Iron Bioavailability from Ferric Pyrophosphate in Extruded Rice Cofortified with Zinc Sulfate Is Greater than When Cofortified with Zinc Oxide in a Human Stable Isotope Study

Journal of Nutrition

Volumn 147, Issue 3, 2017, Pages 377-383

  Hackl, Laura ^a   Zimmermann, Michael B ^a   Zeder, Christophe ^a   Parker, Megan ^b   Johns, Paul W ^c   Hurrell, Richard F ^a   Moretti, Diego ^a  

^a ETH ZURICH   (Switzerland)

^b PATH   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

fortification; human iron absorption; iron deficiency; rice; zinc iron interaction

Indexed keywords

FERRIC PYROPHOSPHATE; IRON; PYROPHOSPHORIC ACID DERIVATIVE; ZINC OXIDE; ZINC SULFATE;

ADULT; BIOAVAILABILITY; CHEMISTRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOOD HANDLING; FORTIFIED FOOD; HUMAN; METABOLISM; ORYZA; YOUNG ADULT;

ADULT; BIOLOGICAL AVAILABILITY; DIPHOSPHATES; FEMALE; FOOD HANDLING; FOOD, FORTIFIED; HUMANS; IRON; IRON ISOTOPES; ORYZA; YOUNG ADULT; ZINC OXIDE; ZINC SULFATE;

EID: 85021854359     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn/116.241778     Document Type: Article

References (39)

1. Muthayya, S, Hall, J, Bagriansky, J, Sugimoto, J, Gundry, D, Matthias, D, Prigge, S, Hindle, P, Moench-Pfanner, R, Maberly, G, Rice fortification: an emerging opportunity to contribute to the elimination of vitamin and mineral deficiency worldwide. Food Nutr Bull 33 (2012), 296–307.
2. Allen, L, De Benoist, B, Hurrell, RF, Dary, O, Guidelines for food fortification with micronutrients. Guidelines for food fortification with micronutrients, 2006.
3. Moretti, D, Zimmermann, MB, Wegmuller, R, Walczyk, T, Zeder, C, Hurrell, RF, Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans. Am J Clin Nutr 83 (2006), 632–638.
4. Johns, PW, Patel, GC, Parker, ME, Lasekan, JB, Milani, P, Nixon, MK, Tigner, M, Schmitz, DJ, Evaluation of the effect of Ultra Rice(R) EDTA supplementation on the soluble iron, visual acceptance and vitamin A stability of commercial milled rice blends. Int J Food Sci Technol 50 (2015), 1615–1624.
5. Parker, ME, Mosites, E, Reider, K, Ndayishimiye, N, Waring, M, Nyandimbane, G, Masumbuko, D, Ndikuriyo, L, Matthias, DA, Blinded, cluster-randomized, placebo-controlled school feeding trial in Burundi using rice fortified with iron, zinc, thiamine, and folic acid. Food Nutr Bull 36 (2015), 481–492.
6. Perignon, M, Fiorentino, M, Kuong, K, Dijkhuizen, MA, Burja, K, Parker, M, Chamnan, C, Berger, J, Wieringa, FT, Impact of multi-micronutrient fortified rice on hemoglobin, iron and vitamin A status of Cambodian schoolchildren: a double-blind cluster-randomized controlled trial. Nutrients, 8, 2016, pii E29.
7. Herman, S, Griffin, IJ, Suwarti, S, Ernawati, S, Permaesih, D, Pambudi, D, Abrams, SA, Cofortification of iron-fortified flour with zinc sulfate, but not zinc oxide, decreases iron absorption in Indonesian children. Am J Clin Nutr 76 (2002), 813–817.
8. Olivares, M, Pizarro, F, Ruz, M, Zinc inhibits nonheme iron bioavailability in humans. Biol Trace Elem Res 117 (2007), 7–14.
9. Olivares, M, Wiedeman, A, Bolivar, L, de Romana, DL, Pizarro, F, Effect of increasing concentrations of zinc on the absorption of iron from iron-fortified milk. Biol Trace Elem Res 150 (2012), 21–25.
10. Crofton, RW, Gvozdanovic, D, Gvozdanovic, S, Khin, CC, Brunt, PW, Mowat, NAG, Aggett, PJ, Inorganic zinc and the intestinal-absorption of ferrous iron. Am J Clin Nutr 50 (1989), 141–144.
11. Olivares, M, Pizarro, F, López de Romaña, D, Effect of zinc sulfate fortificant on iron absorption from low extraction wheat flour co-fortified with ferrous sulfate. Biol Trace Elem Res 151 (2013), 471–475.
12. Hettiarachchi, M, Liyanage, C, Hilmers, D, Griffin, I, Abrams, SA, Changing the zinc:iron ratio in a cereal-based nutritional supplement has no effect on percent absorption of iron and zinc in Sri Lankan children. Br J Nutr 103 (2010), 1015–1022.
13. Olivares, M, Pizarro, F, Ruz, M, de Romana, DL, Acute inhibition of iron bioavailability by zinc: studies in humans. Biometals 25 (2012), 657–664.
14. Olivares, M, Pizarro, F, Gaitan, D, Ruz, M, Acute inhibition of iron absorption by zinc. Nutr Res 27 (2007), 279–282.
15. Rossander-Hultén, L, Brune, M, Sandstr öm, B, Lönnerdal, B, Hallberg, L, Competitive-inhibition of iron-absorption by manganese and zinc in humans. Am J Clin Nutr 54 (1991), 152–156.
16. Moretti, D, Lee, TC, Zimmermann, MB, Nuessli, J, Hurrell, RF, Development and evaluation of iron-fortified extruded rice grains. J Food Sci 70 (2005), S330–S336.
17. Johns, PW, Parker, ME, Patel, GC, Lasekan, JB, Frey, M, Matthias, D, Chanin, ZB, Forsman, CF, Schmitz, DJ, In vitro assay of iron in fortified rice analogues. Food Anal Methods 7 (2014), 902–911.
18. Hackl, L, Cercamondi, CI, Zeder, C, Wild, D, Adelmann, H, Zimmermann, MB, Moretti, D, Cofortification of ferric pyrophosphate and citric acid/trisodium citrate into extruded rice grains doubles iron bioavailability through in situ generation of soluble ferric pyrophosphate citrate complexes. Am J Clin Nutr 103 (2016), 1252–1259.
19. Cercamondi, CI, Egli, IM, Mitchikpe, E, Tossou, F, Zeder, C, Hounhouigan, JD, Hurrell, RF, Total iron absorption by young women from iron-biofortified pearl millet composite meals is double that from regular millet meals but less than that from post-harvest iron-fortified millet meals. J Nutr 143 (2013), 1376–1382.
20. Cercamondi, CI, Egli, IM, Ahouandjinou, E, Dossa, R, Zeder, C, Salami, L, Tjalsma, H, Wiegerinck, E, Tanno, T, Hurrell, RF, Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women. Am J Clin Nutr 92 (2010), 1385–1392.
21. WHO. Iron deficiency anemia. Iron deficiency anemia., 2001.
22. Hotz, K, Krayenbuehl, P-A, Walczyk, T, Mobilization of storage iron is reflected in the iron isotopic composition of blood in humans. J Biol Inorg Chem 17 (2012), 301–309.
23. Turnbull, A, Cleton, F, Finch, CA, Iron absorption. IV. The absorption of hemoglobin iron. J Clin Invest, 41, 1962, 1897.
24. International Atomic Energy Agency. Assessment of iron bioavailability in humans using stable isotope techniques. Assessment of iron bioavailability in humans using stable isotope techniques., 2012.
25. Walczyk, T, Davidsson, L, Zavaleta, N, Hurrell, RF, Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal. Fresenius J Anal Chem 359 (1997), 445–449.
26. Cercamondi, CI, Duchateau, GS, Harika, RK, van den Berg, R, Murray, P, Koppenol, WP, Zeder, C, Zimmermann, MB, Moretti, D, Sodium pyrophosphate enhances iron bioavailability from bouillon cubes fortified with ferric pyrophosphate. Br J Nutr 116 (2016), 496–503.
27. Lawlor, PG, Lynch, PB, Caffrey, PJ, O'Reilly, JJ, O'Connell, MK, Measurements of the acid-binding capacity of ingredients used in pig diets. Ir Vet J 58 (2005), 447–452.
28. Friel, JK, Serfass, RE, Fennessey, PV, Miller, LV, Andrews, WL, Simmons, BS, Downton, GF, Kwa, PG, Elevated intakes of zinc in infant formulas do not interfere with iron absorption in premature infants. J Pediatr Gastroenterol Nutr 27 (1998), 312–316.
29. Espinoza, A, Le Blanc, S, Olivares, M, Pizarro, F, Ruz, M, Arredondo, M, Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA. Biol Trace Elem Res 146 (2012), 281–286.
30. Olivares, M, Fernando, P, Ruz, M, New insights about iron bioavailability inhibition by zinc. Nutrition 23 (2007), 292–295.
31. Iyengar, V, Pullakhandam, R, Nair, KM, Iron-zinc interaction during uptake in human intestinal Caco-2 cell line: kinetic analyses and possible mechanism. Indian J Biochem Biophys 46 (2009), 299–306.
32. Mitchell, CJ, Shawki, A, Ganz, T, Nemeth, E, Mackenzie, B, Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. Am J Physiol Cell Physiol 306 (2014), C450–C459.
33. Hur, SJ, Lim, BO, Decker, EA, McClements, DJ, In vitro human digestion models for food applications. Food Chem 125 (2011), 1–12.
34. Fairweather-Tait, S, Phillips, I, Wortley, G, Harvey, L, Glahn, R, The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability. Int J Vitam Nutr Res 77 (2007), 158–165.
35. Etcheverry, P, Grusak, MA, Fleige, LE, Application of in vitro bioaccessibility and bioavailability methods for calcium, carotenoids, folate, iron, magnesium, polyphenols, zinc, and vitamins B(6), B(12), D, and E. Front Physiol, 3, 2012, 317.
36. de Pee, S, Proposing nutrients and nutrient levels for rice fortification. Ann N Y Acad Sci 1324 (2014), 55–66.
37. Deutsche Gesellschaft für Ernährung ÖGfE, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung. Deutsche Gesellschaft für Ernährung ÖGfE, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung., 2013.
38. Pinkaew, S, Wegmuller, R, Hurrell, R, Vitamin A stability in triple fortified extruded, artificial rice grains containing iron, zinc and vitamin A. Int J Food Sci Technol 47 (2012), 2212–2220.
39. Hunt, JR, Roughead, ZK, Adaptation of iron absorption in men consuming diets with high or low iron bioavailability. Am J Clin Nutr 71 (2000), 94–102.