Molecular Cloning: A Laboratory Manual, 3rd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
23. Schomburg, I., Chang, A., Placzek, S., Söhngen, C., Rother, M. et al. (2013) BRENDA in 2013: Integrated reactions, kinetic data, enzyme function data, improved disease classification: New options and contents in BRENDA. Nucleic Acids Res., 41, D764-D772.
24. van der Straat, L., Vernooij, M., Lammers, M., van den Berg, W., Schonewille, T. et al. (2014) Expression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger. Microb. Cell Fact., 13, 11.
25. Tate, B. E. (1981) Itaconic acid and derivatives. Kirk-Othmer. In Encycl. Chem. Technol., Vol. 13, 3rd ed., ed. by Mark, H. F., Othmer, D. F., Overberger, C. G., and Seaborg, G. T., Wiley, New York, pp. 865-873.
26. Tevz, G., Bencina, M., and LegiŞ M. (2010) Enhancing itaconic acid production by Aspergillus terreus. Appl. Microbiol. Biotechnol., 87, 1657-1664.
27. Träger, M., Qazi, G. N., Onken, U., and Chopra, C. L. (1989) Comparison of airlift and stirred reactors for fermentation with Aspergillus niger. J. Ferment. Bioeng., 68, 112-116.
28. Wagner, C., Odom, R., and Briggs, W. T. (1972) The uptake of acetate by Escherichia coli w. Biochem. Biophys. Res. Commun., 47, 1036-1043.
29. Walden, W. E. (2002) From bacteria to mitochondria: Aconitase yields surprises. Proc. Natl. Acad. Sci. USA, 99, 4138-4140.
30. Willke, T. and Vorlop, K. D. (2001) Biotechnological production of itaconic acid. Appl. Microbiol. Biotechnol., 56, 289-295
31. Wolfe, A. J. (2005) The acetate switch. Microbiol. Mol. Biol. Rev., 69, 12-50.
32. Yahiro, K., Takahama, T., Jia, S., Park, Y., and Okabe, M. (1997) Comparison of air-lift and stirred tank reactors for itaconic acid production by Aspergillus terreus. Biotechnol. Lett., 19, 619-621
33. Yahiro, K., Takahama, T., Park, Y., and Okabe, M. (1995) Breeding of Aspergillus terreus mutant TN-484 for an itaconic acid production with high yield. J. Ferm. Bioeng., 79, 506-508.
34. Yu, C., Cao, Y., Zou, H., and Xian, M. (2011) Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols. Appl. Microbiol. Biotechnol., 89, 573-583.