Anaphylatoxin C5a contributes to the pathogenesis of cisplatin-induced nephrotoxicity

American Journal of Physiology - Renal Physiology

Volumn 296, Issue 3, 2009, Pages

  Pan, Hao ^a,b   Shen, Zhoujun ^a   Mukhopadhyay, Partha ^b   Wang, Hua ^b   Pacher, Pal ^b   Qin, Xuebin ^c   Gao, Bin ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Caspase; Cytokines; NF B; STAT3

Indexed keywords

CASPASE; CISPLATIN; COMPLEMENT COMPONENT C5A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; KIDNEY INJURY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD59; ANTINEOPLASTIC AGENTS; CASPASES; CISPLATIN; COMPLEMENT ACTIVATION; COMPLEMENT C5A; COMPLEMENT MEMBRANE ATTACK COMPLEX; CYTOKINES; GENE EXPRESSION; KIDNEY; KIDNEY DISEASES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ANAPHYLATOXIN C5A;

EID: 66049134876     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90443.2008     Document Type: Article

References (36)

1. Acosta J, Qin X, Halperin J. Complement and complement regulatory proteins as potential molecular targets for vascular diseases. Curr Pharm Des 10: 203-211, 2004. (Pubitemid 38072756)
2. Arumugam TV, Shiels IA, Woodruff TM, Granger DN, Taylor SM. The role of the complement system in ischemia-reperfusion injury. Shock 21: 401-409, 2004.
3. Batkai S, Osei-Hyiaman D, Pan H, El-Assal O, Rajesh M, Mukhopadhyay P, Hong F, Harvey-White J, Jafri A, Hasko G, Huffman JW, Gao B, Kunos G, Pacher P. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J 21: 1788-1800, 2007. (Pubitemid 46855625)
4. Berger SP, Daha MR. Complement in glomerular injury. Semin Immunopathol 29: 375-384, 2007.
5. Brown KM, Sacks SH, Sheerin NS. Mechanisms of disease: the complement system in renal injury-new ways of looking at an old foe. Nat Clin Pract Nephrol 3: 277-286, 2007.
6. de Vries B, Kohl J, Leclercq WK, Wolfs TG, van Bijnen AA, Heeringa P, Buurman WA. Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils. J Immunol 170: 3883-3889, 2003. (Pubitemid 36359260)
7. Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther 322: 8-15, 2007. (Pubitemid 46956357)
8. Faubel S, Ljubanovic D, Reznikov L, Somerset H, Dinarello CA, Edelstein CL. Caspase-1-deficient mice are protected against cisplatininduced apoptosis and acute tubular necrosis. Kidney Int 66: 2202-2213, 2004. (Pubitemid 41115283)
9. Horiguchi N, Wang L, Mukhopadhyay P, Park O, Jeong WI, Lafdil F, Osei-Hyiaman D, Moh A, Fu XY, Pacher P, Kunos G, Gao B. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134: 1148-1158, 2008.
10. Lebwohl D, Canetta R. Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer 34: 1522-1534, 1998. (Pubitemid 28446332)
11. Li S, Gokden N, Okusa MD, Bhatt R, Portilla D. Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF. Am J Physiol Renal Physiol 289: F469-F480, 2005. (Pubitemid 41003677)
12. Liu M, Chien CC, Burne-Taney M, Molls RR, Racusen LC, Colvin RB, Rabb H. A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol 17: 765-774, 2006.
13. Matsushima H, Yonemura K, Ohishi K, Hishida A. The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. J Lab Clin Med 131: 518-526, 1998. (Pubitemid 28278570)
14. Megyesi J, Safirstein RL, Price PM. Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure. J Clin Invest 101: 777-782, 1998. (Pubitemid 28096074)
15. Mukhopadhyay P, Batkai S, Rajesh M, Czifra N, Harvey-White J, Hasko G, Zsengeller Z, Gerard NP, Liaudet L, Kunos G, Pacher P. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol 50: 528-536, 2007. (Pubitemid 47126779)
16. Nangaku M, Shankland SJ, Couser WG. Cellular response to injury in membranous nephropathy. J Am Soc Nephrol 16: 1195-1204, 2005. (Pubitemid 41716504)
17. Pickering MC, Warren J, Rose KL, Carlucci F, Wang Y, Walport MJ, Cook HT, Botto M. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci USA 103: 9649-9654, 2006. (Pubitemid 43955879)
18. Pritchard MT, McMullen MR, Stavitsky AB, Cohen JI, Lin F, Medof ME, Nagy LE. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132: 1117-1126, 2007. (Pubitemid 46440876)
19. Qin X, Dobarro M, Bedford SJ, Ferris S, Miranda PV, Song W, Bronson RT, Visconti PE, Halperin JA. Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction. J Immunol 175: 6294-6302, 2005. (Pubitemid 41598868)
20. Qin XHW, Song W, Grubissich L, Hu X, Wu G, Ferris S, Dobarro M, Halperin JA. Generation and phenotyping of mCd59a and mCd59b double-knockout mice. Am J Hematol. In press.
21. Qin X, Krumrei N, Grubissich L, Dobarro M, Aktas H, Perez G, Halperin JA. Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility. Immunity 18: 217-227, 2003. (Pubitemid 36262997)
22. Qin XB, Gao B. The complement system in liver diseases. Cell Mol Immunol 3: 333-340, 2006.
23. Ramesh G, Reeves WB. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 110: 835-842, 2002.
24. Ries F, Klastersky J. Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity. Am J Kidney Dis 8: 368-379, 1986. (Pubitemid 17235084)
25. Schrier RW. Cancer therapy and renal injury. J Clin Invest 110: 743-745, 2002.
26. Sorace JM, Rollins S, Aniagolu JU, Mergner WJ, Cole K, Swartz GM Jr, Green SJ. Role of atheroma liposomes and malondialdehyde-modified low-density lipoproteins in complement activation. Pathobiology 64: 73-78, 1996. (Pubitemid 26297674)
27. Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, Lambris JD. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 198: 913-923, 2003. (Pubitemid 37152928)
28. Sugiyama S, Hayakawa M, Kato T, Hanaki Y, Shimizu K, Ozawa T. Adverse effects of anti-tumor drug, cisplatin, on rat kidney mitochondria: disturbances in glutathione peroxidase activity. Biochem Biophys Res Commun 159: 1121-1127, 1989. (Pubitemid 19101098)
29. Tamano M, Ohi H. Complement activation in cisplatin nephropathy. Nephron 81: 442-443, 1999. (Pubitemid 29150131)
30. Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ischemia/reperfusion. J Immunol 178: 1819-1828, 2007. (Pubitemid 46154654)
31. Walport Complement MJ. First of two parts. N Engl J Med 344: 1058-1066, 2001.
32. Welch TR. The complement system in renal diseases. Nephron 88: 199-204, 2001.
33. Yamada K, Miwa T, Liu J, Nangaku M, Song WC. Critical protection from renal ischemia reperfusion injury by CD55 and CD59. J Immunol 172: 3869-3875, 2004. (Pubitemid 38337974)
34. Yamate J, Tatsumi M, Nakatsuji S, Kuwamura M, Kotani T, Sakuma S. Immunohistochemical observations on the kinetics of macrophages and myofibroblasts in rat renal interstitial fibrosis induced by cis-diamminedichloroplatinum. J Comp Pathol 112: 27-39, 1995.
35. Zheng X, Zhang X, Feng B, Sun H, Suzuki M, Ichim T, Kubo N, Wong A, Min LR, Budohn ME, Garcia B, Jevnikar AM, Min WP. Gene silencing of complement C5a receptor using siRNA for preventing ischemia/reperfusion injury. Am J Pathol 173: 973-980, 2008.
36. Zhou W, Farrar CA, Abe K, Pratt JR, Marsh JE, Wang Y, Stahl GL, Sacks SH. Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 105: 1363-1371, 2000. (Pubitemid 30322402)