Cutting edge: Active TGF-β1 Released from GARP/TGF-β1 complexes on the surface of stimulated human b lymphocytes increases class-switch recombination and production of IgA

Journal of Immunology

Volumn 199, Issue 2, 2017, Pages 391-396

  Dedobbeleer, Olivier ^a,b,c   Stockis, Julie ^a,b,c   Van Der Woning, Bas ^d   Coulie, Pierre G ^a,b,c   Lucas, Sophie ^a,b,c  

^a DE DUVE INSTITUTE   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c Walloon Excellence in Life Sciences and Biotechnology (WELBIO)   (Belgium)

^d ArGEN X BVBA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; MEMBRANE PROTEIN; PROTEIN GARP; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; CPG-OLIGONUCLEOTIDE; CYTOKINE; LRRC32 PROTEIN, HUMAN; OLIGODEOXYRIBONUCLEOTIDE; PROTEIN BINDING;

ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; SURFACE PROPERTY; BIOSYNTHESIS; DRUG EFFECTS; GENE REARRANGEMENT; GENETIC RECOMBINATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

B-LYMPHOCYTES; CYTOKINES; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS SWITCHING; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN BINDING; RECOMBINATION, GENETIC; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85023159435     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1601882     Document Type: Article

References (30)

1. Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693-699.
2. Kulkarni, A. B., C. G. Huh, D. Becker, A. Geiser, M. Lyght, K. C. Flanders, A. B. Roberts, M. B. Sporn, J. M. Ward, and S. Karlsson. 1993. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90: 770-774.
3. Marie, J. C., D. Liggitt, and A. Y. Rudensky. 2006. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-454.
4. Reed, N. I., H. Jo, C. Chen, K. Tsujino, T. D. Arnold, W. F. DeGrado, and D. Sheppard. 2015. The avb1 integrin plays a critical in vivo role in tissue fibrosis. Sci. Transl. Med. 7: 288ra79.
5. Munger, J. S., X. Huang, H. Kawakatsu, M. J. Griffiths, S. L. Dalton, J. Wu, J. F. Pittet, N. Kaminski, C. Garat, M. A. Matthay, et al. 1999. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96: 319-328.
6. Travis, M. A., B. Reizis, A. C. Melton, E. Masteller, Q. Tang, J. M. Proctor, Y. Wang, X. Bernstein, X. Huang, L. F. Reichardt, et al. 2007. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449: 361-365.
7. Arnold, T. D., G. M. Ferrero, H. Qiu, I. T. Phan, R. J. Akhurst, E. J. Huang, and L. F. Reichardt. 2012. Defective retinal vascular endothelial cell development as a consequence of impaired integrin aVb8-mediated activation of transforming growth factor-b. J. Neurosci. 32: 1197-1206.
8. Kitamura, H., S. Cambier, S. Somanath, T. Barker, S. Minagawa, J. Markovics, A. Goodsell, J. Publicover, L. Reichardt, D. Jablons, et al. 2011. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avb8-mediated activation of TGF-β. J. Clin. Invest. 121: 2863-2875.
9. Tran, D. Q., J. Andersson, R. Wang, H. Ramsey, D. Unutmaz, and E. M. Shevach. 2009. GARP (LRRC32) is essential for the surface expression of latent TGF-βeta on platelets and activated FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 106: 13445-13450.
10. Stockis, J., D. Colau, P. G. Coulie, and S. Lucas. 2009. Membrane protein GARP is a receptor for latent TGF-βeta on the surface of activated human Treg. Eur. J. Immunol. 39: 3315-3322.
11. Wang, R., J. Zhu, X. Dong, M. Shi, C. Lu, and T. A. Springer. 2012. GARP regulates the bioavailability and activation of TGFb. Mol. Biol. Cell 23: 1129-1139.
12. Gauthy, E., J. Cuende, J. Stockis, C. Huygens, B. Lethé, J. F. Collet, G. Bommer, P. G. Coulie, and S. Lucas. 2013. GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells. PLoS One 8: e76186.
13. Stockis, J., W. Fink, V. François, T. Connerotte, C. de Smet, L. Knoops, P. van der Bruggen, T. Boon, P. G. Coulie, and S. Lucas. 2009. Comparison of stable human Treg and Th clones by transcriptional profiling. Eur. J. Immunol. 39: 869-882.
14. Cuende, J., S. Liénart, O. Dedobbeleer, B. van der Woning, G. De Boeck, J. Stockis, C. Huygens, D. Colau, J. Somja, P. Delvenne, et al. 2015. Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo. Sci. Transl. Med. 7: 284ra56.
15. Massagué, J. 2008. TGFbeta in cancer. Cell 134: 215-230.
16. Macaulay, I. C., M. R. Tijssen, D. C. Thijssen-Timmer, A. Gusnanto, M. Steward, P. Burns, C. F. Langford, P. D. Ellis, F. Dudbridge, J. J. Zwaginga, et al. 2007. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood 109: 3260-3269.
17. Roubin, R., S. Pizette, V. Ollendorff, J. Planche, D. Birnbaum, and O. Delapeyriere. 1996. Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein. Int. J. Dev. Biol. 40: 545-555.
18. +CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells. J. Hepatol. 61: 594-599.
19. Li, Y., B. G. Kim, S. Qian, J. J. Letterio, J. J. Fung, L. Lu, and F. Lin. 2015. Hepatic stellate cells inhibit T cells through active TGF-β1 from a cell surface-bound latent TGF-β1/GARP complex. J. Immunol. 195: 2648-2656.
20. Carrillo-Galvez, A. B., M. Cobo, S. Cuevas-Ocanã, A. Gutiérrez-Guerrero, A. Sánchez-Gilabert, P. Bongarzone, A. Garca-Pérez, P. Munõz, K. Benabdellah, M. G. Toscano, et al. 2015. Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells 33: 183-195.
21. Cerutti, A., H. Zan, A. Schaffer, L. Bergsagel, N. Harindranath, E. E. Max, and P. Casali. 1998. CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line. J. Immunol. 160: 2145-2157.
22. Edwards, J. P., A. M. Thornton, and E. M. Shevach. 2014. Release of active TGFb1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin b8. J. Immunol. 193: 2843-2849.
23. Li, M. O., Y. Y. Wan, S. Sanjabi, A. K. Robertson, and R. A. Flavell. 2006. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 24: 99-146.
24. Coffman, R. L., D. A. Lebman, and B. Shrader. 1989. Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 170: 1039-1044.
25. Cazac, B. B., and J. Roes. 2000. TGF-βeta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13: 443-451.
26. Cerutti, A. 2008. The regulation of IgA class switching. Nat. Rev. Immunol. 8: 421-434.
27. Sonoda, E., R. Matsumoto, Y. Hitoshi, T. Ishii, M. Sugimoto, S. Araki, A. Tominaga, N. Yamaguchi, and K. Takatsu. 1989. Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production. J. Exp. Med. 170: 1415-1420.
28. Stavnezer, J., J. E. Guikema, and C. E. Schrader. 2008. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26: 261-292.
29. Reboldi, A., T. I. Arnon, L. B. Rodda, A. Atakilit, D. Sheppard, and J. G. Cyster. 2016. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science 352: aaf4822.
30. Singh, K., C. Chang, and M. E. Gershwin. 2014. IgA deficiency and autoimmunity. Autoimmun. Rev. 13: 163-177.