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Volumn 82, Issue , 2017, Pages 155-166

Immune checkpoint inhibitors and elderly people: A review

Author keywords

Adverse events; Elderly people; Immune checkpoint inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; TUMOR ANTIGEN;

EID: 85021700064     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2017.05.044     Document Type: Review
Times cited : (152)

References (101)
  • 2
    • 1842732152 scopus 로고    scopus 로고
    • Cancer in older persons: an international issue in an ageing world
    • Yancik, R., Ries, L.A.G., Cancer in older persons: an international issue in an ageing world. Semin Oncol 31 (2004), 128–136.
    • (2004) Semin Oncol , vol.31 , pp. 128-136
    • Yancik, R.1    Ries, L.A.G.2
  • 3
    • 16544371710 scopus 로고    scopus 로고
    • Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration
    • Talarico, L., Chen, G., Pazdur, R., Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol 22 (2004), 4626–4631.
    • (2004) J Clin Oncol , vol.22 , pp. 4626-4631
    • Talarico, L.1    Chen, G.2    Pazdur, R.3
  • 4
    • 0038518557 scopus 로고    scopus 로고
    • Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier?
    • Yee, K.W.L., Pater, J.L., Pho, L., Zee, B., Siu, L.L., Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier?. J Clin Oncol 21 (2003), 1618–1623.
    • (2003) J Clin Oncol , vol.21 , pp. 1618-1623
    • Yee, K.W.L.1    Pater, J.L.2    Pho, L.3    Zee, B.4    Siu, L.L.5
  • 6
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • Linton, P.J., Dorshkind, K., Age-related changes in lymphocyte development and function. Nat Immunol 5 (2004), 133–139.
    • (2004) Nat Immunol , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 8
    • 84961918796 scopus 로고    scopus 로고
    • Effects of ageing on the immune system: infants to elderly
    • Valiathan, R., Ashman, M., Asthana, D., Effects of ageing on the immune system: infants to elderly. Scand J Immunol 83 (2016), 255–266.
    • (2016) Scand J Immunol , vol.83 , pp. 255-266
    • Valiathan, R.1    Ashman, M.2    Asthana, D.3
  • 9
    • 84863593963 scopus 로고    scopus 로고
    • Immune ageing and autoimmunity
    • Goronzy, J.J., Weyand, C.M., Immune ageing and autoimmunity. Cell Mol Life Sci 69 (2012), 1615–1623.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1615-1623
    • Goronzy, J.J.1    Weyand, C.M.2
  • 10
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L., Moorhead, P.S., The serial cultivation of human diploid cell strains. Exp Cell Res 25 (1961), 585–621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 11
    • 84990847690 scopus 로고    scopus 로고
    • Ageing of the immune system: focus on inflammation and vaccination
    • Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., et al. Ageing of the immune system: focus on inflammation and vaccination. Eur J Immunol 46 (2016), 2286–2301.
    • (2016) Eur J Immunol , vol.46 , pp. 2286-2301
    • Pinti, M.1    Appay, V.2    Campisi, J.3    Frasca, D.4    Fülöp, T.5    Sauce, D.6
  • 12
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumour suppressor
    • Coppé, J.-P., Patil, C.K., Rodier, F., Sun, Y., Muñoz, D.P., Goldstein, J., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumour suppressor. PLoS Biol 6 (2008), 2853–2868.
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppé, J.-P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Muñoz, D.P.5    Goldstein, J.6
  • 13
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on ageing and longevity emerged from studies in humans
    • Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., et al. Inflammaging and anti-inflammaging: a systemic perspective on ageing and longevity emerged from studies in humans. Mech Ageing Dev 128 (2007), 92–105.
    • (2007) Mech Ageing Dev , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5    Sevini, F.6
  • 15
    • 85009359407 scopus 로고    scopus 로고
    • Mechanisms underlying T cell immunosenescence: ageing and cytomegalovirus infection
    • Tu, W., Rao, S., Mechanisms underlying T cell immunosenescence: ageing and cytomegalovirus infection. Front Microbiol, 7, 2016, 2111.
    • (2016) Front Microbiol , vol.7 , pp. 2111
    • Tu, W.1    Rao, S.2
  • 19
    • 80052373429 scopus 로고    scopus 로고
    • Immunoaging induced by hematopoietic stem cell ageing
    • Wang, J., Geiger, H., Rudolph, K.L., Immunoaging induced by hematopoietic stem cell ageing. Curr Opin Immunol 23 (2011), 532–536.
    • (2011) Curr Opin Immunol , vol.23 , pp. 532-536
    • Wang, J.1    Geiger, H.2    Rudolph, K.L.3
  • 20
    • 84055200841 scopus 로고    scopus 로고
    • Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
    • Pang, W.W., Price, E.A., Sahoo, D., Beerman, I., Maloney, W.J., Rossi, D.J., et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA 108 (2011), 20012–20017.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 20012-20017
    • Pang, W.W.1    Price, E.A.2    Sahoo, D.3    Beerman, I.4    Maloney, W.J.5    Rossi, D.J.6
  • 22
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi, D.J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., Weissman, I.L., Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447 (2007), 725–729.
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 24
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: the cancer-immunity cycle
    • Chen, D.S., Mellman, I., Oncology meets immunology: the cancer-immunity cycle. Immunity 39 (2013), 1–10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 25
    • 78149319109 scopus 로고    scopus 로고
    • Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
    • Fang, M., Roscoe, F., Sigal, L.J., Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking. J Exp Med 207 (2010), 2369–2381.
    • (2010) J Exp Med , vol.207 , pp. 2369-2381
    • Fang, M.1    Roscoe, F.2    Sigal, L.J.3
  • 26
    • 84927711067 scopus 로고    scopus 로고
    • Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors
    • Metcalf, T.U., Cubas, R.A., Ghneim, K., Cartwright, M.J., Grevenynghe, J.V., Richner, J.M., et al. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Ageing Cell 14 (2015), 421–432.
    • (2015) Ageing Cell , vol.14 , pp. 421-432
    • Metcalf, T.U.1    Cubas, R.A.2    Ghneim, K.3    Cartwright, M.J.4    Grevenynghe, J.V.5    Richner, J.M.6
  • 27
    • 84939516469 scopus 로고    scopus 로고
    • Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance
    • Manser, A.R., Uhrberg, M., Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance. Cancer Immunol Immunother 65 (2016), 417–426.
    • (2016) Cancer Immunol Immunother , vol.65 , pp. 417-426
    • Manser, A.R.1    Uhrberg, M.2
  • 29
    • 84897998839 scopus 로고    scopus 로고
    • Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens
    • White, M.J., Nielsen, C.M., McGregor, R.H.C., Riley, E.H.C., Goodier, M.R., Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens. Immunology 142 (2014), 140–150.
    • (2014) Immunology , vol.142 , pp. 140-150
    • White, M.J.1    Nielsen, C.M.2    McGregor, R.H.C.3    Riley, E.H.C.4    Goodier, M.R.5
  • 30
    • 84866443820 scopus 로고    scopus 로고
    • Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity
    • Hazeldine, J., Hampson, P., Lord, J.M., Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity. Ageing Cell 11 (2012), 751–759.
    • (2012) Ageing Cell , vol.11 , pp. 751-759
    • Hazeldine, J.1    Hampson, P.2    Lord, J.M.3
  • 31
    • 84866449395 scopus 로고    scopus 로고
    • Ageing is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function
    • Hearps, A.C., Martin, G.E., Angelovich, T.A., Cheng, W.-J., Maisa, A., Landay, A.L., et al. Ageing is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Ageing Cell 11 (2012), 867–875.
    • (2012) Ageing Cell , vol.11 , pp. 867-875
    • Hearps, A.C.1    Martin, G.E.2    Angelovich, T.A.3    Cheng, W.-J.4    Maisa, A.5    Landay, A.L.6
  • 32
  • 33
    • 0021279193 scopus 로고
    • Age-dependent changes of the Fc gamma-receptor-mediated functions of human monocytes
    • Fülöp, T., Fóris, G., Wórum, I., Leövey, A., Age-dependent changes of the Fc gamma-receptor-mediated functions of human monocytes. Int Arch Allergy Appl Immunol 74 (1984), 76–79.
    • (1984) Int Arch Allergy Appl Immunol , vol.74 , pp. 76-79
    • Fülöp, T.1    Fóris, G.2    Wórum, I.3    Leövey, A.4
  • 34
    • 78651275576 scopus 로고    scopus 로고
    • Impaired functions of peripheral blood monocyte subpopulations in aged humans
    • Nyugen, J., Agrawal, S., Gollapudi, S., Gupta, S., Impaired functions of peripheral blood monocyte subpopulations in aged humans. J Clin Immunol 30 (2010), 806–813.
    • (2010) J Clin Immunol , vol.30 , pp. 806-813
    • Nyugen, J.1    Agrawal, S.2    Gollapudi, S.3    Gupta, S.4
  • 35
    • 84938984463 scopus 로고    scopus 로고
    • The prognostic landscape of genes and infiltrating immune cells across human cancers
    • Gentles, A.J., Newman, A.M., Liu, C.L., Bratman, S.V., Feng, W., Kim, D., et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med 21 (2015), 938–945.
    • (2015) Nat Med , vol.21 , pp. 938-945
    • Gentles, A.J.1    Newman, A.M.2    Liu, C.L.3    Bratman, S.V.4    Feng, W.5    Kim, D.6
  • 36
    • 4944231755 scopus 로고    scopus 로고
    • Impaired antigen-induced CD8+ T cell clonal expansion in ageing is due to defects in antigen presenting cell function
    • Plowden, J., Renshaw-Hoelscher, M., Gangappa, S., Engleman, C., Katz, J.M., Sambhara, S., Impaired antigen-induced CD8+ T cell clonal expansion in ageing is due to defects in antigen presenting cell function. Cell Immunol 229 (2004), 86–92.
    • (2004) Cell Immunol , vol.229 , pp. 86-92
    • Plowden, J.1    Renshaw-Hoelscher, M.2    Gangappa, S.3    Engleman, C.4    Katz, J.M.5    Sambhara, S.6
  • 37
    • 0035116898 scopus 로고    scopus 로고
    • IFN-γ–dependent transcription of MHC class II IA is impaired in macrophages from aged mice
    • Herrero, C., Marqués, L., Lloberas, J., Celada, A., IFN-γ–dependent transcription of MHC class II IA is impaired in macrophages from aged mice. J Clin Invest 107 (2001), 485–493.
    • (2001) J Clin Invest , vol.107 , pp. 485-493
    • Herrero, C.1    Marqués, L.2    Lloberas, J.3    Celada, A.4
  • 38
    • 51049091671 scopus 로고    scopus 로고
    • Impaired dendritic cell function in ageing leads to defective antitumor immunity
    • Grolleau-Julius, A., Harning, E.K., Abernathy, L.M., Yung, R.L., Impaired dendritic cell function in ageing leads to defective antitumor immunity. Cancer Res 68 (2008), 6341–6349.
    • (2008) Cancer Res , vol.68 , pp. 6341-6349
    • Grolleau-Julius, A.1    Harning, E.K.2    Abernathy, L.M.3    Yung, R.L.4
  • 39
    • 84928473003 scopus 로고    scopus 로고
    • Naive T cell maintenance and function in human ageing
    • Goronzy, J.J., Fang, F., Cavanagh, M.M., Qi, Q., Weyand, C.M., Naive T cell maintenance and function in human ageing. J Immunol 194 (2015), 4073–4080.
    • (2015) J Immunol , vol.194 , pp. 4073-4080
    • Goronzy, J.J.1    Fang, F.2    Cavanagh, M.M.3    Qi, Q.4    Weyand, C.M.5
  • 41
    • 0024329970 scopus 로고
    • Combined grafting of bone marrow and thymus, and sequential multiple thymus graftings in various strains of mice. The effect on immune functions and life span
    • Hirokawa, K., Utsuyama, M., Combined grafting of bone marrow and thymus, and sequential multiple thymus graftings in various strains of mice. The effect on immune functions and life span. Mech Ageing Dev 49 (1989), 49–60.
    • (1989) Mech Ageing Dev , vol.49 , pp. 49-60
    • Hirokawa, K.1    Utsuyama, M.2
  • 42
    • 85006999434 scopus 로고    scopus 로고
    • Lymphocyte generation and population homeostasis throughout life
    • Yanes, R.E., Gustafson, C.E., Weyand, C.M., Goronzy, J.J., Lymphocyte generation and population homeostasis throughout life. Semin Hematol 54 (2017), 33–38.
    • (2017) Semin Hematol , vol.54 , pp. 33-38
    • Yanes, R.E.1    Gustafson, C.E.2    Weyand, C.M.3    Goronzy, J.J.4
  • 43
    • 0034194058 scopus 로고    scopus 로고
    • Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in ageing
    • Fagnoni, F.F., Vescovini, R., Passeri, G., Bologna, G., Pedrazzoni, M., Lavagetto, G., et al. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in ageing. Blood 95 (2000), 2860–2868.
    • (2000) Blood , vol.95 , pp. 2860-2868
    • Fagnoni, F.F.1    Vescovini, R.2    Passeri, G.3    Bologna, G.4    Pedrazzoni, M.5    Lavagetto, G.6
  • 44
    • 84938777751 scopus 로고    scopus 로고
    • Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of west nile virus infection
    • Richner, J.M., Gmyrek, G.B., Govero, J., Tu, Y., van der Windt, G.J.W., Metcalf, T.U., et al. Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of west nile virus infection. PLoS Pathog, 11, 2015, e1005027.
    • (2015) PLoS Pathog , vol.11
    • Richner, J.M.1    Gmyrek, G.B.2    Govero, J.3    Tu, Y.4    van der Windt, G.J.W.5    Metcalf, T.U.6
  • 45
    • 34147138857 scopus 로고    scopus 로고
    • Dendritic cells in human ageing
    • Agrawal, A., Agrawal, S., Gupta, S., Dendritic cells in human ageing. Exp Gerontol 42 (2007), 421–426.
    • (2007) Exp Gerontol , vol.42 , pp. 421-426
    • Agrawal, A.1    Agrawal, S.2    Gupta, S.3
  • 46
    • 84868210702 scopus 로고    scopus 로고
    • Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    • Li, G., Smithey, M.J., Rudd, B.D., Nikolich-Žugich, J., Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium. Ageing Cell 11 (2012), 968–977.
    • (2012) Ageing Cell , vol.11 , pp. 968-977
    • Li, G.1    Smithey, M.J.2    Rudd, B.D.3    Nikolich-Žugich, J.4
  • 47
    • 80655125143 scopus 로고    scopus 로고
    • Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
    • Sridharan, A., Esposo, M., Kaushal, K., Tay, J., Osann, K., Agrawal, S., et al. Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. Age Dordr 33 (2011), 363–376.
    • (2011) Age Dordr , vol.33 , pp. 363-376
    • Sridharan, A.1    Esposo, M.2    Kaushal, K.3    Tay, J.4    Osann, K.5    Agrawal, S.6
  • 49
    • 84864017351 scopus 로고    scopus 로고
    • Role of CD8 T cell replicative senescence in human ageing and in HIV-mediated immunosenescence
    • Dock, J.N., Effros, R.B., Role of CD8 T cell replicative senescence in human ageing and in HIV-mediated immunosenescence. Ageing Dis 2 (2011), 382–397.
    • (2011) Ageing Dis , vol.2 , pp. 382-397
    • Dock, J.N.1    Effros, R.B.2
  • 50
    • 84897530472 scopus 로고    scopus 로고
    • Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling
    • Britanova, O.V., Putintseva, E.V., Shugay, M., Merzlyak, E.M., Turchaninova, M.A., Staroverov, D.B., et al. Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling. J Immunol 192 (2014), 2689–2698.
    • (2014) J Immunol , vol.192 , pp. 2689-2698
    • Britanova, O.V.1    Putintseva, E.V.2    Shugay, M.3    Merzlyak, E.M.4    Turchaninova, M.A.5    Staroverov, D.B.6
  • 51
    • 0032883594 scopus 로고    scopus 로고
    • Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells
    • Whisler, R.L., Chen, M., Liu, B., Newhouse, Y.G., Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells. Mech Ageing Dev 111 (1999), 49–66.
    • (1999) Mech Ageing Dev , vol.111 , pp. 49-66
    • Whisler, R.L.1    Chen, M.2    Liu, B.3    Newhouse, Y.G.4
  • 52
    • 84939566590 scopus 로고    scopus 로고
    • Immunosenescence: implications for response to infection and vaccination in older people
    • Pera, A., Campos, C., López, N., Hassouneh, F., Alonso, C., Tarazona, R., et al. Immunosenescence: implications for response to infection and vaccination in older people. Maturitas 82 (2015), 50–55.
    • (2015) Maturitas , vol.82 , pp. 50-55
    • Pera, A.1    Campos, C.2    López, N.3    Hassouneh, F.4    Alonso, C.5    Tarazona, R.6
  • 53
    • 84886033654 scopus 로고    scopus 로고
    • Human T cell ageing and the impact of persistent viral infections
    • Fülöp, T., Larbi, A., Pawelec, G., Human T cell ageing and the impact of persistent viral infections. Front Immunol, 4, 2013, 271.
    • (2013) Front Immunol , vol.4 , pp. 271
    • Fülöp, T.1    Larbi, A.2    Pawelec, G.3
  • 54
    • 20344379893 scopus 로고    scopus 로고
    • CD28 extinction in human T cells: altered functions and the program of T-cell senescence
    • Vallejo, A.N., CD28 extinction in human T cells: altered functions and the program of T-cell senescence. Immunol Rev 205 (2005), 158–169.
    • (2005) Immunol Rev , vol.205 , pp. 158-169
    • Vallejo, A.N.1
  • 55
    • 0028043586 scopus 로고
    • Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence
    • Effros, R.B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R.L., et al. Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29 (1994), 601–609.
    • (1994) Exp Gerontol , vol.29 , pp. 601-609
    • Effros, R.B.1    Boucher, N.2    Porter, V.3    Zhu, X.4    Spaulding, C.5    Walford, R.L.6
  • 56
    • 0035915738 scopus 로고    scopus 로고
    • Hypothesis: loss of telomerase inducibility and subsequent replicative senescence in cultured human T cells is a result of altered costimulation
    • Pawelec, G., Hypothesis: loss of telomerase inducibility and subsequent replicative senescence in cultured human T cells is a result of altered costimulation. Mech Ageing Dev 121 (2000), 181–185.
    • (2000) Mech Ageing Dev , vol.121 , pp. 181-185
    • Pawelec, G.1
  • 57
    • 49749119446 scopus 로고    scopus 로고
    • Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people
    • Koch, S., Larbi, A., Derhovanessian, E., Ozcelik, D., Naumova, E., Pawelec, G., Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing, 5, 2008, 6.
    • (2008) Immun Ageing , vol.5 , pp. 6
    • Koch, S.1    Larbi, A.2    Derhovanessian, E.3    Ozcelik, D.4    Naumova, E.5    Pawelec, G.6
  • 58
    • 19344370239 scopus 로고    scopus 로고
    • Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    • Papagno, L., Spina, C.A., Marchant, A., Salio, M., Rufer, N., Little, S., et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol, 2, 2004, E20.
    • (2004) PLoS Biol , vol.2 , pp. E20
    • Papagno, L.1    Spina, C.A.2    Marchant, A.3    Salio, M.4    Rufer, N.5    Little, S.6
  • 59
    • 63149184826 scopus 로고    scopus 로고
    • OX40-enhanced tumour rejection and effector T cell differentiation decreases with age
    • Ruby, C.E., Weinberg, A.D., OX40-enhanced tumour rejection and effector T cell differentiation decreases with age. J Immunol 182 (2009), 1481–1489.
    • (2009) J Immunol , vol.182 , pp. 1481-1489
    • Ruby, C.E.1    Weinberg, A.D.2
  • 60
    • 84961677958 scopus 로고    scopus 로고
    • T cells and cancer: how metabolism shapes immunity
    • Molon, B., Calì, B., Viola, A., T cells and cancer: how metabolism shapes immunity. Front Immunol, 7, 2016, 20.
    • (2016) Front Immunol , vol.7 , pp. 20
    • Molon, B.1    Calì, B.2    Viola, A.3
  • 61
    • 0019402106 scopus 로고
    • Lymphokines and ageing: interleukin-2 production and activity in aged animals
    • Thoman, M.L., Weigle, W.O., Lymphokines and ageing: interleukin-2 production and activity in aged animals. J Immunol 127 (1981), 2102–2106.
    • (1981) J Immunol , vol.127 , pp. 2102-2106
    • Thoman, M.L.1    Weigle, W.O.2
  • 62
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    • Wikby, A., Johansson, B., Olsson, J., Löfgren, S., Nilsson, B.O., Ferguson, F., Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 37 (2002), 445–453.
    • (2002) Exp Gerontol , vol.37 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3    Löfgren, S.4    Nilsson, B.O.5    Ferguson, F.6
  • 63
    • 0032524932 scopus 로고    scopus 로고
    • Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study
    • Wikby, A., Maxson, P., Olsson, J., Johansson, B., Ferguson, F.G., Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev 102 (1998), 187–198.
    • (1998) Mech Ageing Dev , vol.102 , pp. 187-198
    • Wikby, A.1    Maxson, P.2    Olsson, J.3    Johansson, B.4    Ferguson, F.G.5
  • 64
    • 84893710050 scopus 로고    scopus 로고
    • Human memory T cells: generation, compartmentalization and homeostasis
    • Farber, D.L., Yudanin, N.A., Restifo, N.P., Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol 14 (2014), 24–35.
    • (2014) Nat Rev Immunol , vol.14 , pp. 24-35
    • Farber, D.L.1    Yudanin, N.A.2    Restifo, N.P.3
  • 65
    • 0037198022 scopus 로고    scopus 로고
    • Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection
    • Po, J.L.Z., Gardner, E.M., Anaraki, F., Katsikis, P.D., Murasko, D.M., Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection. Mech Ageing Dev 123 (2002), 1167–1181.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1167-1181
    • Po, J.L.Z.1    Gardner, E.M.2    Anaraki, F.3    Katsikis, P.D.4    Murasko, D.M.5
  • 66
    • 85013040506 scopus 로고    scopus 로고
    • Immunotherapy comes of age: immune ageing & checkpoint inhibitors
    • Elias, R., Karantanos, T., Sira, E., Hartshorn, K.L., Immunotherapy comes of age: immune ageing & checkpoint inhibitors. J Geriatr Oncol 8 (2017), 229–235.
    • (2017) J Geriatr Oncol , vol.8 , pp. 229-235
    • Elias, R.1    Karantanos, T.2    Sira, E.3    Hartshorn, K.L.4
  • 67
    • 84875658458 scopus 로고    scopus 로고
    • Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer
    • Verschoor, C.P., Johnstone, J., Millar, J., Dorrington, M.G., Habibagahi, M., Lelic, A., et al. Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer. J Leukoc Biol 93 (2013), 633–637.
    • (2013) J Leukoc Biol , vol.93 , pp. 633-637
    • Verschoor, C.P.1    Johnstone, J.2    Millar, J.3    Dorrington, M.G.4    Habibagahi, M.5    Lelic, A.6
  • 68
    • 85013191507 scopus 로고    scopus 로고
    • Immunosenescence and cancer
    • [Epub ahead of print]
    • Pawelec, G., Immunosenescence and cancer. Biogerontology, 2017, 10.1007/s10522-017-9682-z [Epub ahead of print].
    • (2017) Biogerontology
    • Pawelec, G.1
  • 69
    • 37349003404 scopus 로고    scopus 로고
    • Age-related increase of tumour susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice
    • Grizzle, W.E., Xu, X., Zhang, S., Stockard, C.R., Liu, C., Yu, S., et al. Age-related increase of tumour susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice. Mech Ageing Dev 128 (2007), 672–680.
    • (2007) Mech Ageing Dev , vol.128 , pp. 672-680
    • Grizzle, W.E.1    Xu, X.2    Zhang, S.3    Stockard, C.R.4    Liu, C.5    Yu, S.6
  • 70
    • 64249115813 scopus 로고    scopus 로고
    • Induction of myeloid-derived suppressor cells by tumour exosomes
    • Xiang, X., Poliakov, A., Liu, C., Liu, Y., Deng, Z., Wang, J., et al. Induction of myeloid-derived suppressor cells by tumour exosomes. Int J Cancer 124 (2009), 2621–2633.
    • (2009) Int J Cancer , vol.124 , pp. 2621-2633
    • Xiang, X.1    Poliakov, A.2    Liu, C.3    Liu, Y.4    Deng, Z.5    Wang, J.6
  • 71
    • 84927637387 scopus 로고    scopus 로고
    • IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age
    • Tsukamoto, H., Senju, S., Matsumura, K., Swain, S.L., Nishimura, Y., IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age. Nat Commun, 6, 2015, 6702.
    • (2015) Nat Commun , vol.6 , pp. 6702
    • Tsukamoto, H.1    Senju, S.2    Matsumura, K.3    Swain, S.L.4    Nishimura, Y.5
  • 72
    • 49649117750 scopus 로고    scopus 로고
    • Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
    • Lages, C.S., Suffia, I., Velilla, P.A., Huang, B., Warshaw, G., Hildeman, D.A., et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol 181 (2008), 1835–1848.
    • (2008) J Immunol , vol.181 , pp. 1835-1848
    • Lages, C.S.1    Suffia, I.2    Velilla, P.A.3    Huang, B.4    Warshaw, G.5    Hildeman, D.A.6
  • 73
    • 80054108255 scopus 로고    scopus 로고
    • The ageing immune system and its relationship with cancer
    • Foster, A.D., Sivarapatna, A., Gress, R.E., The ageing immune system and its relationship with cancer. Ageing Health 7 (2011), 707–718.
    • (2011) Ageing Health , vol.7 , pp. 707-718
    • Foster, A.D.1    Sivarapatna, A.2    Gress, R.E.3
  • 74
    • 84969988424 scopus 로고    scopus 로고
    • Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial
    • Seiwert, T.Y., Burtness, B., Mehra, R., Weiss, J., Berger, R., Eder, J.P., et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol 17 (2016), 956–965.
    • (2016) Lancet Oncol , vol.17 , pp. 956-965
    • Seiwert, T.Y.1    Burtness, B.2    Mehra, R.3    Weiss, J.4    Berger, R.5    Eder, J.P.6
  • 75
    • 84995489253 scopus 로고    scopus 로고
    • Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: results from the phase Ib KEYNOTE-012 expansion cohort
    • Chow, L.Q.M., Haddad, R., Gupta, S., Mahipal, A., Mehra, R., Tahara, M., et al. Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: results from the phase Ib KEYNOTE-012 expansion cohort. J Clin Oncol 34:32 (2016), 3838–3845, 10.1200/JCO.2016.68.1478.
    • (2016) J Clin Oncol , vol.34 , Issue.32 , pp. 3838-3845
    • Chow, L.Q.M.1    Haddad, R.2    Gupta, S.3    Mahipal, A.4    Mehra, R.5    Tahara, M.6
  • 77
    • 84962497081 scopus 로고    scopus 로고
    • Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study
    • McDermott, D.F., Sosman, J.A., Sznol, M., Massard, C., Gordon, M.S., Hamid, O., et al. Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study. J Clin Oncol 34 (2016), 833–842.
    • (2016) J Clin Oncol , vol.34 , pp. 833-842
    • McDermott, D.F.1    Sosman, J.A.2    Sznol, M.3    Massard, C.4    Gordon, M.S.5    Hamid, O.6
  • 79
    • 85009252187 scopus 로고    scopus 로고
    • Safety and activity of pembrolizumab in patients with locally advanced or metastatic urothelial cancer (KEYNOTE-012): a non-randomised, open-label, phase 1b study
    • Plimack, E.R., Bellmunt, J., Gupta, S., Berger, R., Chow, L.Q.M., Juco, J., et al. Safety and activity of pembrolizumab in patients with locally advanced or metastatic urothelial cancer (KEYNOTE-012): a non-randomised, open-label, phase 1b study. Lancet Oncol 18 (2017), 212–220.
    • (2017) Lancet Oncol , vol.18 , pp. 212-220
    • Plimack, E.R.1    Bellmunt, J.2    Gupta, S.3    Berger, R.4    Chow, L.Q.M.5    Juco, J.6
  • 80
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
    • Rosenberg, J.E., Hoffman-Censits, J., Powles, T., van der Heijden, M.S., Balar, A.V., Necchi, A., et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 387 (2016), 1909–1920.
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    van der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6
  • 81
    • 84989918072 scopus 로고    scopus 로고
    • Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death Ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer
    • Massard, C., Gordon, M.S., Sharma, S., Rafii, S., Wainberg, Z.A., Luke, J., et al. Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death Ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer. J Clin Oncol 34 (2016), 3119–3125.
    • (2016) J Clin Oncol , vol.34 , pp. 3119-3125
    • Massard, C.1    Gordon, M.S.2    Sharma, S.3    Rafii, S.4    Wainberg, Z.A.5    Luke, J.6
  • 82
    • 85007564166 scopus 로고    scopus 로고
    • Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial
    • Balar, A.V., Galsky, M.D., Rosenberg, J.E., Powles, T., Petrylak, D.P., Bellmunt, J., et al. Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial. Lancet 389 (2017), 67–76.
    • (2017) Lancet , vol.389 , pp. 67-76
    • Balar, A.V.1    Galsky, M.D.2    Rosenberg, J.E.3    Powles, T.4    Petrylak, D.P.5    Bellmunt, J.6
  • 83
    • 85015755043 scopus 로고    scopus 로고
    • Pembrolizumab as second-line therapy for advanced urothelial carcinoma
    • Bellmunt, J., de Wit, R., Vaughn, D.J., Fradet, Y., Lee, J.-L., Fong, L., et al. Pembrolizumab as second-line therapy for advanced urothelial carcinoma. N Engl J Med 376 (2017), 1015–1026.
    • (2017) N Engl J Med , vol.376 , pp. 1015-1026
    • Bellmunt, J.1    de Wit, R.2    Vaughn, D.J.3    Fradet, Y.4    Lee, J.-L.5    Fong, L.6
  • 85
    • 84899543113 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab in elderly patients with pretreated advanced melanoma treated at Italian centres through the expanded access programme
    • Chiarion Sileni, V., Pigozzo, J., Ascierto, P.A., Grimaldi, A.M., Maio, M., Di Guardo, L., et al. Efficacy and safety of ipilimumab in elderly patients with pretreated advanced melanoma treated at Italian centres through the expanded access programme. J Exp Clin Cancer Res, 33, 2014, 30.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 30
    • Chiarion Sileni, V.1    Pigozzo, J.2    Ascierto, P.A.3    Grimaldi, A.M.4    Maio, M.5    Di Guardo, L.6
  • 86
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert, C., Thomas, L., Bondarenko, I., O'Day, S., Weber, J., Garbe, C., et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364 (2011), 2517–2526.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.4    Weber, J.5    Garbe, C.6
  • 87
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert, C., Long, G.V., Brady, B., Dutriaux, C., Maio, M., Mortier, L., et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 372 (2015), 320–330.
    • (2015) N Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3    Dutriaux, C.4    Maio, M.5    Mortier, L.6
  • 88
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
    • Weber, J.S., D'Angelo, S.P., Minor, D., Hodi, F.S., Gutzmer, R., Neyns, B., et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 16 (2015), 375–384.
    • (2015) Lancet Oncol , vol.16 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3    Hodi, F.S.4    Gutzmer, R.5    Neyns, B.6
  • 92
    • 85021763900 scopus 로고    scopus 로고
    • Efficacy and safety of checkpoint blockade for treatment of advanced melanoma (mel) in patients (pts) age 80 and older (80+)
    • (suppl; abstr 10009)
    • Friedman, C.F., Claire Frances, T.Z., Minehart, J., Panageas, K., Callahan, M.K., Chapman, P.B., et al. Efficacy and safety of checkpoint blockade for treatment of advanced melanoma (mel) in patients (pts) age 80 and older (80+). J Clin Oncol, 34, 2016 (suppl; abstr 10009).
    • (2016) J Clin Oncol , vol.34
    • Friedman, C.F.1    Claire Frances, T.Z.2    Minehart, J.3    Panageas, K.4    Callahan, M.K.5    Chapman, P.B.6
  • 93
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
    • Herbst, R.S., Baas, P., Kim, D.-W., Felip, E., Pérez-Gracia, J.L., Han, J.-Y., et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387 (2016), 1540–1550.
    • (2016) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.-W.3    Felip, E.4    Pérez-Gracia, J.L.5    Han, J.-Y.6
  • 94
    • 84994802263 scopus 로고    scopus 로고
    • Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer
    • Reck, M., Rodríguez-Abreu, D., Robinson, A.G., Hui, R., Csőszi, T., Fülöp, A., et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med 375 (2016), 1823–1833.
    • (2016) N Engl J Med , vol.375 , pp. 1823-1833
    • Reck, M.1    Rodríguez-Abreu, D.2    Robinson, A.G.3    Hui, R.4    Csőszi, T.5    Fülöp, A.6
  • 95
    • 85008239423 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial
    • Rittmeyer, A., Barlesi, F., Waterkamp, D., Park, K., Ciardiello, F., von Pawel, J., et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet Lond Engl 389 (2017), 255–265.
    • (2017) Lancet Lond Engl , vol.389 , pp. 255-265
    • Rittmeyer, A.1    Barlesi, F.2    Waterkamp, D.3    Park, K.4    Ciardiello, F.5    von Pawel, J.6
  • 96
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D.R., Steins, M., Ready, N.E., et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 373 (2015), 1627–1639.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3    Spigel, D.R.4    Steins, M.5    Ready, N.E.6
  • 98
    • 85018307376 scopus 로고    scopus 로고
    • Efficacy and safety of nivolumab in elderly patients (pts) with advanced squamous non small cell lung cancer (Sq-NSCLC) participating in the expanded access programme (EAP) in Italy
    • 1079P
    • Grossi, F., Crinò, L., Bidoli, P., Delmonte, A., Gelsomino, F., Proto, C., et al. Efficacy and safety of nivolumab in elderly patients (pts) with advanced squamous non small cell lung cancer (Sq-NSCLC) participating in the expanded access programme (EAP) in Italy. Ann Oncol, 27(Suppl. 6), 2016 1079P.
    • (2016) Ann Oncol , vol.27
    • Grossi, F.1    Crinò, L.2    Bidoli, P.3    Delmonte, A.4    Gelsomino, F.5    Proto, C.6
  • 99
    • 84960498096 scopus 로고    scopus 로고
    • Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study
    • Antonia, S., Goldberg, S.B., Balmanoukian, A., Chaft, J.E., Sanborn, R.E., Gupta, A., et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study. Lancet Oncol 17 (2016), 299–308.
    • (2016) Lancet Oncol , vol.17 , pp. 299-308
    • Antonia, S.1    Goldberg, S.B.2    Balmanoukian, A.3    Chaft, J.E.4    Sanborn, R.E.5    Gupta, A.6
  • 100
    • 85013762676 scopus 로고    scopus 로고
    • Treatment of the immune-related adverse effects of immune checkpoint inhibitors: a review
    • Friedman, C.F., Proverbs-Singh, T.A., Postow, M.A., Treatment of the immune-related adverse effects of immune checkpoint inhibitors: a review. JAMA Oncol 2 (2016), 1346–1353.
    • (2016) JAMA Oncol , vol.2 , pp. 1346-1353
    • Friedman, C.F.1    Proverbs-Singh, T.A.2    Postow, M.A.3
  • 101
    • 85006183359 scopus 로고    scopus 로고
    • FDA subset analysis of the safety of nivolumab in elderly patients with advanced cancers
    • (suppl; abstr 10010)
    • Singh, H., Kim, G., Maher, V.E., Beaver, J.A., Pai-Scherf, L.H., Balasubramaniam, S., et al. FDA subset analysis of the safety of nivolumab in elderly patients with advanced cancers. J Clin Oncol, 34, 2016 (suppl; abstr 10010).
    • (2016) J Clin Oncol , vol.34
    • Singh, H.1    Kim, G.2    Maher, V.E.3    Beaver, J.A.4    Pai-Scherf, L.H.5    Balasubramaniam, S.6


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