IgA deficiency and autoimmunity

Autoimmunity Reviews

Volumn 13, Issue 2, 2014, Pages 163-177

  Singh, Karmtej ^a   Chang, Christopher ^b   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

Author keywords

Autoimmune disease; Combined variable immunodeficiency (CVID); IgA; Immunodeficiency; Immunoglobulins; Selective IgA deficiency

Indexed keywords

CD40 LIGAND; IMMUNOGLOBULIN A; INTERLEUKIN 10; INTERLEUKIN 21; INTERLEUKIN 4; THYROTROPIN RECEPTOR ANTIBODY;

AFRICA; AUSTRIA; AUTOIMMUNE THYROIDITIS; AUTOIMMUNITY; CELIAC DISEASE; CLINICAL FEATURE; DIABETES MELLITUS; DISEASE ASSOCIATION; GENE MUTATION; GENE SWITCHING; GENETIC ASSOCIATION; GENETIC LINKAGE; HAPLOTYPE; HUMAN; IMMUNOGLOBULIN A DEFICIENCY; JUVENILE RHEUMATOID ARTHRITIS; MEMORY CELL; NORTH AMERICA; PROTEIN POLYMORPHISM; REVIEW; SOUTH AMERICA; SYSTEMATIC REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

AUTOIMMUNE DISEASE; COMBINED VARIABLE IMMUNODEFICIENCY (CVID); IGA; IMMUNODEFICIENCY; IMMUNOGLOBULINS; SELECTIVE IGA DEFICIENCY;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-LYMPHOCYTES; HUMANS; IGA DEFICIENCY; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A;

EID: 84888005938     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2013.10.005     Document Type: Review

References (173)

1. Etzioni A. Immune deficiency and autoimmunity. Autoimmun Rev 2003, 2:364-369.
2. Liblau R.S., Bach J.F. Selective IgA deficiency and autoimmunity. Int Arch Allergy Immunol 1992, 99:16-27.
3. Mestecky J., McGhee J.R. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol 1987, 40:153-245.
4. Corthesy B. Role of secretory IgA in infection and maintenance of homeostasis. Autoimmun Rev 2013, 12:661-665.
5. Pillai S. Rethinking mechanisms of autoimmune pathogenesis. J Autoimmun 2013, 45:97-103.
6. Horai R., Silver P.B., Chen J., Agarwal R.K., Chong W.P., Jittayasothorn Y., et al. Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun 2013, 44:21-33.
7. Yu C., Chang C., Zhang J. Immunologic and genetic considerations of cutaneous lupus erythematosus: a comprehensive review. J Autoimmun 2013, 41:34-45.
8. Andreu-Ballester J.C., Perez-Griera J., Ballester F., Colomer-Rubio E., Ortiz-Tarin I., Penarroja Otero C. Secretory immunoglobulin A (sIgA) deficiency in serum of patients with GALTectomy (appendectomy and tonsillectomy). Clin Immunol 2007, 123:289-297.
9. Yel L. Selective IgA deficiency. J Clin Immunol 2010, 30:10-16.
10. Schaffer F.M., Monteiro R.C., Volanakis J.E., Cooper M.D. IgA deficiency. Immunodefic Rev 1991, 3:15-44.
11. Rosen F.S. Autoimmunity and immunodeficiency disease. Ciba Found Symp 1987, 129:135-148.
12. De Laat P.C., Weemaes C.M., Gonera R., Van Munster P.J., Bakkeren J.A., Stoelinga G.B. Clinical manifestations in selective IgA deficiency in childhood. A follow-up report. Acta Paediatr Scand 1991, 80:798-804.
13. Oxelius V.A., Laurell A.B., Lindquist B., Golebiowska H., Axelsson U., Bjorkander J., et al. IgG subclasses in selective IgA deficiency: importance of IgG2-IgA deficiency. N Engl J Med 1981, 304:1476-1477.
14. Latiff A.H., Kerr M.A. The clinical significance of immunoglobulin A deficiency. Ann Clin Biochem 2007, 44:131-139.
15. Hanson L.A., Bjorkander J., Carlsson B., Roberton D., Soderstrom T. The heterogeneity of IgA deficiency. J Clin Immunol 1988, 8:159-162.
16. Bardana E.J. A conceptual approach to immunodeficiency. Med Clin North Am 1981, 65:959-976.
17. Ballow M. Primary immunodeficiency disorders: antibody deficiency. J Allergy Clin Immunol 2002, 109:581-591.
18. Aghamohammadi A., Cheraghi T., Gharagozlou M., Movahedi M., Rezaei N., Yeganeh M., et al. IgA deficiency: correlation between clinical and immunological phenotypes. J Clin Immunol 2009, 29:130-136.
19. Schaffer F.M. Clinical assessment and management of abnormal IgA levels. Ann Allergy Asthma Immunol 2008, 100:280-282.
20. Sandler S.G., Mallory D., Malamut D., Eckrich R. IgA anaphylactic transfusion reactions. Transfus Med Rev 1995, 9:1-8.
21. Castigli E., Scott S., Dedeoglu F., Bryce P., Jabara H., Bhan A.K., et al. Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A 2004, 101:3903-3908.
22. Cerutti A. The regulation of IgA class switching. Nat Rev Immunol 2008, 8:421-434.
23. Lopez-Mejias R., del Pozo N., Fernandez-Arquero M., Ferreira A., Garcia-Rodriguez M.C., de la Concha E.G., et al. Role of polymorphisms in the TNFRSF13B (TACI) gene in Spanish patients with immunoglobulin A deficiency. Tissue Antigens 2009, 74:42-45.
24. Ortiz J., Fernandez-Arquero M., Urcelay E., Lopez-Mejias R., Ferreira A., Fontan G., et al. Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family study. BMC Med Genet 2006, 7:56.
25. Lopez-Mejias R., Martinez A., Del Pozo N., Fernandez-Arquero M., Ferreira A., Urcelay E., et al. Interleukin-6 gene variation in Spanish patients with immunoglobulin-A deficiency. Hum Immunol 2008, 69:301-305.
26. Janzi M., Kull I., Sjoberg R., Wan J., Melen E., Bayat N., et al. Selective IgA deficiency in early life: association to infections and allergic diseases during childhood. Clin Immunol 2009, 133:78-85.
27. Feng M.L., Zhao Y.L., Shen T., Huang H., Yin B., Liu R.Z., et al. Prevalence of immunoglobulin A deficiency in Chinese blood donors and evaluation of anaphylactic transfusion reaction risk. Transfus Med 2011, 21:338-343.
28. Kanoh T., Mizumoto T., Yasuda N., Koya M., Ohno Y., Uchino H., et al. Selective IgA deficiency in Japanese blood donors: frequency and statistical analysis. Vox Sang 1986, 50:81-86.
29. al-Attas R.A., Rahi A.H. Primary antibody deficiency in Arabs: first report from eastern Saudi Arabia. J Clin Immunol 1998, 18:368-371.
30. Kanoh T., Uchino H. Selective IgA deficiency in Japan. Frequency among 18,200 hospital patients and 22,522 blood donors. Nihon Ketsueki Gakkai Zasshi 1982, 45:929-934.
31. Baumgart K.W., Britton W.J., Kemp A., French M., Roberton D. The spectrum of primary immunodeficiency disorders in Australia. J Allergy Clin Immunol 1997, 100:415-423.
32. Feng L. Epidemiologic, immunologic and clinical study on selective IgA deficiency. Zhonghua Yi Xue Za Zhi 1987, 67:343-345.
33. Yadav M., Iyngkaran N. Low incidence of selective IgA deficiency in normal Malaysians. Med J Malaysia 1979, 34:145-148.
34. Melamed I., Kark J.D., Zakuth V., Margalit G., Spirer Z. Serum immunoglobulin A levels and ethnicity in an Israeli population sample. Clin Immunol Immunopathol 1987, 42:259-264.
35. Sharon R., Amar A. IgA deficiency in Israeli blood donors. J Clin Pathol 1982, 35:582-583.
36. Chandran S., Khetan D., Chaudhary R., Misra R., Aggarwal A. Low prevalence of IgA deficiency in north Indian population. Indian J Med Res 2006, 123:653-656.
37. Rezvan H., Ahmadi D., Esmailzadeh S., Dayhimi I. Selective deficiency of immunoglobulin A among healthy voluntary blood donors in Iran. Blood Transfus 2009, 7:152-154.
38. Winter P.M., Manndorff P. The frequency of IgA-deficiency in the Austrian population. A protocol for large-scale screening by ELISA and a study on 3056 blood donors. Infusionstherapie 1988, 15:221-224.
39. Weber-Mzell D., Kotanko P., Hauer A.C., Goriup U., Haas J., Lanner N., et al. Gender, age and seasonal effects on IgA deficiency: a study of 7293 Caucasians. Eur J Clin Invest 2004, 34:224-228.
40. Gudmundsson S., Jensson O. Frequency of IgA deficiency in blood donors and Rh negative women in Iceland. Acta Pathol Microbiol Scand C 1977, 85:87-89.
41. Ulfarsson J., Gudmundsson S., Birgisdottir B., Kjeld J.M., Jensson O. Selective serum IgA deficiency in Icelanders. Frequency, family studies and Ig levels. Acta Med Scand 1982, 211:481-487.
42. Holt P.D., Tandy N.P., Anstee D.J. Screening of blood donors for IgA deficiency: a study of the donor population of south-west England. J Clin Pathol 1977, 30:1007-1010.
43. Ertekin V., Selimoglu M.A., Kardas F., Akcay F. Screening of healthy school children aged 6-17years old for immunoglobulin A deficiency in eastern Turkey. Eur J Clin Invest 2004, 34:716. [author reply 7].
44. Basturk B., Sari S., Aral A., Dalgic B. Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children. Turk J Pediatr 2011, 53:364-368.
45. Perez Vaquero M.A., Vesga Carasa M.A., Lopez Urrutia A. Frequency of selective IgA deficiency in Basque Country. Med Clin (Barc) 2000, 115:339-440.
46. Litzman J., Sevcikova I., Stikarovska D., Pikulova Z., Pazdirkova A., Lokaj J. IgA deficiency in Czech healthy individuals and selected patient groups. Int Arch Allergy Immunol 2000, 123:177-180.
47. Frommel D., Moullec J., Lambin P., Fine J.M. Selective serum IgA deficiency. Frequency among 15,200 French blood donors. Vox Sang 1973, 25:513-518.
48. Koistinen J. Selective IgA deficiency in blood donors. Vox Sang 1975, 29:192-202.
49. Kramer J., Kassai T., Medgyesi G.A., Tauszik T., Fust G. Screening of IgA deficiency by ELISA: population frequency in Hungary. Haematologia (Budap) 1988, 21:233-238.
50. Carneiro-Sampaio M.M., Carbonare S.B., Rozentraub R.B., de Araujo M.N., Riberiro M.A., Porto M.H. Frequency of selective IgA deficiency among Brazilian blood donors and healthy pregnant women. Allergol Immunopathol (Madr) 1989, 17:213-216.
51. Collins-Williams C., Kokubu H.L., Lamenza C., Nizami R., Chiu A.W., Lewis-McKinley C., et al. Incidence of isolated deficiency of IgA in the serum of Canadian children. Ann Allergy 1972, 30:11-23.
52. Strothman R., White M.B., Testin J., Chen S.N., Ball M.J. HLA and IgA deficiency in blood donors. Hum Immunol 1986, 16:289-294.
53. Ezeoke A.C. Selective IgA deficiency (SIgAD) in Eastern Nigeria. Afr J Med Med Sci 1988, 17:17-21.
54. Luzi G., Businco L., Aiuti F. Primary immunodeficiency syndromes in Italy: a report of the national register in children and adults. J Clin Immunol 1983, 3:316-320.
55. Ryser O., Morell A., Hitzig W.H. Primary immunodeficiencies in Switzerland: first report of the national registry in adults and children. J Clin Immunol 1988, 8:479-485.
56. Rezaei N., Aghamohammadi A., Moin M., Pourpak Z., Movahedi M., Gharagozlou M., et al. Frequency and clinical manifestations of patients with primary immunodeficiency disorders in Iran: update from the Iranian Primary Immunodeficiency Registry. J Clin Immunol 2006, 26:519-532.
57. Hayakawa H., Iwata T., Yata J., Kobayashi N. Primary immunodeficiency syndrome in Japan. I. Overview of a nationwide survey on primary immunodeficiency syndrome. J Clin Immunol 1981, 1:31-39.
58. Fasth A. Primary immunodeficiency disorders in Sweden: cases among children, 1974-1979. J Clin Immunol 1982, 2:86-92.
59. Gathmann B., Binder N., Ehl S., Kindle G. The European internet-based patient and research database for primary immunodeficiencies: update 2011. Clin Exp Immunol 2012, 167:479-491.
60. Rockey J.H., Hanson L.A., Heremans J.F., Kunkel H.G. Beta-2a aglobulinemia in two healthy men. J Lab Clin Med 1964, 63:205-212.
61. Saghafi S., Pourpak Z., Aghamohammadi A., Pourfathollah A.A., Samadian A., Farghadan M., et al. Selective immunoglobulin A deficiency in Iranian blood donors: prevalence, laboratory and clinical findings. Iran J Allergy Asthma Immunol 2008, 7:157-162.
62. Buckley R.H., Dees S.C. Serum immunoglobulins. 3. Abnormalities associated with chronic urticaria in children. J Allergy 1967, 40:294-303.
63. Stiehm E.R., Fudenberg H.H. Serum levels of immune globulins in health and disease: a survey. Pediatrics 1966, 37:715-727.
64. Rigante D., Mazzoni M.B., Esposito S. The cryptic interplay between systemic lupus erythematosus and infections. Autoimmun Rev 2013 Sep 17, pii: S1568-9972(13)00156-0. 10.1016/j.autrev.2013.09.004.
65. Gianchecchi E., Delfino D.V., Fierabracci A. Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity. Autoimmun Rev 2013, 12:1091-1100.
66. Cassinotti A., Sarzi-Puttini P., Fichera M., Shoenfeld Y., de Franchis R., Ardizzone S. Immunity, autoimmunity and inflammatory bowel disease. Autoimmun Rev 2013 Jun 15, doi:pii: S1568-9972(13)00107-9. 10.1016/j.autrev.2013.06.007.
67. Geremia A., Biancheri P., Allan P., Corazza G.R., Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev 2013 Jun 15, pii: S1568-9972(13)00104-3. http://dx.doi.org/10.1016/j.autrev.2013.06.004.
68. Osnes L.T., Nakken B., Bodolay E., Szodoray P. Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies-novel tool for diagnostics and patient follow-up. Autoimmun Rev 2013, 12:967-971.
69. Bogdanos D.P., Smyk D.S., Invernizzi P., Rigopoulou E.I., Blank M., Pouria S., et al. Infectome: a platform to trace infectious triggers of autoimmunity. Autoimmun Rev 2013, 12:726-740.
70. Baldovino S., Montin D., Martino S., Sciascia S., Menegatti E., Roccatello D. Common variable immunodeficiency: crossroads between infections, inflammation and autoimmunity. Autoimmun Rev 2013, 12:796-801.
71. Bailey M., Christoforidou Z., Lewis M. Evolution of immune systems: specificity and autoreactivity. Autoimmun Rev 2013, 12:643-647.
72. Sciascia S., Ceberio L., Garcia-Fernandez C., Roccatello D., Karim Y., Cuadrado M.J. Systemic lupus erythematosus and infections: clinical importance of conventional and upcoming biomarkers. Autoimmun Rev 2012, 12:157-163.
73. Nahum A., Dadi H., Bates A., Roifman C.M. The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity. Autoimmun Rev 2012, 11:341-347.
74. Gu Y., Jensen P.E., Chen X. Immunodeficiency and autoimmunity in H2-O-deficient mice. J Immunol 2013, 190:126-137.
75. Catucci M., Castiello M.C., Pala F., Bosticardo M., Villa A. Autoimmunity in Wiskott-Aldrich syndrome: an unsolved enigma. Front Immunol 2012, 3:209.
76. Jorgensen G.H., Thorsteinsdottir I., Gudmundsson S., Hammarstrom L., Ludviksson B.R. Familial aggregation of IgAD and autoimmunity. Clin Immunol 2009, 131:233-239.
77. Mohammadi J., Ramanujam R., Jarefors S., Rezaei N., Aghamohammadi A., Gregersen P.K., et al. IgA deficiency and the MHC: assessment of relative risk and microheterogeneity within the HLA A1 B8, DR3 (8.1) haplotype. J Clin Immunol 2010, 30:138-143.
78. Tobon G.J., Pers J.O., Canas C.A., Rojas-Villarraga A., Youinou P., Anaya J.M. Are autoimmune diseases predictable?. Autoimmun Rev 2012, 11:259-266.
79. Hammarstrom L., Vorechovsky I., Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol 2000, 120:225-231.
80. Johnson M.L., Keeton L.G., Zhu Z.B., Volanakis J.E., Cooper M.D., Schroeder H.W. Age-related changes in serum immunoglobulins in patients with familial IgA deficiency and common variable immunodeficiency (CVID). Clin Exp Immunol 1997, 108:477-483.
81. Espanol T., Catala M., Hernandez M., Caragol I., Bertran J.M. Development of a common variable immunodeficiency in IgA-deficient patients. Clin Immunol Immunopathol 1996, 80:333-335.
82. Gutierrez M.G., Kirkpatrick C.H. Progressive immunodeficiency in a patient with IgA deficiency. Ann Allergy Asthma Immunol 1997, 79:297-301.
83. Vorechovsky I., Webster A.D., Plebani A., Hammarstrom L. Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition. Am J Hum Genet 1999, 64:1096-1109.
84. Koistinen J. Familial clustering of selective IgA deficiency. Vox Sang 1976, 30:181-190.
85. Vorechovsky I., Zetterquist H., Paganelli R., Koskinen S., Webster A.D., Bjorkander J., et al. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin Immunol Immunopathol 1995, 77:185-192.
86. Jorgensen G.H., Ornolfsson A.E., Johannesson A., Gudmundsson S., Janzi M., Wang N., et al. Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries. Hum Immunol 2011, 72:166-172.
87. Price P., Witt C., Allcock R., Sayer D., Garlepp M., Kok C.C., et al. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol Rev 1999, 167:257-274.
88. Lio D., D'Anna C., Leone F., Curro M.F., Candore G., Caruso C. Hypothesis: interleukin-5 production impairment can be a key point in the pathogenesis of the MHC-linked selective IgA deficiency. Autoimmunity 1998, 27:185-188.
89. Ferreira R.C., Pan-Hammarstrom Q., Graham R.R., Gateva V., Fontan G., Lee A.T., et al. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet 2010, 42:777-780.
90. Rioux J.D., Goyette P., Vyse T.J., Hammarstrom L., Fernando M.M., Green T., et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 2009, 106:18680-18685.
91. Cruz-Tapias P., Perez-Fernandez O.M., Rojas-Villarraga A., Rodriguez-Rodriguez A., Arango M.T., Anaya J.M. Shared HLA class II in six autoimmune diseases in Latin America: a meta-analysis. Autoimmune Dis 2012, 2012:569728.
92. Wang N., Shen N., Vyse T.J., Anand V., Gunnarson I., Sturfelt G., et al. Selective IgA deficiency in autoimmune diseases. Mol Med 2011, 17:1383-1396.
93. Ferreira R.C., Pan-Hammarstrom Q., Graham R.R., Fontan G., Lee A.T., Ortmann W., et al. High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency. PLoS Genet 2012, 8:e1002476.
94. Fiore M., Pera C., Delfino L., Scotese I., Ferrara G.B., Pignata C. DNA typing of DQ and DR alleles in IgA-deficient subjects. Eur J Immunogenet 1995, 22:403-411.
95. Jacob C.M., Pastorino A.C., Fahl K., Carneiro-Sampaio M., Monteiro R.C. Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. J Clin Immunol 2008, 28(Suppl. 1):S56-S61.
96. Cunningham-Rundles C., Brandeis W.E., Pudifin D.J., Day N.K., Good R.A. Autoimmunityin selective IgA deficiency: relationship to anti-bovine protein antibodies, circulating immune complexes and clinical disease. Clin Exp Immunol 1981, 45:299-304.
97. Wells J.V., Michaeli D., Fudenberg H.H. Autoimmunity in selective IgA deficiency. Birth Defects Orig Artic Ser 1975, 11:144-146.
98. Walker L.S. Treg and CTLA-4: two intertwining pathways to immune tolerance. J Autoimmun 2013, 45:49-57.
99. Bour-Jordan H., Thompson H.L., Giampaolo J.R., Davini D., Rosenthal W., Bluestone J.A. Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background. J Autoimmun 2013, 45:58-67.
100. Satake A., Schmidt A.M., Archambault A., Leichner T.M., Wu G.F., Kambayashi T. Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells. J Autoimmun 2013, 44:13-20.
101. Dooms H. Interleukin-7: fuel for the autoimmune attack. J Autoimmun 2013, 45:40-48.
102. Takahashi H., Yamamoto M., Tabeya T., Suzuki C., Naishiro Y., Shinomura Y., et al. The immunobiology and clinical characteristics of IgG4 related diseases. J Autoimmun 2012, 39:93-96.
103. Duarte-Rey C., Bogdanos D.P., Leung P.S., Anaya J.M., Gershwin M.E. IgM predominance in autoimmune disease: genetics and gender. Autoimmun Rev 2012, 11:A404-A412.
104. Pedulla M., Miraglia Del Giudice M., Fierro V., Arrigo T., Gitto E., Salpietro A., et al. Atopy as a risk factor for thyroid autoimmunity in children. J Biol Regul Homeost Agents 2012, 26:S9-S14.
105. Galli L., Chiappini E., de Martino M. Infections and autoimmunity. Pediatr Infect Dis J 2012, 31:1295-1297.
106. Amador-Patarroyo M.J., Arbelaez J.G., Mantilla R.D., Rodriguez-Rodriguez A., Cardenas-Roldan J., Pineda-Tamayo R., et al. Sjogren's syndrome at the crossroad of polyautoimmunity. J Autoimmun 2012, 39:199-205.
107. Rojas-Villarraga A., Amaya-Amaya J., Rodriguez-Rodriguez A., Mantilla R.D., Anaya J.M. Introducing polyautoimmunity: secondary autoimmune diseases no longer exist. Autoimmune Dis 2012, 2012:254319.
108. Singh N., Cohen P.L. The T cell in Sjogren's syndrome: force majeure, not spectateur. J Autoimmun 2012, 39:229-233.
109. Thabet Y., Canas F., Ghedira I., Youinou P., Mageed R.A., Renaudineau Y. Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. J Autoimmun 2012, 39:154-160.
110. Tzioufas A.G., Tatouli I.P., Moutsopoulos H.M. Autoantibodies in Sjogren's syndrome: clinical presentation and regulatory mechanisms. Presse Med 2012, 41:e451-e460.
111. Tzioufas A.G., Vlachoyiannopoulos P.G. Sjogren's syndrome: an update on clinical, basic and diagnostic therapeutic aspects. J Autoimmun 2012, 39:1-3.
112. Tzioufas A.G., Kapsogeorgou E.K., Moutsopoulos H.M. Pathogenesis of Sjogren's syndrome: what we know and what we should learn. J Autoimmun 2012, 39:4-8.
113. Selmi C., Feghali-Bostwick C.A., Lleo A., Lombardi S.A., De Santis M., Cavaciocchi F., et al. X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma. Clin Exp Immunol 2012, 169:253-262.
114. Selmi C., Brunetta E., Raimondo M.G., Meroni P.L. The X chromosome and the sex ratio of autoimmunity. Autoimmun Rev 2012, 11:A531-A537.
115. Moroni L., Bianchi I., Lleo A. Geoepidemiology, gender and autoimmune disease. Autoimmun Rev 2012, 11:A386-A392.
116. Costenbader K.H., Gay S., Alarcon-Riquelme M.E., Iaccarino L., Doria A. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?. Autoimmun Rev 2012, 11:604-609.
117. Lessard C.J., Ice J.A., Adrianto I., Wiley G.B., Kelly J.A., Gaffney P.M., et al. The genomics of autoimmune disease in the era of genome-wide association studies and beyond. Autoimmun Rev 2012, 11:267-275.
118. Santana-de Anda K., Gomez-Martin D., Diaz-Zamudio M., Alcocer-Varela J. Interferon regulatory factors: beyond the antiviral response and their link to the development of autoimmune pathology. Autoimmun Rev 2011, 11:98-103.
119. Cutolo M., Pizzorni C., Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases. Autoimmun Rev 2011, 11:84-87.
120. Selmi C. Autoimmunity in 2010. Autoimmun Rev 2011, 10:725-732.
121. Meda F., Folci M., Baccarelli A., Selmi C. The epigenetics of autoimmunity. Cell Mol Immunol 2011, 8:226-236.
122. Selmi C., Mackay I.R., Gershwin M.E. The autoimmunity of primary biliary cirrhosis and the clonal selection theory. Immunol Cell Biol 2011, 89:70-80.
123. Farhat S.C., Silva C.A., Orione M.A., Campos L.M., Sallum A.M., Braga A.L. Air pollution in autoimmune rheumatic diseases: a review. Autoimmun Rev 2011, 11:14-21.
124. Amur S., Parekh A., Mummaneni P. Sex differences and genomics in autoimmune diseases. J Autoimmun 2012, 38:J254-J265.
125. Persani L., Bonomi M., Lleo A., Pasini S., Civardi F., Bianchi I., et al. Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis. J Autoimmun 2012, 38:J193-J196.
126. Bianchi I., Lleo A., Gershwin M.E., Invernizzi P. The X chromosome and immune associated genes. J Autoimmun 2012, 38:J187-J192.
127. Bogdanos D.P., Smyk D.S., Rigopoulou E.I., Mytilinaiou M.G., Heneghan M.A., Selmi C., et al. Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun 2012, 38:J156-J169.
128. D'Amico F., Skarmoutsou E., Mazzarino M.C. The sex bias in systemic sclerosis: on the possible mechanisms underlying the female disease preponderance. Clin Rev Allergy Immunol 2013 Oct 15, [Electronic publication ahead of print].
129. Takada H. Primary immunodeficiency in Japan; epidemiology, diagnosis, and pathogenesis. Pediatr Int 2013 Sep 24, 10.1111/ped.12224.
130. Jenks J.A., Seki S., Kanai T., Huang J., Morgan A.A., Scalco R.C., et al. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol 2013, 148:227-236.
131. Meini A., Pillan N.M., Villanacci V., Monafo V., Ugazio A.G., Plebani A. Prevalence and diagnosis of celiac disease in IgA-deficient children. Ann Allergy Asthma Immunol 1996, 77:333-336.
132. McGowan K.E., Lyon M.E., Butzner J.D. Celiac disease and IgA deficiency: complications of serological testing approaches encountered in the clinic. Clin Chem 2008, 54:1203-1209.
133. Savilahti E., Pelkonen P., Visakorpi J.K. IgA deficiency in children. A clinical study with special reference to intestinal findings. Arch Dis Child 1971, 46:665-670.
134. Liblau R.S., Caillat-Zucman S., Fischer A.M., Bach J.F., Boitard C. The prevalence of selective IgA deficiency in type 1 diabetes mellitus. APMIS 1992, 100:709-712.
135. Mano T., Kawakubo A., Yamamoto M. Isolated IgA deficiency accompanied by autoimmune thyroid disease. Intern Med 1992, 31:1201-1203.
136. Claman H.N., Merrill D. Serum immunoglobulins in rheumatoid arthritis. J Lab Clin Med 1966, 67:850-854.
137. Huntley C.C., Thorpe D.P., Lyerly A.D., Kelsey W.M. Rheumatoid arthritis with IgA deficiency. Am J Dis Child 1967, 113:411-418.
138. Cassidy J.T., Burt A. Selective hypogammaglobulinemia in rheumatoid arthritis. Univ Mich Med Cent J 1968, 241-243.
139. Tomasi T.B. Human immunoglobulin A. N Engl J Med 1968, 279:1327-1330.
140. Cassidy J.T., Petty R.E., Sullivan D.B. Abnormalities in the distribution of serum immunoglobulin concentrations in juvenile rheumatoid arthritis. J Clin Invest 1973, 52:1931-1936.
141. Panush R.S., Bianco N.E., Schur P.H., Rocklin R.E., David J.R., Stillman J.S. Juvenile rheumatoid arthritis. Cellular hypersensitivity and selective IgA deficiency. Clin Exp Immunol 1972, 10:103-115.
142. Badcock L.J., Clarke S., Jones P.W., Dawes P.T., Mattey D.L. Abnormal IgA levels in patients with rheumatoid arthritis. Ann Rheum Dis 2003, 62:83-84.
143. Davies K., Stiehm E.R., Woo P., Murray K.J. Juvenile idiopathic polyarticular arthritis and IgA deficiency in the 22q11 deletion syndrome. J Rheumatol 2001, 28:2326-2334.
144. Herrero-Beaumont G., Armas J.B., Elswood J., Will R.K., Calin A. Selective IgA deficiency and spondyloarthropathy: a distinct disease?. Ann Rheum Dis 1990, 49:636-637.
145. Mantovani A.P., Monclaro M.P., Skare T.L. Prevalence of IgA deficiency in adult systemic lupus erythematosus and the study of the association with its clinical and autoantibody profiles. Rev Bras Reumatol 2010, 50:273-282.
146. Gershwin M.E., Blaese R.M., Steinberg A.D., Wistar R., Strober W. Antibodies to nucleic acids in congenital immune deficiency states. J Pediatr 1976, 89:377-381.
147. Rankin E.C., Isenberg D.A. IgA deficiency and SLE: prevalence in a clinic population and a review of the literature. Lupus 1997, 6:390-394.
148. Cassidy J.T., Kitson R.K., Selby C.L. Selective IgA deficiency in children and adults with systemic lupus erythematosus. Lupus 2007, 16:647-650.
149. Hansen O.P., Sorensen C.H., Astrup L. Evans' syndrome in IgA deficiency. Episodic autoimmune haemolytic anaemia and thrombocytopenia during a 10years observation period. Scand J Haematol 1982, 29:265-270.
150. Simpson J.A., Behan P.O., Dick H.M. Studies on the nature of autoimmunity in myasthenia gravis. Evidence for an immunodeficiency type. Ann N Y Acad Sci 1976, 274:382-389.
151. Ramanujam R., Piehl F., Pirskanen R., Gregersen P.K., Hammarstrom L. Concomitant autoimmunity in myasthenia gravis-lack of association with IgA deficiency. J Neuroimmunol 2011, 236:118-122.
152. Liblau R., Fischer A.M., Shapiro D.E., Morel E., Bach J.F. The frequency of selective IgA deficiency in myasthenia gravis. Neurology 1992, 42:516-518.
153. Lisak R.P., Zweiman B. Serum immunogloblin levels in myasthenia gravis, polymyositis, and dermatomyositis. J Neurol Neurosurg Psychiatry 1976, 39:34-37.
154. Butler J.E., Oskvig R. Cancer, autoimmunity and IgA-deficiency related by a common antigen-antibody system. Nature 1974, 249:830-833.
155. Plebani A., Monafo V., Ugazio A.G., Monti C., Avanzini M.A., Massimi P., et al. Comparison of the frequency of atopic diseases in children with severe and partial IgA deficiency. Int Arch Allergy Appl Immunol 1987, 82:485-486.
156. Franco A., Parrella R., Murru F., Ames P.R., Martucci F., Rotiroti G., et al. Lack of association between IgA deficiency and respiratory atopy in young male adults. In Vivo 2011, 25:829-832.
157. Kanok J.M., Steinberg P., Cassidy J.T., Petty R.E., Bayne N.K. Serum IgE levels in patients with selective IgA deficiency. Ann Allergy 1978, 41:22-23.
158. Ben Mkaddem S., Rossato E., Heming N., Monteiro R.C. Anti-inflammatory role of the IgA Fc receptor (CD89): from autoimmunity to therapeutic perspectives. Autoimmun Rev 2013, 12:666-669.
159. Ben Mkaddem S., Rossato E., Heming N., Monteiro R.C. Anti-inflammatory role of the IgA Fc receptor (CD89): from autoimmunity to therapeutic perspectives. Autoimmun Rev 2013, 12:666-669.
160. Koistinen J., Sarna S. Immunological abnormalities in the sera of IgA-deficient blood donors. Vox Sang 1975, 29:203-213.
161. Pelkonen P., Savilahti E., Makela A.L. Persistent and transient IgA deficiency in juvenile rheumatoid arthritis. Scand J Rheumatol 1983, 12:273-279.
162. Klemola T. Deficiency of immunoglobulin A. Ann Clin Res 1987, 19:248-257.
163. Koskinen S. Long-term follow-up of health in blood donors with primary selective IgA deficiency. J Clin Immunol 1996, 16:165-170.
164. Jorgensen G.H., Arnlaugsson S., Theodors A., Ludviksson B.R. Immunoglobulin A deficiency and oral health status: a case-control study. J Clin Periodontol 2010, 37:1-8.
165. Heneghan M.A., McHugh P., Stevens F.M., McCarthy C.F. Addison's disease and selective IgA deficiency in two coeliac patients. Scand J Gastroenterol 1997, 32:509-511.
166. Shkalim V., Monselize Y., Segal N., Zan-Bar I., Hoffer V., Garty B.Z. Selective IgA deficiency in children in Israel. J Clin Immunol 2010, 30:761-765.
167. Burgio G.R., Duse M., Monafo V., Ascione A., Nespoli L. Selective IgA deficiency: clinical and immunological evaluation of 50 pediatric patients. Eur J Pediatr 1980, 133:101-106.
168. Luzi G., Businco L., Aiuti F. A national registry for primary immunodeficiency syndromes in Italy: a report for the period 1972-1982. Birth Defects Orig Artic Ser 1983, 19:161-163.
169. Out T.A., van Munster P.J., De Graeff P.A., The T.H., Vossen J.M., Zegers B.J. Immunological investigations in individuals with selective IgA deficiency. Clin Exp Immunol 1986, 64:510-517.
170. Ammann A.J., Hong R. Selective IgA deficiency and autoimmunity. Clin Exp Immunol 1970, 7:833-838.
171. Ammann A.J., Hong R. Selective IgA deficiency and autoimmunity. N Engl J Med 1971, 284:985-986.
172. Stites D.P., Ishizaka K., Fudenberg H.H. Serum IgE concentrations in hypogammaglobulinaemia and selective IgA deficiency. Studies on patients and family members. Clin Exp Immunol 1972, 10:391-397.
173. Edwards E., Razvi S., Cunningham-Rundles C. IgA deficiency: clinical correlates and responses to pneumococcal vaccine. Clin Immunol 2004, 111:93-97.