Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

Science Translational Medicine

Volumn 7, Issue 284, 2015, Pages 284ec65-

  Cuende, Julia ^a   Liénart, Stéphanie ^a   Dedobbeleer, Olivier ^a   Van Der Woning, Bas ^b   De Boeck, Gitte ^b   Stockis, Julie ^a   Huygens, Caroline ^a   Colau, Didier ^c   Somja, Joan ^d   Delvenne, Philippe ^d   Hannon, Muriel ^d   Baron, Frédéric ^d   Dumoutier, Laure ^c   Renauld, Jean Christophe ^c   De Haard, Hans ^b   Saunders, Michael ^b   Coulie, Pierre G ^a   Lucas, Sophie ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b ArGEN X BVBA   (Belgium)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY LHG 10; MONOCLONAL ANTIBODY MHG 8; PROTEIN GARP; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; IMMUNOSUPPRESSIVE AGENT; LRRC32 PROTEIN, HUMAN; LRRC32 PROTEIN, MOUSE; PROTEIN BINDING; TGFB1 PROTEIN, HUMAN; TGFB1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; COMPLEX FORMATION; CONFORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EDITORIAL; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; ANIMAL; AUTOIMMUNITY; BAGG ALBINO MOUSE; CHEMISTRY; IMMUNOLOGY; METABOLISM; METHYLATION; NONOBESE DIABETIC MOUSE; PROTEIN CONFORMATION; SCID MOUSE; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNITY; EPITOPES; GRAFT VS HOST DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MEMBRANE PROTEINS; METHYLATION; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; PROTEIN BINDING; PROTEIN CONFORMATION; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84928683095     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaa1983     Document Type: Editorial

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