Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation

Food and Chemical Toxicology

Volumn 107, Issue , 2017, Pages 215-225

  Potočnjak, Iva ^a   Broznić, Dalibor ^a   Kindl, Marija ^b   Kropek, Matija ^c   Vladimir Knežević, Sanda ^b   Domitrović, Robert ^a  

^a UNIVERSITY OF RIJEKA   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c BELUPO Pharmaceuticals   (Croatia)

Author keywords

Apoptosis; Cisplatin nephrotoxicity; Inflammation; Oxidative stress; Stevia rebaudiana; Stevioside

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; CASPASE 9; CISPLATIN; CYCLIN D1; HEME OXYGENASE 1; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; STAT3 PROTEIN; STEVIA REBAUDIANA EXTRACT; STEVIOSIDE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GLUCOSIDE; KAURANE DERIVATIVE; PROTECTIVE AGENT; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; G1 PHASE CELL CYCLE CHECKPOINT; LIMIT OF QUANTITATION; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STEVIA REBAUDIANA; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; KIDNEY; METABOLISM; PATHOPHYSIOLOGY; STEVIA; TOXIC HEPATITIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 9; CHEMICAL AND DRUG INDUCED LIVER INJURY; CISPLATIN; DITERPENES, KAURANE; GLUCOSIDES; HEME OXYGENASE-1; HUMANS; KIDNEY; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; PROTECTIVE AGENTS; STEVIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85021765797     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2017.06.043     Document Type: Article

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