Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 28, 2017, Pages E5559-E5568

  Shydlovskyi, Sergii ^a   Zienert, Anke Y ^b   Ince, Semra ^a   Dovengerds, Christine ^a   Hohendahl, Annika ^c   Dargazanli, Julia M ^b   Blum, Ailisa ^b   Günther, Saskia D ^b   Kladt, Nikolay ^b   Stürzl, Michael ^d   Schauss, Astrid C ^b   Kutsch, Miriam ^a   Roux, Aurélien ^c   Praefcke, Gerrit J K ^b,e   Herrmann, Christian ^a   Novick, Peter J ^f  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e PAUL EHRLICH INSTITUT   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

GBPs; Large GTPases; Membrane binding; Membrane tethering; Polymerization

Indexed keywords

CYCLIC NUCLEOTIDE DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GBP1 PROTEIN, HUMAN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; LIPOSOME; POLYMER; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; FARNESYLATION; HUMAN; HUMAN CELL; LIPID BILAYER; MEMBRANE BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN POLYMERIZATION; PROTEIN PURIFICATION; REGULATORY MECHANISM; BINDING SITE; CATALYSIS; CELL MEMBRANE; CHEMISTRY; ELECTRON MICROSCOPY; HELA CELL LINE; HYDROLYSIS; INNATE IMMUNITY; METABOLISM; PHAGOCYTOSIS; POLYMERIZATION; PRENYLATION;

BINDING SITES; CATALYSIS; CELL MEMBRANE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; HELA CELLS; HUMANS; HYDROLYSIS; IMMUNITY, INNATE; LIPOSOMES; MICROSCOPY, ELECTRON; PHAGOCYTOSIS; POLYMERIZATION; POLYMERS; PRENYLATION; PROTEIN BINDING;

EID: 85023185201     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1620959114     Document Type: Article

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