-
1
-
-
0346492610
-
Thrombin and phenotypic modulation of the endothelium
-
Minami T, Sugiyama A, Wu SQ, Abid R, Kodama T, Aird WC. Thrombin and phenotypic modulation of the endothelium. Arterioscler Thromb Vasc Biol. 2004;24:41-53.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 41-53
-
-
Minami, T.1
Sugiyama, A.2
Wu, S.Q.3
Abid, R.4
Kodama, T.5
Aird, W.C.6
-
2
-
-
3943079832
-
Autoprothrombin II and autoprothrombin II anticoagulant
-
Ulutin ON, Seegers WH. Autoprothrombin II and autoprothrombin II anticoagulant. Thromb Diath Haemorrh. 1962;7:256-263.
-
(1962)
Thromb Diath Haemorrh
, vol.7
, pp. 256-263
-
-
Ulutin, O.N.1
Seegers, W.H.2
-
3
-
-
0017111698
-
A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase
-
Esmon CT, Stenflo J, Suttie JW. A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase. J Biol Chem. 1976; 251:3052-3056.
-
(1976)
J Biol Chem
, vol.251
, pp. 3052-3056
-
-
Esmon, C.T.1
Stenflo, J.2
Suttie, J.W.3
-
4
-
-
0017283234
-
A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization
-
Stenflo J. A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization. J Biol Chem. 1976;251: 355-363.
-
(1976)
J Biol Chem
, vol.251
, pp. 355-363
-
-
Stenflo, J.1
-
5
-
-
0017567792
-
Anticoagulant properties of bovine plasma protein C following activation of thrombin
-
Kisiel W, Canfield WM, Ericsson EH, Davie EW. Anticoagulant properties of bovine plasma protein C following activation of thrombin. Biochem. 1977;16:5824-5831.
-
(1977)
Biochem
, vol.16
, pp. 5824-5831
-
-
Kisiel, W.1
Canfield, W.M.2
Ericsson, E.H.3
Davie, E.W.4
-
6
-
-
0020491258
-
Amino acid sequence of the heavy chain of bovine protein C
-
Stenflo J, Fernlund P. Amino acid sequence of the heavy chain of bovine protein C. J Biol Chem. 1982;257:12180-12190.
-
(1982)
J Biol Chem
, vol.257
, pp. 12180-12190
-
-
Stenflo, J.1
Fernlund, P.2
-
7
-
-
0020063793
-
Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C
-
Esmon CT, Esmon NL, Harris KW. Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem. 1982;257:7944-7947.
-
(1982)
J Biol Chem
, vol.257
, pp. 7944-7947
-
-
Esmon, C.T.1
Esmon, N.L.2
Harris, K.W.3
-
8
-
-
0029790055
-
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
-
Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A. 1996;93:10212-10216.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10212-10216
-
-
Stearns-Kurosawa, D.J.1
Kurosawa, S.2
Mollica, J.S.3
Ferrell, G.L.4
Esmon, C.T.5
-
9
-
-
0037630133
-
Platelet factor 4 enhances generation of activated protein C in vitro and in vivo
-
Slungaard A, Fernandez JA, Griffin JH, Key NS, Long JR, Piegors DJ, Lentz SR. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood. 2003;102:146-151.
-
(2003)
Blood
, vol.102
, pp. 146-151
-
-
Slungaard, A.1
Fernandez, J.A.2
Griffin, J.H.3
Key, N.S.4
Long, J.R.5
Piegors, D.J.6
Lentz, S.R.7
-
10
-
-
0024507770
-
The clinical spectrum of heterozygous protein C deficiency in a large New England kindred
-
Bovill EG, Bauer KA, Dickerman JD, Callas P, West B. The clinical spectrum of heterozygous protein C deficiency in a large New England kindred. Blood. 1989;73:712-717.
-
(1989)
Blood
, vol.73
, pp. 712-717
-
-
Bovill, E.G.1
Bauer, K.A.2
Dickerman, J.D.3
Callas, P.4
West, B.5
-
11
-
-
0021343348
-
Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn
-
Seligsohn U, Berger A, Abend M, Rubin L, Attias D, Zivelin A, Rapaport SI. Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Eng J Med. 1984;310:559-561.
-
(1984)
N Eng J Med
, vol.310
, pp. 559-561
-
-
Seligsohn, U.1
Berger, A.2
Abend, M.3
Rubin, L.4
Attias, D.5
Zivelin, A.6
Rapaport, S.I.7
-
12
-
-
0029080341
-
Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis
-
Bertina RM, Reitsma PH, Rosendaal FR, Vandenbroucke JP. Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis. Thromb Haemost. 1995;74:449-453.
-
(1995)
Thromb Haemost
, vol.74
, pp. 449-453
-
-
Bertina, R.M.1
Reitsma, P.H.2
Rosendaal, F.R.3
Vandenbroucke, J.P.4
-
13
-
-
0025738726
-
Baboon model of Escherichia coli sepsis: Description of its four stages and the role of tumor necrosis factor, tissue factors, and the protein C system in septic shock
-
Taylor FJ, Chang A, Esmon CT, Hinshaw LB. Baboon model of Escherichia coli sepsis: Description of its four stages and the role of tumor necrosis factor, tissue factors, and the protein C system in septic shock. Curr Stud Hematol Blood Transfus. 1991;58:8-14.
-
(1991)
Curr Stud Hematol Blood Transfus
, vol.58
, pp. 8-14
-
-
Taylor, F.J.1
Chang, A.2
Esmon, C.T.3
Hinshaw, L.B.4
-
14
-
-
0023122016
-
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
-
Taylor FB, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest. 1987;79:918-925.
-
(1987)
J Clin Invest
, vol.79
, pp. 918-925
-
-
Taylor, F.B.1
Chang, A.2
Esmon, C.T.3
D'Angelo, A.4
Vigano-D'Angelo, S.5
Blick, K.E.6
-
15
-
-
0034145311
-
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
-
Taylor FB, Jr., Stearns-Kurosawa DJ, Kurosawa S, Ferrell G, Chang AC, Laszik Z, Kosanke S, Peer G, Esmon CT. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood. 2000;95:1680-1686.
-
(2000)
Blood
, vol.95
, pp. 1680-1686
-
-
Taylor Jr., F.B.1
Stearns-Kurosawa, D.J.2
Kurosawa, S.3
Ferrell, G.4
Chang, A.C.5
Laszik, Z.6
Kosanke, S.7
Peer, G.8
Esmon, C.T.9
-
16
-
-
0038115187
-
Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice
-
Levi M, Dorffler-Melly J, Reitsma P, Buller H, Florquin S, van der Poll T, Carmeliet P. Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice. Blood. 2003;101:4823-4827.
-
(2003)
Blood
, vol.101
, pp. 4823-4827
-
-
Levi, M.1
Dorffler-Melly, J.2
Reitsma, P.3
Buller, H.4
Florquin, S.5
Van Der Poll, T.6
Carmeliet, P.7
-
17
-
-
0031861489
-
Protein C anticoagulant system in patients with interstitial lung disease
-
Kobayashi H, Gabazza EC, Taguchi O, Wada H, Takeya H, Nishioka J, Yasui H, Kobayashi T, Hataji O, Suzuki K, Adachi Y. Protein C anticoagulant system in patients with interstitial lung disease. Am J Respir Crit Care Med. 1998;157:1850-1854.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 1850-1854
-
-
Kobayashi, H.1
Gabazza, E.C.2
Taguchi, O.3
Wada, H.4
Takeya, H.5
Nishioka, J.6
Yasui, H.7
Kobayashi, T.8
Hataji, O.9
Suzuki, K.10
Adachi, Y.11
-
18
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ, Jr. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699-709.
-
(2001)
N Engl J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
LaRosa, S.P.4
Dhainaut, J.F.5
Lopez-Rodriguez, A.6
Steingrub, J.S.7
Garber, G.E.8
Helterbrand, J.D.9
Ely, E.W.10
Fisher Jr., C.J.11
-
19
-
-
0022470963
-
Thrombin-induced chemotaxis and aggregation of neutrophils
-
Bizios R, Lai L, Fenton JW, 2nd, Malik AB. Thrombin-induced chemotaxis and aggregation of neutrophils. J Cell Physiol. 1986;128: 485-490.
-
(1986)
J Cell Physiol
, vol.128
, pp. 485-490
-
-
Bizios, R.1
Lai, L.2
Fenton II, J.W.3
Malik, A.B.4
-
20
-
-
0026462843
-
Thrombin enhancement of interleukin-1 and tumor necrosis factor-α induced polymorphonuclear leukocyte migration
-
Drake WT, Lopes NN, Fenton JW, 2nd, Issekutz AC. Thrombin enhancement of interleukin-1 and tumor necrosis factor-α induced polymorphonuclear leukocyte migration. Lab Invest. 1992;67:617-627.
-
(1992)
Lab Invest
, vol.67
, pp. 617-627
-
-
Drake, W.T.1
Lopes, N.N.2
Fenton II, J.W.3
Issekutz, A.C.4
-
21
-
-
0027998013
-
Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ, or phorbol ester
-
Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ, or phorbol ester. J Immunol. 1994;153:3664-3672.
-
(1994)
J Immunol
, vol.153
, pp. 3664-3672
-
-
Grey, S.T.1
Tsuchida, A.2
Hau, H.3
Orthner, C.L.4
Salem, H.H.5
Hancock, W.W.6
-
22
-
-
0035815747
-
Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis
-
Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW. Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis. J Biol Chem. 2001;276: 11199-11203.
-
(2001)
J Biol Chem
, vol.276
, pp. 11199-11203
-
-
Joyce, D.E.1
Gelbert, L.2
Ciaccia, A.3
DeHoff, B.4
Grinnell, B.W.5
-
23
-
-
0028299926
-
Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide
-
Grinnell BW, Hermann RB, Yan SB. Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology. 1994;4:221-225.
-
(1994)
Glycobiology
, vol.4
, pp. 221-225
-
-
Grinnell, B.W.1
Hermann, R.B.2
Yan, S.B.3
-
24
-
-
0030034186
-
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
-
Murakami K, Okajima K, Uchiba M, Johno M, Nakagaki T, Okabe H, Takatsuki K. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood. 1996;87:642-647.
-
(1996)
Blood
, vol.87
, pp. 642-647
-
-
Murakami, K.1
Okajima, K.2
Uchiba, M.3
Johno, M.4
Nakagaki, T.5
Okabe, H.6
Takatsuki, K.7
-
25
-
-
0030909690
-
Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production
-
Murakami K, Okajima K, Uchiba M, Johno M, Nakagaki T, Okabe H, Takatsuki K. Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am J Physiol. 1997; 272:L197-202.
-
(1997)
Am J Physiol
, vol.272
-
-
Murakami, K.1
Okajima, K.2
Uchiba, M.3
Johno, M.4
Nakagaki, T.5
Okabe, H.6
Takatsuki, K.7
-
26
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002;296:1880-1882.
-
(2002)
Science
, vol.296
, pp. 1880-1882
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
Mueller, B.M.4
Ruf, W.5
-
27
-
-
0043240071
-
Expression and function of the endothelial protein C receptor in human neutrophils
-
Sturn DH, Kaneider NC, Feistritzer C, Djanani A, Fukudome K, Wiedermann CJ. Expression and function of the endothelial protein C receptor in human neutrophils. Blood. 2003;102:1499-1505.
-
(2003)
Blood
, vol.102
, pp. 1499-1505
-
-
Sturn, D.H.1
Kaneider, N.C.2
Feistritzer, C.3
Djanani, A.4
Fukudome, K.5
Wiedermann, C.J.6
-
28
-
-
0141446361
-
Activated protein C signals through the thrombin receptor PARI in endothelial cells
-
Riewald M, Petrovan RJ, Donner A, Ruf W. Activated protein C signals through the thrombin receptor PARI in endothelial cells. J Endotoxin Res. 2003;9:317-321.
-
(2003)
J Endotoxin Res
, vol.9
, pp. 317-321
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
Ruf, W.4
-
29
-
-
0037352279
-
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
-
Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003;9:338-342.
-
(2003)
Nat Med
, vol.9
, pp. 338-342
-
-
Cheng, T.1
Liu, D.2
Griffin, J.H.3
Fernandez, J.A.4
Castellino, F.5
Rosen, E.D.6
Fukudome, K.7
Zlokovic, B.V.8
-
30
-
-
0038682435
-
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor
-
Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J. 2003;373:65-70.
-
(2003)
Biochem J
, vol.373
, pp. 65-70
-
-
Mosnier, L.O.1
Griffin, J.H.2
-
31
-
-
0029044322
-
Purification and characterization of TAFI, a thrombin-activatable fibrinolysis inhibitor
-
Bajzar L, Manuel R, Nesheim M. Purification and characterization of TAFI, a thrombin-activatable fibrinolysis inhibitor. J Biol Chem. 1995;270:14477-14484.
-
(1995)
J Biol Chem
, vol.270
, pp. 14477-14484
-
-
Bajzar, L.1
Manuel, R.2
Nesheim, M.3
-
33
-
-
0036191244
-
Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N
-
Campbell WD, Lazoura E, Okada N, Okada H. Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Microbiol Immunol. 2002;46:131-134.
-
(2002)
Microbiol Immunol
, vol.46
, pp. 131-134
-
-
Campbell, W.D.1
Lazoura, E.2
Okada, N.3
Okada, H.4
-
34
-
-
0345803939
-
Thrombin activatable fibrinolysis inhibitor: A potential regulator of vascular inflammation
-
Myles T, Nishimura T, Yun TH, Nagashima M, Morser J, Patterson AJ, Pearl RG, Leung LL. Thrombin activatable fibrinolysis inhibitor: A potential regulator of vascular inflammation. J Biol Chem. 2003.
-
(2003)
J Biol Chem
-
-
Myles, T.1
Nishimura, T.2
Yun, T.H.3
Nagashima, M.4
Morser, J.5
Patterson, A.J.6
Pearl, R.G.7
Leung, L.L.8
-
35
-
-
0019861825
-
Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
-
Owen WG, Esmon CT. Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. J Biol Chem. 1981;256:5532-5535.
-
(1981)
J Biol Chem
, vol.256
, pp. 5532-5535
-
-
Owen, W.G.1
Esmon, C.T.2
-
36
-
-
3943093083
-
The discovery of thrombomodulin
-
Esmon CT, Owen WG. The discovery of thrombomodulin. J Thromb Haemost. 2004;2:209-213.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 209-213
-
-
Esmon, C.T.1
Owen, W.G.2
-
37
-
-
0026358002
-
Thrombomodulin in the central nervous system
-
Boffa M, Jackman R, Peyri N, Boffa J, George B. Thrombomodulin in the central nervous system. Nouv Rev Fr Hematol. 1991;33:423-429.
-
(1991)
Nouv Rev Fr Hematol
, vol.33
, pp. 423-429
-
-
Boffa, M.1
Jackman, R.2
Peyri, N.3
Boffa, J.4
George, B.5
-
38
-
-
0023763075
-
Functionally active thrombomodulin is present in human platelets
-
Suzuki K, Nishioka J, Hayashi T, Kosaka Y. Functionally active thrombomodulin is present in human platelets. J Biochem. 1988;104:628-632.
-
(1988)
J Biochem
, vol.104
, pp. 628-632
-
-
Suzuki, K.1
Nishioka, J.2
Hayashi, T.3
Kosaka, Y.4
-
39
-
-
0026328854
-
Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages
-
McCachren SS, Diggs J, Weinberg JB, Dittman WA. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood. 1991;78:3128-3132.
-
(1991)
Blood
, vol.78
, pp. 3128-3132
-
-
McCachren, S.S.1
Diggs, J.2
Weinberg, J.B.3
Dittman, W.A.4
-
40
-
-
0025836103
-
Regional distribution of thrombomodulin in human brain
-
Wong V, Hofman FM, Ishii H, Fisher M. Regional distribution of thrombomodulin in human brain. Brain Res. 1991;556:1-5.
-
(1991)
Brain Res
, vol.556
, pp. 1-5
-
-
Wong, V.1
Hofman, F.M.2
Ishii, H.3
Fisher, M.4
-
41
-
-
3943084660
-
Biologically active thrombomodulin is present in synovial fluid and elevated in effusions of patients with rheumatoid arthritis
-
Conway E, Nowakowski B, Steiner-Mosonyi M. Biologically active thrombomodulin is present in synovial fluid and elevated in effusions of patients with rheumatoid arthritis. Clin Res. 1992;40:241a.
-
(1992)
Clin Res
, vol.40
-
-
Conway, E.1
Nowakowski, B.2
Steiner-Mosonyi, M.3
-
42
-
-
0028258643
-
Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation
-
Raife TJ, Lager DJ, Madison KC, Piette WW, Howard EJ, Sturm MT, Chen Y, Lentz SR. Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation. J Clin Invest. 1994;93:1846-1851.
-
(1994)
J Clin Invest
, vol.93
, pp. 1846-1851
-
-
Raife, T.J.1
Lager, D.J.2
Madison, K.C.3
Piette, W.W.4
Howard, E.J.5
Sturm, M.T.6
Chen, Y.7
Lentz, S.R.8
-
43
-
-
0033562859
-
Structure-function analyses of thrombomodulin by gene-targeting in mice: The cytoplasmic domain is not required for normal fetal development
-
Conway EM, Pollefeyt S, Cornelissen J, DeBaere I, Steiner-Mosonyi M, Weitz JI, Weiler-Guettler H, Carmeliet P, Collen D. Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development. Blood. 1999;93:3442-3450.
-
(1999)
Blood
, vol.93
, pp. 3442-3450
-
-
Conway, E.M.1
Pollefeyt, S.2
Cornelissen, J.3
DeBaere, I.4
Steiner-Mosonyi, M.5
Weitz, J.I.6
Weiler-Guettler, H.7
Carmeliet, P.8
Collen, D.9
-
44
-
-
0025763975
-
Different glycoforms of human thrombomodulin-Their glycosaminoglycan- dependent modulatory effects on thrombin inactivation by heparin cofactor II and antithrombin III
-
Koyama T, Parkinson JF, Sié P, Bang NU, Müller BG, Preissner KT. Different glycoforms of human thrombomodulin-Their glycosaminoglycan- dependent modulatory effects on thrombin inactivation by heparin cofactor II and antithrombin III. Eur J Biochem. 1991;198: 563-570.
-
(1991)
Eur J Biochem
, vol.198
, pp. 563-570
-
-
Koyama, T.1
Parkinson, J.F.2
Sié, P.3
Bang, N.U.4
Müller, B.G.5
Preissner, K.T.6
-
45
-
-
0029050715
-
The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells
-
Hamada H, Ishii H, Sakyo K, Horie S, Nishiki K, Kazama M. The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells. Blood. 1995;86:225-233.
-
(1995)
Blood
, vol.86
, pp. 225-233
-
-
Hamada, H.1
Ishii, H.2
Sakyo, K.3
Horie, S.4
Nishiki, K.5
Kazama, M.6
-
46
-
-
0031674015
-
Expression of thrombomodulin in atherosclerotic lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells
-
Tohda G, Oida K, Okada Y, Kosaka S, Okada E, Takahashi S, Ishii H, Miyamori I. Expression of thrombomodulin in atherosclerotic lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1998;18:1861-1869.
-
(1998)
Arterioscler Thromb Vasc Biol
, vol.18
, pp. 1861-1869
-
-
Tohda, G.1
Oida, K.2
Okada, Y.3
Kosaka, S.4
Okada, E.5
Takahashi, S.6
Ishii, H.7
Miyamori, I.8
-
47
-
-
0023943394
-
A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site
-
Kurosawa S, Stearns DJ, Jackson KW, Esmon CT. A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site. J Biol Chem. 1988;263:5993-5996.
-
(1988)
J Biol Chem
, vol.263
, pp. 5993-5996
-
-
Kurosawa, S.1
Stearns, D.J.2
Jackson, K.W.3
Esmon, C.T.4
-
48
-
-
0024559613
-
A domain composed of epidermal growth factor-like structures of human thrombomodulin is essential for thrombin binding and for protein C activation
-
Suzuki K, Hayashi T, Nishioka J, Kosaka Y, Zushi M, Honda G, Yamamoto S. A domain composed of epidermal growth factor-like structures of human thrombomodulin is essential for thrombin binding and for protein C activation. J Biol Chem. 1989;264:4872-4876.
-
(1989)
J Biol Chem
, vol.264
, pp. 4872-4876
-
-
Suzuki, K.1
Hayashi, T.2
Nishioka, J.3
Kosaka, Y.4
Zushi, M.5
Honda, G.6
Yamamoto, S.7
-
49
-
-
0024396997
-
The last three consecutive epidermal growth factor-like structures of human thrombomodulin comprise the minimum functional domain for protein C-activating cofactor activity and anticoagulant activity
-
Zushi M, Gomi K, Yamamoto S, Maruyama I, Hayashi T, Suzuki K. The last three consecutive epidermal growth factor-like structures of human thrombomodulin comprise the minimum functional domain for protein C-activating cofactor activity and anticoagulant activity. J Biol Chem. 1989;264:10351-10353.
-
(1989)
J Biol Chem
, vol.264
, pp. 10351-10353
-
-
Zushi, M.1
Gomi, K.2
Yamamoto, S.3
Maruyama, I.4
Hayashi, T.5
Suzuki, K.6
-
50
-
-
0034725622
-
Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation
-
Wang W, Nagashima M, Schneider M, Morser J, Nesheim M. Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation. J Biol Chem. 2000; 275:22942-22947.
-
(2000)
J Biol Chem
, vol.275
, pp. 22942-22947
-
-
Wang, W.1
Nagashima, M.2
Schneider, M.3
Morser, J.4
Nesheim, M.5
-
51
-
-
0026775230
-
Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/ threonine-rich domain are required for cofactor activity
-
Tsiang M, Lentz SR, Sadler JE. Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/ threonine-rich domain are required for cofactor activity. J Biol Chem. 1992;267:6164-6170.
-
(1992)
J Biol Chem
, vol.267
, pp. 6164-6170
-
-
Tsiang, M.1
Lentz, S.R.2
Sadler, J.E.3
-
52
-
-
0032524918
-
Activation of thrombin-activatable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C
-
Kokame K, Zheng X, Sadler J. Activation of thrombin-activatable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C. J Biol Chem. 1998;273:12135-12139.
-
(1998)
J Biol Chem
, vol.273
, pp. 12135-12139
-
-
Kokame, K.1
Zheng, X.2
Sadler, J.3
-
53
-
-
0035722791
-
Identification of the epidermal growth factor-like domains of thrombomodulin essential for the acceleration of thrombin-mediated inactivation of single-chain urokinase-type plasminogen activator
-
Schenk-Braat EA, Morser J, Rijken DC. Identification of the epidermal growth factor-like domains of thrombomodulin essential for the acceleration of thrombin-mediated inactivation of single-chain urokinase-type plasminogen activator. Eur J Biochem. 2001;268:5562-5569.
-
(2001)
Eur J Biochem
, vol.268
, pp. 5562-5569
-
-
Schenk-Braat, E.A.1
Morser, J.2
Rijken, D.C.3
-
54
-
-
0025889743
-
Acceleration of the thrombin inactivation of single chain urokinase-type plasminogen activator (Pro-urokinase) by thrombomodulin
-
DeMunk G, Groeneveld E, Rijken DC. Acceleration of the thrombin inactivation of single chain urokinase-type plasminogen activator (Pro-urokinase) by thrombomodulin. J Clin Invest. 1991;88:1680-1684.
-
(1991)
J Clin Invest
, vol.88
, pp. 1680-1684
-
-
DeMunk, G.1
Groeneveld, E.2
Rijken, D.C.3
-
55
-
-
0026594613
-
Thrombomodulin is a cofactor for thrombin degradation of recombinant single-chain urokinase plasminogen activator "in vitro" and in a perfused rabbit heart model
-
Molinari A, Giorgetti C, Lansen J, Vaghi F, Orsini G, Faioni E, Mannucci P. Thrombomodulin is a cofactor for thrombin degradation of recombinant single-chain urokinase plasminogen activator "in vitro" and in a perfused rabbit heart model. Thromb Haemost. 1992;67:226-232.
-
(1992)
Thromb Haemost
, vol.67
, pp. 226-232
-
-
Molinari, A.1
Giorgetti, C.2
Lansen, J.3
Vaghi, F.4
Orsini, G.5
Faioni, E.6
Mannucci, P.7
-
56
-
-
0023374585
-
Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation
-
Suzuki K, Kusomoto H, Deyashiki Y, Hishioka J, Maruyama I, Zushi M, Kawahara S, Honda G, Yamamoto S, Horiguchi S. Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J. 1987;6:1891-1897.
-
(1987)
EMBO J
, vol.6
, pp. 1891-1897
-
-
Suzuki, K.1
Kusomoto, H.2
Deyashiki, Y.3
Hishioka, J.4
Maruyama, I.5
Zushi, M.6
Kawahara, S.7
Honda, G.8
Yamamoto, S.9
Horiguchi, S.10
-
57
-
-
0024320616
-
The active site of the thrombin-thrombomodulin complex
-
Lu R, Esmon NL, Esmon CT, Johnson AE. The active site of the thrombin-thrombomodulin complex. J Biol Chem. 1989;264:12956-12962.
-
(1989)
J Biol Chem
, vol.264
, pp. 12956-12962
-
-
Lu, R.1
Esmon, N.L.2
Esmon, C.T.3
Johnson, A.E.4
-
58
-
-
0029958045
-
The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy
-
Weisel JW, Nagaswami C, Young TA, Light DR. The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy. J Biol Chem. 1996;271:31485-31490.
-
(1996)
J Biol Chem
, vol.271
, pp. 31485-31490
-
-
Weisel, J.W.1
Nagaswami, C.2
Young, T.A.3
Light, D.R.4
-
59
-
-
0000398357
-
Molecular model for the C-type lectin domain of human thrombomodulin
-
Villoutreix B, Dahlback B. Molecular model for the C-type lectin domain of human thrombomodulin. J Mol Model. 1998;4:310-322.
-
(1998)
J Mol Model
, vol.4
, pp. 310-322
-
-
Villoutreix, B.1
Dahlback, B.2
-
60
-
-
0028925756
-
Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR)
-
Fukudome K, Esmon C. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). J Biol Chem. 1995;270:5571-5577.
-
(1995)
J Biol Chem
, vol.270
, pp. 5571-5577
-
-
Fukudome, K.1
Esmon, C.2
-
61
-
-
0032489916
-
Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor
-
Fukudome K, Ye X, Tsuneyoshi N, Tokunaga O, Sugawara K, Mizokami H, Kimoto M. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J Exp Med. 1998;187:1029-1035.
-
(1998)
J Exp Med
, vol.187
, pp. 1029-1035
-
-
Fukudome, K.1
Ye, X.2
Tsuneyoshi, N.3
Tokunaga, O.4
Sugawara, K.5
Mizokami, H.6
Kimoto, M.7
-
62
-
-
0030776168
-
Human Protein C Receptor Is Present Primarily on Endothelium of Large Blood Vessels: Implications for the Control of the Protein C Pathway
-
Laszik Z, Mitro A, Taylor FB, Jr., Ferrell G, Esmon CT. Human Protein C Receptor Is Present Primarily on Endothelium of Large Blood Vessels: Implications for the Control of the Protein C Pathway. Circulation. 1997;96:3633-3640.
-
(1997)
Circulation
, vol.96
, pp. 3633-3640
-
-
Laszik, Z.1
Mitro, A.2
Taylor Jr., F.B.3
Ferrell, G.4
Esmon, C.T.5
-
63
-
-
0023145052
-
Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily
-
Suzuki K, Deyashiki Y, Nishioka J, Kurachi K, Akira M, Yamamoto S, Hashimoto S. Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily. J Biol Chem. 1987;262:611-616.
-
(1987)
J Biol Chem
, vol.262
, pp. 611-616
-
-
Suzuki, K.1
Deyashiki, Y.2
Nishioka, J.3
Kurachi, K.4
Akira, M.5
Yamamoto, S.6
Hashimoto, S.7
-
64
-
-
0025983879
-
Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen
-
Espana F, Gilabert J, Estelles A, Romeu A, Aznar J, Cabo A. Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. Thromb Res. 1991;64:309-320.
-
(1991)
Thromb Res
, vol.64
, pp. 309-320
-
-
Espana, F.1
Gilabert, J.2
Estelles, A.3
Romeu, A.4
Aznar, J.5
Cabo, A.6
-
65
-
-
0033593595
-
Local overexpression of thrombomodulin for in vivo prevention of arterial thrombosis in a rabbit model
-
Waugh JM, Yuksel E, Li J, Kuo MD, Kattash M, Saxena R, Geske R, Thung SN, Shenaq SM, Woo SL. Local overexpression of thrombomodulin for in vivo prevention of arterial thrombosis in a rabbit model. Circ Res. 1999;84:84-92.
-
(1999)
Circ Res
, vol.84
, pp. 84-92
-
-
Waugh, J.M.1
Yuksel, E.2
Li, J.3
Kuo, M.D.4
Kattash, M.5
Saxena, R.6
Geske, R.7
Thung, S.N.8
Shenaq, S.M.9
Woo, S.L.10
-
66
-
-
0035572892
-
Characterization of a mouse model for thrombomodulin deficiency
-
Weiler H, Lindner V, Kerlin B, Isermann B, Hendrickson S, Cooley B, Meh D, Mosesson M, Shworak N, Post M, Conway E, Ulfman L, von Andrian U, Weitz J. Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol. 2001;21:1531-1537.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 1531-1537
-
-
Weiler, H.1
Lindner, V.2
Kerlin, B.3
Isermann, B.4
Hendrickson, S.5
Cooley, B.6
Meh, D.7
Mosesson, M.8
Shworak, N.9
Post, M.10
Conway, E.11
Ulfman, L.12
Von Andrian, U.13
Weitz, J.14
-
67
-
-
1442308091
-
Thrombomodulin mutant mice with a strongly reduced capacity to generate Activated Protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide
-
Rijneveld AW, Weijer S, Florquin S, Esmon CT, Meijers JC, Speelman P, Reitsma PH, Ten Cate H, Van Der Poll T. Thrombomodulin mutant mice with a strongly reduced capacity to generate Activated Protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. Blood. 2004;103:1702-1709.
-
(2004)
Blood
, vol.103
, pp. 1702-1709
-
-
Rijneveld, A.W.1
Weijer, S.2
Florquin, S.3
Esmon, C.T.4
Meijers, J.C.5
Speelman, P.6
Reitsma, P.H.7
Ten Cate, H.8
Van Der Poll, T.9
-
68
-
-
0036151725
-
Effects of human soluble thrombomodulin on experimental glomerulonephritis
-
Ikeguchi H, Maruyama S, Morita Y, Fujita Y, Kato T, Natori Y, Akatsu H, Campbell W, Okada N, Okada H, Yuzawa Y, Matsuo S. Effects of human soluble thrombomodulin on experimental glomerulonephritis. Kidney Int. 2002;61:490-501.
-
(2002)
Kidney Int
, vol.61
, pp. 490-501
-
-
Ikeguchi, H.1
Maruyama, S.2
Morita, Y.3
Fujita, Y.4
Kato, T.5
Natori, Y.6
Akatsu, H.7
Campbell, W.8
Okada, N.9
Okada, H.10
Yuzawa, Y.11
Matsuo, S.12
-
69
-
-
0033052588
-
C-type lectins and galactins mediate innate and adaptive immune functions: Their roles in the complement activation pathway
-
Vasta GR, Quesenberry M, Ahmed H, O'Leary N. C-type lectins and galactins mediate innate and adaptive immune functions: their roles in the complement activation pathway. Dev Comp Immunol. 1999;23: 401-420.
-
(1999)
Dev Comp Immunol
, vol.23
, pp. 401-420
-
-
Vasta, G.R.1
Quesenberry, M.2
Ahmed, H.3
O'Leary, N.4
-
70
-
-
0034920428
-
Lectin-like proteins in model organisms: Implications for evolution of carbohydrate-binding activity
-
Dodd RB, Drickamer K. Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity. Glycobiology. 2001;11:71R-79R.
-
(2001)
Glycobiology
, vol.11
-
-
Dodd, R.B.1
Drickamer, K.2
-
71
-
-
0036719075
-
The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
-
Conway EM, Van de Wouwer M, Pollefeyt S, Jurk K, Van Aken H, De Vriese A, Weitz JI, Weiler H, Hellings PW, Schaeffer P, Herbert JM, Collen D, Theilmeier G. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med. 2002;196:565-577.
-
(2002)
J Exp Med
, vol.196
, pp. 565-577
-
-
Conway, E.M.1
Van De Wouwer, M.2
Pollefeyt, S.3
Jurk, K.4
Van Aken, H.5
De Vriese, A.6
Weitz, J.I.7
Weiler, H.8
Hellings, P.W.9
Schaeffer, P.10
Herbert, J.M.11
Collen, D.12
Theilmeier, G.13
-
72
-
-
3943077046
-
Establishing links between coagulation and inflammation: The lectin-like domain of thrombomodulin confers protection in a murine model of rheumatoid arthritis
-
Van de Wouwer M, Clijsters K, Plaisance S, Collen D, Conway E. Establishing links between coagulation and inflammation: The lectin-like domain of thrombomodulin confers protection in a murine model of rheumatoid arthritis. J Thromb Haemost. 2003;1:266.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 266
-
-
Van De Wouwer, M.1
Clijsters, K.2
Plaisance, S.3
Collen, D.4
Conway, E.5
-
73
-
-
0344443722
-
Thrombomodulin-mediated cell adhesion: Involvement of its lectin-like domain
-
Huang HC, Shi GY, Jiang SJ, Shi CS, Wu CM, Yang HY, Wu HL. Thrombomodulin-mediated cell adhesion: Involvement of its lectin-like domain. J Biol Chem. 2003.
-
(2003)
J Biol Chem
-
-
Huang, H.C.1
Shi, G.Y.2
Jiang, S.J.3
Shi, C.S.4
Wu, C.M.5
Yang, H.Y.6
Wu, H.L.7
-
74
-
-
0030066667
-
Release of thrombomodulin from endothelial cells by concerted action of TNF-α and neutrophils: In vivo and in vitro studies
-
Boehme MW, Deng Y, Raeth U, Bierhaus A, Ziegler R, Stremmel W, Nawroth PP. Release of thrombomodulin from endothelial cells by concerted action of TNF-α and neutrophils: in vivo and in vitro studies. Immunology. 1996;87:134-140.
-
(1996)
Immunology
, vol.87
, pp. 134-140
-
-
Boehme, M.W.1
Deng, Y.2
Raeth, U.3
Bierhaus, A.4
Ziegler, R.5
Stremmel, W.6
Nawroth, P.P.7
-
75
-
-
1242288387
-
Diverse substrate recognition mechanisms for rhomboids: Thrombomodulin is cleaved by mammalian rhomboids
-
Lohi O, Urban S, Freeman M. Diverse substrate recognition mechanisms for rhomboids: thrombomodulin is cleaved by mammalian rhomboids. Current Biology. 2004;14:236-241.
-
(2004)
Current Biology
, vol.14
, pp. 236-241
-
-
Lohi, O.1
Urban, S.2
Freeman, M.3
-
76
-
-
0031730635
-
Thrombomodulin: An overview and potential implications in vascular disorders
-
Boffa MC, Karmochkine M. Thrombomodulin: an overview and potential implications in vascular disorders. Lupus. 1998;7:S120-S125.
-
(1998)
Lupus
, vol.7
-
-
Boffa, M.C.1
Karmochkine, M.2
-
77
-
-
0033594760
-
Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: A case-cohort study
-
Salomaa V, Matei C, Aleksic N, Sansores-Garcia L, Folsom AR, Juneja H, Chambless LE, Wu KK. Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: a case-cohort study. Lancet. 1999;353:1729-1734.
-
(1999)
Lancet
, vol.353
, pp. 1729-1734
-
-
Salomaa, V.1
Matei, C.2
Aleksic, N.3
Sansores-Garcia, L.4
Folsom, A.R.5
Juneja, H.6
Chambless, L.E.7
Wu, K.K.8
-
78
-
-
0043127016
-
Soluble thrombomodulin and coronary heart disease
-
Wu KK. Soluble thrombomodulin and coronary heart disease. Curr Opin Lipidol. 2003;14:373-375.
-
(2003)
Curr Opin Lipidol
, vol.14
, pp. 373-375
-
-
Wu, K.K.1
-
79
-
-
0037426381
-
Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease
-
Wu KK, Aleksic N, Ballantyne CM, Ahn C, Juneja H, Boerwinkle E. Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease. Circulation. 2003;107:1729-1732.
-
(2003)
Circulation
, vol.107
, pp. 1729-1732
-
-
Wu, K.K.1
Aleksic, N.2
Ballantyne, C.M.3
Ahn, C.4
Juneja, H.5
Boerwinkle, E.6
-
80
-
-
0028876697
-
Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system
-
Healy A, Rayburn H, Rosenberg R, Weiler H. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci (USA). 1995;92:850-854.
-
(1995)
Proc Natl Acad Sci (USA)
, vol.92
, pp. 850-854
-
-
Healy, A.1
Rayburn, H.2
Rosenberg, R.3
Weiler, H.4
-
81
-
-
0037349926
-
The thrombomodulin-protein C system is essential for the maintenance of pregnancy
-
Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med. 2003;9:331-337.
-
(2003)
Nat Med
, vol.9
, pp. 331-337
-
-
Isermann, B.1
Sood, R.2
Pawlinski, R.3
Zogg, M.4
Kalloway, S.5
Degen, J.L.6
Mackman, N.7
Weiler, H.8
-
82
-
-
0000686636
-
Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity
-
Zhang Y, Weiler-Guettler H, Chen J, Wilhelm O, Deng Y, Qiu F, Nakagawa K, Klevesath M, Wilhelm S, Bohrer H, Nakagawa M, Graeff H, Martin E, Stern D, Rosenberg R, Ziegler R, Nawroth P. Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity. J Clin Invest. 1998;101:1301-1309.
-
(1998)
J Clin Invest
, vol.101
, pp. 1301-1309
-
-
Zhang, Y.1
Weiler-Guettler, H.2
Chen, J.3
Wilhelm, O.4
Deng, Y.5
Qiu, F.6
Nakagawa, K.7
Klevesath, M.8
Wilhelm, S.9
Bohrer, H.10
Nakagawa, M.11
Graeff, H.12
Martin, E.13
Stern, D.14
Rosenberg, R.15
Ziegler, R.16
Nawroth, P.17
-
83
-
-
0023755932
-
Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
-
Conway EM, Rosenberg RD. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol. 1988;8:5588-5592.
-
(1988)
Mol Cell Biol
, vol.8
, pp. 5588-5592
-
-
Conway, E.M.1
Rosenberg, R.D.2
-
84
-
-
0024418881
-
Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin
-
Dittman WA, Kumada T, Majerus PW. Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin. Proc Natl Acad Sci U S A. 1989;86:7179-7182.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7179-7182
-
-
Dittman, W.A.1
Kumada, T.2
Majerus, P.W.3
-
85
-
-
0025908301
-
Increased expression of thrombomodulin on the cultured human umbilical vein endothelial cells and mouse hemangioma cells by cyclic AMP
-
Maruyama I, Soejima Y, Osame M, Ito T, Ogawa K, Yamamoto S, Dittman WA, Saito H. Increased expression of thrombomodulin on the cultured human umbilical vein endothelial cells and mouse hemangioma cells by cyclic AMP. Thromb Res. 1991;61:301-310.
-
(1991)
Thromb Res
, vol.61
, pp. 301-310
-
-
Maruyama, I.1
Soejima, Y.2
Osame, M.3
Ito, T.4
Ogawa, K.5
Yamamoto, S.6
Dittman, W.A.7
Saito, H.8
-
86
-
-
0025652431
-
Upregulation of thrombomodulin on cultured endothelial cells by cAMP
-
Maruyama I, Soejima Y. Upregulation of thrombomodulin on cultured endothelial cells by cAMP. Ann NY Acad Sci. 1990;598:538-539.
-
(1990)
Ann NY Acad Sci
, vol.598
, pp. 538-539
-
-
Maruyama, I.1
Soejima, Y.2
-
87
-
-
0026589829
-
Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal carcinoma cells
-
Weiler GH, Yu K, Soff G, Gudas LJ, Rosenberg RD. Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal carcinoma cells. Proc Natl Acad Sci (USA). 1992;89:2155-2159.
-
(1992)
Proc Natl Acad Sci (USA)
, vol.89
, pp. 2155-2159
-
-
Weiler, G.H.1
Yu, K.2
Soff, G.3
Gudas, L.J.4
Rosenberg, R.D.5
-
88
-
-
0031866873
-
Thrombomodulin-dependent anticoagulant activity is regulated by vascular endothelial growth factor
-
Calnek DS, Grinnell BW. Thrombomodulin-dependent anticoagulant activity is regulated by vascular endothelial growth factor. Exp Cell Res. 1998;238:294-298.
-
(1998)
Exp Cell Res
, vol.238
, pp. 294-298
-
-
Calnek, D.S.1
Grinnell, B.W.2
-
89
-
-
10744233133
-
Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor α-induced thrombomodulin downregulation
-
Shi J, Wang J, Zheng H, Ling W, Joseph J, Li D, Mehta JL, Ponnappan U, Lin P, Fink LM, Hauer-Jensen M. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor α-induced thrombomodulin downregulation. Blood Coagul Fibrinolysis. 2003;14:575-585.
-
(2003)
Blood Coagul Fibrinolysis
, vol.14
, pp. 575-585
-
-
Shi, J.1
Wang, J.2
Zheng, H.3
Ling, W.4
Joseph, J.5
Li, D.6
Mehta, J.L.7
Ponnappan, U.8
Lin, P.9
Fink, L.M.10
Hauer-Jensen, M.11
-
90
-
-
0028314277
-
Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress
-
Malek AM, Jackman R, Rosenberg RD, Izumo S. Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress. Circ Res. 1994;74:852-860.
-
(1994)
Circ Res
, vol.74
, pp. 852-860
-
-
Malek, A.M.1
Jackman, R.2
Rosenberg, R.D.3
Izumo, S.4
-
91
-
-
0037428059
-
Wall tension is a potent negative regulator of in vivo thrombomodulin expression
-
Sperry JL, Deming CB, Bian C, Walinsky PL, Kass DA, Kolodgie FD, Virmani R, Kim AY, Rade JJ. Wall tension is a potent negative regulator of in vivo thrombomodulin expression. Circ Res. 2003;92:41-47.
-
(2003)
Circ Res
, vol.92
, pp. 41-47
-
-
Sperry, J.L.1
Deming, C.B.2
Bian, C.3
Walinsky, P.L.4
Kass, D.A.5
Kolodgie, F.D.6
Virmani, R.7
Kim, A.Y.8
Rade, J.J.9
-
92
-
-
0029069178
-
Transforming growth factor β1 and β2 induce down-modulation of thrombomodulin in human umbilical vein endothelial cells
-
Ohji T, Urano H, Shirahata A, Yamagishi M, Higashi K, Gotoh S, Karasaki Y. Transforming growth factor β1 and β2 induce down-modulation of thrombomodulin in human umbilical vein endothelial cells. Thromb Haemost. 1995;73:812-818.
-
(1995)
Thromb Haemost
, vol.73
, pp. 812-818
-
-
Ohji, T.1
Urano, H.2
Shirahata, A.3
Yamagishi, M.4
Higashi, K.5
Gotoh, S.6
Karasaki, Y.7
-
93
-
-
0038115239
-
Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARβ-RXRα heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter
-
Ishii H, Tezuka T, Ishikawa H, Takada K, Oida K, Horie S. Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARβ-RXRα heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter. Blood. 2003;101:4765-4774.
-
(2003)
Blood
, vol.101
, pp. 4765-4774
-
-
Ishii, H.1
Tezuka, T.2
Ishikawa, H.3
Takada, K.4
Oida, K.5
Horie, S.6
-
94
-
-
0037147152
-
Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads
-
Sandusky G, Berg DT, Richardson MA, Myers L, Grinnell BW. Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads. J Biol Chem. 2002;277:49815-49819.
-
(2002)
J Biol Chem
, vol.277
, pp. 49815-49819
-
-
Sandusky, G.1
Berg, D.T.2
Richardson, M.A.3
Myers, L.4
Grinnell, B.W.5
-
95
-
-
0031960553
-
Differential effect of tumor necrosis factor-α on thrombomodulin gene expression by human monocytoid (THP-1) cell versus endothelial cells
-
In Process Citation
-
Grey ST, Csizmadia V, Hancock WW. Differential effect of tumor necrosis factor-α on thrombomodulin gene expression by human monocytoid (THP-1) cell versus endothelial cells [In Process Citation]. Int J Hematol. 1998;67:53-62.
-
(1998)
Int J Hematol
, vol.67
, pp. 53-62
-
-
Grey, S.T.1
Csizmadia, V.2
Hancock, W.W.3
-
96
-
-
0024589205
-
Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture
-
Moore, K.L., Esmon CT., Esmon NL. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood. 1989;73:159-165.
-
(1989)
Blood
, vol.73
, pp. 159-165
-
-
Moore, K.L.1
Esmon, C.T.2
Esmon, N.L.3
-
97
-
-
0027103736
-
Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity
-
Glaser C, Morser J, Clarke J, Blasko E, McLean K, Kuhn I, Chang R-J, Lin J-H, Vilander L, Andrews W, Light D. Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. J Clin Invest. 1992;90:2565-2573.
-
(1992)
J Clin Invest
, vol.90
, pp. 2565-2573
-
-
Glaser, C.1
Morser, J.2
Clarke, J.3
Blasko, E.4
McLean, K.5
Kuhn, I.6
Chang, R.-J.7
Lin, J.-H.8
Vilander, L.9
Andrews, W.10
Light, D.11
-
98
-
-
0034161458
-
Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
-
Gu JM, Katsuura Y, Ferrell GL, Grammas P, Esmon CT. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood. 2000;95:1687-1693.
-
(2000)
Blood
, vol.95
, pp. 1687-1693
-
-
Gu, J.M.1
Katsuura, Y.2
Ferrell, G.L.3
Grammas, P.4
Esmon, C.T.5
-
99
-
-
0034009976
-
Metalloproteolytic release of endothelial cell protein C receptor
-
Xu J, Qu D, Esmon NL, Esmon CT. Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem. 2000;275:6038-6044.
-
(2000)
J Biol Chem
, vol.275
, pp. 6038-6044
-
-
Xu, J.1
Qu, D.2
Esmon, N.L.3
Esmon, C.T.4
-
100
-
-
0034050886
-
Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function
-
Liaw PC, Neuenschwander PF, Smirnov MD, Esmon CT. Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. J Biol Chem. 2000;275:5447-5452.
-
(2000)
J Biol Chem
, vol.275
, pp. 5447-5452
-
-
Liaw, P.C.1
Neuenschwander, P.F.2
Smirnov, M.D.3
Esmon, C.T.4
-
101
-
-
0030036189
-
The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors
-
Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem. 1996;271:17499-17503.
-
(1996)
J Biol Chem
, vol.271
, pp. 17499-17503
-
-
Regan, L.M.1
Stearns-Kurosawa, D.J.2
Kurosawa, S.3
Mollica, J.4
Fukudome, K.5
Esmon, C.T.6
-
103
-
-
0031973176
-
Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes
-
Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A, Della Valle P, Esmon CT. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood. 1998;91:725-727.
-
(1998)
Blood
, vol.91
, pp. 725-727
-
-
Kurosawa, S.1
Stearns-Kurosawa, D.J.2
Carson, C.W.3
D'Angelo, A.4
Della Valle, P.5
Esmon, C.T.6
-
104
-
-
0038683379
-
Coagulation and inflammation
-
Esmon CT. Coagulation and inflammation. J Endotoxin Res. 2003;9:192-198.
-
(2003)
J Endotoxin Res
, vol.9
, pp. 192-198
-
-
Esmon, C.T.1
-
105
-
-
0034668005
-
The soluble endothelial protein C receptor binds to activated neutrophils: Involvement of proteinase-3 and CD11b/CD18
-
Kurosawa S, Esmon CT, Stearns-Kurosawa DJ. The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. J Immunol. 2000;165:4697-4703.
-
(2000)
J Immunol
, vol.165
, pp. 4697-4703
-
-
Kurosawa, S.1
Esmon, C.T.2
Stearns-Kurosawa, D.J.3
-
106
-
-
2942720560
-
Structure and functions of the endothelial cell protein C receptor
-
Esmon CT. Structure and functions of the endothelial cell protein C receptor. Crit Care Med. 2004;32:S298-S301.
-
(2004)
Crit Care Med
, vol.32
-
-
Esmon, C.T.1
-
107
-
-
0037067752
-
The crystal structure of the endothelial protein C receptor and a bound phospholipid
-
Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL, Esmon CT. The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem. 2002;277:24851-24854.
-
(2002)
J Biol Chem
, vol.277
, pp. 24851-24854
-
-
Oganesyan, V.1
Oganesyan, N.2
Terzyan, S.3
Qu, D.4
Dauter, Z.5
Esmon, N.L.6
Esmon, C.T.7
-
108
-
-
0029793068
-
The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
-
Bajzar L, Nesheim M, Tracy P. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood. 1996;88:2093-2100.
-
(1996)
Blood
, vol.88
, pp. 2093-2100
-
-
Bajzar, L.1
Nesheim, M.2
Tracy, P.3
-
109
-
-
0141609935
-
Inflammation and thrombosis
-
Esmon CT. Inflammation and thrombosis. J Thromb Haemost. 2003;1:1343-1348.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 1343-1348
-
-
Esmon, C.T.1
-
110
-
-
0026534242
-
Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies
-
Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest. 1992;101:816-823.
-
(1992)
Chest
, vol.101
, pp. 816-823
-
-
Fourrier, F.1
Chopin, C.2
Goudemand, J.3
Hendrycx, S.4
Caron, C.5
Rime, A.6
Marey, A.7
Lestavel, P.8
-
111
-
-
0027214771
-
Time course of hemostatic abnormalities in sepsis and its relation to outcome
-
Lorente JA, Garcia-Frade LJ, Landin L, de Pablo R, Torrado C, Renes E, Garcia-Avello A. Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest. 1993;103:1536-1542.
-
(1993)
Chest
, vol.103
, pp. 1536-1542
-
-
Lorente, J.A.1
Garcia-Frade, L.J.2
Landin, L.3
De Pablo, R.4
Torrado, C.5
Renes, E.6
Garcia-Avello, A.7
-
112
-
-
0002295408
-
Recombinant human activated protein C (rfAPC) improves coagulation abnormalities associated with severe sepsis
-
Hartman D, Bernard G, Helterbrand J, Yan S, Fisher C. Recombinant human activated protein C (rfAPC) improves coagulation abnormalities associated with severe sepsis. Intensive Care Med. 1998;24:S77.
-
(1998)
Intensive Care Med
, vol.24
-
-
Hartman, D.1
Bernard, G.2
Helterbrand, J.3
Yan, S.4
Fisher, C.5
-
113
-
-
0037904903
-
Activated protein C: More effective than nonactivated protein C?
-
Schwarz HP, Ehrlich HJ. Activated protein C: more effective than nonactivated protein C? Crit Care Med. 2003;31:1597.
-
(2003)
Crit Care Med
, vol.31
, pp. 1597
-
-
Schwarz, H.P.1
Ehrlich, H.J.2
-
114
-
-
0037248228
-
Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis
-
Bernard GR. Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis. Crit Care Med. 2003;31:S85-93.
-
(2003)
Crit Care Med.
, vol.31
-
-
Bernard, G.R.1
-
115
-
-
0037251850
-
Recombinant human activated protein C in sepsis: Inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials
-
Eichacker PQ, Natanson C. Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials. Crit Care Med. 2003;31:S94-S96.
-
(2003)
Crit Care Med
, vol.31
-
-
Eichacker, P.Q.1
Natanson, C.2
-
116
-
-
2942701914
-
Beyond sepsis: Activated protein C and ischemia-reperfusion injury
-
Levi M, Choi G, Schools I, Schultz M, Van Der Poll T. Beyond sepsis: Activated protein C and ischemia-reperfusion injury. Crit Care Med. 2004;32:S309-S312.
-
(2004)
Crit Care Med
, vol.32
-
-
Levi, M.1
Choi, G.2
Schools, I.3
Schultz, M.4
Van Der Poll, T.5
-
117
-
-
0028230847
-
Intravenous extended infusion of recombinant human soluble thrombomodulin prevented tissue factor-induced disseminated intravascular coagulation in rats
-
Mohri M, Oka M, Aoki Y, Gonda Y, Hirata S, Gomi K, Kiyota T, Sugihara T, Yamamoto S, Ishida T, Maruyama I. Intravenous extended infusion of recombinant human soluble thrombomodulin prevented tissue factor-induced disseminated intravascular coagulation in rats. Am J Hematol. 1994;45:298-303.
-
(1994)
Am J Hematol
, vol.45
, pp. 298-303
-
-
Mohri, M.1
Oka, M.2
Aoki, Y.3
Gonda, Y.4
Hirata, S.5
Gomi, K.6
Kiyota, T.7
Sugihara, T.8
Yamamoto, S.9
Ishida, T.10
Maruyama, I.11
-
118
-
-
0027291336
-
Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxin-induced disseminated intravascular coagulation in rats
-
Gonda Y, Hirata S, Saitoh K, Aoki Y, Mohri M, Gomi K, Sugihara T, Kiyota T, Yamamoto S, Ishida T, Maruyama I. Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxin-induced disseminated intravascular coagulation in rats. Thromb Res. 1993;71:325-335.
-
(1993)
Thromb Res
, vol.71
, pp. 325-335
-
-
Gonda, Y.1
Hirata, S.2
Saitoh, K.3
Aoki, Y.4
Mohri, M.5
Gomi, K.6
Sugihara, T.7
Kiyota, T.8
Yamamoto, S.9
Ishida, T.10
Maruyama, I.11
-
119
-
-
0028853552
-
Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats
-
Uchiba M, Okajima K, Murakami K, Nawa K, Okabe H, Takatsuki K. Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats. Thromb Haemost. 1995;74:1265-1270.
-
(1995)
Thromb Haemost
, vol.74
, pp. 1265-1270
-
-
Uchiba, M.1
Okajima, K.2
Murakami, K.3
Nawa, K.4
Okabe, H.5
Takatsuki, K.6
-
120
-
-
0842307339
-
A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis
-
Saposnik B, Reny JL, Gaussem P, Emmerich J, Aiach M, Gandrille S. A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis. Blood. 2004;103:1311-1318.
-
(2004)
Blood
, vol.103
, pp. 1311-1318
-
-
Saposnik, B.1
Reny, J.L.2
Gaussem, P.3
Emmerich, J.4
Aiach, M.5
Gandrille, S.6
|